Result of FASTA (omim) for pF1KA0054
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0054, 1942 aa
  1>>>pF1KA0054 1942 - 1942 aa - 1942 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.1806+/-0.000502; mu= -6.6964+/- 0.031
 mean_var=459.1821+/-96.596, 0's: 0 Z-trim(120.0): 83  B-trim: 333 in 2/57
 Lambda= 0.059852
 statistics sampled from 34560 (34647) to 34560 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.406), width:  16
 Scan time: 20.810

The best scores are:                                      opt bits E(85289)
NP_055692 (OMIM: 606699) probable helicase with zi (1942) 13193 1155.8       0
NP_001317376 (OMIM: 606699) probable helicase with (1943) 13181 1154.8       0
XP_016880966 (OMIM: 606699) PREDICTED: probable he (1707) 11618 1019.7       0
XP_016880967 (OMIM: 606699) PREDICTED: probable he (1551) 10564 928.7       0
XP_005257945 (OMIM: 606699) PREDICTED: probable he (1969) 10050 884.4       0
XP_006722279 (OMIM: 606699) PREDICTED: probable he (1578) 10038 883.3       0
XP_006722278 (OMIM: 606699) PREDICTED: probable he (1735) 10038 883.3       0
XP_011523846 (OMIM: 606699) PREDICTED: probable he (1970) 10038 883.4       0
XP_006722277 (OMIM: 606699) PREDICTED: probable he (1970) 10038 883.4       0
NP_001032412 (OMIM: 611265) helicase with zinc fin (2649) 1101 111.8 9.8e-23
NP_208384 (OMIM: 611265) helicase with zinc finger (2080)  769 83.0 3.5e-14
XP_016856808 (OMIM: 610742) PREDICTED: putative he ( 936)  352 46.7  0.0014


>>NP_055692 (OMIM: 606699) probable helicase with zinc f  (1942 aa)
 initn: 13193 init1: 13193 opt: 13193  Z-score: 6173.9  bits: 1155.8 E(85289):    0
Smith-Waterman score: 13193; 100.0% identity (100.0% similar) in 1942 aa overlap (1-1942:1-1942)

               10        20        30        40        50        60
pF1KA0 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 KVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 KQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 CEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQ
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 LPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LPPVLIIGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 QARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 LDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNL
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 HVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 HVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPL
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGI
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 TFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDH
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 FQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYG
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 GNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVT
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 IGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPES
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 RPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLL
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 NQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRP
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KA0 QSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIH
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KA0 GSVALETLRQQQARFQQWSEHHAFLSQGSVPYPHHHHPHLQHLPQPPLGLHQPPVRADWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GSVALETLRQQQARFQQWSEHHAFLSQGSVPYPHHHHPHLQHLPQPPLGLHQPPVRADWK
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KA0 LTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPS
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KA0 PPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPD
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KA0 GAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSS
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KA0 SLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSS
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KA0 PESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVL
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KA0 QHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPL
             1870      1880      1890      1900      1910      1920

             1930      1940  
pF1KA0 SLFQELSLGSSSGSNGFYSYFK
       ::::::::::::::::::::::
NP_055 SLFQELSLGSSSGSNGFYSYFK
             1930      1940  

>>NP_001317376 (OMIM: 606699) probable helicase with zin  (1943 aa)
 initn: 8663 init1: 8663 opt: 13181  Z-score: 6168.3  bits: 1154.8 E(85289):    0
Smith-Waterman score: 13181; 99.9% identity (99.9% similar) in 1943 aa overlap (1-1942:1-1943)

               10        20        30        40        50        60
pF1KA0 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 KVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVP
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 KQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 CEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQ
              610       620       630       640       650       660

              670       680       690        700       710         
pF1KA0 LPPVLIIGPYGTGKTFTLAQAVKHILQQQET-RILICTHSNSAADLYIKDYLHPYVEAGN
       ::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 LPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGN
              670       680       690       700       710       720

     720       730       740       750       760       770         
pF1KA0 PQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLC
              730       740       750       760       770       780

     780       790       800       810       820       830         
pF1KA0 QLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERN
              790       800       810       820       830       840

     840       850       860       870       880       890         
pF1KA0 LHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYP
              850       860       870       880       890       900

     900       910       920       930       940       950         
pF1KA0 LTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQ
              910       920       930       940       950       960

     960       970       980       990      1000      1010         
pF1KA0 VFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDS
              970       980       990      1000      1010      1020

    1020      1030      1040      1050      1060      1070         
pF1KA0 TEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHG
             1030      1040      1050      1060      1070      1080

    1080      1090      1100      1110      1120      1130         
pF1KA0 ITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQND
             1090      1100      1110      1120      1130      1140

    1140      1150      1160      1170      1180      1190         
pF1KA0 HFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVY
             1150      1160      1170      1180      1190      1200

    1200      1210      1220      1230      1240      1250         
pF1KA0 GGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPV
             1210      1220      1230      1240      1250      1260

    1260      1270      1280      1290      1300      1310         
pF1KA0 TIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPE
             1270      1280      1290      1300      1310      1320

    1320      1330      1340      1350      1360      1370         
pF1KA0 SRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTL
             1330      1340      1350      1360      1370      1380

    1380      1390      1400      1410      1420      1430         
pF1KA0 LNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHR
             1390      1400      1410      1420      1430      1440

    1440      1450      1460      1470      1480      1490         
pF1KA0 PQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRI
             1450      1460      1470      1480      1490      1500

    1500      1510      1520      1530      1540      1550         
pF1KA0 HGSVALETLRQQQARFQQWSEHHAFLSQGSVPYPHHHHPHLQHLPQPPLGLHQPPVRADW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGSVALETLRQQQARFQQWSEHHAFLSQGSVPYPHHHHPHLQHLPQPPLGLHQPPVRADW
             1510      1520      1530      1540      1550      1560

    1560      1570      1580      1590      1600      1610         
pF1KA0 KLTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVP
             1570      1580      1590      1600      1610      1620

