Result of FASTA (omim) for
pF1KB8643
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB8643, 517 aa
1>>>pF1KB8643 517 - 517 aa - 517 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4653+/-0.000345; mu= 4.4472+/- 0.022
mean_var=159.6327+/-32.520, 0's: 0 Z-trim(119.2): 72 B-trim: 16 in 3/57
Lambda= 0.101511
statistics sampled from 32800 (32882) to 32800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.729), E-opt: 0.2 (0.386), width: 16
Scan time: 8.180
The best scores are: opt bits E(85289)
NP_055161 (OMIM: 616879) TBC1 domain family member ( 517) 3497 524.0 4.2e-148
NP_001271233 (OMIM: 616879) TBC1 domain family mem ( 487) 3218 483.1 8e-136
XP_016884232 (OMIM: 616879) PREDICTED: TBC1 domain ( 530) 3217 483.0 9.5e-136
XP_011528401 (OMIM: 616879) PREDICTED: TBC1 domain ( 491) 3216 482.8 9.9e-136
XP_016884233 (OMIM: 616879) PREDICTED: TBC1 domain ( 470) 3170 476.1 1e-133
NP_001271234 (OMIM: 616879) TBC1 domain family mem ( 470) 3170 476.1 1e-133
XP_011528402 (OMIM: 616879) PREDICTED: TBC1 domain ( 401) 2675 403.5 5.9e-112
XP_011528403 (OMIM: 616879) PREDICTED: TBC1 domain ( 376) 2516 380.2 5.7e-105
XP_016884231 (OMIM: 616879) PREDICTED: TBC1 domain ( 549) 2517 380.5 7.1e-105
XP_016884235 (OMIM: 616879) PREDICTED: TBC1 domain ( 388) 2514 380.0 7.2e-105
XP_016884236 (OMIM: 616879) PREDICTED: TBC1 domain ( 364) 2267 343.8 5.3e-94
XP_011528404 (OMIM: 616879) PREDICTED: TBC1 domain ( 362) 2265 343.5 6.4e-94
XP_005261553 (OMIM: 616879) PREDICTED: TBC1 domain ( 371) 2265 343.5 6.5e-94
NP_001271232 (OMIM: 616879) TBC1 domain family mem ( 439) 2100 319.3 1.4e-86
XP_016884234 (OMIM: 616879) PREDICTED: TBC1 domain ( 458) 2100 319.4 1.5e-86
NP_060242 (OMIM: 616880) TBC1 domain family member ( 505) 1805 276.2 1.6e-73
XP_011513040 (OMIM: 616880) PREDICTED: TBC1 domain ( 504) 1599 246.0 2e-64
XP_011513041 (OMIM: 616880) PREDICTED: TBC1 domain ( 389) 1116 175.2 3.1e-43
XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 245 47.7 8.7e-05
XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 245 47.7 8.7e-05
XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain ( 530) 245 47.7 0.0001
XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain ( 547) 245 47.7 0.0001
XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 245 47.7 0.00011
XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 245 47.7 0.00011
XP_006719629 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 245 47.7 0.00011
XP_011536982 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 245 47.7 0.00011
XP_016875313 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 245 47.7 0.00011
XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 245 47.7 0.00011
NP_001139685 (OMIM: 612662) TBC1 domain family mem ( 674) 245 47.8 0.00012
XP_006719628 (OMIM: 612662) PREDICTED: TBC1 domain ( 682) 245 47.8 0.00012
NP_001139686 (OMIM: 612662) TBC1 domain family mem ( 682) 245 47.8 0.00012
NP_073608 (OMIM: 612662) TBC1 domain family member ( 691) 245 47.8 0.00013
XP_006719627 (OMIM: 612662) PREDICTED: TBC1 domain ( 699) 245 47.8 0.00013
XP_005252117 (OMIM: 616218) PREDICTED: TBC1 domain ( 324) 235 46.2 0.00018
NP_060671 (OMIM: 616218) TBC1 domain family member ( 400) 235 46.2 0.00022
>>NP_055161 (OMIM: 616879) TBC1 domain family member 22A (517 aa)
initn: 3497 init1: 3497 opt: 3497 Z-score: 2779.8 bits: 524.0 E(85289): 4.2e-148
Smith-Waterman score: 3497; 100.0% identity (100.0% similar) in 517 aa overlap (1-517:1-517)
10 20 30 40 50 60
pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF
430 440 450 460 470 480
490 500 510
pF1KB8 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
:::::::::::::::::::::::::::::::::::::
