Result of FASTA (omim) for pF1KB7183
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7183, 503 aa
  1>>>pF1KB7183 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.9619+/-0.000407; mu= 20.2867+/- 0.025
 mean_var=64.5927+/-13.440, 0's: 0 Z-trim(111.3): 173  B-trim: 1026 in 1/49
 Lambda= 0.159582
 statistics sampled from 19678 (19869) to 19678 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.233), width:  16
 Scan time:  9.550

The best scores are:                                      opt bits E(85289)
NP_000489 (OMIM: 124080,203400,610600) cytochrome  ( 503) 3385 788.4       0
NP_000488 (OMIM: 103900,202010,610613) cytochrome  ( 503) 3144 732.9  5e-211
NP_001021384 (OMIM: 103900,202010,610613) cytochro ( 437) 2507 586.2 6.2e-167
XP_011515176 (OMIM: 103900,202010,610613) PREDICTE ( 529) 2305 539.8 7.3e-153
XP_011515177 (OMIM: 103900,202010,610613) PREDICTE ( 528) 1497 353.8 7.2e-97
NP_000772 (OMIM: 118485,613743) cholesterol side-c ( 521) 1198 284.9 3.8e-76
XP_016868635 (OMIM: 103900,202010,610613) PREDICTE ( 282)  944 226.3 9.3e-59
NP_001093243 (OMIM: 118485,613743) cholesterol sid ( 363)  872 209.8 1.1e-53
NP_000776 (OMIM: 264700,609506) 25-hydroxyvitamin  ( 508)  746 180.9 7.8e-45
XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514)  736 178.6 3.9e-44
XP_016883181 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514)  736 178.6 3.9e-44
NP_000773 (OMIM: 126065,143880) 1,25-dihydroxyvita ( 514)  736 178.6 3.9e-44
XP_005260361 (OMIM: 126065,143880) PREDICTED: 1,25 ( 514)  736 178.6 3.9e-44
NP_000775 (OMIM: 213700,606530) sterol 26-hydroxyl ( 531)  683 166.4 1.9e-40
XP_016858977 (OMIM: 213700,606530) PREDICTED: ster ( 391)  587 144.2 6.7e-34
XP_016883182 (OMIM: 126065,143880) PREDICTED: 1,25 ( 448)  541 133.6 1.1e-30
NP_001122387 (OMIM: 126065,143880) 1,25-dihydroxyv ( 448)  541 133.6 1.1e-30
NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389)  361 92.1 3.1e-18
XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389)  361 92.1 3.1e-18
XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389)  361 92.1 3.1e-18
NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492)  362 92.4 3.1e-18
NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502)  362 92.4 3.2e-18
NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502)  342 87.8 7.8e-17
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503)  341 87.6 9.1e-17
XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322)  337 86.6 1.2e-16
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503)  337 86.7 1.7e-16
NP_000766 (OMIM: 601258) cytochrome P450 2J2 [Homo ( 502)  336 86.5   2e-16
NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504)  333 85.8 3.3e-16
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393)  327 84.3   7e-16
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525)  327 84.4 8.8e-16
XP_016868032 (OMIM: 606534) PREDICTED: cytochrome  ( 394)  322 83.2 1.6e-15
XP_016868031 (OMIM: 606534) PREDICTED: cytochrome  ( 394)  322 83.2 1.6e-15
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503)  317 82.1 4.2e-15
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524)  316 81.9 5.1e-15
XP_011526509 (OMIM: 611485) PREDICTED: cytochrome  ( 334)  313 81.0 5.7e-15
XP_011526505 (OMIM: 611485) PREDICTED: cytochrome  ( 352)  313 81.1   6e-15
XP_011526507 (OMIM: 611485) PREDICTED: cytochrome  ( 352)  313 81.1   6e-15
XP_011526506 (OMIM: 611485) PREDICTED: cytochrome  ( 352)  313 81.1   6e-15
XP_011526510 (OMIM: 611485) PREDICTED: cytochrome  ( 375)  313 81.1 6.3e-15
XP_006722913 (OMIM: 611485) PREDICTED: cytochrome  ( 375)  313 81.1 6.3e-15
XP_011526504 (OMIM: 611485) PREDICTED: cytochrome  ( 375)  313 81.1 6.3e-15
NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524)  313 81.2 8.2e-15
NP_000755 (OMIM: 608054) cytochrome P450 2A7 isofo ( 494)  311 80.7 1.1e-14
NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519)  310 80.5 1.3e-14
NP_078790 (OMIM: 600081,608713) vitamin D 25-hydro ( 501)  307 79.8 2.1e-14
NP_006659 (OMIM: 604087) cholesterol 24-hydroxylas ( 500)  306 79.6 2.4e-14
NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393)  304 79.0 2.7e-14
NP_000753 (OMIM: 122700,122720,188890,211980) cyto ( 494)  304 79.1 3.3e-14
NP_000762 (OMIM: 122700,601130) cytochrome P450 2C ( 490)  302 78.6 4.5e-14
XP_016871247 (OMIM: 122700,601130) PREDICTED: cyto ( 490)  302 78.6 4.5e-14


