Result of FASTA (omim) for pF1KA0705
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0705, 1441 aa
  1>>>pF1KA0705 1441 - 1441 aa - 1441 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.1498+/-0.000466; mu= -6.0264+/- 0.029
 mean_var=528.6381+/-112.069, 0's: 0 Z-trim(122.4): 107  B-trim: 1104 in 1/60
 Lambda= 0.055782
 statistics sampled from 40292 (40427) to 40292 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.474), width:  16
 Scan time: 20.940

The best scores are:                                      opt bits E(85289)
NP_001288057 (OMIM: 606382) membrane-associated gu (1441) 9878 811.2       0
XP_016868335 (OMIM: 606382) PREDICTED: membrane-as (1483) 8363 689.3 5.7e-197
XP_016868332 (OMIM: 606382) PREDICTED: membrane-as (1526) 5666 472.3 1.3e-131
NP_036433 (OMIM: 606382) membrane-associated guany (1455) 5492 458.3  2e-127
XP_011515020 (OMIM: 606382) PREDICTED: membrane-as (1497) 5411 451.7 1.9e-125
XP_016868334 (OMIM: 606382) PREDICTED: membrane-as (1495) 5410 451.7  2e-125
XP_016868333 (OMIM: 606382) PREDICTED: membrane-as (1498) 4722 396.3 9.3e-109
XP_016868337 (OMIM: 606382) PREDICTED: membrane-as (1334) 4323 364.1   4e-99
XP_016868338 (OMIM: 606382) PREDICTED: membrane-as (1332) 4322 364.1 4.2e-99
XP_016868331 (OMIM: 606382) PREDICTED: membrane-as (1538) 3213 274.9 3.4e-72
XP_011515030 (OMIM: 606382) PREDICTED: membrane-as (1106) 3207 274.2 3.8e-72
XP_011515028 (OMIM: 606382) PREDICTED: membrane-as (1149) 3207 274.3 3.9e-72
XP_011515021 (OMIM: 606382) PREDICTED: membrane-as (1377) 3207 274.3 4.4e-72
XP_011515022 (OMIM: 606382) PREDICTED: membrane-as (1377) 3207 274.3 4.4e-72
XP_016868336 (OMIM: 606382) PREDICTED: membrane-as (1377) 3207 274.3 4.4e-72
XP_016868330 (OMIM: 606382) PREDICTED: membrane-as (1539) 3207 274.4 4.8e-72
XP_016868329 (OMIM: 606382) PREDICTED: membrane-as (1540) 3207 274.4 4.8e-72
XP_016868340 (OMIM: 606382) PREDICTED: membrane-as (1298) 3187 272.7 1.3e-71
XP_016868339 (OMIM: 606382) PREDICTED: membrane-as (1326) 3186 272.6 1.4e-71
XP_016868341 (OMIM: 606382) PREDICTED: membrane-as (1284) 3181 272.2 1.8e-71
XP_011532538 (OMIM: 602625) PREDICTED: membrane-as (1480) 1741 156.4 1.5e-36
XP_006713473 (OMIM: 602625) PREDICTED: membrane-as (1479) 1722 154.9 4.4e-36
XP_005265625 (OMIM: 602625) PREDICTED: membrane-as (1478) 1716 154.4 6.1e-36
XP_016862997 (OMIM: 602625) PREDICTED: membrane-as (1168) 1690 152.2 2.2e-35
XP_016862996 (OMIM: 602625) PREDICTED: membrane-as (1224) 1690 152.2 2.3e-35
XP_005265623 (OMIM: 602625) PREDICTED: membrane-as (1479) 1687 152.0 3.1e-35
XP_016862995 (OMIM: 602625) PREDICTED: membrane-as (1276) 1594 144.5   5e-33
XP_005265622 (OMIM: 602625) PREDICTED: membrane-as (1481) 1475 135.0 4.2e-30
NP_004733 (OMIM: 602625) membrane-associated guany (1256) 1325 122.8 1.6e-26
NP_056335 (OMIM: 602625) membrane-associated guany (1287) 1325 122.8 1.7e-26
XP_005265631 (OMIM: 602625) PREDICTED: membrane-as (1288) 1325 122.8 1.7e-26
XP_005265628 (OMIM: 602625) PREDICTED: membrane-as (1395) 1325 122.9 1.7e-26
NP_001028229 (OMIM: 602625) membrane-associated gu (1462) 1325 122.9 1.8e-26
XP_006713475 (OMIM: 602625) PREDICTED: membrane-as (1463) 1325 122.9 1.8e-26
XP_016862987 (OMIM: 602625) PREDICTED: membrane-as (1490) 1325 122.9 1.8e-26
XP_005265621 (OMIM: 602625) PREDICTED: membrane-as (1491) 1325 122.9 1.8e-26
XP_016862994 (OMIM: 602625) PREDICTED: membrane-as (1288) 1320 122.4 2.2e-26
XP_016862991 (OMIM: 602625) PREDICTED: membrane-as (1289) 1320 122.4 2.2e-26
XP_016862993 (OMIM: 602625) PREDICTED: membrane-as (1288) 1319 122.4 2.3e-26
XP_016862990 (OMIM: 602625) PREDICTED: membrane-as (1452) 1320 122.5 2.4e-26
XP_016862986 (OMIM: 602625) PREDICTED: membrane-as (1491) 1320 122.5 2.4e-26
XP_006713472 (OMIM: 602625) PREDICTED: membrane-as (1492) 1320 122.5 2.4e-26
XP_006713471 (OMIM: 602625) PREDICTED: membrane-as (1492) 1319 122.4 2.6e-26
XP_016862989 (OMIM: 602625) PREDICTED: membrane-as (1455) 1231 115.3 3.4e-24
XP_016862988 (OMIM: 602625) PREDICTED: membrane-as (1458) 1231 115.3 3.4e-24
XP_016862992 (OMIM: 602625) PREDICTED: membrane-as (1289) 1125 106.8 1.2e-21
XP_006713477 (OMIM: 602625) PREDICTED: membrane-as (1290) 1125 106.8 1.2e-21
XP_005265627 (OMIM: 602625) PREDICTED: membrane-as (1425) 1125 106.8 1.2e-21
XP_006713474 (OMIM: 602625) PREDICTED: membrane-as (1465) 1125 106.8 1.3e-21
XP_005265620 (OMIM: 602625) PREDICTED: membrane-as (1492) 1125 106.8 1.3e-21


