Result of FASTA (omim) for pF1KB6108
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6108, 617 aa
  1>>>pF1KB6108 617 - 617 aa - 617 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.3318+/-0.000427; mu= -8.6543+/- 0.026
 mean_var=308.5224+/-63.585, 0's: 0 Z-trim(120.4): 32  B-trim: 1154 in 1/54
 Lambda= 0.073018
 statistics sampled from 35463 (35506) to 35463 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.416), width:  16
 Scan time:  9.980

The best scores are:                                      opt bits E(85289)
NP_689853 (OMIM: 609843) mRNA-decapping enzyme 1B  ( 617) 4096 445.4 2.8e-124
XP_011519229 (OMIM: 609843) PREDICTED: mRNA-decapp ( 515) 3400 372.0 2.8e-102
NP_001306221 (OMIM: 609843) mRNA-decapping enzyme  ( 153)  695 86.7 6.2e-17
NP_060873 (OMIM: 607010) mRNA-decapping enzyme 1A  ( 582)  701 87.7 1.2e-16
NP_001277133 (OMIM: 607010) mRNA-decapping enzyme  ( 544)  699 87.5 1.3e-16


>>NP_689853 (OMIM: 609843) mRNA-decapping enzyme 1B isof  (617 aa)
 initn: 4096 init1: 4096 opt: 4096  Z-score: 2352.2  bits: 445.4 E(85289): 2.8e-124
Smith-Waterman score: 4096; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617)

               10        20        30        40        50        60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 PKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATC
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 QETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVR
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 SADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 SADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 STPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 STPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQ
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 AHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 AQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 RESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 RESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNII
              550       560       570       580       590       600

              610       
pF1KB6 YEAYLFSMTQAAMKKTM
       :::::::::::::::::
NP_689 YEAYLFSMTQAAMKKTM
              610       

>>XP_011519229 (OMIM: 609843) PREDICTED: mRNA-decapping   (515 aa)
 initn: 3400 init1: 3400 opt: 3400  Z-score: 1957.2  bits: 372.0 E(85289): 2.8e-102
Smith-Waterman score: 3400; 99.6% identity (100.0% similar) in 512 aa overlap (106-617:4-515)

          80        90       100       110       120       130     
pF1KB6 NRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEECQRIAELMKNLTQYEQ
                                     ..::::::::::::::::::::::::::::
XP_011                            MQIKVSIYGIWFYDKEECQRIAELMKNLTQYEQ
                                          10        20        30   

         140       150       160       170       180       190     
pF1KB6 LKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSEPKKITSSSAIYDNPN
            40        50        60        70        80        90   

         200       210       220       230       240       250     
pF1KB6 LIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQDKATCQETVEPPQTLHQQQQ
           100       110       120       130       140       150   

         260       270       280       290       300       310     
pF1KB6 QQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQQQQEKLPIRQGVVRSLSYEEPRRHSPPIEKQLCPAIQKLMVRSADLHPLSELPENRP
           160       170       180       190       200       210   

         320       330       340       350       360       370     
pF1KB6 CENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CENGSTHSAGEFFTGPVQPGSPHNIGTSRGVQNASRTQNLFEKLQSTPGAANKCDPSTPA
           220       230       240       250       260       270   

         380       390       400       410       420       430     
pF1KB6 PASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PASSAALNRSRAPTSVTPVAPGKGLAQPPQAYFNGSLPPQTVGHQAHGREQSTLPRQTLP
           280       290       300       310       320       330   

         440       450       460       470       480       490     
pF1KB6 ISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISGSQTGSSGVISPQELLKKLQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWIN
           340       350       360       370       380       390   

         500       510       520       530       540       550     
pF1KB6 KTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTPNTEQQTPLFQVISPQRIPATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPA
           400       410       420       430       440       450   

         560       570       580       590       600       610     
pF1KB6 AATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AATSLLLPIQSPEPSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKK
           460       470       480       490       500       510   

         
pF1KB6 TM
       ::
XP_011 TM
         

>>NP_001306221 (OMIM: 609843) mRNA-decapping enzyme 1B i  (153 aa)
 initn: 695 init1: 695 opt: 695  Z-score: 425.0  bits: 86.7 E(85289): 6.2e-17
Smith-Waterman score: 695; 100.0% identity (100.0% similar) in 106 aa overlap (1-106:1-106)

