Result of FASTA (omim) for pF1KF0156
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KF0156, 1858 aa
  1>>>pF1KF0156 1858 - 1858 aa - 1858 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.6831+/-0.000463; mu= 17.6221+/- 0.029
 mean_var=112.9912+/-23.018, 0's: 0 Z-trim(111.9): 212  B-trim: 267 in 1/54
 Lambda= 0.120657
 statistics sampled from 20360 (20625) to 20360 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.242), width:  16
 Scan time: 18.360

The best scores are:                                      opt bits E(85289)
XP_016871953 (OMIM: 613316) PREDICTED: WD repeat-  (1992) 12047 2109.8       0
XP_011538290 (OMIM: 613316) PREDICTED: WD repeat-  (3184) 12047 2110.0       0
NP_065996 (OMIM: 613316) WD repeat- and FYVE domai (3184) 12047 2110.0       0
XP_005270061 (OMIM: 613316) PREDICTED: WD repeat-  (3184) 12047 2110.0       0
XP_016871952 (OMIM: 613316) PREDICTED: WD repeat-  (3184) 12047 2110.0       0
XP_011538288 (OMIM: 613316) PREDICTED: WD repeat-  (3224) 12047 2110.0       0
XP_011538289 (OMIM: 613316) PREDICTED: WD repeat-  (3217) 11977 2097.8       0
XP_011538292 (OMIM: 613316) PREDICTED: WD repeat-  (2435) 7072 1243.9       0
XP_011538293 (OMIM: 613316) PREDICTED: WD repeat-  (2045) 4426 783.2       0
XP_016871954 (OMIM: 613316) PREDICTED: WD repeat-  (1614) 1908 344.9 3.9e-93
XP_011538294 (OMIM: 613316) PREDICTED: WD repeat-  (1654) 1908 344.9   4e-93
XP_016861506 (OMIM: 139090,614169) PREDICTED: neur (1606) 1149 212.7 2.3e-53
XP_016861505 (OMIM: 139090,614169) PREDICTED: neur (2602) 1149 212.9 3.4e-53
XP_016861504 (OMIM: 139090,614169) PREDICTED: neur (2659) 1149 212.9 3.5e-53
XP_006713135 (OMIM: 139090,614169) PREDICTED: neur (2727) 1149 212.9 3.5e-53
XP_016861503 (OMIM: 139090,614169) PREDICTED: neur (2748) 1149 212.9 3.6e-53
NP_055990 (OMIM: 139090,614169) neurobeachin-like  (2754) 1149 212.9 3.6e-53
XP_016861501 (OMIM: 139090,614169) PREDICTED: neur (2755) 1149 212.9 3.6e-53
XP_016861500 (OMIM: 139090,614169) PREDICTED: neur (2775) 1149 212.9 3.6e-53
XP_016861499 (OMIM: 139090,614169) PREDICTED: neur (2782) 1149 212.9 3.6e-53
NP_001191126 (OMIM: 604889) neurobeachin isoform 2 ( 739) 1140 211.0 3.7e-53
XP_016876034 (OMIM: 604889) PREDICTED: neurobeachi (2940) 1140 211.3 1.1e-52
XP_006719869 (OMIM: 604889) PREDICTED: neurobeachi (2943) 1140 211.3 1.1e-52
NP_056493 (OMIM: 604889) neurobeachin isoform 1 [H (2946) 1140 211.3 1.1e-52
XP_016864363 (OMIM: 606453,614700) PREDICTED: lipo ( 756) 1096 203.3 7.5e-51
XP_016864362 (OMIM: 606453,614700) PREDICTED: lipo ( 758) 1096 203.3 7.6e-51
NP_001186211 (OMIM: 606453,614700) lipopolysacchar (2851) 1100 204.4 1.4e-50
XP_005263432 (OMIM: 606453,614700) PREDICTED: lipo (2852) 1100 204.4 1.4e-50
XP_011530736 (OMIM: 606453,614700) PREDICTED: lipo (2863) 1100 204.4 1.4e-50
NP_006717 (OMIM: 606453,614700) lipopolysaccharide (2863) 1100 204.4 1.4e-50
XP_016860218 (OMIM: 609816) PREDICTED: neurobeachi (1547) 1092 202.8 2.2e-50
XP_005263431 (OMIM: 606453,614700) PREDICTED: lipo (2857) 1096 203.7 2.2e-50
XP_016864361 (OMIM: 606453,614700) PREDICTED: lipo (2857) 1096 203.7 2.2e-50
XP_005263430 (OMIM: 606453,614700) PREDICTED: lipo (2868) 1096 203.7 2.2e-50
XP_005263429 (OMIM: 606453,614700) PREDICTED: lipo (2868) 1096 203.7 2.2e-50
XP_005246845 (OMIM: 609816) PREDICTED: neurobeachi (1624) 1092 202.8 2.3e-50
XP_016860217 (OMIM: 609816) PREDICTED: neurobeachi (2080) 1092 202.9 2.8e-50
XP_011509964 (OMIM: 609816) PREDICTED: neurobeachi (2387) 1092 202.9 3.1e-50
XP_011509962 (OMIM: 609816) PREDICTED: neurobeachi (2598) 1092 203.0 3.3e-50
NP_001107604 (OMIM: 609816) neurobeachin-like prot (2694) 1092 203.0 3.4e-50
XP_005246844 (OMIM: 609816) PREDICTED: neurobeachi (2707) 1092 203.0 3.4e-50
XP_006712762 (OMIM: 609816) PREDICTED: neurobeachi (2723) 1092 203.0 3.4e-50
XP_006712761 (OMIM: 609816) PREDICTED: neurobeachi (2736) 1092 203.0 3.4e-50
XP_011509960 (OMIM: 609816) PREDICTED: neurobeachi (2736) 1092 203.0 3.4e-50
XP_011509961 (OMIM: 609816) PREDICTED: neurobeachi (2736) 1092 203.0 3.4e-50
XP_006719868 (OMIM: 604889) PREDICTED: neurobeachi (2938) 1077 200.4 2.2e-49
XP_005266403 (OMIM: 604889) PREDICTED: neurobeachi (2941) 1077 200.4 2.2e-49
XP_011531835 (OMIM: 139090,614169) PREDICTED: neur (2724) 1052 196.0 4.3e-48
XP_016861502 (OMIM: 139090,614169) PREDICTED: neur (2752) 1052 196.0 4.3e-48
XP_006719866 (OMIM: 604889) PREDICTED: neurobeachi (2962) 1006 188.0 1.2e-45


