Result of FASTA (ccds) for pF1KE0353
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0353, 543 aa
  1>>>pF1KE0353 543 - 543 aa - 543 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.4143+/-0.000827; mu= 13.5111+/- 0.050
 mean_var=94.1859+/-18.419, 0's: 0 Z-trim(109.7): 24  B-trim: 0 in 0/52
 Lambda= 0.132154
 statistics sampled from 11045 (11068) to 11045 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.34), width:  16
 Scan time:  3.480

The best scores are:                                      opt bits E(32554)
CCDS5025.1 GJA10 gene_id:84694|Hs108|chr6          ( 543) 3781 731.2 7.6e-211
CCDS432.1 GJA9 gene_id:81025|Hs108|chr1            ( 515) 1213 241.5 1.8e-63
CCDS30834.1 GJA8 gene_id:2703|Hs108|chr1           ( 433)  955 192.3 9.8e-49
CCDS9289.1 GJA3 gene_id:2700|Hs108|chr13           ( 435)  955 192.3 9.9e-49
CCDS929.1 GJA5 gene_id:2702|Hs108|chr1             ( 358)  916 184.8 1.4e-46
CCDS30669.1 GJA4 gene_id:2701|Hs108|chr1           ( 333)  881 178.1 1.4e-44
CCDS5123.1 GJA1 gene_id:2697|Hs108|chr6            ( 382)  847 171.7 1.4e-42
CCDS9290.1 GJB2 gene_id:2706|Hs108|chr13           ( 226)  457 97.2 2.2e-20
CCDS1569.1 GJC2 gene_id:57165|Hs108|chr1           ( 439)  455 97.0 4.9e-20
CCDS383.1 GJB4 gene_id:127534|Hs108|chr1           ( 266)  441 94.2 2.1e-19
CCDS11487.1 GJC1 gene_id:10052|Hs108|chr17         ( 396)  438 93.7 4.3e-19
CCDS384.1 GJB3 gene_id:2707|Hs108|chr1             ( 270)  431 92.3 7.8e-19
CCDS9291.1 GJB6 gene_id:10804|Hs108|chr13          ( 261)  427 91.5 1.3e-18
CCDS14408.1 GJB1 gene_id:2705|Hs108|chrX           ( 283)  413 88.9 8.8e-18
CCDS5008.1 GJB7 gene_id:375519|Hs108|chr6          ( 223)  407 87.7 1.6e-17
CCDS382.1 GJB5 gene_id:2709|Hs108|chr1             ( 273)  398 86.0 6.2e-17
CCDS10040.1 GJD2 gene_id:57369|Hs108|chr15         ( 321)  399 86.2 6.2e-17
CCDS58547.1 GJD3 gene_id:125111|Hs108|chr17        ( 294)  362 79.2 7.7e-15
CCDS7191.1 GJD4 gene_id:219770|Hs108|chr10         ( 370)  300 67.4 3.4e-11
CCDS34697.1 GJC3 gene_id:349149|Hs108|chr7         ( 279)  298 67.0 3.5e-11


>>CCDS5025.1 GJA10 gene_id:84694|Hs108|chr6               (543 aa)
 initn: 3781 init1: 3781 opt: 3781  Z-score: 3898.8  bits: 731.2 E(32554): 7.6e-211
Smith-Waterman score: 3781; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:1-543)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 TLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 TMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSSFGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 TMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSSFGL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 QNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMRESGVWI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 QNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMRESGVWI
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 DRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 DRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSM
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 VRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGGGDYLWRDKIIHSIHSVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS50 VRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGGGDYLWRDKIIHSIHSVK
              490       500       510       520       530       540

          
pF1KE0 FNS
       :::
CCDS50 FNS
          

>>CCDS432.1 GJA9 gene_id:81025|Hs108|chr1                 (515 aa)
 initn: 1190 init1: 1190 opt: 1213  Z-score: 1253.1  bits: 241.5 E(32554): 1.8e-63
Smith-Waterman score: 1219; 47.7% identity (70.1% similar) in 461 aa overlap (1-414:1-453)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
       ::::::::  ::::: :::..:::::::::::::::: :::::::.::::.: :::.:::
CCDS43 MGDWNLLGDTLEEVHIHSTMIGKIWLTILFIFRMLVLGVAAEDVWNDEQSGFICNTEQPG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       : :.:::.::::::::.::::.:::::::::::::::::::..:..::: :..::...:.
CCDS43 CRNVCYDQAFPISLIRYWVLQVIFVSSPSLVYMGHALYRLRVLEEERQRMKAQLRVELEE
               70        80        90       100       110       120