>>NP_000489 (OMIM: 124080,203400,610600) cytochrome P450  (503 aa)
 initn: 3385 init1: 3385 opt: 3385  Z-score: 4209.5  bits: 788.4 E(85289):    0
Smith-Waterman score: 3385; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)

               10        20        30        40        50        60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
              430       440       450       460       470       480

              490       500   
pF1KB7 IKMVYSFILRPGTSPLLTFRAIN
       :::::::::::::::::::::::
NP_000 IKMVYSFILRPGTSPLLTFRAIN
              490       500   

>>NP_000488 (OMIM: 103900,202010,610613) cytochrome P450  (503 aa)
 initn: 3144 init1: 3144 opt: 3144  Z-score: 3909.6  bits: 732.9 E(85289): 5e-211
Smith-Waterman score: 3144; 93.2% identity (97.6% similar) in 503 aa overlap (1-503:1-503)

               10        20        30        40        50        60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
       ::::::::::.:.::::::::.::::::::.:::::::::::..::::::::::::::::
NP_000 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
       :: ::::.:::::::::::::.:::  ::::::::::::::::::::: :: ::::::::
NP_000 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
       ::::::::::::::::::::::::::.::::.::::::::::::::::::::::::::::
NP_000 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
       ::::::: ::::::::::::::::::::::::::::::::.:::.::.:::::::.::::
NP_000 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
        .:::::::::::::::::.::::::::::::::.::: :::::::::::::::::::::
NP_000 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
       :::::::::::::::::::::::::.:::::::::::::::::.::::::::: ::::::
NP_000 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB7 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
       ::::::::::::::::::.:::::::::::::::::::::::::::::::. ::::::::
NP_000 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
              430       440       450       460       470       480

              490       500   
pF1KB7 IKMVYSFILRPGTSPLLTFRAIN
       :::::::::::.  :::::::::
NP_000 IKMVYSFILRPSMFPLLTFRAIN
              490       500   

>>NP_001021384 (OMIM: 103900,202010,610613) cytochrome P  (437 aa)
 initn: 2506 init1: 2506 opt: 2507  Z-score: 3117.9  bits: 586.2 E(85289): 6.2e-167
Smith-Waterman score: 2555; 80.7% identity (84.7% similar) in 503 aa overlap (1-503:1-437)

               10        20        30        40        50        60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
       ::::::::::.:.::::::::.::::::::.:::::::::::..::::::::::::::::
NP_001 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
       :: ::::.:::::::::::::.:::  ::::::::::::::::::::: :: ::::::::
NP_001 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
       ::::::::::::::::::::::::::.::::.::::::::::::::::::::::::::::
NP_001 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
       ::::::: ::::::::::::::::::::::::::::::::.:::.::.:::::::.::::
NP_001 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
        .:::::::::::::::::.::::::::::::::.::: :::::::::::::::::::::
NP_001 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
       :::::::::::::::::::::::::.::::::::::::::                    
NP_001 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAG--------------------
              370       380       390       400                    