>>NP_001288057 (OMIM: 606382) membrane-associated guanyl  (1441 aa)
 initn: 9878 init1: 9878 opt: 9878  Z-score: 4316.3  bits: 811.2 E(85289):    0
Smith-Waterman score: 9878; 100.0% identity (100.0% similar) in 1441 aa overlap (1-1441:1-1441)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KA0 KSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPS
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KA0 DPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGG
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KA0 QGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGG
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KA0 GGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAAS
             1390      1400      1410      1420      1430      1440

        
pF1KA0 R
       :
NP_001 R
        

>>XP_016868335 (OMIM: 606382) PREDICTED: membrane-associ  (1483 aa)
 initn: 9864 init1: 8337 opt: 8363  Z-score: 3657.2  bits: 689.3 E(85289): 5.7e-197
Smith-Waterman score: 9723; 97.1% identity (97.1% similar) in 1473 aa overlap (1-1431:1-1473)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASH
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA0 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA0 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLA
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KA0 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQP
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KA0 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KA0 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELI
             1150      1160      1170      1180      1190      1200

             1210      1220                                        
pF1KA0 KSGGRRVRLLLKRGTGQVPEY---------------------------------------
       :::::::::::::::::::::                                       
XP_016 KSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTD
             1210      1220      1230      1240      1250      1260

               1230      1240      1250      1260      1270        
pF1KA0 ---DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREH
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREH
             1270      1280      1290      1300      1310      1320

