Result of FASTA (omim) for pF1KB5402
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5402, 384 aa
  1>>>pF1KB5402 384 - 384 aa - 384 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.5413+/-0.000348; mu= 11.3413+/- 0.022
 mean_var=112.7297+/-22.965, 0's: 0 Z-trim(116.7): 148  B-trim: 0 in 0/56
 Lambda= 0.120797
 statistics sampled from 27816 (27998) to 27816 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.693), E-opt: 0.2 (0.328), width:  16
 Scan time:  8.880

The best scores are:                                      opt bits E(85289)
NP_004410 (OMIM: 603069) dual specificity protein  ( 384) 2552 455.6  9e-128
NP_001385 (OMIM: 602747) dual specificity protein  ( 394)  960 178.2   3e-44
NP_004408 (OMIM: 600714) dual specificity protein  ( 367)  949 176.2 1.1e-43
XP_011542730 (OMIM: 602747) PREDICTED: dual specif ( 303)  749 141.3 2.9e-33
NP_476499 (OMIM: 602747) dual specificity protein  ( 303)  749 141.3 2.9e-33
NP_004409 (OMIM: 603068) dual specificity protein  ( 314)  676 128.6   2e-29
XP_016859035 (OMIM: 603068) PREDICTED: dual specif ( 342)  615 118.0 3.4e-26
NP_009138 (OMIM: 608867) dual specificity protein  ( 482)  456 90.4 9.8e-18
NP_001305432 (OMIM: 300134) dual specificity prote ( 384)  424 84.7 3.9e-16
XP_011529426 (OMIM: 300134) PREDICTED: dual specif ( 384)  424 84.7 3.9e-16
NP_001386 (OMIM: 300134) dual specificity protein  ( 384)  424 84.7 3.9e-16
XP_011529425 (OMIM: 300134) PREDICTED: dual specif ( 415)  424 84.8 4.1e-16
NP_001938 (OMIM: 602749) dual specificity protein  ( 419)  424 84.8 4.2e-16
NP_001937 (OMIM: 602748,615269) dual specificity p ( 381)  408 82.0 2.7e-15
XP_006719218 (OMIM: 607175) PREDICTED: dual specif ( 665)  368 75.1 5.2e-13
XP_011519158 (OMIM: 607175) PREDICTED: dual specif ( 665)  368 75.1 5.2e-13
NP_085143 (OMIM: 607175) dual specificity protein  ( 665)  368 75.1 5.2e-13
XP_011519159 (OMIM: 607175) PREDICTED: dual specif ( 665)  368 75.1 5.2e-13
XP_011518235 (OMIM: 602038) PREDICTED: dual specif ( 625)  334 69.2   3e-11
XP_011518234 (OMIM: 602038) PREDICTED: dual specif ( 625)  334 69.2   3e-11
NP_004411 (OMIM: 602038) dual specificity protein  ( 625)  334 69.2   3e-11
NP_008957 (OMIM: 606618) dual specificity protein  ( 198)  322 66.8 5.2e-11
XP_011522536 (OMIM: 606618) PREDICTED: dual specif ( 198)  322 66.8 5.2e-11
XP_005257034 (OMIM: 606618) PREDICTED: dual specif ( 198)  322 66.8 5.2e-11
NP_001154802 (OMIM: 606778) protein phosphatase Sl ( 692)  329 68.4   6e-11
NP_001154803 (OMIM: 606778) protein phosphatase Sl ( 703)  329 68.4   6e-11
XP_016874981 (OMIM: 606778) PREDICTED: protein pho ( 923)  329 68.5 7.5e-11
XP_011536803 (OMIM: 606778) PREDICTED: protein pho ( 969)  329 68.5 7.8e-11
XP_011536802 (OMIM: 606778) PREDICTED: protein pho ( 969)  329 68.5 7.8e-11
XP_005269042 (OMIM: 606778) PREDICTED: protein pho ( 969)  329 68.5 7.8e-11
XP_016874980 (OMIM: 606778) PREDICTED: protein pho (1033)  329 68.5 8.2e-11
XP_005269041 (OMIM: 606778) PREDICTED: protein pho (1049)  329 68.5 8.3e-11
NP_061857 (OMIM: 606778) protein phosphatase Sling (1049)  329 68.5 8.3e-11
XP_011536799 (OMIM: 606778) PREDICTED: protein pho (1060)  329 68.5 8.4e-11
XP_016880742 (OMIM: 606779) PREDICTED: protein pho ( 529)  324 67.4 8.8e-11
XP_016880743 (OMIM: 606779) PREDICTED: protein pho ( 480)  320 66.7 1.3e-10
XP_016880741 (OMIM: 606779) PREDICTED: protein pho (1328)  324 67.7 1.8e-10
XP_011523708 (OMIM: 606779) PREDICTED: protein pho (1347)  324 67.7 1.8e-10
XP_011523709 (OMIM: 606779) PREDICTED: protein pho (1347)  324 67.7 1.8e-10
XP_011523707 (OMIM: 606779) PREDICTED: protein pho (1394)  324 67.7 1.9e-10
XP_006722212 (OMIM: 606779) PREDICTED: protein pho (1401)  324 67.7 1.9e-10
XP_011523706 (OMIM: 606779) PREDICTED: protein pho (1405)  324 67.7 1.9e-10
NP_203747 (OMIM: 606779) protein phosphatase Sling (1423)  324 67.7 1.9e-10
XP_011523704 (OMIM: 606779) PREDICTED: protein pho (1430)  324 67.7 1.9e-10
XP_005258116 (OMIM: 606779) PREDICTED: protein pho (1430)  324 67.7 1.9e-10
XP_016880740 (OMIM: 606779) PREDICTED: protein pho (1449)  324 67.7   2e-10
NP_001269058 (OMIM: 606779) protein phosphatase Sl (1450)  324 67.7   2e-10
XP_005258115 (OMIM: 606779) PREDICTED: protein pho (1450)  324 67.7   2e-10
XP_005253545 (OMIM: 607175) PREDICTED: dual specif ( 517)  313 65.5 3.3e-10
XP_016875477 (OMIM: 607175) PREDICTED: dual specif ( 517)  313 65.5 3.3e-10