              430       440       450       460       470       480
pF1KB7 ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
                                                     ::::. ::::::::
NP_001 ----------------------------------------------VLKHLQVETLTQED
                                                            410    

              490       500   
pF1KB7 IKMVYSFILRPGTSPLLTFRAIN
       :::::::::::.  :::::::::
NP_001 IKMVYSFILRPSMFPLLTFRAIN
          420       430       

>>XP_011515176 (OMIM: 103900,202010,610613) PREDICTED: c  (529 aa)
 initn: 2305 init1: 2305 opt: 2305  Z-score: 2865.4  bits: 539.8 E(85289): 7.3e-153
Smith-Waterman score: 3082; 88.7% identity (92.8% similar) in 529 aa overlap (1-503:1-529)

               10        20        30        40        50        60
pF1KB7 MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
       ::::::::::.:.::::::::.::::::::.:::::::::::..::::::::::::::::
XP_011 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
       :: ::::.:::::::::::::.:::  ::::::::::::::::::::: :: ::::::::
XP_011 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
               70        80        90       100       110       120

              130                                 140       150    
pF1KB7 QHRGHKCGVFLLN--------------------------GPEWRFNRLRLNPDVLSPKAV
       :::::::::::::                          :::::::::::::.::::.::
XP_011 QHRGHKCGVFLLNVADRGNSSPPFPGGIHGAPTHSGCRNGPEWRFNRLRLNPEVLSPNAV
              130       140       150       160       170       180

          160       170       180       190       200       210    
pF1KB7 QRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGH
              190       200       210       220       230       240

          220       230       240       250       260       270    
pF1KB7 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKI
       ::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_011 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKI
              250       260       270       280       290       300

          280       290       300       310       320       330    
pF1KB7 YQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP
       ::::::.:::.::.:::::::.:::: .:::::::::::::::::.::::::::::::::
XP_011 YQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP
              310       320       330       340       350       360

          340       350       360       370       380       390    
pF1KB7 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQN
       .::: ::::::::::::::::::::::::::::::::::::::::::::::.::::::::
XP_011 NVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQN
              370       380       390       400       410       420

          400       410       420       430       440       450    
pF1KB7 YHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRR
       :::::::::.::::::::: ::::::::::::::::::::::::.:::::::::::::::
XP_011 YHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRR
              430       440       450       460       470       480

          460       470       480       490       500   
pF1KB7 LAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
       ::::::::::::::::. :::::::::::::::::::.  :::::::::
XP_011 LAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
              490       500       510       520         

>>XP_011515177 (OMIM: 103900,202010,610613) PREDICTED: c  (528 aa)
 initn: 1523 init1: 1497 opt: 1497  Z-score: 1860.1  bits: 353.8 E(85289): 7.2e-97
Smith-Waterman score: 2305; 80.1% identity (84.7% similar) in 457 aa overlap (88-495:1-454)

        60        70        80        90       100       110       
pF1KB7 EQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWV
                                     ::::::::::::::::::::: :: :::::
XP_011                               MVCVMLPEDVEKLQQVDSLHPHRMSLEPWV
                                             10        20        30

       120       130                                 140       150 
pF1KB7 AYRQHRGHKCGVFLLN--------------------------GPEWRFNRLRLNPDVLSP
       ::::::::::::::::                          :::::::::::::.::::
XP_011 AYRQHRGHKCGVFLLNVADRGNSSPPFPGGIHGAPTHSGCRNGPEWRFNRLRLNPEVLSP
               40        50        60        70        80        90

             160       170       180       190       200       210 
pF1KB7 KAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGL
       .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGL
              100       110       120       130       140       150

             220       230       240       250       260       270 
pF1KB7 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCI
       :::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
XP_011 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCI
              160       170       180       190       200       210

