Result of FASTA (omim) for pF1KB7742
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7742, 486 aa
  1>>>pF1KB7742 486 - 486 aa - 486 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.3513+/-0.000432; mu= -7.8834+/- 0.027
 mean_var=426.5599+/-88.598, 0's: 0 Z-trim(122.4): 59  B-trim: 35 in 1/60
 Lambda= 0.062099
 statistics sampled from 40384 (40473) to 40384 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.475), width:  16
 Scan time: 10.800

The best scores are:                                      opt bits E(85289)
NP_005326 (OMIM: 601306) hematopoietic lineage cel ( 486) 3305 310.3   8e-84
NP_001278970 (OMIM: 601306) hematopoietic lineage  ( 449) 2399 229.1 2.1e-59
XP_006718510 (OMIM: 164765) PREDICTED: src substra ( 476) 1134 115.8 2.8e-25
XP_016872801 (OMIM: 164765) PREDICTED: src substra ( 277) 1115 113.8 6.2e-25
NP_612632 (OMIM: 164765) src substrate cortactin i ( 513) 1120 114.5 7.1e-25
NP_001171669 (OMIM: 164765) src substrate cortacti ( 634) 1120 114.6 8.2e-25
XP_006718511 (OMIM: 164765) PREDICTED: src substra ( 369) 1111 113.6 9.8e-25
NP_005222 (OMIM: 164765) src substrate cortactin i ( 550) 1111 113.8 1.3e-24
NP_001271244 (OMIM: 610106) drebrin-like protein i ( 336)  368 47.0  0.0001
NP_054782 (OMIM: 610106) drebrin-like protein isof ( 431)  368 47.1 0.00012
NP_001271242 (OMIM: 610106) drebrin-like protein i ( 327)  363 46.5 0.00013
NP_001014436 (OMIM: 610106) drebrin-like protein i ( 430)  363 46.6 0.00016
XP_011513627 (OMIM: 610106) PREDICTED: drebrin-lik ( 438)  337 44.3 0.00083
NP_001116428 (OMIM: 610106) drebrin-like protein i ( 439)  333 44.0  0.0011


>>NP_005326 (OMIM: 601306) hematopoietic lineage cell-sp  (486 aa)
 initn: 3305 init1: 3305 opt: 3305  Z-score: 1625.9  bits: 310.3 E(85289): 8e-84
Smith-Waterman score: 3305; 99.8% identity (100.0% similar) in 486 aa overlap (1-486:1-486)

               10        20        30        40        50        60
pF1KB7 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_005 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
              430       440       450       460       470       480

             
pF1KB7 YVKLLE
       ::::::
NP_005 YVKLLE
             

>>NP_001278970 (OMIM: 601306) hematopoietic lineage cell  (449 aa)
 initn: 2379 init1: 2379 opt: 2399  Z-score: 1187.6  bits: 229.1 E(85289): 2.1e-59
Smith-Waterman score: 2959; 92.2% identity (92.4% similar) in 486 aa overlap (1-486:1-449)

               10        20        30        40        50        60
pF1KB7 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGF
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGE
       :::::::::::::::::::::::::::::::::                           
NP_001 GGKYGVERDRADKSAVGFDYKGEVEKHTSQKDY---------------------------
              130       140       150                              

              190       200       210       220       230       240
pF1KB7 TEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKA
                 ::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_001 ----------AKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKA
                     160       170       180       190       200   

              250       260       270       280       290       300
pF1KB7 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISS
           210       220       230       240       250       260   

              310       320       330       340       350       360
pF1KB7 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVY
           270       280       290       300       310       320   

              370       380       390       400       410       420
pF1KB7 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPA
           330       340       350       360       370       380   

              430       440       450       460       470       480
pF1KB7 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPAN
           390       400       410       420       430       440   

             
pF1KB7 YVKLLE
       ::::::
NP_001 YVKLLE
             

>>XP_006718510 (OMIM: 164765) PREDICTED: src substrate c  (476 aa)
 initn: 1361 init1: 1049 opt: 1134  Z-score: 574.8  bits: 115.8 E(85289): 2.8e-25
Smith-Waterman score: 1459; 45.6% identity (66.5% similar) in 529 aa overlap (1-484:1-474)