     1280      1290      1300      1310      1320      1330        
pF1KA0 DVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGL
             1330      1340      1350      1360      1370      1380

     1340      1350      1360      1370      1380      1390        
pF1KA0 AAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGP
             1390      1400      1410      1420      1430      1440

     1400      1410      1420      1430      1440 
pF1KA0 RPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
       :::::::::::::::::::::::::::::::::          
XP_016 RPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
             1450      1460      1470      1480   

>>XP_016868332 (OMIM: 606382) PREDICTED: membrane-associ  (1526 aa)
 initn: 9850 init1: 5563 opt: 5666  Z-score: 2484.0  bits: 472.3 E(85289): 1.3e-131
Smith-Waterman score: 9551; 94.4% identity (94.4% similar) in 1505 aa overlap (12-1431:12-1516)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
                  :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400                    
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFR------------
       ::::::::::::::::::::::::::::::::::::::::::::::::            
XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPK
              370       380       390       400       410       420

                                     410       420       430       
pF1KA0 -------------------------------EKPLFTRDASQLKGTFLSTTLKKSNMGFG
                                      :::::::::::::::::::::::::::::
XP_016 SIRPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFG
              430       440       450       460       470       480

       440       450       460       470       480       490       
pF1KA0 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP
              490       500       510       520       530       540

       500       510       520       530       540       550       
pF1KA0 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS
              550       560       570       580       590       600

       560       570       580       590       600       610       
pF1KA0 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF
              610       620       630       640       650       660

       620       630       640       650       660       670       
pF1KA0 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL
              670       680       690       700       710       720

       680       690       700       710       720       730       
pF1KA0 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP
              730       740       750       760       770       780

       740       750       760       770       780       790       
pF1KA0 RKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKPDPYELYEKSRAIYESRRPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMG
              790       800       810       820       830       840

       800       810       820       830       840       850       
pF1KA0 SADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE
              850       860       870       880       890       900

       860       870       880       890       900       910       
pF1KA0 NGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGF
              910       920       930       940       950       960

       920       930       940       950       960       970       
pF1KA0 GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADI
              970       980       990      1000      1010      1020

       980       990      1000      1010      1020      1030       
pF1KA0 VKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPI
             1030      1040      1050      1060      1070      1080

      1040      1050      1060      1070      1080      1090       
pF1KA0 AQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPP
             1090      1100      1110      1120      1130      1140

      1100      1110      1120      1130      1140      1150       
pF1KA0 LDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDL
             1150      1160      1170      1180      1190      1200

      1160      1170      1180      1190      1200      1210       
pF1KA0 YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQ
             1210      1220      1230      1240      1250      1260

      1220                                                1230     
pF1KA0 VPEY------------------------------------------DEPAPWSSPAAAAP
       ::::                                          ::::::::::::::
XP_016 VPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTDNRKDEPAPWSSPAAAAP
             1270      1280      1290      1300      1310      1320

        1240      1250      1260      1270      1280      1290     
pF1KA0 GLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQR
             1330      1340      1350      1360      1370      1380

        1300      1310      1320      1330      1340      1350     
pF1KA0 LGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAP
             1390      1400      1410      1420      1430      1440

        1360      1370      1380      1390      1400      1410     
pF1KA0 RAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAV
             1450      1460      1470      1480      1490      1500

        1420      1430      1440 
pF1KA0 APGPWKVPGSDKLPSVLKPGASAASR
       ::::::::::::::::          
XP_016 APGPWKVPGSDKLPSVLKPGASAASR
             1510      1520      

>>NP_036433 (OMIM: 606382) membrane-associated guanylate  (1455 aa)
 initn: 5312 init1: 5161 opt: 5492  Z-score: 2408.6  bits: 458.3 E(85289): 2e-127
Smith-Waterman score: 9834; 99.0% identity (99.0% similar) in 1455 aa overlap (1-1441:1-1455)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
              670       680       690       700       710       720