             280       290       300       310       320       330 
pF1KB7 QKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELA
       :::::::::.:::.::.:::::::.:::: .:::::::::::::::::.:::::::::::
XP_011 QKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELA
              220       230       240       250       260       270

             340       350       360       370                     
pF1KB7 RNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR-----------------
       :::.::: :::::::::::::::::::::::::::::::::::                 
XP_011 RNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRKGAESTGSPIQLRTLSM
              280       290       300       310       320       330

                380       390       400       410       420        
pF1KB7 ------LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRW
             :::::::::::.:::::::::::::::::.::::::::: ::::::::::::::
XP_011 DAPTSRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW
              340       350       360       370       380       390

      430       440       450       460       470       480        
pF1KB7 LDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFI
       ::::::::::.:::::::::::::::::::::::::::   : : .    . .. :... 
XP_011 LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH---HNLCNFEGLRRLHHVHGLR
              400       410       420          430       440       

      490       500                                                
pF1KB7 LRPGTSPLLTFRAIN                                             
        .:  .:                                                     
XP_011 TKPDGNPASVLGAETPPGGDTNPRGHKDGLQLHIEAQHVPPPHLQSHQLITSLHPGSQPG
       450       460       470       480       490       500       

>>NP_000772 (OMIM: 118485,613743) cholesterol side-chain  (521 aa)
 initn: 1173 init1: 618 opt: 1198  Z-score: 1488.1  bits: 284.9 E(85289): 3.8e-76
Smith-Waterman score: 1198; 38.9% identity (69.0% similar) in 496 aa overlap (11-503:20-515)

                        10        20         30        40        50
pF1KB7          MALRAKAEVCVAAPWLSLQRARA-LGTRAARAPRTVLPFEAMPQHPGNRWL
                          ..::  .: : :.  :  :. . :.  ::. .:.   : ::
NP_000 MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
               10        20        30        40        50        60

               60        70        80        90       100       110
pF1KB7 RLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCR
        : ..::: : ...::.  :.::. :::.: .::. . : :. ::::  : . .. .: :
NP_000 NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
               70        80        90       100       110       120

              120       130       140       150       160       170
pF1KB7 MILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQ
       ... :::::.:.  .  ::.: ..  :. .:. :: .:..:.:.. :::..:::.::: .
NP_000 FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
              130       140       150       160       170       180

              180       190       200       210       220       230
pF1KB7 ALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVM
       .:.... . . :. . :.. ..:....:. . ..:::: :.. .  .  .  :. :.  :
NP_000 VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
              190       200       210       220       230       240

              240       250       260       270       280          
pF1KB7 FKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQH--YTG
       :...: .. .: .: : .  :.::.:  ::: ::. .:   :..: ::  .   :  : :
NP_000 FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
              250       260       270       280       290       300

      290       300       310       320       330       340        
pF1KB7 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA
       :. .::  ...:.: ::::  :. ::.::::.. :   :.:.:::  ::..:: : ::: 
NP_000 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
              310       320       330       340       350       360

      350       360       370       380       390       400        
pF1KB7 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY
        . .         .:::.:..::::::.:... :.: . .::::..: ::: ::::: .:
NP_000 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
              370       380       390       400       410       420

      410       420       430       440       450       460        
pF1KB7 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL
       .:::. ..:  :: ..: :::.   .   :... ::.:.:::::::.:: :: ..: ..:
NP_000 ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
              430       440       450       460       470       480

      470       480       490       500         
pF1KB7 KHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN      
       ..: ::     :.  ....:: :     .::  .:      
NP_000 ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
              490       500       510       520 

>>XP_016868635 (OMIM: 103900,202010,610613) PREDICTED: c  (282 aa)
 initn: 962 init1: 936 opt: 944  Z-score: 1175.9  bits: 226.3 E(85289): 9.3e-59
Smith-Waterman score: 944; 82.5% identity (90.4% similar) in 177 aa overlap (319-495:35-208)

