Result of FASTA (omim) for
pF1KB7648
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7648, 392 aa
1>>>pF1KB7648 392 - 392 aa - 392 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2144+/-0.000365; mu= 17.8226+/- 0.023
mean_var=71.4659+/-14.839, 0's: 0 Z-trim(114.3): 62 B-trim: 1318 in 2/49
Lambda= 0.151714
statistics sampled from 24031 (24094) to 24031 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.282), width: 16
Scan time: 7.730
The best scores are: opt bits E(85289)
NP_001243055 (OMIM: 615336) ceramide synthase 6 is ( 392) 2736 608.0 1.2e-173
NP_982288 (OMIM: 615336) ceramide synthase 6 isofo ( 384) 2644 587.9 1.4e-167
NP_671723 (OMIM: 615335) ceramide synthase 5 isofo ( 392) 1777 398.1 1.9e-110
XP_005269277 (OMIM: 615335) PREDICTED: ceramide sy ( 409) 1672 375.1 1.6e-103
NP_001318000 (OMIM: 615335) ceramide synthase 5 is ( 381) 1663 373.2 6e-103
NP_001317999 (OMIM: 615335) ceramide synthase 5 is ( 392) 1661 372.7 8.2e-103
XP_016859238 (OMIM: 615336) PREDICTED: ceramide sy ( 251) 1651 370.4 2.6e-102
NP_001268660 (OMIM: 615335) ceramide synthase 5 is ( 334) 1581 355.2 1.4e-97
NP_001317998 (OMIM: 615335) ceramide synthase 5 is ( 323) 1467 330.2 4.3e-90
XP_016875691 (OMIM: 615335) PREDICTED: ceramide sy ( 334) 1465 329.8 6e-90
XP_016875693 (OMIM: 615335) PREDICTED: ceramide sy ( 290) 1399 315.3 1.2e-85
XP_005246497 (OMIM: 615336) PREDICTED: ceramide sy ( 200) 1357 306.0 5.2e-83
NP_001318001 (OMIM: 615335) ceramide synthase 5 is ( 248) 1170 265.1 1.3e-70
NP_071358 (OMIM: 606920) ceramide synthase 2 [Homo ( 380) 1063 241.8 2e-63
NP_859530 (OMIM: 606920) ceramide synthase 2 [Homo ( 380) 1063 241.8 2e-63
XP_011507754 (OMIM: 606920) PREDICTED: ceramide sy ( 380) 1063 241.8 2e-63
XP_011507753 (OMIM: 606920) PREDICTED: ceramide sy ( 400) 1063 241.8 2.1e-63
XP_011526592 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_016882792 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_016882794 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_011526595 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_016882793 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_011526594 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
NP_078828 (OMIM: 615334) ceramide synthase 4 [Homo ( 394) 1062 241.6 2.4e-63
XP_011526597 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_011526593 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_011526596 (OMIM: 615334) PREDICTED: ceramide sy ( 394) 1062 241.6 2.4e-63
XP_016875694 (OMIM: 615335) PREDICTED: ceramide sy ( 237) 1056 240.2 4e-63
NP_001318002 (OMIM: 615335) ceramide synthase 5 is ( 237) 1056 240.2 4e-63
XP_016877492 (OMIM: 615023,615276) PREDICTED: cera ( 383) 1012 230.7 4.7e-60
XP_016877493 (OMIM: 615023,615276) PREDICTED: cera ( 383) 1012 230.7 4.7e-60
NP_849164 (OMIM: 615023,615276) ceramide synthase ( 383) 1012 230.7 4.7e-60
NP_001277272 (OMIM: 615023,615276) ceramide syntha ( 383) 1012 230.7 4.7e-60
NP_001277271 (OMIM: 615023,615276) ceramide syntha ( 383) 1012 230.7 4.7e-60
XP_016877491 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1012 230.7 4.8e-60
XP_011519659 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1012 230.7 4.8e-60
XP_011519660 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1012 230.7 4.8e-60
XP_011519657 (OMIM: 615023,615276) PREDICTED: cera ( 394) 1012 230.7 4.8e-60
NP_001277270 (OMIM: 615023,615276) ceramide syntha ( 394) 1012 230.7 4.8e-60
NP_937850 (OMIM: 606919,616230) ceramide synthase ( 337) 258 65.6 2e-10
NP_067090 (OMIM: 606919,616230) ceramide synthase ( 350) 258 65.6 2.1e-10
NP_001277194 (OMIM: 606919,616230) ceramide syntha ( 239) 244 62.4 1.3e-09
XP_016868755 (OMIM: 605190) PREDICTED: translocati ( 278) 209 54.8 2.9e-07