              730       740       750                     760      
pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRR--------------PDYKELDVH
       ::::::::::::::::::::::::::::::::::::.              :::::::::
NP_036 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH
              730       740       750       760       770       780

        770       780       790       800       810       820      
pF1KA0 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY
              790       800       810       820       830       840

        830       840       850       860       870       880      
pF1KA0 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA
              850       860       870       880       890       900

        890       900       910       920       930       940      
pF1KA0 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG
              910       920       930       940       950       960

        950       960       970       980       990      1000      
pF1KA0 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS
              970       980       990      1000      1010      1020

       1010      1020      1030      1040      1050      1060      
pF1KA0 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK
             1030      1040      1050      1060      1070      1080

       1070      1080      1090      1100      1110      1120      
pF1KA0 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP
             1090      1100      1110      1120      1130      1140

       1130      1140      1150      1160      1170      1180      
pF1KA0 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE
             1150      1160      1170      1180      1190      1200

       1190      1200      1210      1220      1230      1240      
pF1KA0 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDD
             1210      1220      1230      1240      1250      1260

       1250      1260      1270      1280      1290      1300      
pF1KA0 GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASP
             1270      1280      1290      1300      1310      1320

       1310      1320      1330      1340      1350      1360      
pF1KA0 QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 QRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRR
             1330      1340      1350      1360      1370      1380

       1370      1380      1390      1400      1410      1420      
pF1KA0 EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSD
             1390      1400      1410      1420      1430      1440

       1430      1440 
pF1KA0 KLPSVLKPGASAASR
       :::::::::::::::
NP_036 KLPSVLKPGASAASR
             1450     

>>XP_011515020 (OMIM: 606382) PREDICTED: membrane-associ  (1497 aa)
 initn: 6839 init1: 5161 opt: 5411  Z-score: 2373.2  bits: 451.7 E(85289): 1.9e-125
Smith-Waterman score: 9573; 96.1% identity (96.2% similar) in 1473 aa overlap (1-1417:1-1473)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
              670       680       690       700       710       720

              730       740       750                     760      
pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRR--------------PDYKELDVH
       ::::::::::::::::::::::::::::::::::::.              :::::::::
XP_011 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVH
              730       740       750       760       770       780

        770       780       790       800       810       820      
pF1KA0 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY
              790       800       810       820       830       840

        830       840       850       860       870       880      
pF1KA0 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAA
              850       860       870       880       890       900

        890       900       910       920       930       940      
pF1KA0 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDG
              910       920       930       940       950       960

        950       960       970       980       990      1000      
pF1KA0 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPS
              970       980       990      1000      1010      1020

       1010      1020      1030      1040      1050      1060      
pF1KA0 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVK
             1030      1040      1050      1060      1070      1080

       1070      1080      1090      1100      1110      1120      
pF1KA0 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQP
             1090      1100      1110      1120      1130      1140

       1130      1140      1150      1160      1170      1180      
pF1KA0 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGE
             1150      1160      1170      1180      1190      1200

       1190      1200      1210      1220                          
pF1KA0 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEY-------------------------
       :::::::::::::::::::::::::::::::::::                         
XP_011 STRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLG
             1210      1220      1230      1240      1250      1260

                             1230      1240      1250      1260    
pF1KA0 -----------------DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSH
                        :::::::::::::::::::::::::::::::::::::::::::
XP_011 HPKDTERSKLARTDNRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSH
             1270      1280      1290      1300      1310      1320

         1270      1280      1290      1300      1310      1320    
pF1KA0 QISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRP
             1330      1340      1350      1360      1370      1380

         1330      1340      1350      1360      1370      1380    
pF1KA0 EAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSG
             1390      1400      1410      1420      1430      1440

         1390      1400      1410      1420      1430      1440 
pF1KA0 ALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
       :::::::::::::::::::::::::::::::::                        
XP_011 ALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
             1450      1460      1470      1480      1490       