      290       300       310       320       330       340        
pF1KB7 IVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA
                                     :.::::::::::::::.::: :::::::::
XP_016 TPHREVVLGGVSRGLSPPVQGLTLQLCLLQTVFPLLMTLFELARNPNVQQALRQESLAAA
           10        20        30        40        50        60    

      350       360       370       380       390       400        
pF1KB7 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLY
       :::::::::::::::::::::::::::::::::::::.:::::::::::::::::.::::
XP_016 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLY
           70        80        90       100       110       120    

      410       420       430       440       450       460        
pF1KB7 SLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVL
       ::::: ::::::::::::::::::::::::.:::::::::::::::::::::::::::  
XP_016 SLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH--
          130       140       150       160       170       180    

      470       480       490       500                            
pF1KB7 KHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN                         
        : : .    . .. :...  .:  .:                                 
XP_016 -HNLCNFEGLRRLHHVHGLRTKPDGNPASVLGAETPPGGDTNPRGHKDGLQLHIEAQHVP
             190       200       210       220       230       240 

>>NP_001093243 (OMIM: 118485,613743) cholesterol side-ch  (363 aa)
 initn: 868 init1: 569 opt: 872  Z-score: 1084.7  bits: 209.8 E(85289): 1.1e-53
Smith-Waterman score: 872; 39.2% identity (69.7% similar) in 357 aa overlap (149-503:1-357)

      120       130       140       150       160       170        
pF1KB7 YRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQ
                                     ..:.:.. :::..:::.::: ..:.... .
NP_001                               MAPEATKNFLPLLDAVSRDFVSVLHRRIKK
                                             10        20        30

      180       190       200       210       220       230        
pF1KB7 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM
        . :. . :.. ..:....:. . ..:::: :.. .  .  .  :. :.  ::...: ..
NP_001 AGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPML
               40        50        60        70        80        90

      240       250       260       270       280         290      
pF1KB7 FMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQH--YTGIVAELLLK
        .: .: : .  :.::.:  ::: ::. .:   :..: ::  .   :  : ::. .::  
NP_001 NLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD
              100       110       120       130       140       150

        300       310       320       330       340       350      
pF1KB7 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ
       ...:.: ::::  :. ::.::::.. :   :.:.:::  ::..:: : :::  . .    
NP_001 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA
              160       170       180       190       200       210

        360       370       380       390       400       410      
pF1KB7 KATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAAL
            .:::.:..::::::.:... :.: . .::::..: ::: ::::: .:.:::. ..
NP_001 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF
              220       230       240       250       260       270

        420       430       440       450       460       470      
pF1KB7 FPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL
       :  :: ..: :::.   .   :... ::.:.:::::::.:: :: ..: ..:..: ::  
NP_001 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ
              280       290       300       310       320       330

        480       490       500         
pF1KB7 TQEDIKMVYSFILRPGTSPLLTFRAIN      
          :.  ....:: :     .::  .:      
NP_001 HLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
              340       350       360   

>>NP_000776 (OMIM: 264700,609506) 25-hydroxyvitamin D-1   (508 aa)
 initn: 729 init1: 333 opt: 746  Z-score: 925.9  bits: 180.9 E(85289): 7.8e-45
Smith-Waterman score: 755; 32.5% identity (60.6% similar) in 464 aa overlap (23-474:24-479)

                10        20        30        40        50         
pF1KB7  MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQ
                              .:: :  .. :  :     :. :.     : ... . 
NP_000 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPS----FLAELFCKG
               10        20        30        40            50      

      60        70        80        90       100       110         
pF1KB7 GYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAY
       :  .::  . :   ..::..  ..:  : : :  :  ::.: . .. .: :  . ::. .
NP_000 GLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEH
         60        70        80        90       100       110      

     120       130       140       150       160       170         
pF1KB7 RQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQN
       :. : . ::..  .: ::.  :  : : .: :.:. :.   .. :. :. . :..   : 
NP_000 RRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRR---QR
        120       130       140       150       160       170      

