Result of FASTA (ccds) for pF1KE0347
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE0347, 853 aa
  1>>>pF1KE0347 853 - 853 aa - 853 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.6610+/-0.000955; mu= 15.3405+/- 0.058
 mean_var=128.5572+/-25.242, 0's: 0 Z-trim(108.6): 30  B-trim: 38 in 1/51
 Lambda= 0.113117
 statistics sampled from 10284 (10302) to 10284 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.316), width:  16
 Scan time:  4.460

The best scores are:                                      opt bits E(32554)
CCDS13205.1 DNMT3B gene_id:1789|Hs108|chr20        ( 853) 5871 970.2       0
CCDS13206.1 DNMT3B gene_id:1789|Hs108|chr20        ( 833) 3339 557.0 4.8e-158
CCDS13204.1 DNMT3B gene_id:1789|Hs108|chr20        ( 845) 3339 557.0 4.9e-158
CCDS33157.1 DNMT3A gene_id:1788|Hs108|chr2         ( 912) 2711 454.6 3.7e-127
CCDS1718.2 DNMT3A gene_id:1788|Hs108|chr2          ( 723) 2709 454.2 3.9e-127
CCDS56184.1 DNMT3B gene_id:1789|Hs108|chr20        ( 694) 2603 436.8 6.1e-122
CCDS56183.1 DNMT3B gene_id:1789|Hs108|chr20        ( 728) 2603 436.9 6.3e-122
CCDS13207.1 DNMT3B gene_id:1789|Hs108|chr20        ( 770) 2603 436.9 6.5e-122
CCDS46650.1 DNMT3L gene_id:29947|Hs108|chr21       ( 386)  623 113.5 7.2e-25
CCDS13705.1 DNMT3L gene_id:29947|Hs108|chr21       ( 387)  623 113.5 7.2e-25


>>CCDS13205.1 DNMT3B gene_id:1789|Hs108|chr20             (853 aa)
 initn: 5871 init1: 5871 opt: 5871  Z-score: 5183.8  bits: 970.2 E(32554):    0
Smith-Waterman score: 5871; 100.0% identity (100.0% similar) in 853 aa overlap (1-853:1-853)

               10        20        30        40        50        60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
              790       800       810       820       830       840

              850   
pF1KE0 HLFAPLKDYFACE
       :::::::::::::
CCDS13 HLFAPLKDYFACE
              850   

>>CCDS13206.1 DNMT3B gene_id:1789|Hs108|chr20             (833 aa)
 initn: 5736 init1: 3338 opt: 3339  Z-score: 2950.8  bits: 557.0 E(32554): 4.8e-158
Smith-Waterman score: 5700; 97.7% identity (97.7% similar) in 853 aa overlap (1-853:1-833)

               10        20        30        40        50        60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
CCDS13 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
              310       320       330       340       350          

              370       380       390       400       410       420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                      :::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                        360       370       380       390       400

              430       440       450       460       470       480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
              410       420       430       440       450       460

              490       500       510       520       530       540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
              470       480       490       500       510       520

              550       560       570       580       590       600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
              530       540       550       560       570       580

              610       620       630       640       650       660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
              590       600       610       620       630       640

              670       680       690       700       710       720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
              650       660       670       680       690       700

              730       740       750       760       770       780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
              710       720       730       740       750       760

              790       800       810       820       830       840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
              770       780       790       800       810       820

              850   
pF1KE0 HLFAPLKDYFACE
       :::::::::::::
CCDS13 HLFAPLKDYFACE
              830   

>>CCDS13204.1 DNMT3B gene_id:1789|Hs108|chr20             (845 aa)
 initn: 5736 init1: 3338 opt: 3339  Z-score: 2950.7  bits: 557.0 E(32554): 4.9e-158
Smith-Waterman score: 5700; 97.7% identity (97.7% similar) in 853 aa overlap (1-853:13-845)

