Result of FASTA (omim) for pF1KB6367
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6367, 269 aa
  1>>>pF1KB6367 269 - 269 aa - 269 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5822+/-0.000386; mu= 13.2834+/- 0.024
 mean_var=74.2848+/-14.940, 0's: 0 Z-trim(112.7): 30  B-trim: 0 in 0/54
 Lambda= 0.148807
 statistics sampled from 21665 (21695) to 21665 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.254), width:  16
 Scan time:  5.850

The best scores are:                                      opt bits E(85289)
NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 1820 400.1 2.2e-111
XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 1612 355.4 5.5e-98
NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157)  206 53.5 2.9e-07
XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157)  206 53.5 2.9e-07
XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158)  191 50.3 2.7e-06
XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158)  191 50.3 2.7e-06
XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158)  191 50.3 2.7e-06
NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158)  191 50.3 2.7e-06
XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143)  184 48.7   7e-06
NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143)  184 48.7   7e-06
NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143)  184 48.7   7e-06
XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143)  184 48.7   7e-06
NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159)  184 48.8 7.6e-06
NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177)  184 48.8 8.3e-06
NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180)  184 48.8 8.4e-06
NP_000566 (OMIM: 147760) interleukin-1 alpha precu ( 271)  183 48.7 1.4e-05
XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218)  162 44.1 0.00026
NP_055254 (OMIM: 605510) interleukin-37 isoform 1  ( 218)  162 44.1 0.00026
NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155)  157 43.0 0.00041
NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155)  157 43.0 0.00041
NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169)  156 42.8 0.00052
NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134)  152 41.9 0.00077
NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152)  147 40.8  0.0018
NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152)  147 40.8  0.0018
NP_775297 (OMIM: 605510) interleukin-37 isoform 5  ( 192)  145 40.4   0.003
NP_775294 (OMIM: 605510) interleukin-37 isoform 2  ( 197)  145 40.4   0.003
XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178)  142 39.8  0.0043
NP_775296 (OMIM: 605510) interleukin-37 isoform 4  ( 178)  142 39.8  0.0043


>>NP_000567 (OMIM: 137215,147720) interleukin-1 beta pro  (269 aa)
 initn: 1820 init1: 1820 opt: 1820  Z-score: 2120.7  bits: 400.1 E(85289): 2.2e-111
Smith-Waterman score: 1820; 100.0% identity (100.0% similar) in 269 aa overlap (1-269:1-269)

               10        20        30        40        50        60
pF1KB6 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST
              190       200       210       220       230       240

              250       260         
pF1KB6 SQAENMPVFLGGTKGGQDITDFTMQFVSS
       :::::::::::::::::::::::::::::
NP_000 SQAENMPVFLGGTKGGQDITDFTMQFVSS
              250       260         

>>XP_016859477 (OMIM: 137215,147720) PREDICTED: interleu  (238 aa)
 initn: 1612 init1: 1612 opt: 1612  Z-score: 1880.1  bits: 355.4 E(85289): 5.5e-98
Smith-Waterman score: 1612; 100.0% identity (100.0% similar) in 238 aa overlap (32-269:1-238)

              10        20        30        40        50        60 
pF1KB6 AEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGF
                                     ::::::::::::::::::::::::::::::
XP_016                               MKCSFQDLDLCPLDGGIQLRISDHHYSKGF
                                             10        20        30

              70        80        90       100       110       120 
pF1KB6 RQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRS
               40        50        60        70        80        90

             130       140       150       160       170       180 
pF1KB6 LNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEK
              100       110       120       130       140       150

             190       200       210       220       230       240 
pF1KB6 NLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTS
              160       170       180       190       200       210

             250       260         
pF1KB6 QAENMPVFLGGTKGGQDITDFTMQFVSS
       ::::::::::::::::::::::::::::
XP_016 QAENMPVFLGGTKGGQDITDFTMQFVSS
              220       230        