>>NP_004410 (OMIM: 603069) dual specificity protein phos  (384 aa)
 initn: 2552 init1: 2552 opt: 2552  Z-score: 2414.9  bits: 455.6 E(85289): 9e-128
Smith-Waterman score: 2552; 99.5% identity (99.5% similar) in 384 aa overlap (1-384:1-384)

               10        20        30        40        50        60
pF1KB5 MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 SARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTPLLACLPAGP
       :::::::::::::::::::::::::::::::::::::::::::::::::: :::::::::
NP_004 SARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 RVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPAYDQGGPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPAYDQGGPV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACMTHLHYKWIPVEDSHTADISS
       ::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
NP_004 EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 HFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 SPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASV
              310       320       330       340       350       360

              370       380    
pF1KB5 LAPVPTHSTVSELSRSPVATATSC
       ::::::::::::::::::::::::
NP_004 LAPVPTHSTVSELSRSPVATATSC
              370       380    

>>NP_001385 (OMIM: 602747) dual specificity protein phos  (394 aa)
 initn: 900 init1: 634 opt: 960  Z-score: 915.4  bits: 178.2 E(85289): 3e-44
Smith-Waterman score: 968; 46.7% identity (67.5% similar) in 381 aa overlap (19-384:41-394)

                           10        20        30        40        
pF1KB5             MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLN
                                     ....:..:::::.:: .:. . ::.::  :
NP_001 DCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCN
               20        30        40        50        60        70