XP_016868756 (OMIM: 605190) PREDICTED: translocati ( 278) 209 54.8 2.9e-07
NP_001304734 (OMIM: 605190) translocating chain-as ( 288) 209 54.8 3e-07
NP_001304733 (OMIM: 605190) translocating chain-as ( 343) 209 54.9 3.5e-07
NP_055109 (OMIM: 605190) translocating chain-assoc ( 374) 209 54.9 3.7e-07
XP_011513307 (OMIM: 608485) PREDICTED: translocati ( 333) 180 48.5 2.8e-05
NP_036420 (OMIM: 608485) translocating chain-assoc ( 370) 180 48.6 3e-05
>>NP_001243055 (OMIM: 615336) ceramide synthase 6 isofor (392 aa)
initn: 2736 init1: 2736 opt: 2736 Z-score: 3238.4 bits: 608.0 E(85289): 1.2e-173
Smith-Waterman score: 2736; 100.0% identity (100.0% similar) in 392 aa overlap (1-392:1-392)
10 20 30 40 50 60
pF1KB7 MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 RNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 YYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 ADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 WWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDS
310 320 330 340 350 360
370 380 390
pF1KB7 EPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
::::::::::::::::::::::::::::::::
NP_001 EPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
370 380 390
>>NP_982288 (OMIM: 615336) ceramide synthase 6 isoform 2 (384 aa)
initn: 2343 init1: 2343 opt: 2644 Z-score: 3129.7 bits: 587.9 E(85289): 1.4e-167
Smith-Waterman score: 2644; 98.0% identity (98.0% similar) in 392 aa overlap (1-392:1-384)
10 20 30 40 50 60
pF1KB7 MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_982 MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 KPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_982 KPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 RNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_982 RNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 YYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_982 YYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 ADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_982 ADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 WWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDS
:::::::::::::::::::::::::::::::::: ::::::::::::::::::
NP_982 WWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGK--------VSKDDRSDIESSSDEEDS
310 320 330 340 350
370 380 390
pF1KB7 EPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
::::::::::::::::::::::::::::::::
NP_982 EPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
360 370 380
>>NP_671723 (OMIM: 615335) ceramide synthase 5 isoform 1 (392 aa)
initn: 1776 init1: 1538 opt: 1777 Z-score: 2104.0 bits: 398.1 E(85289): 1.9e-110
Smith-Waterman score: 1777; 63.8% identity (86.8% similar) in 378 aa overlap (7-383:15-384)
10 20 30 40 50
pF1KB7 MAGILAWFWNERFWLPHNVTWADLKNTEEAT-FPQAEDLYLAFPLAFCIFMV
:.:.::::::.::.::::.. .. .:... . .:::: ::.:
NP_671 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 RLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVR
::.::::.:::::. ..:. .:: : ::::::::: .:::.::.::::::::::::.::
NP_671 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 SIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPY
.:: :::.::::.:: :::.::::::::.::: .: ::.::: ..::.:. :.::.:::.
NP_671 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 QPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVG
:::.. :..:::.::.:::::::::::::::::: :::.::::.: ::.:::.:::.:::
NP_671 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB7 TLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFES
::..:::: .: ::::::.:::::.:..:: :::.:..::..:::::.:.:.::::::::
NP_671 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB7 WEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDI
:::.::: :::..: ::: .: :. .:::::..:: ::. ::: ::::::::.