                           10        20        30        40        
pF1KE0             MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRG
                   ::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MEPSPEPPSLESMKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRG
               10        20        30        40        50        60

       50        60        70        80        90       100        
pF1KE0 RRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNN
               70        80        90       100       110       120

      110       120       130       140       150       160        
pF1KE0 NSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 NSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTI
              130       140       150       160       170       180

      170       180       190       200       210       220        
pF1KE0 DLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDL
              190       200       210       220       230       240

      230       240       250       260       270       280        
pF1KE0 VWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 VWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFN
              250       260       270       280       290       300

      290       300       310       320       330       340        
pF1KE0 LATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 LATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGL
              310       320       330       340       350       360

      350       360       370       380       390       400        
pF1KE0 KPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGK
       :::::::                    :::::::::::::::::::::::::::::::::
CCDS13 KPNNTQP--------------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGK
                                  370       380       390       400

      410       420       430       440       450       460        
pF1KE0 DRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYM
              410       420       430       440       450       460

      470       480       490       500       510       520        
pF1KE0 YDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCL
              470       480       490       500       510       520

      530       540       550       560       570       580        
pF1KE0 PQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGY
              530       540       550       560       570       580

      590       600       610       620       630       640        
pF1KE0 LVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 LVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGG
              590       600       610       620       630       640

      650       660       670       680       690       700        
pF1KE0 SPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKR
              650       660       670       680       690       700

      710       720       730       740       750       760        
pF1KE0 DISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKL
              710       720       730       740       750       760

      770       780       790       800       810       820        
pF1KE0 KKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 KKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQK
              770       780       790       800       810       820

      830       840       850   
pF1KE0 LLGRSWSVPVIRHLFAPLKDYFACE
       :::::::::::::::::::::::::
CCDS13 LLGRSWSVPVIRHLFAPLKDYFACE
              830       840     

>>CCDS33157.1 DNMT3A gene_id:1788|Hs108|chr2              (912 aa)
 initn: 2812 init1: 2281 opt: 2711  Z-score: 2396.4  bits: 454.6 E(32554): 3.7e-127
Smith-Waterman score: 2802; 51.0% identity (71.9% similar) in 861 aa overlap (12-852:80-911)

                                  10        20        30        40 
pF1KE0                    MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAI
                                     .:.:. :  .: ::    .:  .:   :. 
CCDS33 RPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASE--LLPNGDLEKRSEPQPE--EG-
      50        60        70        80          90       100       

              50        60        70        80         90          
pF1KE0 RTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMP-KLFRETRTRS--
        .:   :.....    . ..  :  ..  . .:     .:  .:.   :  .::  .:  
CCDS33 -SPA-GGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMK
            110       120       130       140       150       160  

       100       110       120       130        140         150    
pF1KE0 -ESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPV-EFPAT--RSLRRRATASA
        :.   : :.. .  :  :.:: :: :       ....    :. :   :  ...: . :
CCDS33 MEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIA
            170       180       190       200       210       220  

             160       170       180       190       200       210 
pF1KE0 G---TPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGD
       :   .   . :.    ..  . .  .   : . ..:   .:   .  : .. . .: .. 
CCDS33 GMNAVEENQGPGESQKVE--EASPPAVQQPTDPASP--TVATTPEPVGSDAGDKNATKAG
            230       240         250         260       270        

             220       230       240       250       260       270 
pF1KE0 GDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSE
        :  ::.::. ::::.:::::..::::::. .:::  :.. .:  : :::.:::::::: 
CCDS33 DDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSV
      280       290       300       310       320       330        

             280       290       300       310           320       
pF1KE0 VSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP----SSPGDS---
       : ..::. :. : . :. ::.::   ::::.:..:. :  :::: ::    :. .:.   
CCDS33 VCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKA
      340       350       360       370       380       390        

