FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0043, 544 aa
  1>>>pF1KE0043 544 - 544 aa - 544 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.0624+/-0.00126; mu= 14.0905+/- 0.075
 mean_var=63.1393+/-12.715, 0's: 0 Z-trim(99.8): 30  B-trim: 2 in 1/47
 Lambda= 0.161408
 statistics sampled from 5861 (5864) to 5861 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.527), E-opt: 0.2 (0.18), width:  16
 Scan time:  2.850

The best scores are:                                      opt bits E(32554)
CCDS11850.2 PIEZO2 gene_id:63895|Hs108|chr18       (2752) 1954 464.4 7.9e-130
CCDS54058.1 PIEZO1 gene_id:9780|Hs108|chr16        (2521) 1244 299.0 4.3e-80


>>CCDS11850.2 PIEZO2 gene_id:63895|Hs108|chr18            (2752 aa)
 initn: 1954 init1: 1954 opt: 1954  Z-score: 2444.3  bits: 464.4 E(32554): 7.9e-130
Smith-Waterman score: 3236; 89.1% identity (89.1% similar) in 576 aa overlap (32-544:2177-2752)

              10        20        30        40        50        60 
pF1KE0 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
                                     ::::::::::::::::::::::::::::::
CCDS11 EKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYSAVTDVYVLMFLADTVDFIIIVF
       2150      2160      2170      2180      2190      2200      

              70        80        90       100       110       120 
pF1KE0 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 GFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVIL
       2210      2220      2230      2240      2250      2260      

             130       140       150       160       170       180 
pF1KE0 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 VFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKS
       2270      2280      2290      2300      2310      2320      

             190       200       210       220       230       240 
pF1KE0 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 YNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEK
       2330      2340      2350      2360      2370      2380      

                                                                   
pF1KE0 ------------------------------------------------------------
                                                                   
CCDS11 RYPQPRGQKKKKVVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLG
       2390      2400      2410      2420      2430      2440      

                250       260       270       280       290        
pF1KE0 ---PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 GYQPIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQFLENYEKEDITVAELEGNSNSL
       2450      2460      2470      2480      2490      2500      

      300       310       320       330       340       350        
pF1KE0 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 WTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGAKSEIATDKLSFPLKNITRKNIA
       2510      2520      2530      2540      2550      2560      

      360       370       380       390       400       410        
pF1KE0 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 KMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMDITIILSRDNTTKY
       2570      2580      2590      2600      2610      2620      

      420       430       440       450       460       470        
pF1KE0 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 NSEWWVLNLTGNRIYNPNSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVR
       2630      2640      2650      2660      2670      2680      

      480       490       500       510       520       530        
pF1KE0 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 EFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKW
       2690      2700      2710      2720      2730      2740      

      540    
pF1KE0 TREKTN
       ::::::
CCDS11 TREKTN
       2750  

>>CCDS54058.1 PIEZO1 gene_id:9780|Hs108|chr16             (2521 aa)
 initn: 1849 init1: 1239 opt: 1244  Z-score: 1551.4  bits: 299.0 E(32554): 4.3e-80
Smith-Waterman score: 1924; 53.7% identity (74.7% similar) in 574 aa overlap (10-514:1926-2492)

                                    10        20        30         
pF1KE0                      MEKLQEHLIKAKAFTIKKTLEIYVPIKQFFYNLIHPEYS
                                     . ..: .. .   : :...::....: .: 
CCDS54 EEEGEEEKEAPTGREKRPSRSGGRVRAAGRRLQGFCLSLAQGTYRPLRRFFHDILHTKYR
        1900      1910      1920      1930      1940      1950     

      40        50        60        70        80        90         
pF1KE0 AVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTM
       :.::::.::::::.::::::.::::::::::::.:::::::.::::  ::::.::::.::
CCDS54 AATDVYALMFLADVVDFIIIIFGFWAFGKHSAATDITSSLSDDQVPEAFLVMLLIQFSTM
        1960      1970      1980      1990      2000      2010     

     100       110       120       130       140       150         
pF1KE0 VVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFG
       :::::::::::::::. ::: ::..::.:::::::.:::: :.::.::::::::::.::.
CCDS54 VVDRALYLRKTVLGKLAFQVALVLAIHLWMFFILPAVTERMFNQNVVAQLWYFVKCIYFA
        2020      2030      2040      2050      2060      2070     

     160       170       180       190       200       210         
pF1KE0 LSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSS
       :::::::::::::.:::::::.::..::::::::::::::.:::::::::::::::::::
CCDS54 LSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSS
        2080      2090      2100      2110      2120      2130     

     220       230       240                                       
pF1KE0 WICVEDIYAHIFILKCWRESEK--------------------------------------
       :.:::::::.:::.:: ::.::                                      
CCDS54 WMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMS
        2140      2150      2160      2170      2180      2190     

                                      250       260       270      
pF1KE0 -------------------------PIFTMSAQQSQLKVMDQQSFNKFIQAFSRDTGAMQ
                                :.::::::: ..  .  :..... . :. .  :::
CCDS54 LVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQ
        2200      2210      2220      2230      2240      2250     

        280       290       300       310       320       330      
pF1KE0 FLENYEKEDITVAELEGNSNSLWTISPPSKQKMIHELLDPNSSFSVVFSWSIQRNLSLGA
       :. .:  :::..:..::.:..:: :::::. .: .:: . ...... :.:..::.:. :.
CCDS54 FISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGG
        2260      2270      2280      2290      2300      2310     

        340         350       360       370       380       390    
pF1KE0 KSEIATDK--LSFPLKNITRKNIAKMIAGNSTESSKTPVTIEKIYPYYVKAPSDSNSKPI
         : :..:  :..  .. .:...:... :.: .:    :.: ...: :..::.  ...:.
CCDS54 TVEYANEKHMLALAPNSTARRQLASLLEGTSDQS----VVIPNLFPKYIRAPNGPEANPV
        2320      2330      2340          2350      2360      2370 

            400       410       420         430       440       450
pF1KE0 KQLLS--ENNFMDITIILSRDNTTKYNS--EWWVLNLTGNRIYNPNSQALELVVFNDKVS
       :::    : ... . : : :.. .  ..  ::::..:   :    . . : .:.:.::::
CCDS54 KQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECR---TDCNLLPMVIFSDKVS
            2380      2390      2400      2410         2420        

              460       470       480       490       500       510
pF1KE0 PPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVR
       ::::::::::::::::.:.::::::::: ::: ::::::::::: :::::::: ::::::
CCDS54 PPSLGFLAGYGIMGLYVSIVLVIGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVR
     2430      2440      2450      2460      2470      2480        

              520       530       540    
pF1KE0 ETGELELEEDLYAKLIFLYRSPETMIKWTREKTN
       :: :                              
CCDS54 ETRELELEEELYAKLIFLYRSPETMIKWTREKE 
     2490      2500      2510      2520  




544 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 06:21:11 2016 done: Fri Nov  4 06:21:11 2016
 Total Scan time:  2.850 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]