NP_671 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGK--------VSKDDRSDV
310 320 330 340 350
360 370 380 390
pF1KB7 ESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
::::.::: :.: ....::.. .::..
NP_671 ESSSEEEDVTTCTKSPCDSSSSNGANRVNGHMGGSYWAEE
360 370 380 390
>>XP_005269277 (OMIM: 615335) PREDICTED: ceramide syntha (409 aa)
initn: 1629 init1: 1544 opt: 1672 Z-score: 1979.5 bits: 375.1 E(85289): 1.6e-103
Smith-Waterman score: 1672; 60.8% identity (85.1% similar) in 375 aa overlap (7-373:15-389)
10 20 30 40 50
pF1KB7 MAGILAWFWNERFWLPHNVTWADLKNTEEAT-FPQAEDLYLAFPLAFCIFMV
:.:.::::::.::.::::.. .. .:... . .:::: ::.:
XP_005 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 RLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVR
::.::::.:::::. ..:. .:: : ::::::::: .:::.::.::::::::::::.::
XP_005 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 SIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPY
.:: :::.::::.:: :::.::::::::.::: .: ::.::: ..::.:. :.::.:::.
XP_005 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 QPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVG
:::.. :..:::.::.:::::::::::::::::: :::.::::.: ::.:::.:::.:::
XP_005 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB7 TLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFES
::..:::: .: ::::::.:::::.:..:: :::.:..::..:::::.:.:.::::::::
XP_005 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
300 310 320 330 340
pF1KB7 WEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHV----SKDD
:::.::: :::..: ::: .: :. .:::::..:: ::. :::. . . . ..:
XP_005 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVRMKDGFFLLGMEDRDY
310 320 330 340 350 360
350 360 370 380 390
pF1KB7 RSDIESSSDEED---SEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
.:. : :. . : :.:.:.. ..
XP_005 STDVLSPSNLVSPIYSSRPSKKPRAPKSSPLRYRRMIAVMWRAAQRKKM
370 380 390 400
>>NP_001318000 (OMIM: 615335) ceramide synthase 5 isofor (381 aa)
initn: 1629 init1: 1544 opt: 1663 Z-score: 1969.3 bits: 373.2 E(85289): 6e-103
Smith-Waterman score: 1663; 65.5% identity (88.0% similar) in 342 aa overlap (7-342:15-356)
10 20 30 40 50
pF1KB7 MAGILAWFWNERFWLPHNVTWADLKNTEEAT-FPQAEDLYLAFPLAFCIFMV
:.:.::::::.::.::::.. .. .:... . .:::: ::.:
NP_001 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 RLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVR
::.::::.:::::. ..:. .:: : ::::::::: .:::.::.::::::::::::.::
NP_001 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 SIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPY
.:: :::.::::.:: :::.::::::::.::: .: ::.::: ..::.:. :.::.:::.
NP_001 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 QPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVG
:::.. :..:::.::.:::::::::::::::::: :::.::::.: ::.:::.:::.:::
NP_001 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB7 TLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFES
::..:::: .: ::::::.:::::.:..:: :::.:..::..:::::.:.:.::::::::
NP_001 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
300 310 320 330 340
pF1KB7 WEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKA---GKWNP--LHVSKD
:::.::: :::..: ::: .: :. .:::::..:: ::. :::. :. : ::
NP_001 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKVTCPGRIRPCTLHSFLT
310 320 330 340 350 360
350 360 370 380 390
pF1KB7 DRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
NP_001 SFLFSMPGGSWTVSSLACIEG
370 380
>>NP_001317999 (OMIM: 615335) ceramide synthase 5 isofor (392 aa)
initn: 1629 init1: 1544 opt: 1661 Z-score: 1966.8 bits: 372.7 E(85289): 8.2e-103
Smith-Waterman score: 1661; 66.9% identity (89.7% similar) in 329 aa overlap (7-334:15-343)
10 20 30 40 50
pF1KB7 MAGILAWFWNERFWLPHNVTWADLKNTEEAT-FPQAEDLYLAFPLAFCIFMV
:.:.::::::.::.::::.. .. .:... . .:::: ::.:
NP_001 MATAAQGPLSLLWGWLWSERFWLPENVSWADLEGPADGYGYPRGRHILSVFPLAAGIFFV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB7 RLIFERFVAKPCAIALNIQANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVR
::.::::.:::::. ..:. .:: : ::::::::: .:::.::.::::::::::::.::
NP_001 RLLFERFIAKPCALCIGIEDSGPYQAQPNAILEKVFISITKYPDKKRLEGLSKQLDWNVR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB7 SIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPY
.:: :::.::::.:: :::.::::::::.::: .: ::.::: ..::.:. :.::.:::.