               10        20        30        40        50        60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
       ::::::::::::::::::::::::::::::::::::::::::::::              
NP_001 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARCESFLLQWVVLLLK
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNSGEGKEVDILRMLIKAKDEYTKCKTCSE
                                                                   
NP_001 FGQVFKIVQCLPLCLHLVSVAMGGVSILTNVNV                           
              130       140       150                              

>>NP_060873 (OMIM: 607010) mRNA-decapping enzyme 1A isof  (582 aa)
 initn: 831 init1: 594 opt: 701  Z-score: 419.8  bits: 87.7 E(85289): 1.2e-16
Smith-Waterman score: 817; 33.3% identity (59.0% similar) in 630 aa overlap (13-610:8-575)

               10        20        30        40        50        60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
                   :...:::::..:::::. :.:...:::::::  .::.:::::.:::::
NP_060      MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLF
                    10        20        30        40        50     

               70        80        90       100       110       120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
       :: ::::: :::::.:::.:.: .::..:::.:::..:::::::: ::::.::::::..:
NP_060 VYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDC
          60        70        80        90       100       110     

              130       140       150        160       170         
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNS-GEGKEVDILRMLIKAKDEYTKCK---
       .:::.:: .... :  ...:..    ::   :. .. . .:::.:: .::::: . .   
NP_060 HRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGD
         120       130       140       150       160       170     

         180       190       200       210       220       230     
pF1KB6 -TCSEPKKITSSSAIYDNPNLIKPIPVKPSENQQQRIPQPNQTLDPEPQHLSLTALFGKQ
        . : :    :..   .: .  . .   :: .:..  :. ..       ::..  ::: .
NP_060 SNISSPGLQPSTQ--LSNLGSTETLEEMPSGSQDKSAPSGHK-------HLTVEELFGTS
         180         190       200       210              220      

         240       250       260       270       280        290    
pF1KB6 DKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHSP-PIEKQL--CP
                : : ..  ..    ...:.::   :   . : .::    : :.: ::   :
NP_060 LPK------EQPAVVGLDS----EEMERLP---G---DASQKEPNSFLPFPFE-QLGGAP
              230           240             250       260          

            300               310       320       330        340   
pF1KB6 AIQKLMVRSADLH--------PLSELPENRPCENGSTHSAGEFFTGPV-QPGSPHNIGTS
         . : : ::  :        :.   : .    : .   .  .  .:: .:  : .  :.
NP_060 QSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTA
     270       280       290       300       310       320         

           350       360       370          380           390      
pF1KB6 RGVQNASRTQNLFEKLQSTPGAANKCDP--STPAPA-SSAAL--NRS--RAPTSVTPVAP
       .   .  :...... ...::    . .:  . :.:  : :.:  :.:  ::: .:: .: 
NP_060 QVPPSLPRNSTMMQAVKTTP---RQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTA-
     330       340          350       360       370       380      

        400       410        420       430       440       450     
pF1KB6 GKGLAQPPQAYFNG-SLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQELLKK
         : . :    ..   : ::      : . : : :     . .: . ..: ..  :    
NP_060 --GTSLPSVDLLQKLRLTPQ------HDQIQ-TQPLGKGAMVASFSPAAGQLATPE----
           390       400              410       420       430      

         460       470       480       490        500       510    
pF1KB6 LQIVQQEQQLHASNRPALAAKFPVLAQSSGTGKPLESWI-NKTPNTEQQTPLFQVISP-Q
        ....  ..  :. : : .:..  .. .     ::.:   :. :..  :  ...   :  
NP_060 -SFIEPPSKT-AAARVAASASLSNMVLA-----PLQSMQQNQDPEVFVQPKVLSSAIPVA
             440        450            460       470       480     

                520       530       540       550       560        
pF1KB6 RIP-----ATAAPSLLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQSPE
         :     .::. :.:..: :: : ..     : : :   ...  :    ..  : .. .
NP_060 GAPLVTATTTAVSSVLLAPSVFQQTVT-----RSSDLERKASSPSP---LTIGTPESQRK
         490       500       510            520          530       

      570       580       590       600       610       
pF1KB6 PSVITSSPLTKLQLQEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM
       ::.:    :.: :::..:..::.::..::. ..:.::  .:.       
NP_060 PSII----LSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
       540           550       560       570       580  

>>NP_001277133 (OMIM: 607010) mRNA-decapping enzyme 1A i  (544 aa)
 initn: 831 init1: 594 opt: 699  Z-score: 419.1  bits: 87.5 E(85289): 1.3e-16
Smith-Waterman score: 814; 31.5% identity (58.6% similar) in 616 aa overlap (13-610:8-537)