    1620      1630      1640      1650      1660      1670         
pF1KA0 SPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAP
             1630      1640      1650      1660      1670      1680

    1680      1690      1700      1710      1720      1730         
pF1KA0 DGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSS
             1690      1700      1710      1720      1730      1740

    1740      1750      1760      1770      1780      1790         
pF1KA0 SSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFS
             1750      1760      1770      1780      1790      1800

    1800      1810      1820      1830      1840      1850         
pF1KA0 SPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSV
             1810      1820      1830      1840      1850      1860

    1860      1870      1880      1890      1900      1910         
pF1KA0 LQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDP
             1870      1880      1890      1900      1910      1920

    1920      1930      1940  
pF1KA0 LSLFQELSLGSSSGSNGFYSYFK
       :::::::::::::::::::::::
NP_001 LSLFQELSLGSSSGSNGFYSYFK
             1930      1940   

>>XP_016880966 (OMIM: 606699) PREDICTED: probable helica  (1707 aa)
 initn: 11618 init1: 11618 opt: 11618  Z-score: 5439.6  bits: 1019.7 E(85289):    0
Smith-Waterman score: 11618; 99.9% identity (100.0% similar) in 1707 aa overlap (236-1942:1-1707)

         210       220       230       240       250       260     
pF1KA0 EELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHN
                                     ::::::::::::::::::::::::::::::
XP_016                               METLIEKWMNSLSPEKVLSECIEGVKVEHN
                                             10        20        30

         270       280       290       300       310       320     
pF1KA0 PDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEV
               40        50        60        70        80        90

         330       340       350       360       370       380     
pF1KA0 PENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAAS
              100       110       120       130       140       150

         390       400       410       420       430       440     
pF1KA0 TEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQS
              160       170       180       190       200       210

         450       460       470       480       490       500     
pF1KA0 VLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFMLTGVSGGAKYAQNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFMLTGVSGGAKYAQNG
              220       230       240       250       260       270

         510       520       530       540       550       560     
pF1KA0 QLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKE
              280       290       300       310       320       330

         570       580       590       600       610       620     
pF1KA0 YIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPT
              340       350       360       370       380       390

         630       640       650       660       670       680     
pF1KA0 IPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHI
              400       410       420       430       440       450

         690       700       710       720       730       740     
pF1KA0 LQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYC
              460       470       480       490       500       510

         750       760       770       780       790       800     
pF1KA0 LISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETI
              520       530       540       550       560       570

         810       820       830       840       850       860     
pF1KA0 MPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCEN
              580       590       600       610       620       630

         870       880       890       900       910       920     
pF1KA0 YRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVF
              640       650       660       670       680       690

         930       940       950       960       970       980     
pF1KA0 EVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQG
              700       710       720       730       740       750

         990      1000      1010      1020      1030      1040     
pF1KA0 KQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLV
              760       770       780       790       800       810

        1050      1060      1070      1080      1090      1100     
pF1KA0 AVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAP
              820       830       840       850       860       870

        1110      1120      1130      1140      1150      1160     
pF1KA0 EFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPP
              880       890       900       910       920       930

        1170      1180      1190      1200      1210      1220     
pF1KA0 PPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPR
              940       950       960       970       980       990

        1230      1240      1250      1260      1270      1280     
pF1KA0 IITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTN
             1000      1010      1020      1030      1040      1050

        1290      1300      1310      1320      1330      1340     
pF1KA0 NSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLP
             1060      1070      1080      1090      1100      1110

        1350      1360      1370      1380      1390      1400     
pF1KA0 LPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQ
             1120      1130      1140      1150      1160      1170

        1410      1420      1430      1440      1450      1460     
pF1KA0 SQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPL
             1180      1190      1200      1210      1220      1230

        1470      1480      1490      1500      1510      1520     
pF1KA0 RAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFL
             1240      1250      1260      1270      1280      1290

        1530      1540      1550      1560      1570      1580     
pF1KA0 SQGSVPYPHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSH
       ::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQGSAPYPHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSH
             1300      1310      1320      1330      1340      1350

        1590      1600      1610      1620      1630      1640     
pF1KA0 RDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVAS
             1360      1370      1380      1390      1400      1410

        1650      1660      1670      1680      1690      1700     
pF1KA0 NPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPL
             1420      1430      1440      1450      1460      1470

        1710      1720      1730      1740      1750      1760     
pF1KA0 PHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSS
             1480      1490      1500      1510      1520      1530

        1770      1780      1790      1800      1810      1820     
pF1KA0 SVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTA
             1540      1550      1560      1570      1580      1590

        1830      1840      1850      1860      1870      1880     
pF1KA0 QPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQ
             1600      1610      1620      1630      1640      1650

        1890      1900      1910      1920      1930      1940  
pF1KA0 SSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
             1660      1670      1680      1690      1700       

>>XP_016880967 (OMIM: 606699) PREDICTED: probable helica  (1551 aa)
 initn: 8658 init1: 8658 opt: 10564  Z-score: 4948.3  bits: 928.7 E(85289):    0
Smith-Waterman score: 10564; 99.9% identity (99.9% similar) in 1551 aa overlap (393-1942:1-1551)

            370       380       390       400       410       420  
pF1KA0 QTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETT
                                     ::::::::::::::::::::::::::::::
XP_016                               MHAKQQLVTTAKRWDSSSKTIIDFEPNETT
                                             10        20        30

            430       440       450       460       470       480  
pF1KA0 DLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKV
               40        50        60        70        80        90

            490       500       510       520       530       540  
pF1KA0 QLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQ
              100       110       120       130       140       150

            550       560       570       580       590       600  
pF1KA0 KLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCE
              160       170       180       190       200       210

            610       620       630       640       650       660  
pF1KA0 MHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLAIQLP
              220       230       240       250       260       270

            670       680       690        700       710       720 
pF1KA0 PVLIIGPYGTGKTFTLAQAVKHILQQQET-RILICTHSNSAADLYIKDYLHPYVEAGNPQ
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_016 PVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQ
              280       290       300       310       320       330