>>XP_016871953 (OMIM: 613316) PREDICTED: WD repeat- and   (1992 aa)
 initn: 12041 init1: 12041 opt: 12047  Z-score: 11330.0  bits: 2109.8 E(85289):    0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:127-1974)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_016 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
        100       110       120       130       140       150      

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
        160       170       180       190       200       210      

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
        220       230       240       250       260       270      

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
        280       290       300       310       320       330      

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
        340       350       360       370       380       390      

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
        400       410       420       430       440       450      

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
        460       470       480       490       500       510      

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
        520       530       540       550       560       570      

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
        580       590       600       610       620       630      

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
        640       650       660       670       680       690      

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
        700       710       720       730       740       750      

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
        760       770       780       790       800       810      

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
        820       830       840       850       860       870      

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
        880       890       900       910       920       930      

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
        940       950       960       970       980       990      

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       1000      1010      1020      1030      1040      1050      

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       1060      1070      1080      1090      1100      1110      

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       1120      1130      1140      1150      1160      1170      

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       1180      1190      1200      1210      1220      1230      

             1120      1130      1140      1150      1160      1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       1240      1250      1260      1270      1280      1290      

             1180      1190      1200      1210      1220      1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_016 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
       1300      1310      1320      1330      1340      1350      

             1240      1250      1260      1270      1280      1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       1360      1370      1380      1390      1400      1410      

             1300      1310      1320      1330      1340      1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       1420      1430      1440      1450      1460      1470      

             1360      1370      1380      1390      1400      1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       1480      1490      1500      1510      1520      1530      

             1420      1430      1440      1450      1460      1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       1540      1550      1560      1570      1580      1590      

             1480      1490      1500      1510      1520      1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       1600      1610      1620      1630      1640      1650      

             1540      1550      1560      1570      1580      1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       1660      1670      1680      1690      1700      1710      

             1600      1610      1620      1630      1640      1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       1720      1730      1740      1750      1760      1770      

             1660      1670      1680      1690      1700      1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       1780      1790      1800      1810      1820      1830      

             1720      1730      1740      1750      1760      1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       1840      1850      1860      1870      1880      1890      