               10         20        30        40        50         
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
       :::. .:: ::.. .  : :::.::::::::.:::::::::::..:::. ::::::.::.
XP_006 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
               10        20        30        40        50        60

      60        70        80        90       100                   
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEV------------
       .: .::..:..::.:.::::::::::.::::.:::::::::::: ...            
XP_006 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
               70        80        90       100       110       120

                                110       120       130       140  
pF1KB7 -------------------------EKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKG
                                :::.:: : ..::::::::. ::.:::::::::.:
XP_006 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
              130       140       150       160       170       180

            150       160       170       180       190       200  
pF1KB7 EVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQK
       ..::: ::.:::.::::.::..::: ::.:.:..:.:.:::::::.::.:::::.::.::
XP_006 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYSKGFGGKYGVQK
              190       200       210       220       230       240

            210       220       230       240           250        
pF1KB7 DRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEK----RKREEEEKA
       ::.::.:  :...   ..::.::.:.::..: . ...:.::..:.::    :.. : :.:
XP_006 DRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA
              250       260       270       280       290       300

      260       270       280       290       300       310        
pF1KB7 QQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVR
       :..:...::.. . .:. :    . ..  :. ::: :   . :  :   .  .. :  ..
XP_006 QRMAKERQEQEEA-RRKLEEQARAKTQTPPVSPAPQP---TEERLPSSPVYEDAASFKAE
              310        320       330          340       350      

      320          330       340       350       360       370     
pF1KB7 TSREHPVPLL---PIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPE
        : . ::      :. .    : .:       . .::    : :::.   :   :     
XP_006 LSYRGPVSGTEPEPVYSMEAADYREAS-----SQQGLAYATEAVYESAEAPGHYPA----
        360       370       380            390       400           

         380       390       400       410       420       430     
pF1KB7 NDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVA
          ::          :: :.:                                :::.:::
XP_006 ---ED-------STYDEYEND--------------------------------LGITAVA
                 410                                       420     

         440       450       460       470       480      
pF1KB7 LYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
       :::::. :.::.::::::.::.:::.:.::::: :.:..::::::::.:  
XP_006 LYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
         430       440       450       460       470      

>>XP_016872801 (OMIM: 164765) PREDICTED: src substrate c  (277 aa)
 initn: 1684 init1: 1049 opt: 1115  Z-score: 568.6  bits: 113.8 E(85289): 6.2e-25
Smith-Waterman score: 1115; 58.1% identity (85.2% similar) in 277 aa overlap (1-271:1-270)

               10         20        30        40        50         
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
       :::. .:: ::.. .  : :::.::::::::.:::::::::::..:::. ::::::.::.
XP_016 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
       .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
XP_016 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
       ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
XP_016 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
       .::::::::::.:::::.:::.::.:::::::: :...      ::   :. .. ..:. 
XP_016 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQG------KTEKHESQKDYVKGFG
              190       200       210              220       230   

     240       250            260       270       280       290    
pF1KB7 AKFESMAEEKRK----REEEEKAQ-QVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPL
       .::  ..... :     ...:: : . ... .:. :.                       
XP_016 GKFGVQTDRQDKCALGWDHQEKLQLHESQKAREQTAIEPLFSAQ                
           240       250       260       270                       

          300       310       320       330       340       350    
pF1KB7 PKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQV

>>NP_612632 (OMIM: 164765) src substrate cortactin isofo  (513 aa)
 initn: 1361 init1: 1049 opt: 1120  Z-score: 567.6  bits: 114.5 E(85289): 7.1e-25
Smith-Waterman score: 1392; 44.3% identity (69.6% similar) in 519 aa overlap (1-484:1-511)

               10         20        30        40        50         
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
       :::. .:: ::.. .  : :::.::::::::.:::::::::::..:::. ::::::.::.
NP_612 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
       .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
NP_612 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
       ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
NP_612 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
       .::::::::::.:::::.:::.::.:::::::: :... :  ...      . .:  :..
NP_612 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ
              190       200       210        220       230         