             730       740       750       760       770       780 
pF1KA0 ARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQL
              340       350       360       370       380       390

             790       800       810       820       830       840 
pF1KA0 DLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLH
              400       410       420       430       440       450

             850       860       870       880       890       900 
pF1KA0 VSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLT
              460       470       480       490       500       510

             910       920       930       940       950       960 
pF1KA0 FFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVF
              520       530       540       550       560       570

             970       980       990      1000      1010      1020 
pF1KA0 RIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTE
              580       590       600       610       620       630

            1030      1040      1050      1060      1070      1080 
pF1KA0 DLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGIT
              640       650       660       670       680       690

            1090      1100      1110      1120      1130      1140 
pF1KA0 FEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHF
              700       710       720       730       740       750

            1150      1160      1170      1180      1190      1200 
pF1KA0 QNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGG
              760       770       780       790       800       810

            1210      1220      1230      1240      1250      1260 
pF1KA0 NVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHPPVTI
              820       830       840       850       860       870

            1270      1280      1290      1300      1310      1320 
pF1KA0 GQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESR
              880       890       900       910       920       930

            1330      1340      1350      1360      1370      1380 
pF1KA0 PSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQHTLLN
              940       950       960       970       980       990

            1390      1400      1410      1420      1430      1440 
pF1KA0 QQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVAHRPQ
             1000      1010      1020      1030      1040      1050

            1450      1460      1470      1480      1490      1500 
pF1KA0 SPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALDRIHG
             1060      1070      1080      1090      1100      1110

            1510      1520      1530      1540      1550      1560 
pF1KA0 SVALETLRQQQARFQQWSEHHAFLSQGSVPYPHHHHPHLQHLPQPPLGLHQPPVRADWKL
       ::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
XP_016 SVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPLGLHQPPVRADWKL
             1120      1130      1140      1150      1160      1170

            1570      1580      1590      1600      1610      1620 
pF1KA0 TSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPAVPSP
             1180      1190      1200      1210      1220      1230

            1630      1640      1650      1660      1670      1680 
pF1KA0 PSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYLAPDG
             1240      1250      1260      1270      1280      1290

            1690      1700      1710      1720      1730      1740 
pF1KA0 AWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTVSSSS
             1300      1310      1320      1330      1340      1350

            1750      1760      1770      1780      1790      1800 
pF1KA0 LPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFNFSSP
             1360      1370      1380      1390      1400      1410

            1810      1820      1830      1840      1850      1860 
pF1KA0 ESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNYSVLQ
             1420      1430      1440      1450      1460      1470

            1870      1880      1890      1900      1910      1920 
pF1KA0 HLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSSDPLS
             1480      1490      1500      1510      1520      1530

            1930      1940  
pF1KA0 LFQELSLGSSSGSNGFYSYFK
       :::::::::::::::::::::
XP_016 LFQELSLGSSSGSNGFYSYFK
             1540      1550 

>>XP_005257945 (OMIM: 606699) PREDICTED: probable helica  (1969 aa)
 initn: 13168 init1: 10045 opt: 10050  Z-score: 4707.0  bits: 884.4 E(85289):    0
Smith-Waterman score: 13118; 98.5% identity (98.6% similar) in 1969 aa overlap (1-1942:1-1969)

               10        20        30        40        50        60
pF1KA0 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
              370       380       390       400       410       420

              430       440       450       460       470          
pF1KA0 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISK---
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.   
XP_005 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISNTSG
              430       440       450       460       470       480

                               480       490       500       510   
pF1KA0 ------------------------FNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKL
                               ::::::::::::::::::::::::::::::::::::
XP_005 ASTSRILLQDTTNVTRGFSCCSKLFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKL
              490       500       510       520       530       540

           520       530       540       550       560       570   
pF1KA0 TETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSR
              550       560       570       580       590       600

           580       590       600       610       620       630   
pF1KA0 ECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQ
              610       620       630       640       650       660

           640       650       660       670       680       690   
pF1KA0 WDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETRI
              670       680       690       700       710       720

           700       710       720       730       740       750   
pF1KA0 LICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHST
              730       740       750       760       770       780

           760       770       780       790       800       810   
pF1KA0 FQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQ
              790       800       810       820       830       840

           820       830       840       850       860       870   
pF1KA0 NTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAII
              850       860       870       880       890       900

           880       890       900       910       920       930   
pF1KA0 NYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEE
              910       920       930       940       950       960

           940       950       960       970       980       990   
pF1KA0 LRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFL
              970       980       990      1000      1010      1020

          1000      1010      1020      1030      1040      1050   
pF1KA0 STVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIA
             1030      1040      1050      1060      1070      1080

          1060      1070      1080      1090      1100      1110   
pF1KA0 LCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALR
             1090      1100      1110      1120      1130      1140

          1120      1130      1140      1150      1160      1170   
pF1KA0 LQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPN
             1150      1160      1170      1180      1190      1200

          1180      1190      1200      1210      1220      1230   
pF1KA0 LGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAM
             1210      1220      1230      1240      1250      1260

          1240      1250      1260      1270      1280      1290   
pF1KA0 AYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINK
             1270      1280      1290      1300      1310      1320

          1300      1310      1320      1330      1340      1350   
pF1KA0 IRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQY
             1330      1340      1350      1360      1370      1380

          1360      1370      1380      1390      1400      1410   
pF1KA0 AIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQ
             1390      1400      1410      1420      1430      1440

          1420      1430      1440      1450      1460      1470   
pF1KA0 QPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGP
             1450      1460      1470      1480      1490      1500

          1480      1490      1500      1510      1520      1530   
pF1KA0 ILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSVPYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::
XP_005 ILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPYP
             1510      1520      1530      1540      1550      1560

          1540      1550      1560      1570      1580      1590   
pF1KA0 HHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETRE
             1570      1580      1590      1600      1610      1620

