Result of FASTA (omim) for pF1KB8892
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8892, 215 aa
  1>>>pF1KB8892 215 - 215 aa - 215 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.1566+/-0.000282; mu= 8.6990+/- 0.018
 mean_var=171.7542+/-35.390, 0's: 0 Z-trim(124.0): 60  B-trim: 443 in 2/54
 Lambda= 0.097863
 statistics sampled from 44794 (44859) to 44794 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.824), E-opt: 0.2 (0.526), width:  16
 Scan time:  7.500

The best scores are:                                      opt bits E(85289)
NP_004812 (OMIM: 602406) heart- and neural crest d ( 215) 1507 223.4 2.3e-58
XP_005268588 (OMIM: 602406) PREDICTED: heart- and  ( 214) 1488 220.7 1.4e-57
NP_068808 (OMIM: 602407) heart- and neural crest d ( 217)  689 107.9 1.3e-23
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199)  250 45.9 5.7e-05
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201)  224 42.2 0.00073
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201)  224 42.2 0.00073
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189)  206 39.6  0.0041
NP_005589 (OMIM: 162360) helix-loop-helix protein  ( 133)  202 38.9  0.0047
NP_660161 (OMIM: 609875) protein atonal homolog 7  ( 152)  196 38.1  0.0093


>>NP_004812 (OMIM: 602406) heart- and neural crest deriv  (215 aa)
 initn: 1507 init1: 1507 opt: 1507  Z-score: 1168.9  bits: 223.4 E(85289): 2.3e-58
Smith-Waterman score: 1507; 100.0% identity (100.0% similar) in 215 aa overlap (1-215:1-215)

               10        20        30        40        50        60
pF1KB8 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
              130       140       150       160       170       180

              190       200       210     
pF1KB8 LQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
       :::::::::::::::::::::::::::::::::::
NP_004 LQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
              190       200       210     

>>XP_005268588 (OMIM: 602406) PREDICTED: heart- and neur  (214 aa)
 initn: 1319 init1: 1264 opt: 1488  Z-score: 1154.5  bits: 220.7 E(85289): 1.4e-57
Smith-Waterman score: 1488; 99.5% identity (99.5% similar) in 215 aa overlap (1-215:1-214)

               10        20        30        40        50        60
pF1KB8 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELREC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRE
              130       140       150       160       170       180

              190       200       210     
pF1KB8 LQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
       :: ::::::::::::::::::::::::::::::::
XP_005 LQ-HEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
               190       200       210    

>>NP_068808 (OMIM: 602407) heart- and neural crest deriv  (217 aa)
 initn: 678 init1: 386 opt: 689  Z-score: 544.7  bits: 107.9 E(85289): 1.3e-23
Smith-Waterman score: 689; 54.2% identity (73.6% similar) in 227 aa overlap (1-215:1-217)

               10           20        30         40         50     
pF1KB8 MNLVGSYAHH---HHHHHPHPAHPMLHEPFLFGPASRC-HQERPYFQSWLLS-PADAAPD
       :.:::.. ::   ::. .:  :          . :::: :.: :::..::.. :  . ::
NP_068 MSLVGGFPHHPVVHHEGYPFAAAAAAAAA---AAASRCSHEENPYFHGWLIGHPEMSPPD
               10        20           30        40        50       

             60           70        80        90        100        
pF1KB8 FPAG---GPPPAAAAAA---TAYGPDARPGQSPGRLEALGG-RLGRRKGSGPKKERRRTE
       .  .   .:  :..::.   . ::  . :: .:    .::: :  .:.:.. .::::::.
NP_068 YSMALSYSPEYASGAAGLDHSHYG-GVPPGAGP---PGLGGPRPVKRRGTANRKERRRTQ
        60        70        80            90       100       110   

      110       120       130       140       150       160        
pF1KB8 SINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKK
       ::::::::::::::::::::::::::::::::::::::::.:::: :.:. ::::::.::
NP_068 SINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKK
           120       130       140       150       160       170   

      170       180       190       200       210     
pF1KB8 ADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ
       .:  .: :::.::  .: .  ...  .:. ::::::::.::::::.:
NP_068 TDV-KEEKRKKEL--NEILKSTVSSNDKKTKGRTGWPQHVWALELKQ
            180         190       200       210       

>>NP_004600 (OMIM: 601010) transcription factor 15 [Homo  (199 aa)
 initn: 252 init1: 201 opt: 250  Z-score: 210.2  bits: 45.9 E(85289): 5.7e-05
Smith-Waterman score: 250; 43.0% identity (65.3% similar) in 121 aa overlap (73-176:43-162)

             50        60        70           80        90         
pF1KB8 QSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDAR---PGQSPGRLEALGGRLG-----R
                                     ::.:    :: . ::  . ::  :     :
NP_004 VLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVR
             20        30        40        50        60        70  

          100       110       120       130       140       150    
pF1KB8 RKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVL--AK
       .. ..  .:: ::.:.:.::. ::  ::. :.: :::::.:::::.::::.: .::  . 
NP_004 QRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETLRLASSYIAHLANVLLLGD
             80        90       100       110       120       130  

            160              170       180       190       200     
pF1KB8 DAQSGDPEAFKAELKK-------ADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWP
       .:..:.:  :.:  .        :::::. .                             
NP_004 SADDGQP-CFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGV
             140       150       160       170       180       190 

         210     
pF1KB8 QQVWALELNQ
                 
NP_004 APLRGPRR  
                 

>>NP_001073983 (OMIM: 609067) basic helix-loop-helix tra  (201 aa)
 initn: 218 init1: 218 opt: 224  Z-score: 190.3  bits: 42.2 E(85289): 0.00073
Smith-Waterman score: 230; 35.2% identity (54.5% similar) in 145 aa overlap (64-208:56-178)