          330       340       350       360       370       380    
pF1KE0 LEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTA
       .: : :::.::: :::.:.: .::.:    :  .:.  .            :  :   . 
CCDS33 VEVQNKPMIEWALGGFQPSGPKGLEP----PEEEKNPYK------------EVYTDMWVE
      400       410       420           430                   440  

          390       400       410          420       430       440 
pF1KE0 DDSATSDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNKSSLEDGCLSCGRK
        ..:.  : : :   :    .  : .  :   ...::... .: ..  ..:: :.:::  
CCDS33 PEAAA--YAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSL
              450       460       470       480       490       500

             450       460       470       480       490       500 
pF1KE0 NPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCV
       : .  :::: ::.::.:.. :::  :.:::::::::::.:: :::.:.:.:..:::::::
CCDS33 NVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCV
              510       520       530       540       550       560

             510       520       530       540       550       560 
pF1KE0 ECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAP
       ::...::: :.:  :  ..::.::::  .  .:.::::.::  ::: ::...   :.. :
CCDS33 ECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPP
              570       580       590       600       610       620

             570       580       590       600       610       620 
pF1KE0 KLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGN
       :.:: .:: .:.:::::::::::::: ::::.:::.: .:.::::::.::.:: :.:.:.
CCDS33 KVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGK
              630       640       650       660       670       680

             630       640       650       660       670       680 
pF1KE0 IKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNY
       : ::.:::..:.:.:.:::::::::::::::::: ::::::::::::::::::::.::. 
CCDS33 IMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHD
              690       700       710       720       730       740

             690       700       710       720       730       740 
pF1KE0 SRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPG
       .::::::::::::.::::::: :.:::::::::: ::::::: .::::::::::::::::
CCDS33 ARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPG
              750       760       770       780       790       800

             750       760       770       780       790       800 
pF1KE0 MNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLW
       ::::. .. :::::::.:::..::::..::.::::.::::::::.: ::: :: :::.::
CCDS33 MNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILW
              810       820       830       840       850       860

             810       820       830       840       850   
pF1KE0 CTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
       :::.::.:::::::::::::.: :::.:::::::::::::::::::.:::: 
CCDS33 CTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
              870       880       890       900       910  

>>CCDS1718.2 DNMT3A gene_id:1788|Hs108|chr2               (723 aa)
 initn: 2812 init1: 2281 opt: 2709  Z-score: 2396.0  bits: 454.2 E(32554): 3.9e-127
Smith-Waterman score: 2790; 59.1% identity (78.6% similar) in 682 aa overlap (181-852:61-722)

              160       170       180       190       200       210
pF1KE0 TASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSG
                                     : . ..:   .:   .  : .. . .: ..
CCDS17 VIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASP--TVATTPEPVGSDAGDKNATKA
               40        50        60          70        80        

              220       230       240       250       260       270
pF1KE0 DGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFS
         :  ::.::. ::::.:::::..::::::. .:::  :.. .:  : :::.::::::::
CCDS17 GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFS
       90       100       110       120       130       140        

              280       290       300       310           320      
pF1KE0 EVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFP----SSPGDS--
        : ..::. :. : . :. ::.::   ::::.:..:. :  :::: ::    :. .:.  
CCDS17 VVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAK
      150       160       170       180       190       200        

           330       340       350       360       370       380   
pF1KE0 -LEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRT
        .: : :::.::: :::.:.: .::.:    :  .:.  .            :  :   .
CCDS17 AVEVQNKPMIEWALGGFQPSGPKGLEP----PEEEKNPYK------------EVYTDMWV
      210       220       230           240                   250  

           390       400       410          420       430       440
pF1KE0 ADDSATSDYCPAPKRLKTNCYNNGKDRGDE---DQSREQMASDVANNKSSLEDGCLSCGR
         ..:.  : : :   :    .  : .  :   ...::... .: ..  ..:: :.::: 
CCDS17 EPEAAA--YAPPPPAKKPRKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGS
              260       270       280       290       300       310