               130       140       150       160       170         
pF1KE0 PDLDL-EEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY
        .... ....:...:: .::..: ..:.::.: :: :::.::.::::.:::::::::.::
CCDS43 VEFEMPRDRRRLEQELCQLEKRK-LNKAPLRGTLLCTYVIHIFTRSVVEVGFMIGQYLLY
              130       140        150       160       170         

     180       190       200       210       220       230         
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
       ::...::.::   :::: .:::::::::::::.:::.:::.:::.::::::::::..:: 
CCDS43 GFHLEPLFKCHGHPCPNIIDCFVSRPTEKTIFLLFMQSIATISLFLNILEIFHLGFKKIK
     180       190       200       210       220       230         

     240       250       260          270       280         290    
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKK--YSVAQ-QCMICSSLPERISPLQAN--NQQQVIRV
       : :. : . .  ..:    :: .:   .::. :    .:: .  :  . :   ..:.  .
CCDS43 RGLWGKYKLKKEHNE----FHANKAKQNVAKYQSTSANSLKRLPSAPDYNLLVEKQTHTA
     240       250           260       270       280       290     

            300       310                                     320  
pF1KE0 NVPK--SKTMWQIPQPRQLEVDP------------------------------SNGKKDW
         :.  :....: :.: .  :.                               ::..:: 
CCDS43 VYPSLNSSSVFQ-PNPDNHSVNDEKCILDEQETVLSNEISTLSTSCSHFQHISSNNNKDT
         300        310       320       330       340       350    

               330       340        350        360       370       
pF1KE0 SE---KDQHSGQLHVHSPCPWAGSAGNQHL-GQQS-DHSSFGLQNTMSQSWLGTTTAPRN
        .   :. ...::  .       :  : .  :..:    ..  .:.: ::   . . : :
CCDS43 HKIFGKELNGNQLMEKRETEGKDSKRNYYSRGHRSIPGVAIDGENNMRQSPQTVFSLPAN
          360       370       380       390       400       410    

          380       390       400        410       420       430   
pF1KE0 C---PSFAVGTWEQSQDPEPSGEPLT-DLHSHCRDSEGSMRESGVWIDRSRPGSRKASFL
       :   : .  .:: .: . :  : :   .:... :  .:..:                   
CCDS43 CDWKPRWLRATWGSSTEHENRGSPPKGNLKGQFR--KGTVRTLPPSQGDSQSLDIPNTAD
          420       430       440         450       460       470  

           440       450       460       470       480       490   
pF1KE0 SRLLSEKRHLHSDSGSSGSRNSSCLDFPHWENSPSPLPSVTGHRTSMVRQAALPIMELSQ
                                                                   
CCDS43 SLGGLSFEPGLVRTCNNPVCPPNHVVSLTNNLIGRRVPTDLQI                 
            480       490       500       510                      

>>CCDS30834.1 GJA8 gene_id:2703|Hs108|chr1                (433 aa)
 initn: 973 init1: 557 opt: 955  Z-score: 988.4  bits: 192.3 E(32554): 9.8e-49
Smith-Waterman score: 963; 38.2% identity (66.2% similar) in 456 aa overlap (1-439:1-429)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
       ::::..::.:::::. :::..:..:::.:::::.:.: .::: :: :::: :.:::.:::
CCDS30 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       :.:.:::.::::: ::.:::::::::.:::.:.:::.. .:  :: ..:.  .:  :  .
CCDS30 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT
               70        80        90       100       110       120

                 130       140       150       160       170       
pF1KE0 ---PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI
          ::     :  .    ..   .:  .:  :.: :::::. ::. ....::::..:.:.
CCDS30 NGGPD-----QGSV----KKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYF
                       130       140       150       160       170 

       180       190       200       210       220       230       
pF1KE0 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK
       ::::.. :::.:.. ::::.::::::::::::::.::: :.:..::.::..:. :::.. 
CCDS30 LYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKG
             180       190       200       210       220       230 

       240       250       260       270       280       290       
pF1KE0 IMRTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
       : :.  :.     .:.  :   . . .:.:      ::. .. .  :  ......    :
CCDS30 I-RSALKRP----VEQPLGEIPEKSLHSIA-----VSSI-QKAKGYQLLEEEKIVSHYFP
                  240       250            260        270       280