NP_055 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
490 500 510
>>NP_001271233 (OMIM: 616879) TBC1 domain family member (487 aa)
initn: 3218 init1: 3218 opt: 3218 Z-score: 2559.4 bits: 483.1 E(85289): 8e-136
Smith-Waterman score: 3218; 99.8% identity (100.0% similar) in 479 aa overlap (39-517:9-487)
10 20 30 40 50 60
pF1KB8 QFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNT
:.::::::::::::::::::::::::::::
NP_001 MWEPQPDVGSLLRSTAKMPTTPVKAKRVSTFQEFESNT
10 20 30
70 80 90 100 110 120
pF1KB8 SDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB8 EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB8 ALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPA
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB8 TLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFI
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB8 WAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB8 KLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB8 EVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAH
400 410 420 430 440 450
490 500 510
pF1KB8 WDDEDISLLLAEAYRLKFAFADAPNHYKK
:::::::::::::::::::::::::::::
NP_001 WDDEDISLLLAEAYRLKFAFADAPNHYKK
460 470 480
>>XP_016884232 (OMIM: 616879) PREDICTED: TBC1 domain fam (530 aa)
initn: 3217 init1: 3217 opt: 3217 Z-score: 2558.1 bits: 483.0 E(85289): 9.5e-136
Smith-Waterman score: 3217; 99.8% identity (100.0% similar) in 476 aa overlap (1-476:1-476)
10 20 30 40 50 60
pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQKSPWA
430 440 450 460 470 480
490 500 510
pF1KB8 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
XP_016 PLWADSKPHICEEWTLSTFWLGRENSKEMIDLQQKAVPPLTTPFLLSAPK
490 500 510 520 530
>>XP_011528401 (OMIM: 616879) PREDICTED: TBC1 domain fam (491 aa)
initn: 3216 init1: 3216 opt: 3216 Z-score: 2557.8 bits: 482.8 E(85289): 9.9e-136
Smith-Waterman score: 3216; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB8 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQHCRLR
430 440 450 460 470 480
490 500 510
pF1KB8 LQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK
XP_011 RTGHFYSPSIQ
490
>>XP_016884233 (OMIM: 616879) PREDICTED: TBC1 domain fam (470 aa)
initn: 3170 init1: 3170 opt: 3170 Z-score: 2521.7 bits: 476.1 E(85289): 1e-133
Smith-Waterman score: 3170; 100.0% identity (100.0% similar) in 470 aa overlap (48-517:1-470)
20 30 40 50 60 70
pF1KB8 LPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGED
::::::::::::::::::::::::::::::
XP_016 MPTTPVKAKRVSTFQEFESNTSDAWDAGED
10 20 30
80 90 100 110 120 130
pF1KB8 DDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB8 LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASR
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB8 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB8 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASG
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB8 YVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDN
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB8 YTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIR
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB8 LWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLL
400 410 420 430 440 450
500 510
pF1KB8 LAEAYRLKFAFADAPNHYKK
::::::::::::::::::::
XP_016 LAEAYRLKFAFADAPNHYKK
460 470
>>NP_001271234 (OMIM: 616879) TBC1 domain family member (470 aa)
initn: 3170 init1: 3170 opt: 3170 Z-score: 2521.7 bits: 476.1 E(85289): 1e-133
Smith-Waterman score: 3170; 100.0% identity (100.0% similar) in 470 aa overlap (48-517:1-470)
20 30 40 50 60 70
pF1KB8 LPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVSTFQEFESNTSDAWDAGED
::::::::::::::::::::::::::::::
