FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6377, 271 aa
  1>>>pF1KB6377 271 - 271 aa - 271 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.0546+/-0.0004; mu= 10.3274+/- 0.025
 mean_var=64.3661+/-12.962, 0's: 0 Z-trim(110.3): 27  B-trim: 10 in 1/60
 Lambda= 0.159862
 statistics sampled from 18666 (18681) to 18666 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.583), E-opt: 0.2 (0.219), width:  16
 Scan time:  6.490

The best scores are:                                      opt bits E(85289)
NP_000566 (OMIM: 147760) interleukin-1 alpha precu ( 271) 1747 411.9 6.4e-115
NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269)  183 51.2 2.4e-06
XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238)  153 44.3 0.00026


>>NP_000566 (OMIM: 147760) interleukin-1 alpha precursor  (271 aa)
 initn: 1747 init1: 1747 opt: 1747  Z-score: 2184.2  bits: 411.9 E(85289): 6.4e-115
Smith-Waterman score: 1747; 100.0% identity (100.0% similar) in 271 aa overlap (1-271:1-271)

               10        20        30        40        50        60
pF1KB6 MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 KTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 NVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 TVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHP
              190       200       210       220       230       240

              250       260       270 
pF1KB6 NLFIATKQDYWVCLAGGPPSITDFQILENQA
       :::::::::::::::::::::::::::::::
NP_000 NLFIATKQDYWVCLAGGPPSITDFQILENQA
              250       260       270 

>>NP_000567 (OMIM: 137215,147720) interleukin-1 beta pro  (269 aa)
 initn: 111 init1:  64 opt: 183  Z-score: 234.8  bits: 51.2 E(85289): 2.4e-06
Smith-Waterman score: 190; 26.4% identity (55.2% similar) in 277 aa overlap (1-266:1-264)

               10        20         30        40        50         
pF1KB6 MAKVPDMFEDLKNCYSENEEDSS-SIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISET
       ::.::..  ..   :: ::.:     :  .  . ::  ..  ::     : ...: ::. 
NP_000 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPL-----DGGIQLRISD-
               10        20        30        40             50     

      60        70        80        90       100       110         
pF1KB6 SKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFL
        . ::  :...  ::..  : :.:  .   :.. ..:: ..     ::  .:    :.  
NP_000 HHYSK-GFRQAASVVVAMDK-LRKMLVPCPQTFQENDLSTFFPFIFEE--EP--IFFDTW
            60        70         80        90       100            

     120       130        140       150         160       170      
pF1KB6 SNVKYNFMRIIK-YEFILNDALNQSIIRANDQYLTAAALH--NLDEAVKFDMGAYKSSKD
       .:  :     ..  .  : :. ..:.. ..   : :  :.  .... : :.:.  .. ..
NP_000 DNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEES
      110       120       130       140       150       160        

        180       190        200       210       220       230     
pF1KB6 DAKITVILRISKTQLYVT-AQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNY--
       . :: : : ... .::.. .  .:.:.:  :  . ::.   .. .  : ..    .:   
NP_000 NDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVD-PKNYPKKKMEKRFVFNKIEINNKLE
      170       180       190       200        210       220       

           240         250         260       270 
pF1KB6 FTSVAHPNLFIATKQ--DYWVCLAG--GPPSITDFQILENQA
       : :.  :: .:.:.:  .. : :.:  :  .:::: .     
NP_000 FESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
       230       240       250       260         

>>XP_016859477 (OMIM: 137215,147720) PREDICTED: interleu  (238 aa)
 initn:  81 init1:  64 opt: 153  Z-score: 198.4  bits: 44.3 E(85289): 0.00026
Smith-Waterman score: 153; 26.0% identity (56.7% similar) in 231 aa overlap (47-266:11-233)

         20        30        40         50        60        70     
pF1KB6 ENEEDSSSIDHLSLNQKSFYHVSYGPLHEGC-MDQSVSLSISETSKTSKLTFKESMVVVA
                                     : .: ...: ::.  . ::  :...  ::.
XP_016                     MKCSFQDLDLCPLDGGIQLRISD-HHYSK-GFRQAASVVV
                                   10        20          30        

          80        90       100       110       120       130     
pF1KB6 TNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLSNVKYNFMRIIK-YEF
       .  : :.:  .   :.. ..:: ..     ::  .:    :.  .:  :     ..  . 
XP_016 AMDK-LRKMLVPCPQTFQENDLSTFFPFIFEE--EP--IFFDTWDNEAYVHDAPVRSLNC
       40         50        60          70          80        90   

          140       150         160       170       180       190  
pF1KB6 ILNDALNQSIIRANDQYLTAAALH--NLDEAVKFDMGAYKSSKDDAKITVILRISKTQLY
        : :. ..:.. ..   : :  :.  .... : :.:.  .. ... :: : : ... .::
XP_016 TLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLY
           100       110       120       130       140       150   

             200       210       220       230         240         
pF1KB6 VT-AQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNY--FTSVAHPNLFIATKQ-
       .. .  .:.:.:  :  . ::.   .. .  : ..    .:   : :.  :: .:.:.: 
XP_016 LSCVLKDDKPTLQLESVD-PKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQA
           160       170        180       190       200       210  

       250         260       270 
pF1KB6 -DYWVCLAG--GPPSITDFQILENQA
        .. : :.:  :  .:::: .     
XP_016 ENMPVFLGGTKGGQDITDFTMQFVSS
            220       230        




271 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 01:03:57 2016 done: Sat Nov  5 01:03:58 2016
 Total Scan time:  6.490 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]