       300             310        320              330       340   
pF1KE0 KSKT-MWQI-PQP----RQLEVDPSNGK-KDWSEKDQHS-------GQLHVHSPCPWAGS
        ... : .  : :     :.:   :.:   : :.  :..       :  .:..  : :  
CCDS30 LTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEE
              290       300       310       320       330       340

           350       360       370       380       390       400   
pF1KE0 AGNQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLH
       ... ..:......     . ..      ...:..    . :. ....  ::..: ..   
CCDS30 GAEPEVGEKKEEA-----ERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQG
              350            360       370       380       390     

           410       420       430       440       450       460   
pF1KE0 SHCRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHW
          . . .   :  .  : .:: :: ..  ::  :.                        
CCDS30 LPAEKTPSLCPE--LTTDDARPLSRLSKASSRARSDDLTV                    
         400         410       420       430                       

           470       480       490       500       510       520   
pF1KE0 ENSPSPLPSVTGHRTSMVRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGG

>>CCDS9289.1 GJA3 gene_id:2700|Hs108|chr13                (435 aa)
 initn: 945 init1: 551 opt: 955  Z-score: 988.4  bits: 192.3 E(32554): 9.9e-49
Smith-Waterman score: 955; 52.9% identity (79.7% similar) in 261 aa overlap (1-258:1-253)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
       ::::..:: .::... :::..::.:::.:::::.::: .:::::: :::: :.:::.:::
CCDS92 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       :.:.::: ::::: ::::.:::::::.:.:.:.::.:. .:  :: ..:.. . . . :.
CCDS92 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEE-QLKRES
               70        80        90       100       110          

              130       140       150       160       170       180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
       :.   :  :  :    : ... :..   . : ::::::..:. ....::::. :::.:::
CCDS92 PS-PKEPPQ--DNPSSR-DDRGRVR---MAGALLRTYVFNIIFKTLFEVGFIAGQYFLYG
     120          130        140          150       160       170  

              190       200       210       220       230       240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
       :...:::.: . ::::.::::.:::::::::..:: ..:  :::::.:::.::: .:. .
CCDS92 FELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQ
            180       190       200       210       220       230  

              250          260       270       280       290       
pF1KE0 TLYKKSSSEGIEDETG---PPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP
        . .. . .. :   :   ::                                       
CCDS92 GVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPP
            240       250       260       270       280       290  

>>CCDS929.1 GJA5 gene_id:2702|Hs108|chr1                  (358 aa)
 initn: 917 init1: 558 opt: 916  Z-score: 949.5  bits: 184.8 E(32554): 1.4e-46
Smith-Waterman score: 916; 44.4% identity (69.1% similar) in 324 aa overlap (1-320:1-320)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
       ::::..::..:::::.:::.:::.:::.::::::::: .:::. : :::. : :.: :::
CCDS92 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       :.:.:::.::::: ::.:::::::::.:::::::::.. .:  :: . :.    ::.   
CCDS92 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAE--RAKEVR
               70        80        90       100       110          

              130       140       150       160       170       180
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYG
        . . :       ::   :: .   .. :.: :: :::  :: :...::::..:::..::
CCDS92 GSGSYEYPVAEKAELSCWEEGN--GRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYG
      120       130       140         150       160       170      

              190       200       210       220       230       240
pF1KE0 FQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMR
       . .  :. : . :::. :.:.:::::::..:..:: ..::.::::.. :..::: .:: .
CCDS92 IFLTTLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQ
        180       190       200       210       220       230      

              250       260           270       280       290      
pF1KE0 TLYKKSSSEGIEDETGPPFHLKKYSVA----QQCMICSSLPERISPLQANNQQQVIRVNV
        . :  .  .  . .::   . .  .     .::.  .   . ..:.. :  .:    :.
CCDS92 RFVKPRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNL
        240       250       260       270       280       290      

        300       310       320       330       340       350      
pF1KE0 PKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHS
          ..  :   : .  ..   :.:                                    
CCDS92 VTEQVRGQEQTPGEGFIQVRYGQKPEVPNGVSPGHRLPHGYHSDKRRLSKASSKARSDDL
        300       310       320       330       340       350      

>>CCDS30669.1 GJA4 gene_id:2701|Hs108|chr1                (333 aa)
 initn: 887 init1: 522 opt: 881  Z-score: 913.9  bits: 178.1 E(32554): 1.4e-44
Smith-Waterman score: 881; 41.8% identity (70.9% similar) in 337 aa overlap (1-331:1-329)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
       ::::..:  .:..:. :::.:::::::.:::::.:.: .:.:.:: :::: : ::: :::
CCDS30 MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPG
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRA-QME
       :.:.:::.::::: ::.::::..:::.:.:::.::..:  :  :. :: :...:::   .
CCDS30 CTNVCYDQAFPISHIRYWVLQFLFVSTPTLVYLGHVIYLSRREERLRQ-KEGELRALPAK
               70        80        90       100        110         