             1780      1790      1800      1810         1820       
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
       ::::::::::::::::::::::   :..  :     .  . : . .   .  .: :   .
XP_016 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
       1900      1910      1920      1930      1940      1950      

      1830      1840      1850             
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL     
       :.   :  .   .: ::.                  
XP_016 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
       1960      1970      1980      1990  

>>XP_011538290 (OMIM: 613316) PREDICTED: WD repeat- and   (3184 aa)
 initn: 12041 init1: 12041 opt: 12047  Z-score: 11327.1  bits: 2110.0 E(85289):    0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1290      1300      1310      1320      1330      1340        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1350      1360      1370      1380      1390      1400        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1410      1420      1430      1440      1450      1460        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1470      1480      1490      1500      1510      1520        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1530      1540      1550      1560      1570      1580        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1590      1600      1610      1620      1630      1640        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1650      1660      1670      1680      1690      1700        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1710      1720      1730      1740      1750      1760        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1770      1780      1790      1800      1810      1820        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1830      1840      1850      1860      1870      1880        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1890      1900      1910      1920      1930      1940        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
     1950      1960      1970      1980      1990      2000        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
     2010      2020      2030      2040      2050      2060        

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
     2070      2080      2090      2100      2110      2120        

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
     2130      2140      2150      2160      2170      2180        

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
     2190      2200      2210      2220      2230      2240        

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
     2250      2260      2270      2280      2290      2300        

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
     2310      2320      2330      2340      2350      2360        

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
     2370      2380      2390      2400      2410      2420        

             1120      1130      1140      1150      1160      1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
     2430      2440      2450      2460      2470      2480        

             1180      1190      1200      1210      1220      1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_011 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
     2490      2500      2510      2520      2530      2540        

             1240      1250      1260      1270      1280      1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
     2550      2560      2570      2580      2590      2600        

             1300      1310      1320      1330      1340      1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
     2610      2620      2630      2640      2650      2660        

             1360      1370      1380      1390      1400      1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
     2670      2680      2690      2700      2710      2720        

             1420      1430      1440      1450      1460      1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
     2730      2740      2750      2760      2770      2780        

             1480      1490      1500      1510      1520      1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
     2790      2800      2810      2820      2830      2840        

             1540      1550      1560      1570      1580      1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
     2850      2860      2870      2880      2890      2900        

             1600      1610      1620      1630      1640      1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
     2910      2920      2930      2940      2950      2960        

             1660      1670      1680      1690      1700      1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
     2970      2980      2990      3000      3010      3020        

             1720      1730      1740      1750      1760      1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
     3030      3040      3050      3060      3070      3080        

             1780      1790      1800      1810         1820       
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
       ::::::::::::::::::::::   :..  :     .  . : . .   .  .: :   .
XP_011 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
     3090      3100      3110      3120      3130      3140        

      1830      1840      1850             
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL     
       :.   :  .   .: ::.                  
XP_011 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
     3150      3160      3170      3180    

>>NP_065996 (OMIM: 613316) WD repeat- and FYVE domain-co  (3184 aa)
 initn: 12041 init1: 12041 opt: 12047  Z-score: 11327.1  bits: 2110.0 E(85289):    0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
NP_065 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1290      1300      1310      1320      1330      1340        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1350      1360      1370      1380      1390      1400        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1410      1420      1430      1440      1450      1460        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1470      1480      1490      1500      1510      1520        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1530      1540      1550      1560      1570      1580        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1590      1600      1610      1620      1630      1640        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1650      1660      1670      1680      1690      1700        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1710      1720      1730      1740      1750      1760        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1770      1780      1790      1800      1810      1820        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1830      1840      1850      1860      1870      1880        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1890      1900      1910      1920      1930      1940        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
     1950      1960      1970      1980      1990      2000        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
     2010      2020      2030      2040      2050      2060        

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
     2070      2080      2090      2100      2110      2120        

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
     2130      2140      2150      2160      2170      2180        

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
     2190      2200      2210      2220      2230      2240        

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
     2250      2260      2270      2280      2290      2300        

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
     2310      2320      2330      2340      2350      2360        

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
     2370      2380      2390      2400      2410      2420        

             1120      1130      1140      1150      1160      1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
     2430      2440      2450      2460      2470      2480        

             1180      1190      1200      1210      1220      1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_065 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
     2490      2500      2510      2520      2530      2540        

