Result of FASTA (omim) for pF1KE0413
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0413, 334 aa
  1>>>pF1KE0413 334 - 334 aa - 334 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.9862+/-0.000394; mu= 17.6898+/- 0.024
 mean_var=66.9364+/-13.310, 0's: 0 Z-trim(111.8): 25  B-trim: 35 in 1/54
 Lambda= 0.156763
 statistics sampled from 20490 (20510) to 20490 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.24), width:  16
 Scan time:  7.610

The best scores are:                                      opt bits E(85289)
NP_037415 (OMIM: 605527) methionine adenosyltransf ( 334) 2253 518.6 7.1e-147
NP_877725 (OMIM: 605527) methionine adenosyltransf ( 323) 2113 487.0 2.4e-137
XP_011519367 (OMIM: 616145,616146) PREDICTED: dTDP ( 318)  139 40.5  0.0057
NP_001291359 (OMIM: 616145,616146) dTDP-D-glucose  ( 318)  139 40.5  0.0057
XP_011519368 (OMIM: 616145,616146) PREDICTED: dTDP ( 318)  139 40.5  0.0057
NP_055120 (OMIM: 616145,616146) dTDP-D-glucose 4,6 ( 350)  139 40.6  0.0062


>>NP_037415 (OMIM: 605527) methionine adenosyltransferas  (334 aa)
 initn: 2253 init1: 2253 opt: 2253  Z-score: 2757.9  bits: 518.6 E(85289): 7.1e-147
Smith-Waterman score: 2253; 99.7% identity (99.7% similar) in 334 aa overlap (1-334:1-334)

               10        20        30        40        50        60
pF1KE0 MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQCPRNAQLDCSKL
       :::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_037 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKL
              250       260       270       280       290       300

              310       320       330    
pF1KE0 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
       ::::::::::::::::::::::::::::::::::
NP_037 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
              310       320       330    

>>NP_877725 (OMIM: 605527) methionine adenosyltransferas  (323 aa)
 initn: 2113 init1: 2113 opt: 2113  Z-score: 2586.9  bits: 487.0 E(85289): 2.4e-137
Smith-Waterman score: 2113; 99.4% identity (99.7% similar) in 314 aa overlap (21-334:10-323)

               10        20        30        40        50        60
pF1KE0 MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
                           .:::::::::::::::::::::::::::::::::::::::
NP_877            MPEMPEDMEQEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
                          10        20        30        40         

               70        80        90       100       110       120
pF1KE0 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
      50        60        70        80        90       100         

              130       140       150       160       170       180
pF1KE0 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
     110       120       130       140       150       160         

              190       200       210       220       230       240
pF1KE0 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_877 RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
     170       180       190       200       210       220         

              250       260       270       280       290       300
pF1KE0 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQCPRNAQLDCSKL
       :::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_877 DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKL
     230       240       250       260       270       280         

              310       320       330    
pF1KE0 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
       ::::::::::::::::::::::::::::::::::
NP_877 ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
     290       300       310       320   

>>XP_011519367 (OMIM: 616145,616146) PREDICTED: dTDP-D-g  (318 aa)
 initn:  87 init1:  58 opt: 139  Z-score: 174.3  bits: 40.5 E(85289): 0.0057
Smith-Waterman score: 139; 21.8% identity (52.1% similar) in 284 aa overlap (66-334:39-304)

          40        50        60        70        80        90     
pF1KE0 ATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAA
                                     :: : .. ::. :. ...  .  ...: ::
XP_011 YPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAA
       10        20        30        40        50        60        

         100       110       120         130       140       150   
pF1KE0 ERRPDVVENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIP
       . . :.   .    . .:: ..  :.. :  : :  : ::.:.: :. :.     .:. :
XP_011 QTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSP
       70        80        90       100        110       120       

            160       170           180       190       200        
pF1KE0 A-PLNLYGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSN
         : : :...:  .:  :     . .. ... :   .::  ..  :...  ... .: . 
XP_011 KQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNR
       130       140       150       160        170       180      

      210        220       230       240       250        260      
pF1KE0 KSA-NMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIA
       :   . .  : :   .. ::.      :   .:  .  : ..  : : .:.  ..:  . 
XP_011 KCCIHGSGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELI
        190       200            210       220       230       240 

        270             280       290       300       310       320
pF1KE0 DAFNLPSSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLW
       . ..  .:.      .  ..: :.   . : ...    :.. ::   ..:.. :::... 
XP_011 QLIKETNSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-
             250       260       270           280       290       

              330                  
pF1KE0 PFLIDKRWRQTVFH              
             .: .  ::              
XP_011 ------EWYRENFHNWKNVEKALEPFPV
              300       310        

>>NP_001291359 (OMIM: 616145,616146) dTDP-D-glucose 4,6-  (318 aa)
 initn:  87 init1:  58 opt: 139  Z-score: 174.3  bits: 40.5 E(85289): 0.0057
Smith-Waterman score: 139; 21.8% identity (52.1% similar) in 284 aa overlap (66-334:39-304)

          40        50        60        70        80        90     
pF1KE0 ATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAA
                                     :: : .. ::. :. ...  .  ...: ::
NP_001 YPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAA
       10        20        30        40        50        60        

         100       110       120         130       140       150   
pF1KE0 ERRPDVVENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIP
       . . :.   .    . .:: ..  :.. :  : :  : ::.:.: :. :.     .:. :
NP_001 QTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSP
       70        80        90       100        110       120       