          1600      1610      1620      1630      1640      1650   
pF1KA0 LAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRL
             1630      1640      1650      1660      1670      1680

          1660      1670      1680      1690      1700      1710   
pF1KA0 PPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNP
             1690      1700      1710      1720      1730      1740

          1720      1730      1740      1750      1760      1770   
pF1KA0 FVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEE
             1750      1760      1770      1780      1790      1800

          1780      1790      1800      1810      1820      1830   
pF1KA0 VSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAP
             1810      1820      1830      1840      1850      1860

          1840      1850      1860      1870      1880      1890   
pF1KA0 PKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPA
             1870      1880      1890      1900      1910      1920

          1900      1910      1920      1930      1940  
pF1KA0 MSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
             1930      1940      1950      1960         

>>XP_006722279 (OMIM: 606699) PREDICTED: probable helica  (1578 aa)
 initn: 9169 init1: 8658 opt: 10038  Z-score: 4702.7  bits: 883.3 E(85289):    0
Smith-Waterman score: 10494; 98.1% identity (98.2% similar) in 1578 aa overlap (393-1942:1-1578)

            370       380       390       400       410       420  
pF1KA0 QTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETT
                                     ::::::::::::::::::::::::::::::
XP_006                               MHAKQQLVTTAKRWDSSSKTIIDFEPNETT
                                             10        20        30

            430       440       450       460       470            
pF1KA0 DLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISK-----
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::.     
XP_006 DLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISNTSGAS
               40        50        60        70        80        90

                             480       490       500       510     
pF1KA0 ----------------------FNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTE
                             ::::::::::::::::::::::::::::::::::::::
XP_006 TSRILLQDTTNVTRGFSCCSKLFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTE
              100       110       120       130       140       150

         520       530       540       550       560       570     
pF1KA0 TLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSREC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSREC
              160       170       180       190       200       210

         580       590       600       610       620       630     
pF1KA0 CEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWD
              220       230       240       250       260       270

         640       650       660       670       680       690     
pF1KA0 EQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQET-RIL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
XP_006 EQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRIL
              280       290       300       310       320       330

          700       710       720       730       740       750    
pF1KA0 ICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTF
              340       350       360       370       380       390

          760       770       780       790       800       810    
pF1KA0 QMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQN
              400       410       420       430       440       450

          820       830       840       850       860       870    
pF1KA0 TRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIIN
              460       470       480       490       500       510

          880       890       900       910       920       930    
pF1KA0 YTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEEL
              520       530       540       550       560       570

          940       950       960       970       980       990    
pF1KA0 RRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLS
              580       590       600       610       620       630

         1000      1010      1020      1030      1040      1050    
pF1KA0 TVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIAL
              640       650       660       670       680       690

         1060      1070      1080      1090      1100      1110    
pF1KA0 CSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRL
              700       710       720       730       740       750

         1120      1130      1140      1150      1160      1170    
pF1KA0 QHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNL
              760       770       780       790       800       810

         1180      1190      1200      1210      1220      1230    
pF1KA0 GKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMA
              820       830       840       850       860       870

         1240      1250      1260      1270      1280      1290    
pF1KA0 YNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKI
              880       890       900       910       920       930

         1300      1310      1320      1330      1340      1350    
pF1KA0 RTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYA
              940       950       960       970       980       990

         1360      1370      1380      1390      1400      1410    
pF1KA0 IPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQ
             1000      1010      1020      1030      1040      1050

         1420      1430      1440      1450      1460      1470    
pF1KA0 PPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPI
             1060      1070      1080      1090      1100      1110

         1480      1490      1500      1510      1520      1530    
pF1KA0 LPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSVPYPH
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_006 LPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPYPH
             1120      1130      1140      1150      1160      1170

         1540      1550      1560      1570      1580      1590    
pF1KA0 HHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETREL
             1180      1190      1200      1210      1220      1230

         1600      1610      1620      1630      1640      1650    
pF1KA0 AEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLP
             1240      1250      1260      1270      1280      1290

         1660      1670      1680      1690      1700      1710    
pF1KA0 PQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPF
             1300      1310      1320      1330      1340      1350

         1720      1730      1740      1750      1760      1770    
pF1KA0 VQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEV
             1360      1370      1380      1390      1400      1410

         1780      1790      1800      1810      1820      1830    
pF1KA0 STPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 STPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPP
             1420      1430      1440      1450      1460      1470

         1840      1850      1860      1870      1880      1890    
pF1KA0 KTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAM
             1480      1490      1500      1510      1520      1530

         1900      1910      1920      1930      1940  
pF1KA0 SYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
             1540      1550      1560      1570        

>>XP_006722278 (OMIM: 606699) PREDICTED: probable helica  (1735 aa)
 initn: 10211 init1: 8658 opt: 10038  Z-score: 4702.2  bits: 883.3 E(85289):    0
Smith-Waterman score: 11536; 98.3% identity (98.4% similar) in 1735 aa overlap (236-1942:1-1735)

         210       220       230       240       250       260     
pF1KA0 EELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSECIEGVKVEHN
                                     ::::::::::::::::::::::::::::::
XP_006                               METLIEKWMNSLSPEKVLSECIEGVKVEHN
                                             10        20        30

         270       280       290       300       310       320     
pF1KA0 PDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEV
               40        50        60        70        80        90

         330       340       350       360       370       380     
pF1KA0 PENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAAS
              100       110       120       130       140       150

         390       400       410       420       430       440     
pF1KA0 TEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNETTDLEKSLLIRYQIPLSADQLFTQS
              160       170       180       190       200       210

         450       460       470                                   
pF1KA0 VLDKSLTKSNYQSRLHDLLYIEEIAQYKEISK---------------------------F
       :::::::::::::::::::::::::::::::.                           :
XP_006 VLDKSLTKSNYQSRLHDLLYIEEIAQYKEISNTSGASTSRILLQDTTNVTRGFSCCSKLF
              220       230       240       250       260       270

      480       490       500       510       520       530        
pF1KA0 NLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLP
              280       290       300       310       320       330