>>XP_016868334 (OMIM: 606382) PREDICTED: membrane-associ  (1495 aa)
 initn: 6834 init1: 5156 opt: 5410  Z-score: 2372.8  bits: 451.7 E(85289): 2e-125
Smith-Waterman score: 9583; 96.2% identity (96.2% similar) in 1473 aa overlap (1-1419:1-1473)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVC
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHT
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFP
              670       680       690       700       710       720

              730       740       750                   760        
pF1KA0 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYE------------SRRPDYKELDVHLR
       ::::::::::::::::::::::::::::::::::            :  :::::::::::
XP_016 PALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYEKQVPPRTSFRMDSSGPDYKELDVHLR
              730       740       750       760       770       780

      770       780       790       800       810       820        
pF1KA0 RMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVI
              790       800       810       820       830       840

      830       840       850       860       870       880        
pF1KA0 DLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPS
              850       860       870       880       890       900

      890       900       910       920       930       940        
pF1KA0 SNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSP
              910       920       930       940       950       960

      950       960       970       980       990      1000        
pF1KA0 ADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSE
              970       980       990      1000      1010      1020

     1010      1020      1030      1040      1050      1060        
pF1KA0 KQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPD
             1030      1040      1050      1060      1070      1080

     1070      1080      1090      1100      1110      1120        
pF1KA0 IRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQD
             1090      1100      1110      1120      1130      1140

     1130      1140      1150      1160      1170      1180        
pF1KA0 FDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGEST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGEST
             1150      1160      1170      1180      1190      1200

     1190      1200      1210      1220                            
pF1KA0 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEY---------------------------
       :::::::::::::::::::::::::::::::::                           
XP_016 RDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHP
             1210      1220      1230      1240      1250      1260

                           1230      1240      1250      1260      
pF1KA0 ---------------DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQI
                      :::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDTERSKLARTDNRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQI
             1270      1280      1290      1300      1310      1320

       1270      1280      1290      1300      1310      1320      
pF1KA0 SPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEA
             1330      1340      1350      1360      1370      1380

       1330      1340      1350      1360      1370      1380      
pF1KA0 GRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGAL
             1390      1400      1410      1420      1430      1440

       1390      1400      1410      1420      1430      1440 
pF1KA0 EAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
       :::::::::::::::::::::::::::::::::                      
XP_016 EAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
             1450      1460      1470      1480      1490     

>>XP_016868333 (OMIM: 606382) PREDICTED: membrane-associ  (1498 aa)
 initn: 7474 init1: 4714 opt: 4722  Z-score: 2073.5  bits: 396.3 E(85289): 9.3e-109
Smith-Waterman score: 9572; 96.1% identity (96.1% similar) in 1473 aa overlap (26-1441:26-1498)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
                                :::::::::::::::::::::::::::::::::::
XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400                    
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFR------------
       ::::::::::::::::::::::::::::::::::::::::::::::::            
XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPK
              370       380       390       400       410       420

                                     410       420       430       
pF1KA0 -------------------------------EKPLFTRDASQLKGTFLSTTLKKSNMGFG
                                      :::::::::::::::::::::::::::::
XP_016 SIRPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFG
              430       440       450       460       470       480

       440       450       460       470       480       490       
pF1KA0 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP
              490       500       510       520       530       540

       500       510       520       530       540       550       
pF1KA0 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS
              550       560       570       580       590       600

       560       570       580       590       600       610       
pF1KA0 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF
              610       620       630       640       650       660

       620       630       640       650       660       670       
pF1KA0 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL
              670       680       690       700       710       720

       680       690       700       710       720       730       
pF1KA0 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP
              730       740       750       760       770       780

       740       750                     760       770       780   
pF1KA0 RKPDPYELYEKSRAIYESRR--------------PDYKELDVHLRRMESGFGFRILGGDE
       :::::::::::::::::::.              ::::::::::::::::::::::::::
XP_016 RKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDE
              790       800       810       820       830       840

           790       800       810       820       830       840   
pF1KA0 PGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLT
              850       860       870       880       890       900