             1240      1250      1260      1270      1280      1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
     2550      2560      2570      2580      2590      2600        

             1300      1310      1320      1330      1340      1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
     2610      2620      2630      2640      2650      2660        

             1360      1370      1380      1390      1400      1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
     2670      2680      2690      2700      2710      2720        

             1420      1430      1440      1450      1460      1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
     2730      2740      2750      2760      2770      2780        

             1480      1490      1500      1510      1520      1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
     2790      2800      2810      2820      2830      2840        

             1540      1550      1560      1570      1580      1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
     2850      2860      2870      2880      2890      2900        

             1600      1610      1620      1630      1640      1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
     2910      2920      2930      2940      2950      2960        

             1660      1670      1680      1690      1700      1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
     2970      2980      2990      3000      3010      3020        

             1720      1730      1740      1750      1760      1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
     3030      3040      3050      3060      3070      3080        

             1780      1790      1800      1810         1820       
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
       ::::::::::::::::::::::   :..  :     .  . : . .   .  .: :   .
NP_065 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
     3090      3100      3110      3120      3130      3140        

      1830      1840      1850             
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL     
       :.   :  .   .: ::.                  
NP_065 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
     3150      3160      3170      3180    

>>XP_005270061 (OMIM: 613316) PREDICTED: WD repeat- and   (3184 aa)
 initn: 12041 init1: 12041 opt: 12047  Z-score: 11327.1  bits: 2110.0 E(85289):    0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_005 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1290      1300      1310      1320      1330      1340        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1350      1360      1370      1380      1390      1400        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1410      1420      1430      1440      1450      1460        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1470      1480      1490      1500      1510      1520        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1530      1540      1550      1560      1570      1580        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1590      1600      1610      1620      1630      1640        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1650      1660      1670      1680      1690      1700        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1710      1720      1730      1740      1750      1760        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1770      1780      1790      1800      1810      1820        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1830      1840      1850      1860      1870      1880        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1890      1900      1910      1920      1930      1940        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
     1950      1960      1970      1980      1990      2000        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
     2010      2020      2030      2040      2050      2060        

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
     2070      2080      2090      2100      2110      2120        

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
     2130      2140      2150      2160      2170      2180        

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
     2190      2200      2210      2220      2230      2240        

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
     2250      2260      2270      2280      2290      2300        

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
     2310      2320      2330      2340      2350      2360        

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
     2370      2380      2390      2400      2410      2420        

             1120      1130      1140      1150      1160      1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
     2430      2440      2450      2460      2470      2480        

             1180      1190      1200      1210      1220      1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
     2490      2500      2510      2520      2530      2540        

             1240      1250      1260      1270      1280      1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
     2550      2560      2570      2580      2590      2600        

             1300      1310      1320      1330      1340      1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
     2610      2620      2630      2640      2650      2660        

             1360      1370      1380      1390      1400      1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
     2670      2680      2690      2700      2710      2720        

             1420      1430      1440      1450      1460      1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
     2730      2740      2750      2760      2770      2780        

             1480      1490      1500      1510      1520      1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
     2790      2800      2810      2820      2830      2840        

             1540      1550      1560      1570      1580      1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
     2850      2860      2870      2880      2890      2900        

             1600      1610      1620      1630      1640      1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
     2910      2920      2930      2940      2950      2960        

             1660      1670      1680      1690      1700      1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
     2970      2980      2990      3000      3010      3020        

             1720      1730      1740      1750      1760      1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
     3030      3040      3050      3060      3070      3080        

             1780      1790      1800      1810         1820       
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
       ::::::::::::::::::::::   :..  :     .  . : . .   .  .: :   .
XP_005 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
     3090      3100      3110      3120      3130      3140        

      1830      1840      1850             
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL     
       :.   :  .   .: ::.                  
XP_005 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
     3150      3160      3170      3180    

>>XP_016871952 (OMIM: 613316) PREDICTED: WD repeat- and   (3184 aa)
 initn: 12041 init1: 12041 opt: 12047  Z-score: 11327.1  bits: 2110.0 E(85289):    0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1319-3166)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_016 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1290      1300      1310      1320      1330      1340        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1350      1360      1370      1380      1390      1400        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1410      1420      1430      1440      1450      1460        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1470      1480      1490      1500      1510      1520        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1530      1540      1550      1560      1570      1580        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1590      1600      1610      1620      1630      1640        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1650      1660      1670      1680      1690      1700        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1710      1720      1730      1740      1750      1760        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1770      1780      1790      1800      1810      1820        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1830      1840      1850      1860      1870      1880        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1890      1900      1910      1920      1930      1940        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
     1950      1960      1970      1980      1990      2000        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
     2010      2020      2030      2040      2050      2060        