              450       460       470       480       490       500
pF1KE0 KNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFC
        : .  :::: ::.::.:.. :::  :.:::::::::::.:: :::.:.:.:..::::::
CCDS17 LNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFC
              320       330       340       350       360       370

              510       520       530       540       550       560
pF1KE0 VECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEA
       :::...::: :.:  :  ..::.::::  .  .:.::::.::  ::: ::...   :.. 
CCDS17 VECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDP
              380       390       400       410       420       430

              570       580       590       600       610       620
pF1KE0 PKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEG
       ::.:: .:: .:.:::::::::::::: ::::.:::.: .:.::::::.::.:: :.:.:
CCDS17 PKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQG
              440       450       460       470       480       490

              630       640       650       660       670       680
pF1KE0 NIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLN
       .: ::.:::..:.:.:.:::::::::::::::::: ::::::::::::::::::::.::.
CCDS17 KIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLH
              500       510       520       530       540       550

              690       700       710       720       730       740
pF1KE0 YSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLP
        .::::::::::::.::::::: :.:::::::::: ::::::: .:::::::::::::::
CCDS17 DARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLP
              560       570       580       590       600       610

              750       760       770       780       790       800
pF1KE0 GMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVL
       :::::. .. :::::::.:::..::::..::.::::.::::::::.: ::: :: :::.:
CCDS17 GMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDIL
              620       630       640       650       660       670

              810       820       830       840       850   
pF1KE0 WCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
       ::::.::.:::::::::::::.: :::.:::::::::::::::::::.:::: 
CCDS17 WCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFACV
              680       690       700       710       720   

>>CCDS56184.1 DNMT3B gene_id:1789|Hs108|chr20             (694 aa)
 initn: 4050 init1: 2602 opt: 2603  Z-score: 2302.8  bits: 436.8 E(32554): 6.1e-122
Smith-Waterman score: 4474; 81.4% identity (81.4% similar) in 853 aa overlap (1-853:1-694)

               10        20        30        40        50        60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
       ::::::::                                                    
CCDS56 SSLLSYTQ----------------------------------------------------
                                                                   

              130       140       150       160       170       180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
                               ::::::::::::::::::::::::::::::::::::
CCDS56 ------------------------SLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
                               70        80        90       100    

              190       200       210       220       230       240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
          110       120       130       140       150       160    

              250       260       270       280       290       300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
          170       180       190       200       210       220    

              310       320       330       340       350       360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
CCDS56 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
          230       240       250       260       270              

              370       380       390       400       410       420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                      :::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                    280       290       300       310       320    

              430       440       450       460       470       480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
          330       340       350       360       370       380    

              490       500       510       520       530       540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
          390       400       410       420       430       440    

              550       560       570       580       590       600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
          450       460       470       480       490       500    

              610       620       630       640       650       660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
          510       520       530       540       550       560    

              670       680       690       700       710       720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
          570       580       590       600       610       620    

              730       740       750       760       770       780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
       ::::::::::::::::::::::::                                    
CCDS56 IDAIKVSAAHRARYFWGNLPGMNR------------------------------------
          630       640                                            

              790       800       810       820       830       840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
                                  :::::::::::::::::::::::::::::::::
CCDS56 ---------------------------IFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
                                 650       660       670       680 

              850   
pF1KE0 HLFAPLKDYFACE
       :::::::::::::
CCDS56 HLFAPLKDYFACE
             690    

>>CCDS56183.1 DNMT3B gene_id:1789|Hs108|chr20             (728 aa)
 initn: 4044 init1: 2602 opt: 2603  Z-score: 2302.5  bits: 436.9 E(32554): 6.3e-122
Smith-Waterman score: 4775; 85.3% identity (85.3% similar) in 853 aa overlap (1-853:1-728)

               10        20        30        40        50        60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
       ::::::::::::::::::::::::::::::::::::::::::                  
CCDS56 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPA------------------
               70        80        90       100                    

              130       140       150       160       170       180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
                               ::::::::::::::::::::::::::::::::::::
CCDS56 ------------------------SLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
                                    110       120       130        

