Result of FASTA (omim) for pF1KE0228
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0228, 110 aa
  1>>>pF1KE0228 110 - 110 aa - 110 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.7646+/-0.000302; mu= 12.3046+/- 0.019
 mean_var=54.4417+/-10.902, 0's: 0 Z-trim(115.9): 68  B-trim: 38 in 1/54
 Lambda= 0.173823
 statistics sampled from 26623 (26691) to 26623 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.718), E-opt: 0.2 (0.313), width:  16
 Scan time:  4.390

The best scores are:                                      opt bits E(85289)
NP_001007233 (OMIM: 609490) caspase recruitment do ( 110)  702 183.4 6.3e-47
XP_011541140 (OMIM: 609490) PREDICTED: caspase rec ( 125)  702 183.4   7e-47
NP_150634 (OMIM: 147678) caspase-1 isoform alpha p ( 404)  543 143.9 1.9e-34
NP_001244047 (OMIM: 147678) caspase-1 isoform alph ( 404)  543 143.9 1.9e-34
NP_443121 (OMIM: 615680) caspase recruitment domai (  97)  495 131.5 2.4e-31
NP_001244048 (OMIM: 147678) caspase-1 isoform beta ( 383)  487 129.8   3e-30
NP_001214 (OMIM: 147678) caspase-1 isoform beta pr ( 383)  487 129.8   3e-30
NP_001017534 (OMIM: 615680) caspase recruitment do ( 197)  464 123.9 9.5e-29
XP_011540885 (OMIM: 615680) PREDICTED: caspase rec ( 265)  452 120.9 9.8e-28
XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 i ( 374)  378 102.5   5e-22
XP_016873882 (OMIM: 147678) PREDICTED: caspase-1 i ( 401)  378 102.5 5.3e-22
XP_016873883 (OMIM: 147678) PREDICTED: caspase-1 i ( 401)  378 102.5 5.3e-22
XP_016873884 (OMIM: 147678) PREDICTED: caspase-1 i ( 380)  322 88.4 8.6e-18
NP_067546 (OMIM: 605354) caspase recruitment domai (  90)  302 83.1 8.4e-17
NP_001289433 (OMIM: 606831,616050,616115) NLR fami ( 359)  133 41.0  0.0015
NP_150637 (OMIM: 147678) caspase-1 isoform epsilon (  88)  123 38.2  0.0027
XP_016860108 (OMIM: 606831,616050,616115) PREDICTE ( 788)  127 39.7  0.0082


>>NP_001007233 (OMIM: 609490) caspase recruitment domain  (110 aa)
 initn: 702 init1: 702 opt: 702  Z-score: 963.4  bits: 183.4 E(85289): 6.3e-47
Smith-Waterman score: 702; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:1-110)

               10        20        30        40        50        60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
               10        20        30        40        50        60

               70        80        90       100       110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
               70        80        90       100       110

>>XP_011541140 (OMIM: 609490) PREDICTED: caspase recruit  (125 aa)
 initn: 702 init1: 702 opt: 702  Z-score: 962.6  bits: 183.4 E(85289): 7e-47
Smith-Waterman score: 702; 100.0% identity (100.0% similar) in 110 aa overlap (1-110:16-125)

                              10        20        30        40     
pF1KE0                MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKC
                      :::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLSVSAYTRREERKAMADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKC
               10        20        30        40        50        60

          50        60        70        80        90       100     
pF1KE0 ENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQ
               70        80        90       100       110       120

         110
pF1KE0 IVLPS
       :::::
XP_011 IVLPS
            

>>NP_150634 (OMIM: 147678) caspase-1 isoform alpha precu  (404 aa)
 initn: 543 init1: 543 opt: 543  Z-score: 739.6  bits: 143.9 E(85289): 1.9e-34
Smith-Waterman score: 543; 80.9% identity (90.0% similar) in 110 aa overlap (1-110:1-110)

               10        20        30        40        50        60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
       ::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_150 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS          
       :: ::: ::::::::::::::.:::::::::  ::::.:. :::: :: :          
NP_150 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
               70        80        90       100       110       120

NP_150 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
              130       140       150       160       170       180

>>NP_001244047 (OMIM: 147678) caspase-1 isoform alpha pr  (404 aa)
 initn: 543 init1: 543 opt: 543  Z-score: 739.6  bits: 143.9 E(85289): 1.9e-34
Smith-Waterman score: 543; 80.9% identity (90.0% similar) in 110 aa overlap (1-110:1-110)

               10        20        30        40        50        60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
       ::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS          
       :: ::: ::::::::::::::.:::::::::  ::::.:. :::: :: :          
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
               70        80        90       100       110       120

NP_001 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
              130       140       150       160       170       180