     240          250       260               270       280        
pF1KB7 AKFE---SMAEEKRKREEEEKAQQVARR--------QQERKAVTKRSPEAPQPVIAMEEP
       .  .   ... ..... . ...:.   .        :..:   .  . :    : .  . 
NP_612 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK
     240       250       260       270       280       290         

      290        300       310       320       330       340       
pF1KB7 AVPAP-LPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPR
       .::.  . .: :.      .    .:.:  : .. . .      : . .. .:      :
NP_612 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA------QRMAKERQEQEE-ARR
     300       310       320       330             340        350  

       350       360       370        380               390        
pF1KB7 TLEGLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVE----EMDRHEQ----EDEP-----
        ::     .  .  . : :.:  :  : .  :::.     :.. .      : ::     
NP_612 KLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSME
            360       370       380       390       400       410  

           400       410        420              430       440     
pF1KB7 EGDYEEVLEPEDSSFSS-ALAGSSGCPAGAGAGAVA-------LGISAVALYDYQGEGSD
        .::.:.   .  .... :.  :.  :.   :   .       :::.::::::::. :.:
NP_612 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDD
            420       430       440       450       460       470  

         450       460       470       480      
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
       :.::::::.::.:::.:.::::: :.:..::::::::.:  
NP_612 EISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
            480       490       500       510   

>>NP_001171669 (OMIM: 164765) src substrate cortactin is  (634 aa)
 initn: 1303 init1: 1049 opt: 1120  Z-score: 566.5  bits: 114.6 E(85289): 8.2e-25
Smith-Waterman score: 1334; 43.6% identity (69.0% similar) in 509 aa overlap (1-474:1-501)

               10         20        30        40        50         
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
       :::. .:: ::.. .  : :::.::::::::.:::::::::::..:::. ::::::.::.
NP_001 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
       .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
NP_001 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
       ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
NP_001 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
       .::::::::::.:::::.:::.::.:::::::: :... :  ...      . .:  :..
NP_001 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ
              190       200       210        220       230         

     240          250       260               270       280        
pF1KB7 AKFE---SMAEEKRKREEEEKAQQVARR--------QQERKAVTKRSPEAPQPVIAMEEP
       .  .   ... ..... . ...:.   .        :..:   .  . :    : .  . 
NP_001 TDRQDKCALGWDHQEKLQLHESQKDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQK
     240       250       260       270       280       290         

      290        300       310       320       330       340       
pF1KB7 AVPAP-LPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPR
       .::.  . .: :.      .    .:.:  : .. . .      : . .. .:      :
NP_001 TVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERA------QRMAKERQEQEE-ARR
     300       310       320       330             340        350  

       350       360       370        380               390        
pF1KB7 TLEGLQVEEEPVYEAEPEPEPEPEPEPEND-YEDVE----EMDRHEQ----EDEP-----
        ::     .  .  . : :.:  :  : .  :::.     :.. .      : ::     
NP_001 KLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSME
            360       370       380       390       400       410  

           400       410        420              430       440     
pF1KB7 EGDYEEVLEPEDSSFSS-ALAGSSGCPAGAGAGAVA-------LGISAVALYDYQGEGSD
        .::.:.   .  .... :.  :.  :.   :   .       :::.::::::::. :.:
NP_001 AADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDD
            420       430       440       450       460       470  

         450       460       470       480                         
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE                   
       :.::::::.::.:::.:.::::: :.:.:                               
NP_001 EISFDPDDIITNIEMIDDGWWRGVCKGRFRELAFSCVRVALVPIKCSRDLPGQARGLRSA
            480       490       500       510       520       530  

>>XP_006718511 (OMIM: 164765) PREDICTED: src substrate c  (369 aa)
 initn: 2890 init1: 1049 opt: 1111  Z-score: 565.1  bits: 113.6 E(85289): 9.8e-25
Smith-Waterman score: 1111; 58.2% identity (85.0% similar) in 273 aa overlap (1-269:1-266)