              190       200       210       220       230       240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
      140       150       160       170       180       190        

              250       260       270       280       290       300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
      200       210       220       230       240       250        

              310       320       330       340       350       360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
CCDS56 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
      260       270       280       290       300       310        

              370       380       390       400       410       420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                      :::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                          320       330       340       350        

              430       440       450       460       470       480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
      360       370       380       390       400       410        

              490       500       510       520       530       540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
      420       430       440       450       460       470        

              550       560       570       580       590       600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
      480       490       500       510       520       530        

              610       620       630       640       650       660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
      540       550       560       570       580       590        

              670       680       690       700       710       720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
      600       610       620       630       640       650        

              730       740       750       760       770       780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
       ::::::::::::::::::::::::                                    
CCDS56 IDAIKVSAAHRARYFWGNLPGMNR------------------------------------
      660       670       680                                      

              790       800       810       820       830       840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
                                  :::::::::::::::::::::::::::::::::
CCDS56 ---------------------------IFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
                                       690       700       710     

              850   
pF1KE0 HLFAPLKDYFACE
       :::::::::::::
CCDS56 HLFAPLKDYFACE
         720        

>>CCDS13207.1 DNMT3B gene_id:1789|Hs108|chr20             (770 aa)
 initn: 5000 init1: 2602 opt: 2603  Z-score: 2302.2  bits: 436.9 E(32554): 6.5e-122
Smith-Waterman score: 5154; 90.3% identity (90.3% similar) in 853 aa overlap (1-853:1-770)

               10        20        30        40        50        60
pF1KE0 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE0 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE0 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE0 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE0 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE0 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
CCDS13 AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQP-----
              310       320       330       340       350          

              370       380       390       400       410       420
pF1KE0 KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                      :::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ---------------ENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
                        360       370       380       390       400

              430       440       450       460       470       480
pF1KE0 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
              410       420       430       440       450       460

              490       500       510       520       530       540
pF1KE0 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
              470       480       490       500       510       520

              550       560       570       580       590       600
pF1KE0 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
              530       540       550       560       570       580

              610       620       630       640       650       660
pF1KE0 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
              590       600       610       620       630       640

              670       680       690       700       710       720
pF1KE0 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS13 RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
              650       660       670       680       690       700

              730       740       750       760       770       780
pF1KE0 IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
       ::::::::::::::::::::::::                                    
CCDS13 IDAIKVSAAHRARYFWGNLPGMNR------------------------------------
              710       720                                        

              790       800       810       820       830       840
pF1KE0 IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
                                  :::::::::::::::::::::::::::::::::
CCDS13 ---------------------------IFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
                                     730       740       750       

              850   
pF1KE0 HLFAPLKDYFACE
       :::::::::::::
CCDS13 HLFAPLKDYFACE
       760       770

>>CCDS46650.1 DNMT3L gene_id:29947|Hs108|chr21            (386 aa)
 initn: 820 init1: 522 opt: 623  Z-score: 559.9  bits: 113.5 E(32554): 7.2e-25
Smith-Waterman score: 885; 37.8% identity (65.4% similar) in 376 aa overlap (417-791:35-371)

        390       400       410       420       430       440      
pF1KE0 SATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSF
                                     :. .: .:  :. ..:: :. ::  .  . 
CCDS46 PALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQ
           10        20        30        40        50        60    

        450       460       470       480       490       500      
pF1KE0 HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEV
       :::::::.:  :.:.::. ...::::::::::..:: :. ::.:.: .: ::.: ::.. 
CCDS46 HPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDS
           70        80        90       100       110       120    

        510       520       530       540       550       560      
pF1KE0 LVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAP-KLYP
       ::: ::..... .  : ::.:::.   :.:.::. :  .:.::.      : : : ... 
CCDS46 LVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDR----ESENPLEMFE
          130       140       150       160       170           180