     180           190       200       210       220       230     
pF1KB7 ARGS----LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTV
       .::.    :. ::   .... .:.   .:.: ::: .  .    . .:..:.  .: ::.
NP_000 GRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTL
           180       190       200       210       220       230   

         240       250       260       270       280               
pF1KB7 QLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF---NRPQH--YTGI-
         : ::. : : . :  : .  . :: .: ...  ...   : :.   ..:..   .:  
NP_000 LTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAH
           240        250       260       270       280       290  

     290       300       310       320       330       340         
pF1KB7 VAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAA
       ....:.. ::  ..: .:  ::  ..:::..  :  .:.::.:.:.::  :..:  :: .
NP_000 LTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALS
            300       310       320       330       340       350  

     350         360       370       380       390       400       
pF1KB7 SISEHPQKAT--TELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFL
         :    .::  ..::::.:..::.::::::     :: ..:. . .: :: .::: .  
NP_000 PGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCH
            360       370       380       390       400       410  

       410       420       430       440       450       460       
pF1KB7 YSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHV
       :. .:. : ::.:. . : :::    . . :  .::::: :.:.:::::: :. . : ..
NP_000 YATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQI
            420       430       440       450       460       470  

       470       480       490       500   
pF1KB7 LKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
       : :: :.                             
NP_000 LTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
            480       490       500        

>>XP_016883180 (OMIM: 126065,143880) PREDICTED: 1,25-dih  (514 aa)
 initn: 688 init1: 339 opt: 736  Z-score: 913.3  bits: 178.6 E(85289): 3.9e-44
Smith-Waterman score: 736; 29.5% identity (62.6% similar) in 441 aa overlap (52-491:70-503)

              30        40        50        60        70        80 
pF1KB7 RALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRY
                                     ::::  . : .. :  . .  .. : :::.
XP_016 EVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRM
      40        50        60        70        80        90         

              90       100       110       120       130       140 
pF1KB7 NLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNR
       .::. . : .  :  .: : ...: .: :. ..:: :::..: .  :...:.: .:.  :
XP_016 KLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVR
     100       110       120       130       140       150         

             150       160       170       180       190       200 
pF1KB7 LRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN
         ..  ...:  :...   .. :  ::   . .  : . :: .  :.   . ....:.  
XP_016 SAFQKKLMKPGEVMKLDNKINEVLADFMGRIDE--LCDERGHVE-DLYSELNKWSFESIC
     160       170       180       190         200        210      

             210       220       230       240       250       260 
pF1KB7 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWD
       :.:. .:.::. .. .. ..::. :...:...  ..:  :  : . .. :::..:  :::
XP_016 LVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWD
        220       230       240       250       260       270      

             270       280       290       300       310       320 
pF1KB7 CIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAF
        ::.    ::..  .. .    :  . .. ..  . .:: . . :   ::  ..:.::: 
XP_016 TIFKSVKACIDNRLEKYS---QQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTAN
        280       290          300       310       320       330   

             330       340       350        360       370       380
pF1KB7 PLLMTLFELARNPDVQQILRQESLAAAASISEHPQ-KATTELPLLRAALKETLRLYPVGL
        :.  :..:.:::.::: : .: . ..   .. :. .   ..: :.: :::..:: :   
XP_016 SLMWILYNLSRNPQVQQKLLKE-IQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVP
           340       350        360       370       380       390  

              390       400       410       420       430       440
pF1KB7 FLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHH
       :  :....  :: .: .: ::....    :: .   :    .. :.:::. . .   : :
XP_016 FTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAH
            400       410       420       430       440       450  

              450       460       470       480       490       500
pF1KB7 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFR
       .::: : :.:.:::::: .. : :  ..... ...  .: ..:..:  : :         
XP_016 LPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFC
            460       470       480       490       500       510  

          
pF1KB7 AIN
          
XP_016 QR 
          




503 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 20:27:41 2016 done: Fri Nov  4 20:27:42 2016
 Total Scan time:  9.550 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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