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
     2070      2080      2090      2100      2110      2120        

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
     2130      2140      2150      2160      2170      2180        

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
     2190      2200      2210      2220      2230      2240        

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
     2250      2260      2270      2280      2290      2300        

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
     2310      2320      2330      2340      2350      2360        

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
     2370      2380      2390      2400      2410      2420        

             1120      1130      1140      1150      1160      1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
     2430      2440      2450      2460      2470      2480        

             1180      1190      1200      1210      1220      1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_016 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
     2490      2500      2510      2520      2530      2540        

             1240      1250      1260      1270      1280      1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
     2550      2560      2570      2580      2590      2600        

             1300      1310      1320      1330      1340      1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
     2610      2620      2630      2640      2650      2660        

             1360      1370      1380      1390      1400      1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
     2670      2680      2690      2700      2710      2720        

             1420      1430      1440      1450      1460      1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
     2730      2740      2750      2760      2770      2780        

             1480      1490      1500      1510      1520      1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
     2790      2800      2810      2820      2830      2840        

             1540      1550      1560      1570      1580      1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
     2850      2860      2870      2880      2890      2900        

             1600      1610      1620      1630      1640      1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
     2910      2920      2930      2940      2950      2960        

             1660      1670      1680      1690      1700      1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
     2970      2980      2990      3000      3010      3020        

             1720      1730      1740      1750      1760      1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
     3030      3040      3050      3060      3070      3080        

             1780      1790      1800      1810         1820       
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
       ::::::::::::::::::::::   :..  :     .  . : . .   .  .: :   .
XP_016 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
     3090      3100      3110      3120      3130      3140        

      1830      1840      1850             
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL     
       :.   :  .   .: ::.                  
XP_016 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
     3150      3160      3170      3180    

>>XP_011538288 (OMIM: 613316) PREDICTED: WD repeat- and   (3224 aa)
 initn: 12041 init1: 12041 opt: 12047  Z-score: 11327.0  bits: 2110.0 E(85289):    0
Smith-Waterman score: 12047; 97.5% identity (98.2% similar) in 1848 aa overlap (1-1845:1359-3206)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1330      1340      1350      1360      1370      1380        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1390      1400      1410      1420      1430      1440        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1450      1460      1470      1480      1490      1500        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1510      1520      1530      1540      1550      1560        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1570      1580      1590      1600      1610      1620        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1630      1640      1650      1660      1670      1680        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1690      1700      1710      1720      1730      1740        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1750      1760      1770      1780      1790      1800        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1810      1820      1830      1840      1850      1860        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1870      1880      1890      1900      1910      1920        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1930      1940      1950      1960      1970      1980        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
     1990      2000      2010      2020      2030      2040        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
     2050      2060      2070      2080      2090      2100        

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
     2110      2120      2130      2140      2150      2160        

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
     2170      2180      2190      2200      2210      2220        

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
     2230      2240      2250      2260      2270      2280        

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
     2290      2300      2310      2320      2330      2340        

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
     2350      2360      2370      2380      2390      2400        

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
     2410      2420      2430      2440      2450      2460        

             1120      1130      1140      1150      1160      1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
     2470      2480      2490      2500      2510      2520        

             1180      1190      1200      1210      1220      1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_011 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
     2530      2540      2550      2560      2570      2580        

             1240      1250      1260      1270      1280      1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
     2590      2600      2610      2620      2630      2640        

             1300      1310      1320      1330      1340      1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
     2650      2660      2670      2680      2690      2700        

             1360      1370      1380      1390      1400      1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
     2710      2720      2730      2740      2750      2760        

             1420      1430      1440      1450      1460      1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
     2770      2780      2790      2800      2810      2820        

             1480      1490      1500      1510      1520      1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
     2830      2840      2850      2860      2870      2880        

             1540      1550      1560      1570      1580      1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
     2890      2900      2910      2920      2930      2940        

             1600      1610      1620      1630      1640      1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
     2950      2960      2970      2980      2990      3000        