               10        20        30        40        50        60
pF1KB6 MAAVAAGGLVGKGRDISLAALQRHDPYINRIVDVASQVALYTFGHRANEWEKTDVEGTLF
                   :...:::::..:::::. :.:...:::::::  .::.:::::.:::::
NP_001      MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLF
                    10        20        30        40        50     

               70        80        90       100       110       120
pF1KB6 VYTRSASPKHGFTIMNRLSMENRTEPITKDLDFQLQDPFLLYRNARLSIYGIWFYDKEEC
       :: ::::: :::::.:::.:.: .::..:::.:::..:::::::: ::::.::::::..:
NP_001 VYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDC
          60        70        80        90       100       110     

              130       140       150        160       170         
pF1KB6 QRIAELMKNLTQYEQLKAHQGTGAGISPVILNS-GEGKEVDILRMLIKAKDEYTKCKTCS
       .:::.:: .... :  ...:..    ::   :. .. . .:::.:: .::::: .    .
NP_001 HRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERSAPSG
         120       130       140       150       160       170     

     180           190           200       210           220       
pF1KB6 EP----KKITSSSAIYDNPNLI----KPIPVKPSENQQQR----IPQPNQTLDPEPQHLS
       .     ... ..:   ..: ..    . .   :.. .:..    .: : . :   ::  .
NP_001 HKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSET
         180       190       200       210       220       230     

           230       240       250       260       270       280   
pF1KB6 L----TALFGKQDKATCQETVEPPQTLHQQQQQQQQQQEKLPIRQGVVRSLSYEEPRRHS
       :    .:  . : . :    . : .    :.....     .:.   .  .:  : :  . 
NP_001 LGVPSAAHHSVQPEITTPVLITPASI--TQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQV
         240       250       260         270       280       290   

           290       300       310       320       330       340   
pF1KB6 PPIEKQLCPAIQKLMVRSADLHPLSELPENRPCENGSTHSAGEFFTGPVQPGSPHNIGTS
       ::   .    .: . .   .  ::     :.:  . : :..     .: .  .: :. ..
NP_001 PPSLPRNSTMMQAVKTTPRQRSPL----LNQPVPELS-HASLIANQSPFR--APLNVTNT
           300       310           320        330         340      

           350       360       370       380       390       400   
pF1KB6 RGVQNASRTQNLFEKLQSTPGAANKCDPSTPAPASSAALNRSRAPTSVTPVAPGKGLAQP
        :..  :   .:..::. ::    . :     : ...:.        :.  .:. :    
NP_001 AGTSLPSV--DLLQKLRLTP----QHDQIQTQPLGKGAM--------VASFSPAAGQLAT
        350         360           370               380       390  

           410       420       430       440       450       460   
pF1KB6 PQAYFNGSLPPQTVGHQAHGREQSTLPRQTLPISGSQTGSSGVISPQELLKKLQIVQQEQ
       :.....   ::.   . : .:           ...: . :. :..:      :: .::.:
NP_001 PESFIE---PPS---KTAAAR-----------VAASASLSNMVLAP------LQSMQQNQ
               400                     410       420               

           470        480       490       500       510       520  
pF1KB6 QLHASNRP-ALAAKFPVLAQSSGTGKPLESWINKTPNTEQQTPLFQVISPQRIPATAAPS
       . ..  .: .:.. .::      .: ::   .. :                   .::. :
NP_001 DPEVFVQPKVLSSAIPV------AGAPL---VTAT-------------------TTAVSS
     430       440             450                             460 

            530       540       550       560       570       580  
pF1KB6 LLMSPMVFAQPTSVPPKERESGLLPVGGQEPPAAATSLLLPIQSPEPSVITSSPLTKLQL
       .:..: :: : ..     : : :   ...  :    ..  : .. .::.:    :.: ::
NP_001 VLLAPSVFQQTVT-----RSSDLERKASSPSP---LTIGTPESQRKPSII----LSKSQL
             470            480          490       500             

            590       600       610       
pF1KB6 QEALLYLIQNDDNFLNIIYEAYLFSMTQAAMKKTM
       :..:..::.::..::. ..:.::  .:.       
NP_001 QDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
     510       520       530       540    




617 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 21:46:31 2016 done: Fri Nov  4 21:46:32 2016
 Total Scan time:  9.980 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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