       50        60         70        80        90       100       
pF1KB5 SVVLRRARGGAVSARYVLP-DEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARV
       ..: :::.: .:: . .:: .: .:::: .   :  .::.: :. : . ..:::.:.. .
NP_001 TIVRRRAKG-SVSLEQILPAEEEVRARLRS---GLYSAVIVYDERSPRAESLREDSTVSL
                80        90          100       110       120      

       110       120       130       140              150       160
pF1KB5 VLTPLLACLPAGPRVYFLKGGYETFYSEYPECCVDVK-------PISQEKIESERALISQ
       :.  :         . .:::::: : ::::: :  .:       :.     :      :.
NP_001 VVQALRRNAERTD-ICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSS
        130        140       150       160       170       180     

              170       180       190       200       210       220
pF1KB5 CGKPVVNVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACM
       :: :.        .::::::::::::::::::::.. ..:  : ::::::::    .   
NP_001 CGTPL--------HDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFE
         190               200       210       220       230       

              230       240       250       260       270       280
pF1KB5 THLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMK
        : .:: :::::.: ::::: :.:::..:: :..  :.:::::.:::::: :::.:::: 
NP_001 GHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMM
       240       250       260       270       280       290       

              290       300       310       320       330       340
pF1KB5 TKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIG
        :. ::.:::...:::::..::::.:::::::.::..: .       :: .:::. :  :
NP_001 KKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT-------SCAAEAASPS--G
       300       310       320       330              340          

                   350       360       370         380    
pF1KB5 HLQT-----LSPDMQGAYCTFPASVLAPVPTHSTVSELS--RSPVATATSC
        :.       .:  : .. .::.::     .::. : :   .::..:. ::
NP_001 PLRERGKTPATPTSQFVF-SFPVSV----GVHSAPSSLPYLHSPITTSPSC
      350       360        370           380       390    

>>NP_004408 (OMIM: 600714) dual specificity protein phos  (367 aa)
 initn: 898 init1: 657 opt: 949  Z-score: 905.4  bits: 176.2 E(85289): 1.1e-43
Smith-Waterman score: 1003; 45.4% identity (69.5% similar) in 394 aa overlap (1-384:3-367)

                 10        20        30        40        50        
pF1KB5   MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGG
         :.: .::.  :: .:  : ::.:..:::: ..:: :... ::.:: ....: :::.: 
NP_004 MVMEVGTLDAGGLRALL-GERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKG-
               10         20        30        40        50         

       60        70        80        90       100       110        
pF1KB5 AVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTPLLACLPA
       :.. ....:.   :.:::   .:.  :::.::. :   .  .....  ..:.    :  :
NP_004 AMGLEHIVPNAELRGRLL---AGAYHAVVLLDERSAALDGAKRDGT--LALAAGALCREA
       60        70           80        90       100         110   

       120       130       140              150       160       170
pF1KB5 -GPRVYFLKGGYETFYSEYPECCVDVK-------PISQEKIESERALISQCGKPVVNVSY
        . .:.:::::::.: .  :: :   .       :.:    .: ..  :.:. :.     
NP_004 RAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPL-----
           120       130       140       150       160             

              180       190       200       210       220       230
pF1KB5 RPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACMTHLHYKWIPV
          ::::::::::::::::::::::. ..:  : ::::.:::    .    : .:: :::
NP_004 ---YDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPV
         170       180       190       200       210       220     

              240       250       260       270       280       290
pF1KB5 EDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAF
       ::.: ::::: :.::::::: ... ::.:.:::.:::::: :::.::::.:.. .: :::
NP_004 EDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAF
         230       240       250       260       270       280     

              300       310       320       330       340       350
pF1KB5 DYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQ
       ...:::::..::::.:::::::.::..:        : :..:: ::  .. :.  .    
NP_004 EFVKQRRSIISPNFSFMGQLLQFESQVLA-------PHCSAEA-GSPAMAVLDRGTSTT-
         290       300       310              320        330       