            40        50        60        70        80        90   
pF1KB8 RCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLG
                                     :..  : . :: .:::. :           
NP_001 EDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRRAGGGGPGGRPGREP-----------
          30        40        50        60        70               

           100       110       120       130       140       150   
pF1KB8 RRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKD
       :.. ..  .:: ::.:.:.::. ::  ::. ::: :::::.:::::.:::..: .::   
NP_001 RQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLAG
           80        90       100       110       120       130    

           160       170       180       190       200       210   
pF1KB8 AQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALEL
          :: .  ..      :    .  :      : ::   :      :..  :.:.     
NP_001 EACGDGQPCHS------GPAFFHAARA-----GSPPPPPPPPPARDGENTQPKQICTFCL
          140             150            160       170       180   

                         
pF1KB8 NQ                
                         
NP_001 SNQRKLSKDRDRKTAIRS
           190       200 

>>XP_006716679 (OMIM: 609067) PREDICTED: basic helix-loo  (201 aa)
 initn: 218 init1: 218 opt: 224  Z-score: 190.3  bits: 42.2 E(85289): 0.00073
Smith-Waterman score: 230; 35.2% identity (54.5% similar) in 145 aa overlap (64-208:56-178)

            40        50        60        70        80        90   
pF1KB8 RCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLG
                                     :..  : . :: .:::. :           
XP_006 EDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRRAGGGGPGGRPGREP-----------
          30        40        50        60        70               

           100       110       120       130       140       150   
pF1KB8 RRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKD
       :.. ..  .:: ::.:.:.::. ::  ::. ::: :::::.:::::.:::..: .::   
XP_006 RQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLAG
           80        90       100       110       120       130    

           160       170       180       190       200       210   
pF1KB8 AQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALEL
          :: .  ..      :    .  :      : ::   :      :..  :.:.     
XP_006 EACGDGQPCHS------GPAFFHAARA-----GSPPPPPPPPPARDGENTQPKQICTFCL
          140             150            160       170       180   

                         
pF1KB8 NQ                
                         
XP_006 SNQRKLSKDRDRKTAIRS
           190       200 

>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli  (189 aa)
 initn: 233 init1: 150 opt: 206  Z-score: 176.9  bits: 39.6 E(85289): 0.0041
Smith-Waterman score: 228; 32.8% identity (56.5% similar) in 177 aa overlap (33-200:5-173)

             10        20        30        40        50          60
pF1KB8 LVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPD--FPAGG
                                     .:  ..:   :.   .:....::  .:  :
NP_803                           MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPG
                                         10        20        30    

               70         80        90             100       110   
pF1KB8 PPPAAAAAATAYGPDAR-PGQSPGRLEALGGRLGRRKGS------GPKKERRRTESINSA
       : :: .  .      :: ::..  :  . .:  ::: .:      . ..::.: ...:.:
NP_803 PEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNA
           40        50        60        70        80        90    

           120       130       140       150       160       170   
pF1KB8 FAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGR
       :  ::: ::.: :: :::::.:: :: .::  :  ..   ..:  :        .. : .
NP_803 FQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGL------EGPGPK
          100       110       120       130       140              

           180       190       200       210      
pF1KB8 ESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ 
         .. .. ::  :   ::: .: . .:                
NP_803 LYQHYQQQQQVAG--GALGATEAQPQGHLQRYSTQIHSFREGT
      150       160         170       180         

>>NP_005589 (OMIM: 162360) helix-loop-helix protein 1 [H  (133 aa)
 initn: 197 init1: 175 opt: 202  Z-score: 175.8  bits: 38.9 E(85289): 0.0047
Smith-Waterman score: 211; 43.1% identity (63.3% similar) in 109 aa overlap (52-150:30-131)

              30        40        50        60        70        80 
pF1KB8 MLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQS
                                     :.::    :  :.. ... : ::.  ::. 
NP_005  MMLNSDTMELDLPPTHSETESGFSDCGGGAGPD----GAGPGGPGGGQARGPE--PGE-
                10        20        30            40          50   

                90       100               110       120       130 
pF1KB8 PGR--LEALGGRLGRRKGSGPKK--------ERRRTESINSAFAELRECIPNVPADTKLS
       :::  :. :. .  ::.  .  :        :: :.:..: ::::::. .:..: : :::
NP_005 PGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLS
             60        70        80        90       100       110  

             140       150       160       170       180       190 
pF1KB8 KIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPAL
       ::. ::::  ::.::  ::                                         
NP_005 KIEILRLAICYISYLNHVLDV                                       
            120       130                                          

>>NP_660161 (OMIM: 609875) protein atonal homolog 7 [Hom  (152 aa)
 initn: 198 init1: 162 opt: 196  Z-score: 170.5  bits: 38.1 E(85289): 0.0093
Smith-Waterman score: 196; 38.2% identity (61.8% similar) in 102 aa overlap (57-157:6-103)

         30        40        50        60        70         80     
pF1KB8 FLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPD-ARPGQSPGRL
                                     :.: :  : .:   : : . :    . :::
NP_660                          MKSCKPSGPPAGARVAPPCAGGTECAGTCAGAGRL
                                        10        20        30     

          90       100       110       120       130       140     
pF1KB8 EALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAY
       :. .    ::. ..  .:::: ...:.:: .::. .:.   : :::: .::..: :::  
NP_660 ESAA----RRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIMA
              40        50        60        70        80        90 

         150       160       170       180       190       200     
pF1KB8 LMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWP
       :  .::.  . :                                                
NP_660 LTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKLPGESELYSQRLFGFQPEPFQMA
             100       110       120       130       140       150 




215 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 20:20:08 2016 done: Fri Nov  4 20:20:09 2016
 Total Scan time:  7.500 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]
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