      540       550       560       570       580       590        
pF1KA0 VPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRL
              340       350       360       370       380       390

      600       610       620       630       640       650        
pF1KA0 PLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLA
              400       410       420       430       440       450

      660       670       680       690        700       710       
pF1KA0 IQLPPVLIIGPYGTGKTFTLAQAVKHILQQQET-RILICTHSNSAADLYIKDYLHPYVEA
       ::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_006 IQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEA
              460       470       480       490       500       510

       720       730       740       750       760       770       
pF1KA0 GNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQY
              520       530       540       550       560       570

       780       790       800       810       820       830       
pF1KA0 LCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCQLDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARE
              580       590       600       610       620       630

       840       850       860       870       880       890       
pF1KA0 RNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDF
              640       650       660       670       680       690

       900       910       920       930       940       950       
pF1KA0 YPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYA
              700       710       720       730       740       750

       960       970       980       990      1000      1010       
pF1KA0 DQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLE
              760       770       780       790       800       810

      1020      1030      1040      1050      1060      1070       
pF1KA0 DSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL
              820       830       840       850       860       870

      1080      1090      1100      1110      1120      1130       
pF1KA0 HGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQ
              880       890       900       910       920       930

      1140      1150      1160      1170      1180      1190       
pF1KA0 NDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPA
              940       950       960       970       980       990

      1200      1210      1220      1230      1240      1250       
pF1KA0 VYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLQTHGRGSPIPYGLGHHP
             1000      1010      1020      1030      1040      1050

      1260      1270      1280      1290      1300      1310       
pF1KA0 PVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEINKIRTPEKKPTEPKQVDLESNPQNRS
             1060      1070      1080      1090      1100      1110

      1320      1330      1340      1350      1360      1370       
pF1KA0 PESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQYAIPNRHFHPLPQLPRPPFPIPQQH
             1120      1130      1140      1150      1160      1170

      1380      1390      1400      1410      1420      1430       
pF1KA0 TLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQPQQPPPQLSPAYQAGPNNAFFNSAVA
             1180      1190      1200      1210      1220      1230

      1440      1450      1460      1470      1480      1490       
pF1KA0 HRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPGPILPSHLNSFIDENPSGLPIGEALD
             1240      1250      1260      1270      1280      1290

      1500      1510      1520      1530      1540      1550       
pF1KA0 RIHGSVALETLRQQQARFQQWSEHHAFLSQGSVPYPHHHHPHLQHLPQPPLGLHQPPVRA
       ::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::
XP_006 RIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPYPHHHHPHLQHLPQPPLGLHQPPVRA
             1300      1310      1320      1330      1340      1350

      1560      1570      1580      1590      1600      1610       
pF1KA0 DWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETRELAEMPPPQSRLLQYRQVQSRSPPA
             1360      1370      1380      1390      1400      1410

      1620      1630      1640      1650      1660      1670       
pF1KA0 VPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQRLPPQIFNSPFSLPSEHLAPPPLKYL
             1420      1430      1440      1450      1460      1470

      1680      1690      1700      1710      1720      1730       
pF1KA0 APDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQNPFVQIQNHQHAIGQEPFHPLSSRTV
             1480      1490      1500      1510      1520      1530

      1740      1750      1760      1770      1780      1790       
pF1KA0 SSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSEEVSTPQDSLAQCKELQDHSNQSSFN
             1540      1550      1560      1570      1580      1590

      1800      1810      1820      1830      1840      1850       
pF1KA0 FSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIAPPKTVKPPEDQLKSENLEVSSSFNY
             1600      1610      1620      1630      1640      1650

      1860      1870      1880      1890      1900      1910       
pF1KA0 SVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKPAMSYASALRAPPKPRPPPEQAKKSS
             1660      1670      1680      1690      1700      1710

      1920      1930      1940  
pF1KA0 DPLSLFQELSLGSSSGSNGFYSYFK
       :::::::::::::::::::::::::
XP_006 DPLSLFQELSLGSSSGSNGFYSYFK
             1720      1730     

>>XP_011523846 (OMIM: 606699) PREDICTED: probable helica  (1970 aa)
 initn: 11781 init1: 8658 opt: 10038  Z-score: 4701.4  bits: 883.4 E(85289):    0
Smith-Waterman score: 13106; 98.5% identity (98.6% similar) in 1970 aa overlap (1-1942:1-1970)

               10        20        30        40        50        60
pF1KA0 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
              370       380       390       400       410       420

              430       440       450       460       470          
pF1KA0 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISK---
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.   
XP_011 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISNTSG
              430       440       450       460       470       480

                               480       490       500       510   
pF1KA0 ------------------------FNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKL
                               ::::::::::::::::::::::::::::::::::::
XP_011 ASTSRILLQDTTNVTRGFSCCSKLFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKL
              490       500       510       520       530       540

           520       530       540       550       560       570   
pF1KA0 TETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSR
              550       560       570       580       590       600

           580       590       600       610       620       630   
pF1KA0 ECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQ
              610       620       630       640       650       660

           640       650       660       670       680       690   
pF1KA0 WDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQET-R
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_011 WDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSR
              670       680       690       700       710       720

            700       710       720       730       740       750  
pF1KA0 ILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHS
              730       740       750       760       770       780

            760       770       780       790       800       810  
pF1KA0 TFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALAT
              790       800       810       820       830       840

            820       830       840       850       860       870  
pF1KA0 QNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAI
              850       860       870       880       890       900

            880       890       900       910       920       930  
pF1KA0 INYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 INYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVE
              910       920       930       940       950       960

            940       950       960       970       980       990  
pF1KA0 ELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLF
              970       980       990      1000      1010      1020

           1000      1010      1020      1030      1040      1050  
pF1KA0 LSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPI
             1030      1040      1050      1060      1070      1080

           1060      1070      1080      1090      1100      1110  
pF1KA0 ALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRAL
             1090      1100      1110      1120      1130      1140