           850       860       870       880       890       900   
pF1KA0 VRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQ
              910       920       930       940       950       960

           910       920       930       940       950       960   
pF1KA0 TSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILA
              970       980       990      1000      1010      1020

           970       980       990      1000      1010      1020   
pF1KA0 VNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQS
             1030      1040      1050      1060      1070      1080

          1030      1040      1050      1060      1070      1080   
pF1KA0 PLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLD
             1090      1100      1110      1120      1130      1140

          1090      1100      1110      1120      1130      1140   
pF1KA0 YRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGF
             1150      1160      1170      1180      1190      1200

          1150      1160      1170      1180      1190      1200   
pF1KA0 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG
             1210      1220      1230      1240      1250      1260

          1210      1220      1230      1240      1250      1260   
pF1KA0 GRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPS
             1270      1280      1290      1300      1310      1320

          1270      1280      1290      1300      1310      1320   
pF1KA0 HQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGR
             1330      1340      1350      1360      1370      1380

          1330      1340      1350      1360      1370      1380   
pF1KA0 PEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEAGRPASEARAPGLAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGS
             1390      1400      1410      1420      1430      1440

          1390      1400      1410      1420      1430      1440 
pF1KA0 GALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALEAEGRAGARAGPRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
             1450      1460      1470      1480      1490        

>>XP_016868337 (OMIM: 606382) PREDICTED: membrane-associ  (1334 aa)
 initn: 5751 init1: 4073 opt: 4323  Z-score: 1900.6  bits: 364.1 E(85289): 4e-99
Smith-Waterman score: 8485; 95.6% identity (95.7% similar) in 1310 aa overlap (164-1417:1-1310)

           140       150       160       170       180       190   
pF1KA0 YLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPA
                                     ::::::::::::::::::::::::::::::
XP_016                               MELEKSGALLESGTYEDNYYGTPKPPAEPA
                                             10        20        30

           200       210       220       230       240       250   
pF1KA0 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES
               40        50        60        70        80        90

           260       270       280       290       300       310   
pF1KA0 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT
              100       110       120       130       140       150

           320       330       340       350       360       370   
pF1KA0 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR
              160       170       180       190       200       210

           380       390       400       410       420       430   
pF1KA0 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN
              220       230       240       250       260       270

           440       450       460       470       480       490   
pF1KA0 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF
              280       290       300       310       320       330

           500       510       520       530       540       550   
pF1KA0 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR
              340       350       360       370       380       390

           560       570       580       590       600       610   
pF1KA0 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ
              400       410       420       430       440       450

           620       630       640       650       660       670   
pF1KA0 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS
              460       470       480       490       500       510

           680       690       700       710       720       730   
pF1KA0 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE
              520       530       540       550       560       570

           740       750                     760       770         
pF1KA0 AFDPRKPDPYELYEKSRAIYESRR--------------PDYKELDVHLRRMESGFGFRIL
       :::::::::::::::::::::::.              ::::::::::::::::::::::
XP_016 AFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRIL
              580       590       600       610       620       630

     780       790       800       810       820       830         
pF1KA0 GGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQ
              640       650       660       670       680       690

     840       850       860       870       880       890         
pF1KA0 VNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFAS
              700       710       720       730       740       750

     900       910       920       930       940       950         
pF1KA0 HSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGD
              760       770       780       790       800       810

     960       970       980       990      1000      1010         
pF1KA0 RILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPL
              820       830       840       850       860       870

    1020      1030      1040      1050      1060      1070         
pF1KA0 AQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQ
              880       890       900       910       920       930

    1080      1090      1100      1110      1120      1130         
pF1KA0 PPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKG
              940       950       960       970       980       990

    1140      1150      1160      1170      1180      1190         
pF1KA0 AKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIEL
             1000      1010      1020      1030      1040      1050

    1200      1210      1220                                       
pF1KA0 IKSGGRRVRLLLKRGTGQVPEY--------------------------------------
       ::::::::::::::::::::::                                      
XP_016 IKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLART
             1060      1070      1080      1090      1100      1110