             1660      1670      1680      1690      1700      1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
     3010      3020      3030      3040      3050      3060        

             1720      1730      1740      1750      1760      1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
     3070      3080      3090      3100      3110      3120        

             1780      1790      1800      1810         1820       
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
       ::::::::::::::::::::::   :..  :     .  . : . .   .  .: :   .
XP_011 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
     3130      3140      3150      3160      3170      3180        

      1830      1840      1850             
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL     
       :.   :  .   .: ::.                  
XP_011 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
     3190      3200      3210      3220    

>>XP_011538289 (OMIM: 613316) PREDICTED: WD repeat- and   (3217 aa)
 initn: 11981 init1: 10321 opt: 11977  Z-score: 11261.2  bits: 2097.8 E(85289):    0
Smith-Waterman score: 11977; 97.1% identity (97.8% similar) in 1848 aa overlap (1-1845:1359-3199)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1330      1340      1350      1360      1370      1380        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1390      1400      1410      1420      1430      1440        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1450      1460      1470      1480      1490      1500        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1510      1520      1530      1540      1550      1560        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1570      1580      1590      1600      1610      1620        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1630      1640      1650      1660      1670      1680        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1690      1700      1710      1720      1730      1740        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1750      1760      1770      1780      1790      1800        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1810      1820      1830      1840      1850      1860        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1870      1880      1890      1900      1910      1920        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1930      1940      1950      1960      1970      1980        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
     1990      2000      2010      2020      2030      2040        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
     2050      2060      2070      2080      2090      2100        

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
     2110      2120      2130      2140      2150      2160        

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
     2170      2180      2190      2200      2210      2220        

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
     2230      2240      2250      2260      2270      2280        

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
     2290      2300      2310      2320      2330      2340        

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
     2350      2360      2370      2380      2390      2400        

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
     2410      2420      2430      2440      2450      2460        

             1120      1130      1140      1150      1160      1170
pF1KF0 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFH
     2470      2480      2490      2500      2510      2520        

             1180      1190      1200      1210      1220      1230
pF1KF0 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDIS
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_011 NGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDIS
     2530      2540      2550      2560      2570      2580        

             1240      1250      1260      1270      1280      1290
pF1KF0 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK
     2590      2600      2610      2620      2630      2640        

             1300      1310      1320      1330      1340      1350
pF1KF0 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR
     2650      2660      2670      2680      2690      2700        

             1360      1370      1380      1390      1400      1410
pF1KF0 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA
     2710      2720      2730      2740      2750      2760        

             1420      1430      1440      1450      1460      1470
pF1KF0 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS
     2770      2780      2790      2800      2810      2820        

             1480      1490      1500      1510      1520      1530
pF1KF0 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY
     2830      2840      2850      2860      2870      2880        

             1540      1550      1560      1570      1580      1590
pF1KF0 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
       :::::::::::::       ::::::::::::::::::::::::::::::::::::::::
XP_011 SLQSLRPSQVTVK-------GSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG
     2890      2900             2910      2920      2930      2940 

             1600      1610      1620      1630      1640      1650
pF1KF0 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR
            2950      2960      2970      2980      2990      3000 

             1660      1670      1680      1690      1700      1710
pF1KF0 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS
            3010      3020      3030      3040      3050      3060 

             1720      1730      1740      1750      1760      1770
pF1KF0 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIII
            3070      3080      3090      3100      3110      3120 

             1780      1790      1800      1810         1820       
pF1KF0 TGSQDGMVRVWKTEDVKMSVPGLQMGRKREAAEALAQQCQAEGGRG---DWGLSSAYRRN
       ::::::::::::::::::::::   :..  :     .  . : . .   .  .: :   .
XP_011 TGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGK
            3130      3140      3150      3160      3170      3180 

      1830      1840      1850             
pF1KF0 PQGLLPHSSQGRASGNHSSAAQPSPWPMGLL     
       :.   :  .   .: ::.                  
XP_011 PSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG
            3190      3200      3210       