           1120      1130      1140      1150      1160      1170  
pF1KA0 RLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHP
             1150      1160      1170      1180      1190      1200

           1180      1190      1200      1210      1220      1230  
pF1KA0 NLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAA
             1210      1220      1230      1240      1250      1260

           1240      1250      1260      1270      1280      1290  
pF1KA0 MAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEIN
             1270      1280      1290      1300      1310      1320

           1300      1310      1320      1330      1340      1350  
pF1KA0 KIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQ
             1330      1340      1350      1360      1370      1380

           1360      1370      1380      1390      1400      1410  
pF1KA0 YAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQP
             1390      1400      1410      1420      1430      1440

           1420      1430      1440      1450      1460      1470  
pF1KA0 QQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPG
             1450      1460      1470      1480      1490      1500

           1480      1490      1500      1510      1520      1530  
pF1KA0 PILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSVPY
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_011 PILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPY
             1510      1520      1530      1540      1550      1560

           1540      1550      1560      1570      1580      1590  
pF1KA0 PHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETR
             1570      1580      1590      1600      1610      1620

           1600      1610      1620      1630      1640      1650  
pF1KA0 ELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQR
             1630      1640      1650      1660      1670      1680

           1660      1670      1680      1690      1700      1710  
pF1KA0 LPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQN
             1690      1700      1710      1720      1730      1740

           1720      1730      1740      1750      1760      1770  
pF1KA0 PFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSE
             1750      1760      1770      1780      1790      1800

           1780      1790      1800      1810      1820      1830  
pF1KA0 EVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIA
             1810      1820      1830      1840      1850      1860

           1840      1850      1860      1870      1880      1890  
pF1KA0 PPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKP
             1870      1880      1890      1900      1910      1920

           1900      1910      1920      1930      1940  
pF1KA0 AMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
             1930      1940      1950      1960      1970

>>XP_006722277 (OMIM: 606699) PREDICTED: probable helica  (1970 aa)
 initn: 11781 init1: 8658 opt: 10038  Z-score: 4701.4  bits: 883.4 E(85289):    0
Smith-Waterman score: 13106; 98.5% identity (98.6% similar) in 1970 aa overlap (1-1942:1-1970)

               10        20        30        40        50        60
pF1KA0 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEDRRAEKSCEQACESLKRQDYEMALKHCTEALLSLGQYSMADFTGPCPLEIERIKIESL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYRIASFLQLKNYVQADEDCRHVLGEGLAKGEDAFRAVLCCMQLKGKLQPVSTILAKSLT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GESLNGMVTKDLTRLKTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLI
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKWMNSLSPEKVLSECIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPNE
              370       380       390       400       410       420

              430       440       450       460       470          
pF1KA0 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISK---
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.   
XP_006 TTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISNTSG
              430       440       450       460       470       480

                               480       490       500       510   
pF1KA0 ------------------------FNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKL
                               ::::::::::::::::::::::::::::::::::::
XP_006 ASTSRILLQDTTNVTRGFSCCSKLFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKL
              490       500       510       520       530       540

           520       530       540       550       560       570   
pF1KA0 TETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLRLSR
              550       560       570       580       590       600

           580       590       600       610       620       630   
pF1KA0 ECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQ
              610       620       630       640       650       660

           640       650       660       670       680       690   
pF1KA0 WDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQET-R
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_006 WDEQLDPRLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKTFTLAQAVKHILQQQETSR
              670       680       690       700       710       720

            700       710       720       730       740       750  
pF1KA0 ILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSAHS
              730       740       750       760       770       780

            760       770       780       790       800       810  
pF1KA0 TFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFFTHILLDEAAQAMECETIMPLALAT
              790       800       810       820       830       840

            820       830       840       850       860       870  
pF1KA0 QNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAI
              850       860       870       880       890       900

            880       890       900       910       920       930  
pF1KA0 INYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVE
              910       920       930       940       950       960

            940       950       960       970       980       990  
pF1KA0 ELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLF
              970       980       990      1000      1010      1020

           1000      1010      1020      1030      1040      1050  
pF1KA0 LSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPI
             1030      1040      1050      1060      1070      1080

           1060      1070      1080      1090      1100      1110  
pF1KA0 ALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRAL
             1090      1100      1110      1120      1130      1140

           1120      1130      1140      1150      1160      1170  
pF1KA0 RLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQPNPSVLIGNPIRAYTPPPPLGPHP
             1150      1160      1170      1180      1190      1200

           1180      1190      1200      1210      1220      1230  
pF1KA0 NLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAA
             1210      1220      1230      1240      1250      1260

           1240      1250      1260      1270      1280      1290  
pF1KA0 MAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAYNMNLLQTHGRGSPIPYGLGHHPPVTIGQPQNQHQEKDQHEQNRNGKSDTNNSGPEIN
             1270      1280      1290      1300      1310      1320

           1300      1310      1320      1330      1340      1350  
pF1KA0 KIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIRTPEKKPTEPKQVDLESNPQNRSPESRPSVVYPSTKFPRKDNLNPRHINLPLPAPHAQ
             1330      1340      1350      1360      1370      1380

           1360      1370      1380      1390      1400      1410  
pF1KA0 YAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YAIPNRHFHPLPQLPRPPFPIPQQHTLLNQQQNNLPEQPNQIPPQPNQVVQQQSQLNQQP
             1390      1400      1410      1420      1430      1440

           1420      1430      1440      1450      1460      1470  
pF1KA0 QQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQPPPQLSPAYQAGPNNAFFNSAVAHRPQSPPAEAVIPEQQPPPMLQEGHSPLRAIAQPG
             1450      1460      1470      1480      1490      1500

           1480      1490      1500      1510      1520      1530  
pF1KA0 PILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSVPY
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::
XP_006 PILPSHLNSFIDENPSGLPIGEALDRIHGSVALETLRQQQARFQQWSEHHAFLSQGSAPY
             1510      1520      1530      1540      1550      1560