              360       370         380    
pF1KB5 GAYCTFPASVLAPVPTHSTVSELS--RSPVATATSC
        .  .::.:.    :.::: : ::  .::..:. ::
NP_004 -TVFNFPVSI----PVHSTNSALSYLQSPITTSPSC
         340           350       360       

>>XP_011542730 (OMIM: 602747) PREDICTED: dual specificit  (303 aa)
 initn: 734 init1: 634 opt: 749  Z-score: 718.2  bits: 141.3 E(85289): 2.9e-33
Smith-Waterman score: 757; 49.8% identity (67.0% similar) in 273 aa overlap (126-384:53-303)

         100       110       120       130       140               
pF1KB5 WQKLREESAARVVLTPLLACLPAGPRVYFLKGGYETFYSEYPECCVDVK-------PISQ
                                     .:::: : ::::: :  .:       :.  
XP_011 GRDCKPVRAPSMALGVSQLAGRSRCLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPP
             30        40        50        60        70        80  

      150       160       170       180       190       200        
pF1KB5 EKIESERALISQCGKPVVNVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITAL
          :      :.:: :.        .::::::::::::::::::::.. ..:  : ::::
XP_011 SATEPLDLGCSSCGTPL--------HDQGGPVEILPFLYLGSAYHAARRDMLDALGITAL
             90               100       110       120       130    

      210       220       230       240       250       260        
pF1KB5 LNVSRRTSEACMTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGIS
       ::::    .    : .:: :::::.: ::::: :.:::..:: :..  :.:::::.::::
XP_011 LNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGIS
          140       150       160       170       180       190    

      270       280       290       300       310       320        
pF1KB5 RSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPS
       :: :::.::::  :. ::.:::...:::::..::::.:::::::.::..: .       :
XP_011 RSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT-------S
          200       210       220       230       240              

      330       340            350       360       370         380 
pF1KB5 CQGEAAGSSLIGHLQT-----LSPDMQGAYCTFPASVLAPVPTHSTVSELS--RSPVATA
       : .:::. :  : :.       .:  : .. .::.:    : .::. : :   .::..:.
XP_011 CAAEAASPS--GPLRERGKTPATPTSQFVF-SFPVS----VGVHSAPSSLPYLHSPITTS
       250         260       270        280           290       300

          
pF1KB5 TSC
        ::
XP_011 PSC
          

>>NP_476499 (OMIM: 602747) dual specificity protein phos  (303 aa)
 initn: 734 init1: 634 opt: 749  Z-score: 718.2  bits: 141.3 E(85289): 2.9e-33
Smith-Waterman score: 757; 49.8% identity (67.0% similar) in 273 aa overlap (126-384:53-303)

         100       110       120       130       140               
pF1KB5 WQKLREESAARVVLTPLLACLPAGPRVYFLKGGYETFYSEYPECCVDVK-------PISQ
                                     .:::: : ::::: :  .:       :.  
NP_476 GRDCKPVRAPSMALGVSQLAGRSRCLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPP
             30        40        50        60        70        80  

      150       160       170       180       190       200        
pF1KB5 EKIESERALISQCGKPVVNVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITAL
          :      :.:: :.        .::::::::::::::::::::.. ..:  : ::::
NP_476 SATEPLDLGCSSCGTPL--------HDQGGPVEILPFLYLGSAYHAARRDMLDALGITAL
             90               100       110       120       130    

      210       220       230       240       250       260        
pF1KB5 LNVSRRTSEACMTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGIS
       ::::    .    : .:: :::::.: ::::: :.:::..:: :..  :.:::::.::::
NP_476 LNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGIS
          140       150       160       170       180       190    

      270       280       290       300       310       320        
pF1KB5 RSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPS
       :: :::.::::  :. ::.:::...:::::..::::.:::::::.::..: .       :
NP_476 RSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT-------S
          200       210       220       230       240              