>>XP_011538292 (OMIM: 613316) PREDICTED: WD repeat- and   (2435 aa)
 initn: 7072 init1: 7072 opt: 7072  Z-score: 6648.5  bits: 1243.9 E(85289):    0
Smith-Waterman score: 7072; 100.0% identity (100.0% similar) in 1071 aa overlap (1-1071:1359-2429)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1330      1340      1350      1360      1370      1380        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1390      1400      1410      1420      1430      1440        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1450      1460      1470      1480      1490      1500        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1510      1520      1530      1540      1550      1560        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1570      1580      1590      1600      1610      1620        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1630      1640      1650      1660      1670      1680        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1690      1700      1710      1720      1730      1740        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1750      1760      1770      1780      1790      1800        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1810      1820      1830      1840      1850      1860        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1870      1880      1890      1900      1910      1920        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1930      1940      1950      1960      1970      1980        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
     1990      2000      2010      2020      2030      2040        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL
     2050      2060      2070      2080      2090      2100        

              760       770       780       790       800       810
pF1KF0 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQ
     2110      2120      2130      2140      2150      2160        

              820       830       840       850       860       870
pF1KF0 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNV
     2170      2180      2190      2200      2210      2220        

              880       890       900       910       920       930
pF1KF0 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQR
     2230      2240      2250      2260      2270      2280        

              940       950       960       970       980       990
pF1KF0 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLE
     2290      2300      2310      2320      2330      2340        

             1000      1010      1020      1030      1040      1050
pF1KF0 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSE
     2350      2360      2370      2380      2390      2400        

             1060      1070      1080      1090      1100      1110
pF1KF0 DFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTG
       :::::::::::::::::::::                                       
XP_011 DFLELCRERQVILQELLDKEKPQFSHL                                 
     2410      2420      2430                                      

>>XP_011538293 (OMIM: 613316) PREDICTED: WD repeat- and   (2045 aa)
 initn: 4471 init1: 4426 opt: 4426  Z-score: 4160.4  bits: 783.2 E(85289):    0
Smith-Waterman score: 4426; 99.9% identity (100.0% similar) in 677 aa overlap (1-677:1359-2035)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_011 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1330      1340      1350      1360      1370      1380        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1390      1400      1410      1420      1430      1440        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1450      1460      1470      1480      1490      1500        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1510      1520      1530      1540      1550      1560        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1570      1580      1590      1600      1610      1620        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
     1630      1640      1650      1660      1670      1680        

              340       350       360       370       380       390
pF1KF0 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFL
     1690      1700      1710      1720      1730      1740        

              400       410       420       430       440       450
pF1KF0 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGAL
     1750      1760      1770      1780      1790      1800        

              460       470       480       490       500       510
pF1KF0 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAA
     1810      1820      1830      1840      1850      1860        

              520       530       540       550       560       570
pF1KF0 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLG
     1870      1880      1890      1900      1910      1920        

              580       590       600       610       620       630
pF1KF0 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQP
     1930      1940      1950      1960      1970      1980        

              640       650       660       670       680       690
pF1KF0 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLS
       ::::::::::::::::::::::::::::::::::::::::::::::.             
XP_011 SAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVISAPLQARDFS   
     1990      2000      2010      2020      2030      2040        

              700       710       720       730       740       750
pF1KF0 TLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLL

>>XP_016871954 (OMIM: 613316) PREDICTED: WD repeat- and   (1614 aa)
 initn: 1908 init1: 1908 opt: 1908  Z-score: 1793.0  bits: 344.9 E(85289): 3.9e-93
Smith-Waterman score: 1908; 100.0% identity (100.0% similar) in 295 aa overlap (1-295:1319-1613)

                                             10        20        30
pF1KF0                               MNISSRDNAMPVFLLRNCAGHLSGSLRTIG
                                     ::::::::::::::::::::::::::::::
XP_016 GLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIG
     1290      1300      1310      1320      1330      1340        

               40        50        60        70        80        90
pF1KF0 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMC
     1350      1360      1370      1380      1390      1400        

              100       110       120       130       140       150
pF1KF0 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCN
     1410      1420      1430      1440      1450      1460        

              160       170       180       190       200       210
pF1KF0 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS
     1470      1480      1490      1500      1510      1520        

              220       230       240       250       260       270
pF1KF0 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKT
     1530      1540      1550      1560      1570      1580        

              280       290       300       310       320       330
pF1KF0 IWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLL
       :::::::::::::::::::::::::                                   
XP_016 IWLRNQLLEMLLSVISSPQLHLSSEQ                                  
     1590      1600      1610                                      




1858 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 01:12:14 2016 done: Sat Nov  5 01:12:17 2016
 Total Scan time: 18.360 Total Display time:  0.780

Function used was FASTA [36.3.4 Apr, 2011]
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