           1540      1550      1560      1570      1580      1590  
pF1KA0 PHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PHHHHPHLQHLPQPPLGLHQPPVRADWKLTSSAEDEVETTYSRFQDLIRELSHRDQSETR
             1570      1580      1590      1600      1610      1620

           1600      1610      1620      1630      1640      1650  
pF1KA0 ELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ELAEMPPPQSRLLQYRQVQSRSPPAVPSPPSSTDHSSHFSNFNDNSRDIEVASNPAFPQR
             1630      1640      1650      1660      1670      1680

           1660      1670      1680      1690      1700      1710  
pF1KA0 LPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPPQIFNSPFSLPSEHLAPPPLKYLAPDGAWTFANLQQNHLMGPGFPYGLPPLPHRPPQN
             1690      1700      1710      1720      1730      1740

           1720      1730      1740      1750      1760      1770  
pF1KA0 PFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PFVQIQNHQHAIGQEPFHPLSSRTVSSSSLPSLEEYEPRGPGRPLYQRRISSSSVQPCSE
             1750      1760      1770      1780      1790      1800

           1780      1790      1800      1810      1820      1830  
pF1KA0 EVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EVSTPQDSLAQCKELQDHSNQSSFNFSSPESWVNTTSSTPYQNIPCNGSSRTAQPRELIA
             1810      1820      1830      1840      1850      1860

           1840      1850      1860      1870      1880      1890  
pF1KA0 PPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PPKTVKPPEDQLKSENLEVSSSFNYSVLQHLGQFPPLMPNKQIAESANSSSPQSSAGGKP
             1870      1880      1890      1900      1910      1920

           1900      1910      1920      1930      1940  
pF1KA0 AMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AMSYASALRAPPKPRPPPEQAKKSSDPLSLFQELSLGSSSGSNGFYSYFK
             1930      1940      1950      1960      1970

>>NP_001032412 (OMIM: 611265) helicase with zinc finger   (2649 aa)
 initn: 1199 init1: 406 opt: 1101  Z-score: 529.1  bits: 111.8 E(85289): 9.8e-23
Smith-Waterman score: 1683; 33.8% identity (61.8% similar) in 940 aa overlap (166-1086:76-952)

         140       150       160       170       180       190     
pF1KA0 KTLLSETETATSNALSGYHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRY
                                     :. : :: :..   .. :: .     .:.:
NP_001 LVTCHSQEAFENHCASSEHAQMVAFDQALPWEHRSPPPGLS---KFELCPK---PDLCEY
          50        60        70        80           90            

         200       210       220       230       240       250     
pF1KA0 GAQCTSAHSQEELAEWQKRYASRLIKLKQQNENKQLSGSYMETLIEKWMNSLSPEKVLSE
       :  ::.::: .:: :: .:  .. ..:. :   ..    :.: :. ... : :   ::.:
NP_001 GDACTKAHSAQELQEWVRR--TQAVELRGQAAWQDGLVPYQERLLAEYQRSSSEVLVLAE
     100       110         120       130       140       150       

         260       270       280       290       300       310     
pF1KA0 CIEGVKVEHNPDLSVTVSTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAG
        ..::.:  :  :   .. .:.. .::::.  .    : .:::: .     ::..: .  
NP_001 TLDGVRVTCNQPLMYQAQERKTQYSWTFAVHSEEP--LLHVALLKQEPGADFSLVAPGLP
       160       170       180       190         200       210     

         320          330       340       350       360       370  
pF1KA0 DSTTQVSQE---VPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLE
        .   .  :   :: .  .               ..::.  ..  ::::.: .::::: .
NP_001 PGRLYARGERFRVPSSTAD---------------FQVGVRVQAASFGTFEQWVVFDFGRR
         220       230                      240       250       260

            380       390       400       410        420       430 
pF1KA0 PVLMQRVMIDAASTEDLEYLMHAKQQLVTTAKRWDSSSKTIIDFEPN-ETTDLEKSLLIR
       :::.:.. .. .. .      .         .:: .... ..   :. : :  . .:. .
NP_001 PVLLQKLGLQLGQGRRPGPCRNLALGHPEEMERWHTGNRHVV---PGVERTAEQTALMAK
              270       280       290       300          310       

             440       450       460       470       480       490 
pF1KA0 YQIPLSADQLFTQSVLDKSLTKSNYQSRLHDLLYIEEIAQYKEISKFNLKVQLQILASFM
       :. :  : ..  .:: .  .. .::..:.:..:: :: :: . ..:..:. :. . ....
NP_001 YKGPALALEFNRSSVASGPISPTNYRQRMHQFLYEEEAAQQQLVAKLTLRGQVFLKTALQ
       320       330       340       350       360       370       

             500       510       520       530       540       550 
pF1KA0 LTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTK
         ...    .:  : :...  .  .:  ::  : :.   :... . :::        .  
NP_001 TPALN--MLFAPPGALYAEVPVPSSLMPDTDQGFLLGRAVSTALVAPVP--------APD
       380         390       400       410       420               

             560         570       580       590       600         
pF1KA0 EKVYEATIEEK--TKEYIFLRLSRECCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDR
       . :.:. .:..  ... ..: :  .::  :.:.:.    .:.:::.. . .   : :.: 
NP_001 NTVFEVRLERRASSEQALWLLLPARCCLALGLQPEARLVLEVQFQIDPMTFRLWHQAVDT
       430       440       450       460       470       480       

     610       620       630       640       650          660      
pF1KA0 IKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITT--PL-AIQLPPVLI
       . .. .. ::.  : ..:    : :.     : : ::. ::  :.   :  . ..::.::
NP_001 LPEEQLVVPDLP-TCALP----RPWSVPPLRRGNRKQELAVALIAGWGPGDGRRVPPLLI
       490        500           510       520       530       540  

        670       680       690       700       710       720      
pF1KA0 IGPYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLR
        ::.:::::.:::.:  ..... ::..:::::.:::::.::..:.: .: .:.:.: :::
NP_001 YGPFGTGKTYTLAMASLEVIRRPETKVLICTHTNSAADIYIREYFHSHVSGGHPEATPLR
            550       560       570       580       590       600  