                1230      1240      1250      1260      1270       
pF1KA0 ----DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKRE
           ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNRKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKRE
             1120      1130      1140      1150      1160      1170

      1280      1290      1300      1310      1320      1330       
pF1KA0 HDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPG
             1180      1190      1200      1210      1220      1230

      1340      1350      1360      1370      1380      1390       
pF1KA0 LAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAAADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAG
             1240      1250      1260      1270      1280      1290

      1400      1410      1420      1430      1440 
pF1KA0 PRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
       ::::::::::::::::::::                        
XP_016 PRPGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
             1300      1310      1320      1330    

>>XP_016868338 (OMIM: 606382) PREDICTED: membrane-associ  (1332 aa)
 initn: 5746 init1: 4068 opt: 4322  Z-score: 1900.2  bits: 364.1 E(85289): 4.2e-99
Smith-Waterman score: 8495; 95.7% identity (95.7% similar) in 1310 aa overlap (164-1419:1-1310)

           140       150       160       170       180       190   
pF1KA0 YLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPA
                                     ::::::::::::::::::::::::::::::
XP_016                               MELEKSGALLESGTYEDNYYGTPKPPAEPA
                                             10        20        30

           200       210       220       230       240       250   
pF1KA0 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVNGNGVVVTPES
               40        50        60        70        80        90

           260       270       280       290       300       310   
pF1KA0 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYT
              100       110       120       130       140       150

           320       330       340       350       360       370   
pF1KA0 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRR
              160       170       180       190       200       210

           380       390       400       410       420       430   
pF1KA0 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSN
              220       230       240       250       260       270

           440       450       460       470       480       490   
pF1KA0 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLF
              280       290       300       310       320       330

           500       510       520       530       540       550   
pF1KA0 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISR
              340       350       360       370       380       390

           560       570       580       590       600       610   
pF1KA0 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQ
              400       410       420       430       440       450

           620       630       640       650       660       670   
pF1KA0 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGS
              460       470       480       490       500       510

           680       690       700       710       720       730   
pF1KA0 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTE
              520       530       540       550       560       570

           740       750                   760       770       780 
pF1KA0 AFDPRKPDPYELYEKSRAIYE------------SRRPDYKELDVHLRRMESGFGFRILGG
       :::::::::::::::::::::            :  ::::::::::::::::::::::::
XP_016 AFDPRKPDPYELYEKSRAIYEKQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGG
              580       590       600       610       620       630

             790       800       810       820       830       840 
pF1KA0 DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVN
              640       650       660       670       680       690

             850       860       870       880       890       900 
pF1KA0 LTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHS
              700       710       720       730       740       750

             910       920       930       940       950       960 
pF1KA0 LQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRI
              760       770       780       790       800       810

             970       980       990      1000      1010      1020 
pF1KA0 LAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQ
              820       830       840       850       860       870

            1030      1040      1050      1060      1070      1080 
pF1KA0 QSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPP
              880       890       900       910       920       930

            1090      1100      1110      1120      1130      1140 
pF1KA0 LDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAK
              940       950       960       970       980       990

            1150      1160      1170      1180      1190      1200 
pF1KA0 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK
             1000      1010      1020      1030      1040      1050

            1210      1220                                         
pF1KA0 SGGRRVRLLLKRGTGQVPEY----------------------------------------
       ::::::::::::::::::::                                        
XP_016 SGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTDN
             1060      1070      1080      1090      1100      1110

              1230      1240      1250      1260      1270         
pF1KA0 --DEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHD
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHD
             1120      1130      1140      1150      1160      1170

    1280      1290      1300      1310      1320      1330         
pF1KA0 VRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLA
             1180      1190      1200      1210      1220      1230

    1340      1350      1360      1370      1380      1390         
pF1KA0 AADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AADAADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPR
             1240      1250      1260      1270      1280      1290