               10         20        30        40        50         
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
       :::. .:: ::.. .  : :::.::::::::.:::::::::::..:::. ::::::.::.
XP_006 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
       .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
XP_006 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
       ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
XP_006 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
       .::::::::::.:::::.:::.::.:::::::: :...      ::   :. .. ..:. 
XP_006 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQG------KTEKHESQKDYVKGFG
              190       200       210              220       230   

     240       250          260       270       280       290      
pF1KB7 AKFESMAEEKRKRE---EEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPK
       .::  ..... :     ....  :. . :.. :                           
XP_006 GKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKL
           240       250       260       270       280       290   

        300       310       320       330       340       350      
pF1KB7 KISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEE
                                                                   
XP_006 AKHESQQDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSFWEQLGPA
           300       310       320       330       340       350   

>>NP_005222 (OMIM: 164765) src substrate cortactin isofo  (550 aa)
 initn: 1996 init1: 1049 opt: 1111  Z-score: 562.9  bits: 113.8 E(85289): 1.3e-24
Smith-Waterman score: 1177; 41.0% identity (64.2% similar) in 520 aa overlap (1-455:1-519)

               10         20        30        40        50         
pF1KB7 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN
       :::. .:: ::.. .  : :::.::::::::.:::::::::::..:::. ::::::.::.
NP_005 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
               10        20        30        40        50        60

      60        70        80        90       100       110         
pF1KB7 KVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKG
       .: .::..:..::.:.::::::::::.::::.:::::::::::: ... :: ::.:...:
NP_005 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB7 FGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKG
       ::::.::. ::.:.:::::.:.:..:::.:::::: ::::.:::. :. ::.:.:.::.:
NP_005 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB7 ETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLK
       .::::::::::.:::::.:::.::.:::::::: :... :  ...      . .:  :..
NP_005 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGF-EYQGKTEKHESQKDYVKGFGGKFGVQ
              190       200       210        220       230         

     240             250       260               270            280
pF1KB7 AKFESMA------EEKRKREEEEKAQQ--------VARRQQERKAV-----TKRSPEAPQ
       .  ..        .:: . .: .:  .        :  ..:.  ::      : . .  :
NP_005 TDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQ
     240       250       260       270       280       290         

                           290       300       310        320      
pF1KB7 PVIA-------------MEEPAVPAPLPKKISSEAWPPVGTPP-SSESEPVRTSREHPVP
          .             :.. :       ..::     : .   .:..  .:.. :. . 
NP_005 QDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAK
     300       310       320       330       340       350         

        330       340       350          360       370             
pF1KB7 LLPIRQTLPEDNEEPPALPPRTLEGLQVE---EEPVYEAEPEPEPEPEPEPEND------
           ..    . :.   .  .  :  ...   :: .      :   : :.: ..      
NP_005 EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSP
     360       370       380       390       400       410         

        380               390            400       410        420  
pF1KB7 -YEDVE----EMDRHEQ----EDEP-----EGDYEEVLEPEDSSFSS-ALAGSSGCPAGA
        :::.     :.. .      : ::      .::.:.   .  .... :.  :.  :.  
NP_005 VYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHY
     420       430       440       450       460       470         

                   430       440       450       460       470     
pF1KB7 GAGAVA-------LGISAVALYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFG
        :   .       :::.::::::::. :.::.::::::.:                    
NP_005 PAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYG
     480       490       500       510       520       530         

         480      
pF1KB7 LFPANYVKLLE
                  
NP_005 LFPANYVELRQ
     540       550

>>NP_001271244 (OMIM: 610106) drebrin-like protein isofo  (336 aa)
 initn: 392 init1: 185 opt: 368  Z-score: 205.8  bits: 47.0 E(85289): 0.0001
Smith-Waterman score: 370; 31.1% identity (55.8% similar) in 312 aa overlap (191-486:38-336)