      330       340            350       360       370         380 
pF1KB5 CQGEAAGSSLIGHLQT-----LSPDMQGAYCTFPASVLAPVPTHSTVSELS--RSPVATA
       : .:::. :  : :.       .:  : .. .::.:    : .::. : :   .::..:.
NP_476 CAAEAASPS--GPLRERGKTPATPTSQFVF-SFPVS----VGVHSAPSSLPYLHSPITTS
       250         260       270        280           290       300

          
pF1KB5 TSC
        ::
NP_476 PSC
          

>>NP_004409 (OMIM: 603068) dual specificity protein phos  (314 aa)
 initn: 865 init1: 591 opt: 676  Z-score: 649.3  bits: 128.6 E(85289): 2e-29
Smith-Waterman score: 858; 48.3% identity (69.8% similar) in 321 aa overlap (6-318:9-312)

                  10         20        30        40        50      
pF1KB5    MKVTSLDGRQLRKMLRK-EAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRAR
               :.   :  .::  . : : ..:::::.:::   .::..  :  :... ::::
NP_004 MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
               10        20        30        40        50        60

           60        70        80        90       100       110    
pF1KB5 G--GAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTPLLA
       :  .:: :  .:::.: :.::..   : .: .::::.::    .:: .: :.:.:. :: 
NP_004 GPPAAVLA-CLLPDRALRTRLVR---GELARAVVLDEGSASVAELRPDSPAHVLLAALLH
                70        80           90       100       110      

          120        130       140       150       160       170   
pF1KB5 CLPAGPR-VYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPA
          :::  ::::.::.. : .  :. : .. :          ::     :   . :  :.
NP_004 ETRAGPTAVYFLRGGFDGFQGCCPDLCSEA-PAP--------ALPPTGDKTSRSDSRAPV
        120       130       140                150       160       

           180       190       200       210       220             
pF1KB5 YDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACMTHLH----YKWIP
       :::::::::::.:.:::  :.:  . :    :::.::::     .: .:..    :: ::
NP_004 YDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVS----ASCPNHFEGLFRYKSIP
       170       180       190       200           210       220   

     230       240       250       260       270       280         
pF1KB5 VEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEA
       :::.. ..::. ::::: ::: :...::.:::::.:::::: :::.::::.... :: ::
NP_004 VEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEA
           230       240       250       260       270       280   

     290       300       310       320       330       340         
pF1KB5 FDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDM
       ::..::::...::::.:::::::.:...:                               
NP_004 FDFVKQRRGVISPNFSFMGQLLQFETQVLCH                             
           290       300       310                                 

>>XP_016859035 (OMIM: 603068) PREDICTED: dual specificit  (342 aa)
 initn: 821 init1: 591 opt: 615  Z-score: 591.3  bits: 118.0 E(85289): 3.4e-26
Smith-Waterman score: 793; 45.0% identity (66.3% similar) in 347 aa overlap (6-318:9-340)

                  10         20        30        40        50      
pF1KB5    MKVTSLDGRQLRKMLRK-EAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRAR
               :.   :  .::  . : : ..:::::.:::   .::..  :  :... ::::
XP_016 MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
               10        20        30        40        50        60

           60        70        80        90       100       110    
pF1KB5 G--GAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTPLLA
       :  .:: :  .:::.: :.::..   : .: .::::.::    .:: .: :.:.:. :: 
XP_016 GPPAAVLA-CLLPDRALRTRLVR---GELARAVVLDEGSASVAELRPDSPAHVLLAALLH
                70        80           90       100       110      

          120        130       140       150                       
pF1KB5 CLPAGPR-VYFLKGGYETFYSEYPECCVDVKPISQEKIESERALI--------------S
          :::  ::::.:  :     .:     . : :.  . ..:::               .
XP_016 ETRAGPTAVYFLRG--EQAGRPWP-----APPDSSPAFPADRALPLLAGGFDGFQGCCPD
        120       130              140       150       160         