    1400      1410      1420      1430      1440 
pF1KA0 PGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
       ::::::::::::::::::::                      
XP_016 PGPRPPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
             1300      1310      1320      1330  

>>XP_016868331 (OMIM: 606382) PREDICTED: membrane-associ  (1538 aa)
 initn: 7460 init1: 3173 opt: 3213  Z-score: 1417.1  bits: 274.9 E(85289): 3.4e-72
Smith-Waterman score: 9425; 93.4% identity (93.4% similar) in 1505 aa overlap (24-1431:24-1528)

               10        20        30        40        50        60
pF1KA0 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
                              :::::::::::::::::::::::::::::::::::::
XP_016 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYED
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPEEEEEERP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKPEDNEE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWEKIDDP
              310       320       330       340       350       360

              370       380       390       400                    
pF1KA0 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFR------------
       ::::::::::::::::::::::::::::::::::::::::::::::::            
XP_016 IYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPK
              370       380       390       400       410       420

                                     410       420       430       
pF1KA0 -------------------------------EKPLFTRDASQLKGTFLSTTLKKSNMGFG
                                      :::::::::::::::::::::::::::::
XP_016 SIRPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFG
              430       440       450       460       470       480

       440       450       460       470       480       490       
pF1KA0 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVP
              490       500       510       520       530       540

       500       510       520       530       540       550       
pF1KA0 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQS
              550       560       570       580       590       600

       560       570       580       590       600       610       
pF1KA0 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGF
              610       620       630       640       650       660

       620       630       640       650       660       670       
pF1KA0 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSL
              670       680       690       700       710       720

       680       690       700       710       720       730       
pF1KA0 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDP
              730       740       750       760       770       780

       740       750                   760       770       780     
pF1KA0 RKPDPYELYEKSRAIYE------------SRRPDYKELDVHLRRMESGFGFRILGGDEPG
       :::::::::::::::::            :  ::::::::::::::::::::::::::::
XP_016 RKPDPYELYEKSRAIYEKQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPG
              790       800       810       820       830       840

         790       800       810       820       830       840     
pF1KA0 QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVR
              850       860       870       880       890       900

         850       860       870       880       890       900     
pF1KA0 RKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTS
              910       920       930       940       950       960

         910       920       930       940       950       960     
pF1KA0 DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVN
              970       980       990      1000      1010      1020

         970       980       990      1000      1010      1020     
pF1KA0 GQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPL
             1030      1040      1050      1060      1070      1080

        1030      1040      1050      1060      1070      1080     
pF1KA0 AQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYR
             1090      1100      1110      1120      1130      1140

        1090      1100      1110      1120      1130      1140     
pF1KA0 QPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGF
             1150      1160      1170      1180      1190      1200

        1150      1160      1170      1180      1190      1200     
pF1KA0 SIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGR
             1210      1220      1230      1240      1250      1260

        1210      1220                                             
pF1KA0 RVRLLLKRGTGQVPEY------------------------------------------DE
       ::::::::::::::::                                          ::
XP_016 RVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTDNRKDE
             1270      1280      1290      1300      1310      1320

          1230      1240      1250      1260      1270      1280   
pF1KA0 PAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPWSSPAAAAPGLPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKP
             1330      1340      1350      1360      1370      1380

          1290      1300      1310      1320      1330      1340   
pF1KA0 KELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQGRPEAGRPASEARAPGLAAADA
             1390      1400      1410      1420      1430      1440

          1350      1360      1370      1380      1390      1400   
pF1KA0 ADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADAARAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPR
             1450      1460      1470      1480      1490      1500

          1410      1420      1430      1440 
pF1KA0 PPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
       ::::::::::::::::::::::::::::          
XP_016 PPGGAPARKAAVAPGPWKVPGSDKLPSVLKPGASAASR
             1510      1520      1530        




1441 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 23:21:22 2016 done: Sat Nov  5 23:21:25 2016
 Total Scan time: 20.940 Total Display time:  0.750

Function used was FASTA [36.3.4 Apr, 2011]
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