NP_001 MPTTPVKAKRVSTFQEFESNTSDAWDAGED
10 20 30
80 90 100 110 120 130
pF1KB8 DDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGD
40 50 60 70 80 90
140 150 160 170 180 190
pF1KB8 LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTSDPSTLSSSALSEREASR
100 110 120 130 140 150
200 210 220 230 240 250
pF1KB8 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY
160 170 180 190 200 210
260 270 280 290 300 310
pF1KB8 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWAIRHPASG
220 230 240 250 260 270
320 330 340 350 360 370
pF1KB8 YVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDN
280 290 300 310 320 330
380 390 400 410 420 430
pF1KB8 YTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIR
340 350 360 370 380 390
440 450 460 470 480 490
pF1KB8 LWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLL
400 410 420 430 440 450
500 510
pF1KB8 LAEAYRLKFAFADAPNHYKK
::::::::::::::::::::
NP_001 LAEAYRLKFAFADAPNHYKK
460 470
>>XP_011528402 (OMIM: 616879) PREDICTED: TBC1 domain fam (401 aa)
initn: 2675 init1: 2675 opt: 2675 Z-score: 2131.0 bits: 403.5 E(85289): 5.9e-112
Smith-Waterman score: 2675; 100.0% identity (100.0% similar) in 400 aa overlap (1-400:1-400)
10 20 30 40 50 60
pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
::::::::::::::::::::::::::::::::::::::::
XP_011 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDV
370 380 390 400
430 440 450 460 470 480
pF1KB8 WMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLF
>>XP_011528403 (OMIM: 616879) PREDICTED: TBC1 domain fam (376 aa)
initn: 2562 init1: 2516 opt: 2516 Z-score: 2005.5 bits: 380.2 E(85289): 5.7e-105
Smith-Waterman score: 2516; 99.7% identity (100.0% similar) in 376 aa overlap (1-376:1-376)
10 20 30 40 50 60
pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
:::::::::::::::.
XP_011 ADTYWCMSKLLDGIQE
370
>>XP_016884231 (OMIM: 616879) PREDICTED: TBC1 domain fam (549 aa)
initn: 3483 init1: 2514 opt: 2517 Z-score: 2003.8 bits: 380.5 E(85289): 7.1e-105
Smith-Waterman score: 3423; 94.2% identity (94.2% similar) in 549 aa overlap (1-517:1-549)
10 20 30 40 50 60
pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
310 320 330 340 350 360
370 380
pF1KB8 ADTYWCMSKLLDGIQ--------------------------------DNYTFAQPGIQMK
::::::::::::::: :::::::::::::
XP_016 ADTYWCMSKLLDGIQTGLELLGSSELPMLASQSAGITDVRHRARPQNDNYTFAQPGIQMK
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB8 VKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDG
430 440 450 460 470 480
450 460 470 480 490 500
pF1KB8 FSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFAF
490 500 510 520 530 540
510
pF1KB8 ADAPNHYKK
:::::::::
XP_016 ADAPNHYKK
>>XP_016884235 (OMIM: 616879) PREDICTED: TBC1 domain fam (388 aa)
initn: 2514 init1: 2514 opt: 2514 Z-score: 2003.7 bits: 380.0 E(85289): 7.2e-105
Smith-Waterman score: 2514; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375)
10 20 30 40 50 60
pF1KB8 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB8 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FQEFESNTSDAWDAGEDDDELLAMAAESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB8 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTLGGTS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB8 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB8 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB8 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB8 ADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFR
:::::::::::::::
XP_016 ADTYWCMSKLLDGIQLKNVKKIQHYIDT
370 380
517 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 21:35:08 2016 done: Sat Nov 5 21:35:09 2016
Total Scan time: 8.180 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]