     160              170            180       190       200       
pF1KB5 QCGK-------PVVNVSYR-----PAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITA
        :..       :. . . :     :.:::::::::::.:.:::  :.:  . :    :::
XP_016 LCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITA
     170       180       190       200       210       220         

       210       220           230       240       250       260   
pF1KB5 LLNVSRRTSEACMTHLH----YKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHC
       .::::     .: .:..    :: :::::.. ..::. ::::: ::: :...::.:::::
XP_016 VLNVS----ASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHC
     230           240       250       260       270       280     

           270       280       290       300       310       320   
pF1KB5 EAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPN
       .:::::: :::.::::.... :: ::::..::::...::::.:::::::.:...:     
XP_016 QAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH   
         290       300       310       320       330       340     

           330       340       350       360       370       380   
pF1KB5 PQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATATS

>>NP_009138 (OMIM: 608867) dual specificity protein phos  (482 aa)
 initn: 473 init1: 301 opt: 456  Z-score: 439.4  bits: 90.4 E(85289): 9.8e-18
Smith-Waterman score: 456; 27.7% identity (61.1% similar) in 321 aa overlap (24-331:173-477)

                      10        20        30        40         50  
pF1KB5        MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNL-NSVVL
                                     :..::::.. .  :...:....:  ...  
NP_009 QLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISR
            150       160       170       180       190       200  

             60        70           80        90       100         
pF1KB5 RRARGGAVSARYVLPDEAAR---ARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVL
       :: . : ...  ..  . ..    :....       ..: :... . ...   .  ..::
NP_009 RRLQQGKITVLDLISCREGKDSFKRIFSK------EIIVYDENTNEPSRVMPSQPLHIVL
            210       220       230             240       250      

     110       120       130       140       150          160      
pF1KB5 TPLLACLPAGPRVYFLKGGYETFYSEYPECCVDVKPISQEKIE---SERALISQCGKPVV
         :      : .   ::::  .: ... . : : .   ::  :   .  :  :   .:. 
NP_009 ESLKR---EGKEPLVLKGGLSSFKQNHENLC-DNSLQLQECREVGGGASAASSLLPQPIP
        260          270       280        290       300       310  

        170       180       190       200       210       220      
pF1KB5 NVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACMTH----
       ..   :  ...  . :::::.::.   :.  . .  :.:  ..::   :..  . :    
NP_009 TT---PDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINV---TTHLPLYHYEKG
               320       330       340       350          360      

             230       240       250       260       270       280 
pF1KB5 -LHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKT
        ..:: .:. ::.  .. ..:.::..::. ... :  .:.::.::.::: :: .::::: 
NP_009 LFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKH
        370       380       390       400       410       420      

             290       300       310       320        330       340
pF1KB5 KQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPS-TPNPQPPSCQGEAAGSSLIG
        .. . .:. ..: .: ..:::..::::::..: ..  . ::    :. .:         
NP_009 TRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV    
        430       440       450       460       470       480      

              350       360       370       380    
pF1KB5 HLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATATSC

>>NP_001305432 (OMIM: 300134) dual specificity protein p  (384 aa)
 initn: 538 init1: 315 opt: 424  Z-score: 410.7  bits: 84.7 E(85289): 3.9e-16
Smith-Waterman score: 545; 33.0% identity (57.1% similar) in 382 aa overlap (15-357:11-383)

               10        20           30        40        50       
pF1KB5 MKVTSLDGRQLRKMLRKEAAA---RCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARG
                     ::.: .    : ..::::    . .. . :.:.: : ...::: : 
NP_001     MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRR
                   10        20        30        40        50      

        60        70        80        90       100            110  
pF1KB5 GAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLR-----EESAARVVLTPL
       :..:.: .::        ::      : :.. :::. . .. .     ::  :. ::  :
NP_001 GSLSVRALLPGPP-----LQPPPP--APVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTL
         60             70          80        90       100         