>>NP_775270 (OMIM: 605508) interleukin-36 beta isoform 2  (157 aa)
 initn:  78 init1:  78 opt: 206  Z-score: 251.5  bits: 53.5 E(85289): 2.9e-07
Smith-Waterman score: 206; 32.9% identity (61.0% similar) in 146 aa overlap (126-267:14-156)

         100       110       120       130       140       150     
pF1KB6 FIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQ
                                     .:::.:   :.::   : :  :. .   . 
NP_775                  MNPQREAAPKSYAIRDSRQMVWVLSGN-SLIAAPLSRSI--KP
                                10        20         30          40

         160       170          180       190       200        210 
pF1KB6 VVFSMSFVQGEESNDKIP---VALGLKEKNLYLSCVLKDDKPTLQLESVDPKN-YPKKKM
       :.. .   .  : .::     : ::.: :.: : :.  . ::::::.  .  . : .:: 
NP_775 VTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKA
               50        60        70        80        90       100

             220       230       240       250       260         
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
       .: :.: . . ..   :.:...:.:.:.:: . ..:.::   .:  . :.: .. :  
NP_775 QKPFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE 
              110       120       130       140       150        

>>XP_011509264 (OMIM: 605508) PREDICTED: interleukin-36   (157 aa)
 initn:  78 init1:  78 opt: 206  Z-score: 251.5  bits: 53.5 E(85289): 2.9e-07
Smith-Waterman score: 206; 32.9% identity (61.0% similar) in 146 aa overlap (126-267:14-156)

         100       110       120       130       140       150     
pF1KB6 FIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQ
                                     .:::.:   :.::   : :  :. .   . 
XP_011                  MNPQREAAPKSYAIRDSRQMVWVLSGN-SLIAAPLSRSI--KP
                                10        20         30          40

         160       170          180       190       200        210 
pF1KB6 VVFSMSFVQGEESNDKIP---VALGLKEKNLYLSCVLKDDKPTLQLESVDPKN-YPKKKM
       :.. .   .  : .::     : ::.: :.: : :.  . ::::::.  .  . : .:: 
XP_011 VTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKA
               50        60        70        80        90       100

             220       230       240       250       260         
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
       .: :.: . . ..   :.:...:.:.:.:: . ..:.::   .:  . :.: .. :  
XP_011 QKPFLFFHNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE 
              110       120       130       140       150        

>>XP_016859295 (OMIM: 605509) PREDICTED: interleukin-36   (158 aa)
 initn: 159 init1:  96 opt: 191  Z-score: 234.1  bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)

        130       140       150       160       170       180      
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
                                     ..:   :.  :..   :. :::.  :: : 
XP_016 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
          20        30        40        50        60        70     

        190       200        210       220       230       240     
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
       :.   :.:::::.  :  . : . .  : :.: . . . .  :::. ::.:.:..:.  .
XP_016 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
          80        90       100       110       120       130     

         250       260           
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
        :..:    :  . :::  :: :   
XP_016 CPLILTQELGKANTTDFGLTMLF   
         140       150           

>>XP_011509267 (OMIM: 605509) PREDICTED: interleukin-36   (158 aa)
 initn: 159 init1:  96 opt: 191  Z-score: 234.1  bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)

        130       140       150       160       170       180      
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
                                     ..:   :.  :..   :. :::.  :: : 
XP_011 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
          20        30        40        50        60        70     

        190       200        210       220       230       240     
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
       :.   :.:::::.  :  . : . .  : :.: . . . .  :::. ::.:.:..:.  .
XP_011 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
          80        90       100       110       120       130     

         250       260           
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
        :..:    :  . :::  :: :   
XP_011 CPLILTQELGKANTTDFGLTMLF   
         140       150           

>>XP_005263696 (OMIM: 605509) PREDICTED: interleukin-36   (158 aa)
 initn: 159 init1:  96 opt: 191  Z-score: 234.1  bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)

        130       140       150       160       170       180      
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
                                     ..:   :.  :..   :. :::.  :: : 
XP_005 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
          20        30        40        50        60        70     