              170       180       190       200       210          
pF1KB7 YGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPT-
                                     ::. :..:...:.    . ::    .::. 
NP_001 SAWLAQGGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVG---PQAPVG
        10        20        30        40        50           60    

     220        230       240       250       260       270        
pF1KB7 TAYKKTTPI-EAASSGARGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEA
       ..:.::. . :    :  .. :: :.  ::.:. ::...:.. :.:: :..   ..  ::
NP_001 SVYQKTNAVSEIKRVGKDSFWAKAEK-EEENRRLEEKRRAEE-AQRQLEQERRERELREA
           70        80        90        100        110       120  

      280       290       300       310       320       330        
pF1KB7 PQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQ----TL
        .    ..: .  :  :.. . :    : .   .:.:    :  ::  ..  ..    : 
NP_001 ARREQRYQEQGGEAS-PQSRTWEQQQEVVSRNRNEQE----SAVHPREIFKQKERAMSTT
            130        140       150           160       170       

          340       350       360               370       380      
pF1KB7 PEDNEEPPALPPRTLEGLQVEEEPVYEAEP-----EPE---PEPEPEPENDYEDVEEMDR
         .. .:  :    :.   .. :  .  ::     .:.   :  :: : .    :.  ..
NP_001 SISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEE
       180       190       200       210       220       230       

        390       400       410       420        430       440     
pF1KB7 HEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGA-GAGAVALGISAVALYDYQGEGSD
          :. ::   .:..  .    ..  :::        : :  . :. : ::::::.  . 
NP_001 AVYEEPPE---QETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDT
       240          250       260       270       280       290    

         450       460       470        480      
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRC-HGHFGLFPANYVKLLE
       :.::::...:: ::..:::::::    ::::.::::::.:.:
NP_001 EISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
          300       310       320       330      

>>NP_054782 (OMIM: 610106) drebrin-like protein isoform   (431 aa)
 initn: 392 init1: 185 opt: 368  Z-score: 204.5  bits: 47.1 E(85289): 0.00012
Smith-Waterman score: 370; 31.1% identity (55.8% similar) in 312 aa overlap (191-486:133-431)

              170       180       190       200       210          
pF1KB7 YGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPT-
                                     ::. :..:...:.    . ::    .::. 
NP_054 TMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVG---PQAPVG
            110       120       130       140       150            

     220        230       240       250       260       270        
pF1KB7 TAYKKTTPI-EAASSGARGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEA
       ..:.::. . :    :  .. :: :.  ::.:. ::...:.. :.:: :..   ..  ::
NP_054 SVYQKTNAVSEIKRVGKDSFWAKAEK-EEENRRLEEKRRAEE-AQRQLEQERRERELREA
     160       170       180        190       200        210       

      280       290       300       310       320       330        
pF1KB7 PQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQ----TL
        .    ..: .  :  :.. . :    : .   .:.:    :  ::  ..  ..    : 
NP_054 ARREQRYQEQGGEAS-PQSRTWEQQQEVVSRNRNEQE----SAVHPREIFKQKERAMSTT
       220       230        240       250           260       270  

          340       350       360               370       380      
pF1KB7 PEDNEEPPALPPRTLEGLQVEEEPVYEAEP-----EPE---PEPEPEPENDYEDVEEMDR
         .. .:  :    :.   .. :  .  ::     .:.   :  :: : .    :.  ..
NP_054 SISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEE
            280       290       300       310       320       330  

        390       400       410       420        430       440     
pF1KB7 HEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGA-GAGAVALGISAVALYDYQGEGSD
          :. ::   .:..  .    ..  :::        : :  . :. : ::::::.  . 
NP_054 AVYEEPPE---QETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDT
            340          350       360       370       380         

         450       460       470        480      
pF1KB7 ELSFDPDDVITDIEMVDEGWWRGRC-HGHFGLFPANYVKLLE
       :.::::...:: ::..:::::::    ::::.::::::.:.:
NP_054 EISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
     390       400       410       420       430 




486 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 22:08:15 2016 done: Fri Nov  4 22:08:17 2016
 Total Scan time: 10.800 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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