     120       130         140       150       160       170       
pF1KE0 NPDLDLEEQQRIDRELRRLE--EQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI
       .:... .    ..:.. ..   :. :..   ..: :. :::  .: .::::.::. ::. 
CCDS30 DPQVE-RALAAVERQMAKISVAEDGRLR---IRGALMGTYVASVLCKSVLEAGFLYGQWR
     120        130       140          150       160       170     

       180       190       200       210       220       230       
pF1KE0 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK
       :::. :.:.. : . :::  ::::::::::::::..::  .. :::.::.::. ::  : 
CCDS30 LYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLISLVLNLLELVHLLCRC
         180       190       200       210       220       230     

       240       250         260       270        280       290    
pF1KE0 IMRTLYKKSSSEG--IEDETGPPFHLKKYSVAQQCMICSSLP-ERISPLQANNQQQVIRV
       . : .  ......   .  .. :.  . .      .  :: :    . :....:. .   
CCDS30 LSRGMRARQGQDAPPTQGTSSDPYTDQVFFYLPVGQGPSSPPCPTYNGLSSSEQNWA---
         240       250       260       270       280       290     

          300       310       320       330       340       350    
pF1KE0 NVPKSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSD
       :.   . . .   :  :.  :.::.:  :. .. ...                       
CCDS30 NLTTEERLASSRPPLFLDPPPQNGQKPPSRPSSSASKKQYV                   
            300       310       320       330                      

          360       370       380       390       400       410    
pF1KE0 HSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLHSHCRDSEGSMR

>>CCDS5123.1 GJA1 gene_id:2697|Hs108|chr6                 (382 aa)
 initn: 846 init1: 512 opt: 847  Z-score: 877.9  bits: 171.7 E(32554): 1.4e-42
Smith-Waterman score: 847; 42.5% identity (73.1% similar) in 294 aa overlap (1-291:1-289)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
       ::::. :: .:..:...::  ::.::..:::::.:.: .:.:..: :::::: :::.:::
CCDS51 MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       :.:.::: .:::: .::::::::::: :.:.:..:..: .:  ::  ....    :: ..
CCDS51 CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG
               70        80        90       100       110       120

              130       140        150       160       170         
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIH-KVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY
        ..:.. .:    :.....   . : :: ..: :::::.. :: .:..::.:.. :. .:
CCDS51 VNVDMHLKQI---EIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIY
              130          140       150       160       170       

     180       190       200       210       220       230         
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
       ::..  .: : . :::. ::::.:::::::::..::  .. .:: :::.:.:.. .. . 
CCDS51 GFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVK
       180       190       200       210       220       230       

     240       250       260       270         280       290       
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMI--CSSLPERISPLQANNQQQVIRVNVP
         .  :..:.  .  .:     :  .  .  ..  :::    .::..  . . :      
CCDS51 DRV--KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNN
       240         250       260       270       280       290     

       300       310       320       330       340       350       
pF1KE0 KSKTMWQIPQPRQLEVDPSNGKKDWSEKDQHSGQLHVHSPCPWAGSAGNQHLGQQSDHSS
                                                                   
CCDS51 SSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQP
         300       310       320       330       340       350     

>>CCDS9290.1 GJB2 gene_id:2706|Hs108|chr13                (226 aa)
 initn: 715 init1: 435 opt: 457  Z-score: 479.6  bits: 97.2 E(32554): 2.2e-20
Smith-Waterman score: 715; 47.7% identity (71.9% similar) in 235 aa overlap (3-236:2-216)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
         ::. :  ::  :..::: .::::::.:::::...: :::..:: :::. :.::: :::
CCDS92  MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPG
                10        20        30        40        50         

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       :.:.:::  :::: ::.:.::.::::.:.:.   :. :  :  :: :.  :........ 
CCDS92 CKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAY--RRHEKKRKFIKGEIKSEFK-
      60        70        80        90         100       110       

              130       140       150       160       170          
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY-
          :.::               . .:: ..: :  ::.  :. : ..:..::   :..: 
CCDS92 ---DIEEI--------------KTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYD
           120                     130       140       150         