        190       200        210       220       230       240     
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
       :.   :.:::::.  :  . : . .  : :.: . . . .  :::. ::.:.:..:.  .
XP_005 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
          80        90       100       110       120       130     

         250       260           
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
        :..:    :  . :::  :: :   
XP_005 CPLILTQELGKANTTDFGLTMLF   
         140       150           

>>NP_055255 (OMIM: 605509) interleukin-36 alpha [Homo sa  (158 aa)
 initn: 159 init1:  96 opt: 191  Z-score: 234.1  bits: 50.3 E(85289): 2.7e-06
Smith-Waterman score: 191; 34.5% identity (59.3% similar) in 113 aa overlap (157-266:46-158)

        130       140       150       160       170       180      
pF1KB6 RDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS
                                     ..:   :.  :..   :. :::.  :: : 
NP_055 QDINHRVWVLQDQTLIAVPRKDRMSPVTIALISCRHVETLEKDRGNPIYLGLNGLNLCLM
          20        30        40        50        60        70     

        190       200        210       220       230       240     
pF1KB6 CVLKDDKPTLQLESVDPKN-YPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAEN
       :.   :.:::::.  :  . : . .  : :.: . . . .  :::. ::.:.:..:.  .
NP_055 CAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFYHSQSGRNSTFESVAFPGWFIAVSSEGG
          80        90       100       110       120       130     

         250       260           
pF1KB6 MPVFLGGTKGGQDITDF--TMQFVSS
        :..:    :  . :::  :: :   
NP_055 CPLILTQELGKANTTDFGLTMLF   
         140       150           

>>XP_005263718 (OMIM: 137215,147679,612628,612852) PREDI  (143 aa)
 initn: 174 init1:  94 opt: 184  Z-score: 226.6  bits: 48.7 E(85289): 7e-06
Smith-Waterman score: 184; 30.3% identity (57.2% similar) in 145 aa overlap (128-265:8-140)

       100       110       120       130       140       150       
pF1KB6 FEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVV
                                     : .::.. . .  .: : .::: .      
XP_005                        MQAFRIWDVNQKTFYLRNN-QLVAGYLQGPN------
                                      10         20        30      

       160       170            180       190       200        210 
pF1KB6 FSMSFVQGEESNDKIPVA-----LGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPK-KKM
            :. ::. : .:.      ::..  .. :::: . :.  ::::.:.  .  . .:.
XP_005 -----VNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQ
                    40        50        60        70        80     

             220       230       240       250        260         
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKG-GQDITDFTMQFVSS
       .:::.: . . .    ::::  :.:.. :..  ..:: : .    :  .: : .:    
XP_005 DKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 
          90       100       110       120       130       140    

>>NP_001305843 (OMIM: 137215,147679,612628,612852) inter  (143 aa)
 initn: 174 init1:  94 opt: 184  Z-score: 226.6  bits: 48.7 E(85289): 7e-06
Smith-Waterman score: 184; 30.3% identity (57.2% similar) in 145 aa overlap (128-265:8-140)

       100       110       120       130       140       150       
pF1KB6 FEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVV
                                     : .::.. . .  .: : .::: .      
NP_001                        MQAFRIWDVNQKTFYLRNN-QLVAGYLQGPN------
                                      10         20        30      

       160       170            180       190       200        210 
pF1KB6 FSMSFVQGEESNDKIPVA-----LGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPK-KKM
            :. ::. : .:.      ::..  .. :::: . :.  ::::.:.  .  . .:.
NP_001 -----VNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQ
                    40        50        60        70        80     

             220       230       240       250        260         
pF1KB6 EKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKG-GQDITDFTMQFVSS
       .:::.: . . .    ::::  :.:.. :..  ..:: : .    :  .: : .:    
NP_001 DKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 
          90       100       110       120       130       140    




269 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 22:48:37 2016 done: Fri Nov  4 22:48:38 2016
 Total Scan time:  5.850 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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