            160       170           180       190       200        
pF1KE0 A-PLNLYGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSN
         : : :...:  .:  :     . .. ... :   .::  ..  :...  ... .: . 
NP_001 KQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNR
       130       140       150       160        170       180      

      210        220       230       240       250        260      
pF1KE0 KSA-NMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIA
       :   . .  : :   .. ::.      :   .:  .  : ..  : : .:.  ..:  . 
NP_001 KCCIHGSGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELI
        190       200            210       220       230       240 

        270             280       290       300       310       320
pF1KE0 DAFNLPSSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLW
       . ..  .:.      .  ..: :.   . : ...    :.. ::   ..:.. :::... 
NP_001 QLIKETNSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-
             250       260       270           280       290       

              330                  
pF1KE0 PFLIDKRWRQTVFH              
             .: .  ::              
NP_001 ------EWYRENFHNWKNVEKALEPFPV
              300       310        

>>XP_011519368 (OMIM: 616145,616146) PREDICTED: dTDP-D-g  (318 aa)
 initn:  87 init1:  58 opt: 139  Z-score: 174.3  bits: 40.5 E(85289): 0.0057
Smith-Waterman score: 139; 21.8% identity (52.1% similar) in 284 aa overlap (66-334:39-304)

          40        50        60        70        80        90     
pF1KE0 ATGLLGRAVHKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAA
                                     :: : .. ::. :. ...  .  ...: ::
XP_011 YPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAA
       10        20        30        40        50        60        

         100       110       120         130       140       150   
pF1KE0 ERRPDVVENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIP
       . . :.   .    . .:: ..  :.. :  : :  : ::.:.: :. :.     .:. :
XP_011 QTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSP
       70        80        90       100        110       120       

            160       170           180       190       200        
pF1KE0 A-PLNLYGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSN
         : : :...:  .:  :     . .. ... :   .::  ..  :...  ... .: . 
XP_011 KQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNR
       130       140       150       160        170       180      

      210        220       230       240       250        260      
pF1KE0 KSA-NMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIA
       :   . .  : :   .. ::.      :   .:  .  : ..  : : .:.  ..:  . 
XP_011 KCCIHGSGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELI
        190       200            210       220       230       240 

        270             280       290       300       310       320
pF1KE0 DAFNLPSSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLW
       . ..  .:.      .  ..: :.   . : ...    :.. ::   ..:.. :::... 
XP_011 QLIKETNSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-
             250       260       270           280       290       

              330                  
pF1KE0 PFLIDKRWRQTVFH              
             .: .  ::              
XP_011 ------EWYRENFHNWKNVEKALEPFPV
              300       310        

>>NP_055120 (OMIM: 616145,616146) dTDP-D-glucose 4,6-deh  (350 aa)
 initn: 122 init1:  58 opt: 139  Z-score: 173.7  bits: 40.6 E(85289): 0.0062
Smith-Waterman score: 140; 21.3% identity (51.1% similar) in 348 aa overlap (21-334:7-336)

               10        20           30        40        50       
pF1KE0 MVGREKELSIHFVPGSCRLVEEEVNIPN---RRVLVTGATGLLGRAVHKEFQQN--NWHA
                           ::  ..:.   .::::::..:...  .   . ..  :.  
NP_055               MSAACWEEPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMI
                             10        20        30        40      

                60                70        80        90       100 
pF1KE0 VG------CGF--------RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDV
       ..      :.          .   :: : .. ::. :. ...  .  ...: ::. . :.
NP_055 INLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDL
         50        60        70        80        90       100      

             110       120         130       140       150         
pF1KE0 VENQPDAASQLNVDASGNLAKEA--AAVGAFLIYISSDYVFDGTNPPYREEDIPA-PLNL
          .    . .:: ..  :.. :  : :  : ::.:.: :. :.     .:. :  : : 
NP_055 SFVRAFEFTYVNVYGTHVLVSAAHEARVEKF-IYVSTDEVYGGSLDKEFDESSPKQPTNP
        110       120       130        140       150       160     

      160       170           180       190       200       210    
pF1KE0 YGKTKLDGEKAVL----ENNLGAAVLRIPILYGEVEKLEESAVTVMFDKVQFSNKSA-NM
       :...:  .:  :     . .. ... :   .::  ..  :...  ... .: . :   . 
NP_055 YASSKAAAECFVQSYWEQYKFPVVITRSSNVYGP-HQYPEKVIPKFISLLQHNRKCCIHG
         170       180       190        200       210       220    

           220       230       240       250        260       270  
pF1KE0 DHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSG-NEQMTKYEMACAIADAFNLP
       .  : :   .. ::.      :   .:  .  : ..  : : .:.  ..:  . . ..  
NP_055 SGLQTRNFLYATDVVE-----AFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELIQLIKET
          230       240            250       260       270         

                  280       290       300       310       320      
pF1KE0 SSH------LRPITDSPVLGAQCPRNAQLDCSKLETLGIGQRTPFRIGIKESLWPFLIDK
       .:.      .  ..: :.   . : ...    :.. ::   ..:.. :::...       
NP_055 NSESEMENWVDYVNDRPTNDMRYPMKSE----KIHGLGWRPKVPWKEGIKKTI-------
     280       290       300           310       320               

        330                  
pF1KE0 RWRQTVFH              
       .: .  ::              
NP_055 EWYRENFHNWKNVEKALEPFPV
      330       340       350




334 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 11:37:56 2016 done: Thu Nov  3 11:37:57 2016
 Total Scan time:  7.610 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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