     180       190       200       210       220       230         
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
       ::.:. : ::.  ::::.::::::::::::.: .:: ....: .:::. :. .: ::   
CCDS92 GFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCS
     160       170       180       190       200       210         

     240       250       260       270       280       290         
pF1KE0 RTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKS
                                                                   
CCDS92 GKSKKPV                                                     
     220                                                           

>>CCDS1569.1 GJC2 gene_id:57165|Hs108|chr1                (439 aa)
 initn: 786 init1: 420 opt: 455  Z-score: 473.1  bits: 97.0 E(32554): 4.9e-20
Smith-Waterman score: 713; 36.9% identity (64.1% similar) in 309 aa overlap (4-258:6-305)

                 10        20        30        40        50        
pF1KE0   MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQ
            :..:  .:::.:.:::.:::.:::.: .::...  :..: ...:::. :.:::::
CCDS15 MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGEAIYSDEQAKFTCNTRQ
               10        20        30        40        50        60

       60        70        80        90       100        110       
pF1KE0 PGCNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRL-RAFEKDRQRK-------
       :::.:.:::   :.: .::::.::. .:.::..:.:.:..:: :: :..:.:        
CCDS15 PGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGP
               70        80        90       100       110       120

              120       130            140       150               
pF1KE0 KSHLRAQMENPDLDLEEQQRIDRE-----LRRLEEQKRIHKVPLKG-----------C--
       .   ::..  :     :   . .:     : . ::...   .   :           :  
CCDS15 RRAPRAHLPPPHAGWPEPADLGEEEPMLGLGEEEEEEETGAAEGAGEEAEEAGAEEACTK
              130       140       150       160       170       180

                                        160       170       180    
pF1KE0 ----------------------------LLRTYVLHILTRSVLEVGFMIGQYILYGFQMH
                                   :.:.:: ....:...::.:..:::.::::...
CCDS15 AVGADGKAAGTPGPTGQHDGRRRIQREGLMRVYVAQLVARAAFEVAFLVGQYLLYGFEVR
              190       200       210       220       230       240

          190       200       210       220       230       240    
pF1KE0 PLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIMRTLYK
       :.. :.. :::..::::::::::::.:.: :. .. . ::::. :. :::.         
CCDS15 PFFPCSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGL---------
              250       260       270       280       290          

          250       260       270       280       290       300    
pF1KE0 KSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVPKSKTMWQ
        :...... . :::                                              
CCDS15 GSAQDAVRGRRGPPASAPAPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLA
             300       310       320       330       340       350 

>>CCDS383.1 GJB4 gene_id:127534|Hs108|chr1                (266 aa)
 initn: 628 init1: 423 opt: 441  Z-score: 462.0  bits: 94.2 E(32554): 2.1e-19
Smith-Waterman score: 647; 38.1% identity (67.2% similar) in 265 aa overlap (3-263:2-241)

               10        20        30        40        50        60
pF1KE0 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG
         .: .: :.:  :...::....:::...::::.::  ::::.::::::. :.:::.:::
CCDS38  MNWAFLQGLLSGVNKYSTVLSRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFVCNTKQPG
                10        20        30        40        50         

               70        80        90       100       110       120
pF1KE0 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN
       : :.:::. ::.: .:.:.::.:.:. :::. . :. ::     ..:.::. ::.   . 
CCDS38 CPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYR-----EERERKH-HLKHGPNA
      60        70        80        90            100        110   

              130       140       150       160       170          
pF1KE0 PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILY-
       :.:        :   ..            .: :  ::.: .. ......::.   . :: 
CCDS38 PSL-------YDNLSKK------------RGGLWWTYLLSLIFKAAVDAGFLYIFHRLYK
                  120                   130       140       150    

     180       190       200       210       220       230         
pF1KE0 GFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRKIM
        ..:  .  :.  :::..:::..:::::: .:  :: . ::: .:::. :.:.:  .. :
CCDS38 DYDMPRVVACSVEPCPHTVDCYISRPTEKKVFTYFMVTTAAICILLNLSEVFYLVGKRCM
          160       170       180       190       200       210    

     240          250       260       270       280       290      
pF1KE0 RTL---YKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNV
       . .   ...   .    .: ::. :..                                 
CCDS38 EIFGPRHRRPRCRECLPDTCPPYVLSQGGHPEDGNSVLMKAGSAPVDAGGYP        
          220       230       240       250       260              




543 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 14:34:28 2016 done: Thu Nov  3 14:34:28 2016
 Total Scan time:  3.480 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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