         570       580       590       600       610       620     
pF1KE0 AIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYV
       ..:. ::.:.::::::. :       :::  ..: .. :         :.    :..:.:
CCDS46 TVPVWRRQPVRVLSLFEDIK------KEL-TSLG-FLES---------GS--DPGQLKHV
              190       200               210                  220 

         630       640       650       660       670       680     
pF1KE0 NDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPK
        :: . ..:..::::::::: :..:   :...     . :      .:.:..::.:.:::
CCDS46 VDVTDTVRKDVEEWGPFDLVYGATP--PLGHTCDRPPSWY------LFQFHRLLQYARPK
             230       240         250             260       270   

         690       700       710       720       730       740     
pF1KE0 EGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRP
        :. ::::::: . ....  :    ::::: .:: :  .. .. . :   :.:.     :
CCDS46 PGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNI-----P
           280       290       300       310       320             

         750       760       770       780       790       800     
pF1KE0 VIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTEL
       .: :..  :  ..  : . .:. :. . ...:  . :  :: ..:.              
CCDS46 AIRSRHWALVSEE--ELSLLAQNKQSSKLAAKWPT-KLVKNCFLPLREYFKYFSTELTSS
      330       340         350       360        370       380     

         810       820       830       840       850   
pF1KE0 ERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
                                                       
CCDS46 L                                               
                                                       

>>CCDS13705.1 DNMT3L gene_id:29947|Hs108|chr21            (387 aa)
 initn: 892 init1: 522 opt: 623  Z-score: 559.9  bits: 113.5 E(32554): 7.2e-25
Smith-Waterman score: 886; 37.5% identity (65.7% similar) in 376 aa overlap (417-791:35-372)

        390       400       410       420       430       440      
pF1KE0 SATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSF
                                     :. .: .:  :. ..:: :. ::  .  . 
CCDS13 PALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQ
           10        20        30        40        50        60    

        450       460       470       480       490       500      
pF1KE0 HPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEV
       :::::::.:  :.:.::. ...::::::::::..:: :. ::.:.: .: ::.: ::.. 
CCDS13 HPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDS
           70        80        90       100       110       120    

        510       520       530       540       550       560      
pF1KE0 LVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAP-KLYP
       ::: ::..... .  : ::.:::.   :.:.::. :  .:.::.      : : : ... 
CCDS13 LVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDR----ESENPLEMFE
          130       140       150       160       170           180

         570       580       590       600       610       620     
pF1KE0 AIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYV
       ..:. ::.:.::::::. :       :::  ..: .. :         :.    :..:.:
CCDS13 TVPVWRRQPVRVLSLFEDIK------KEL-TSLG-FLES---------GS--DPGQLKHV
              190       200               210                  220 

         630       640       650       660       670       680     
pF1KE0 NDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPK
        :: . ..:..::::::::: :..:   :...     . :      .:.:..::.:.:::
CCDS13 VDVTDTVRKDVEEWGPFDLVYGATP--PLGHTCDRPPSWY------LFQFHRLLQYARPK
             230       240         250             260       270   

         690       700       710       720       730       740     
pF1KE0 EGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRP
        :. ::::::: . ....  :    ::::: .:: :  .. .. . :   :.:.:..   
CCDS13 PGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIR--
           280       290       300       310       320       330   

         750       760       770       780       790       800     
pF1KE0 VIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTEL
         .:..  :  ..  : . .:. :. . ...:  . :  :: ..:.              
CCDS13 --SSRHWALVSEE--ELSLLAQNKQSSKLAAKWPT-KLVKNCFLPLREYFKYFSTELTSS
               340         350       360        370       380      

         810       820       830       840       850   
pF1KE0 ERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
                                                       
CCDS13 L                                               
                                                       




853 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 14:54:04 2016 done: Thu Nov  3 14:54:04 2016
 Total Scan time:  4.460 Total Display time:  0.280

Function used was FASTA [36.3.4 Apr, 2011]
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