        730       740       750       760       770       780      
pF1KA0 VYFRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPG
       :.. .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :
NP_001 VMYTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVG
            610       620       630       640         650          

        790       800       810       820       830       840      
pF1KA0 FFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLD
       ::.:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: 
NP_001 FFSHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLH
     660       670       680       690       700        710        

        850            860       870       880          890        
pF1KA0 RLYEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFY
       ::.  :  :        :... ::::  .::... :. :: .:   . : :: : :   :
NP_001 RLFLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHY
      720       730       740       750       760       770        

      900       910       920       930       940       950        
pF1KA0 PLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYAD
       :: :  . :   .. . ... : ::. .:::.:.:    ::  ::  ..  : ::. .. 
NP_001 PLMFCHVAGSPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVS-HGA
      780       790       800       810       820       830        

      960       970       980       990      1000      1010        
pF1KA0 QVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLED
       ::  .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .    
NP_001 QVSALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE----
       840       850       860       870          880       890    

     1020      1030      1040      1050      1060      1070        
pF1KA0 STEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL-
               :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :. 
NP_001 --------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVC
                      900       910       920       930       940  

       1080      1090      1100      1110      1120      1130      
pF1KA0 -HGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHT
        .:...::..                                                  
NP_001 PEGLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGD
            950       960       970       980       990      1000  

>--
 initn: 409 init1: 155 opt: 391  Z-score: 197.8  bits: 50.5 E(85289): 0.00028
Smith-Waterman score: 400; 26.7% identity (51.4% similar) in 619 aa overlap (546-1077:2047-2633)

         520       530       540       550       560       570     
pF1KA0 TLSEDTLAGRLVMTKVNAVYLLPVPKQKLVQTQGTKEKVYEATIEEKTKEYIFLR-LSRE
                                     :::   ..      :   . ..:.. .. :
NP_001 APTASPRPGPSSLGPGLNVDPGTYTWVAHGQTQDWDQERRADRQEAPRRVHLFVHHMGME
       2020      2030      2040      2050      2060      2070      

          580       590       600       610       620              
pF1KA0 CCEELNLRPDCDTQVELQFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWS-----
          :  :::     :::  .  .::  . . :.  ... . :  .:..   .:       
NP_001 KVPEEVLRPGTLFTVELLPK--QLPDLRKEEAVRGLEEASPLVTSIALGRPVPQPLCRVI
       2080      2090        2100      2110      2120      2130    

     630         640           650       660       670             
pF1KA0 PNRQWDEQLD--P----RLNAKQKEAVLAITTPLAIQLPPVLIIGPYGTGKT-------F
       :.:  ..:    :    .:: .:. ::       :.. : ..: :: :::::       :
NP_001 PSRFLERQTYNIPGGRHKLNPSQNVAVRE-----ALEKPFTVIQGPPGTGKTIVGLHIVF
         2140      2150      2160           2170      2180         

        680            690            700           710            
pF1KA0 TLAQAVKHILQ-----QQETR-----ILICTHSNSAAD----LYIKDY-LHP---YVEAG
        . .. .. .:     . : :     :: :  ::...:    : .. . :.:   : : .
NP_001 WFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQA
    2190      2200      2210      2220      2230      2240         

      720        730                      740       750            
pF1KA0 NPQARPL-RVYFR------------NRWVKTV---HPVVHQYCLISSAHSTF-------Q
       . .  :. ::  :            :. ....   : . .     ::  ..:       .
NP_001 EASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQRGE
    2250      2260      2270      2280      2290      2300         

         760                      770         780       790        
pF1KA0 MPQKEDIL---------------KHRVVVVTLN--TSQYLCQLDLEPGFFTHILLDEAAQ
       . ..::..               .:.:.. : .  .:  :  ::..     .::.:::..
NP_001 LFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVR-----QILVDEAGM
    2310      2320      2330      2340      2350           2360    

      800       810       820       830       840        850       
pF1KA0 AMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDR-LYEHYPAEFP
       : : ::..::.   :  ..:: ::: :: : : .:  : .::    ::: :.:.:  .  
NP_001 ATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNE--RLQNLG---LDRSLFERYHEDAH
         2370      2380      2390        2400         2410         

       860       870       880         890             900         
pF1KA0 CRILLCENYRSHEAIINYTSELFYEGKLMA-SG-KQP------AHKDFYPLTFFTARGED
          .:  .:: ::.:  . :  ::..:: . .: ..:      : :.  :. :  ..:..
NP_001 ---MLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKESCPVIFGHVQGHE
       2420      2430      2440      2450      2460      2470      

     910       920       930       940        950       960        
pF1KA0 VQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGK-LDDGSIGVVTPYADQVFRIRAELR
        .   ::   :.    .. : .: .:    .. :. ..  .:.:.:::  :. .:   ::
NP_001 RSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALR
       2480      2490      2500      2510      2520      2530      

      970       980       990      1000      1010      1020        
pF1KA0 KKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFL
       .. .. : :  . . ::...: ...:::::       : : :.  . .         ::.
NP_001 REGIAGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKF--------LGFV
       2540      2550      2560      2570      2580                

     1030      1040      1050      1060      1070      1080        
pF1KA0 SNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSLHGITFEQIKAQ
        . . .:.:.::::  . ..:: . :    ::  .:. .. .:. ...:           
NP_001 VDPNQVNVAVTRAQEGLCLIGDHLLL----RCCPLWRSLLDFCEAQQTLVPAGQVRVCRR
     2590      2600      2610          2620      2630      2640    

     1090      1100      1110      1120      1130      1140        
pF1KA0 LEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQNDHFQNDGIVQ
                                                                   
NP_001 PTMPS                                                       
                                                                   




1942 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 17:57:42 2016 done: Wed Nov  2 17:57:45 2016
 Total Scan time: 20.810 Total Display time:  1.170

Function used was FASTA [36.3.4 Apr, 2011]
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