             120       130       140                               
pF1KB5 LACL-PAGPRVYFLKGGYETFYSEYPECC---------VDVKPI----------------
       :  :   :  .:.:.::.  : .: :. :          .. :.                
NP_001 LQKLREEGYLAYYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGS
     110       120       130       140       150       160         

          150       160       170        180       190       200   
pF1KB5 --SQEKIESERALISQCGKPVVNVSYRPAYDQGG-PVEILPFLYLGSAYHASKCEFLANL
         :. . :..:  .: ::    ...  :.  ... ::.::: ::::::  ... : ::.:
NP_001 DCSDAESEADRDSMS-CGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKL
     170       180        190       200       210       220        

           210       220         230       240       250       260 
pF1KB5 HITALLNVSRRTSEACMTH--LHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLV
        :  .:::.    .    .  .::: ::. :  . ..:  : :::.::: .  ..  :::
NP_001 GIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLV
      230       240       250       260       270       280        

             270       280       290       300       310       320 
pF1KB5 HCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPST
       :: ::.::: :. .::::.  .. :..:.: .:...: .::::.::::::..:  .    
NP_001 HCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEE
      290       300       310       320       330       340        

             330       340       350       360       370       380 
pF1KB5 PNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATA
        . :  .  :.:...:    . : .:  .::.   :                        
NP_001 RHSQEQGSGGQASAASNPPSFFT-TPTSDGAFELAPT                       
      350       360       370        380                           

          
pF1KB5 TSC

>>XP_011529426 (OMIM: 300134) PREDICTED: dual specificit  (384 aa)
 initn: 538 init1: 315 opt: 424  Z-score: 410.7  bits: 84.7 E(85289): 3.9e-16
Smith-Waterman score: 545; 33.0% identity (57.1% similar) in 382 aa overlap (15-357:11-383)

               10        20           30        40        50       
pF1KB5 MKVTSLDGRQLRKMLRKEAAA---RCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARG
                     ::.: .    : ..::::    . .. . :.:.: : ...::: : 
XP_011     MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRR
                   10        20        30        40        50      

        60        70        80        90       100            110  
pF1KB5 GAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLR-----EESAARVVLTPL
       :..:.: .::        ::      : :.. :::. . .. .     ::  :. ::  :
XP_011 GSLSVRALLPGPP-----LQPPPP--APVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTL
         60             70          80        90       100         

             120       130       140                               
pF1KB5 LACL-PAGPRVYFLKGGYETFYSEYPECC---------VDVKPI----------------
       :  :   :  .:.:.::.  : .: :. :          .. :.                
XP_011 LQKLREEGYLAYYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGS
     110       120       130       140       150       160         

          150       160       170        180       190       200   
pF1KB5 --SQEKIESERALISQCGKPVVNVSYRPAYDQGG-PVEILPFLYLGSAYHASKCEFLANL
         :. . :..:  .: ::    ...  :.  ... ::.::: ::::::  ... : ::.:
XP_011 DCSDAESEADRDSMS-CGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKL
     170       180        190       200       210       220        

           210       220         230       240       250       260 
pF1KB5 HITALLNVSRRTSEACMTH--LHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLV
        :  .:::.    .    .  .::: ::. :  . ..:  : :::.::: .  ..  :::
XP_011 GIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLV
      230       240       250       260       270       280        

             270       280       290       300       310       320 
pF1KB5 HCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPST
       :: ::.::: :. .::::.  .. :..:.: .:...: .::::.::::::..:  .    
XP_011 HCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEE
      290       300       310       320       330       340        

             330       340       350       360       370       380 
pF1KB5 PNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATA
        . :  .  :.:...:    . : .:  .::.   :                        
XP_011 RHSQEQGSGGQASAASNPPSFFT-TPTSDGAFELAPT                       
      350       360       370        380                           

          
pF1KB5 TSC




384 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 02:11:36 2016 done: Sat Nov  5 02:11:38 2016
 Total Scan time:  8.880 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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