>>NP_443121 (OMIM: 615680) caspase recruitment domain-co  (97 aa)
 initn: 495 init1: 495 opt: 495  Z-score: 683.7  bits: 131.5 E(85289): 2.4e-31
Smith-Waterman score: 495; 82.5% identity (90.7% similar) in 97 aa overlap (1-97:1-97)

               10        20        30        40        50        60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
       ::::::::::: ::.:.::::::::: :::.::::.:::.: :: ::::::::.:::.::
NP_443 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
               10        20        30        40        50        60

               70        80        90       100       110
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
       :: ::: ::::::::::::::.:: ::::::::  ::             
NP_443 VIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN             
               70        80        90                    

>>NP_001244048 (OMIM: 147678) caspase-1 isoform beta pre  (383 aa)
 initn: 487 init1: 487 opt: 487  Z-score: 664.0  bits: 129.8 E(85289): 3e-30
Smith-Waterman score: 487; 83.9% identity (93.5% similar) in 93 aa overlap (1-93:1-93)

               10        20        30        40        50        60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
       ::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS          
       :: ::: ::::::::::::::.:::::::::.:                           
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA
               70        80        90       100       110       120

NP_001 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD
              130       140       150       160       170       180

>>NP_001214 (OMIM: 147678) caspase-1 isoform beta precur  (383 aa)
 initn: 487 init1: 487 opt: 487  Z-score: 664.0  bits: 129.8 E(85289): 3e-30
Smith-Waterman score: 487; 83.9% identity (93.5% similar) in 93 aa overlap (1-93:1-93)

               10        20        30        40        50        60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
       ::::::::::: ::::.::::::::: :::.::::..::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS          
       :: ::: ::::::::::::::.:::::::::.:                           
NP_001 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA
               70        80        90       100       110       120

NP_001 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD
              130       140       150       160       170       180

>>NP_001017534 (OMIM: 615680) caspase recruitment domain  (197 aa)
 initn: 464 init1: 464 opt: 464  Z-score: 637.1  bits: 123.9 E(85289): 9.5e-29
Smith-Waterman score: 464; 83.5% identity (92.3% similar) in 91 aa overlap (1-91:1-91)

               10        20        30        40        50        60
pF1KE0 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS
       ::::::::::: ::.:.::::::::: :::.::::.:::.: :: ::::::::.:::.::
NP_001 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE0 VIRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS          
       :: ::: ::::::::::::::.:: ::::::                             
NP_001 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA
               70        80        90       100       110       120

NP_001 QRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQWLFLRTNFIERFWRNILLLPLHKGSLYP
              130       140       150       160       170       180

>>XP_011540885 (OMIM: 615680) PREDICTED: caspase recruit  (265 aa)
 initn: 452 init1: 452 opt: 452  Z-score: 618.9  bits: 120.9 E(85289): 9.8e-28
Smith-Waterman score: 452; 83.1% identity (92.1% similar) in 89 aa overlap (3-91:71-159)

                                           10        20        30  
pF1KE0                             MADKVLKEKRKQFIRSVGEGTINGLLGELLET
                                     ::::::::: ::.:.::::::::: :::.:
XP_011 LLFQEQVPGKKELWKGLALLEAIISICGSLDKVLKEKRKLFIHSMGEGTINGLLDELLQT
               50        60        70        80        90       100

             40        50        60        70        80        90  
pF1KE0 RVLSQEEIEIVKCENATVMDKARALLDSVIRKGAPACQICITYICEEDSHLAGTLGLSAG
       :::.:::.: :: ::::::::.:::.:::: ::: ::::::::::::::.:: :::::: 
XP_011 RVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAA
              110       120       130       140       150       160

            100       110                                          
pF1KE0 PTSGNHLTTQDSQIVLPS                                          
                                                                   
XP_011 LQAVQDNPAMPTCSSPEGRIKLCFLEDAQRIWKQKLQRCHVQNTIIKWSERYTSGSFEMQ
              170       180       190       200       210       220

>>XP_016873885 (OMIM: 147678) PREDICTED: caspase-1 isofo  (374 aa)
 initn: 378 init1: 378 opt: 378  Z-score: 516.4  bits: 102.5 E(85289): 5e-22
Smith-Waterman score: 378; 78.5% identity (88.6% similar) in 79 aa overlap (32-110:2-80)

              10        20        30        40        50        60 
pF1KE0 ADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDSV
                                     ::::..::.: :: ::::::::.:::.:::
XP_016                              MTRVLNKEEMEKVKRENATVMDKTRALIDSV
                                            10        20        30 

              70        80        90       100       110           
pF1KE0 IRKGAPACQICITYICEEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS           
       : ::: ::::::::::::::.:::::::::  ::::.:. :::: :: :           
XP_016 IPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNP
              40        50        60        70        80        90 

XP_016 AMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTG
             100       110       120       130       140       150 




110 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 20:29:13 2016 done: Thu Nov  3 20:29:14 2016
 Total Scan time:  4.390 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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