NP_001 KIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCIFCYGIRFLWSSPWFWDIRQCWHNYPF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB7 QPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVG
:::.. :..:::.::.:::::::::::::::::: :::.::::.: ::.:::.:::.:::
NP_001 QPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDFLIMFVHHLVTIGLISFSYINNMVRVG
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB7 TLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFES
::..:::: .: ::::::.:::::.:..:: :::.:..::..:::::.:.:.::::::::
NP_001 TLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFVIFSAVFMVTRLGIYPFWILNTTLFES
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB7 WEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDI
:::.::: :::..: ::: .: :. .:::::..:: ::. :::
NP_001 WEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARIALKALIRGKMESRSVAQAGVQCHDLG
310 320 330 340 350 360
360 370 380 390
pF1KB7 ESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLTGSCSMDD
NP_001 SPQPPPPGFKRFSCLSLPSSWDYRRMPPGIEG
370 380 390
>>XP_016859238 (OMIM: 615336) PREDICTED: ceramide syntha (251 aa)
initn: 1651 init1: 1651 opt: 1651 Z-score: 1957.7 bits: 370.4 E(85289): 2.6e-102
Smith-Waterman score: 1651; 100.0% identity (100.0% similar) in 237 aa overlap (156-392:15-251)
130 140 150 160 170 180
pF1KB7 PSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILE
::::::::::::::::::::::::::::::
XP_016 MPTGSWREKSTCMYTPWLWNTRHCWYNYPYQPLTTDLHYYYILE
10 20 30 40
190 200 210 220 230 240
pF1KB7 LSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALL
50 60 70 80 90 100
250 260 270 280 290 300
pF1KB7 EAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFN
110 120 130 140 150 160
310 320 330 340 350 360
pF1KB7 LLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDSEPPGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLLLVQGLNCFWSYLIVKIACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDSEPPGK
170 180 190 200 210 220
370 380 390
pF1KB7 NPHTATTTNGTSGTNGYLLTGSCSMDD
:::::::::::::::::::::::::::
XP_016 NPHTATTTNGTSGTNGYLLTGSCSMDD
230 240 250
>>NP_001268660 (OMIM: 615335) ceramide synthase 5 isofor (334 aa)
initn: 1652 init1: 1470 opt: 1581 Z-score: 1873.1 bits: 355.2 E(85289): 1.4e-97
Smith-Waterman score: 1581; 65.5% identity (87.5% similar) in 328 aa overlap (56-383:7-326)
30 40 50 60 70 80
pF1KB7 NTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEK
.::.:::::. ..:. .:: : :::::::
NP_001 MMKPRPKRFIAKPCALCIGIEDSGPYQAQPNAILEK
10 20 30
90 100 110 120 130 140
pF1KB7 VFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYV
:: .:::.::.::::::::::::.::.:: :::.::::.:: :::.::::::::.::: .
NP_001 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB7 FTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDF
: ::.::: ..::.:. :.::.:::.:::.. :..:::.::.::::::::::::::::::
NP_001 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB7 GIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFV
:::.::::.: ::.:::.:::.:::::..:::: .: ::::::.:::::.:..:: :::
NP_001 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB7 MFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKI
.:..::..:::::.:.:.:::::::::::.::: :::..: ::: .: :. .:::::..:
NP_001 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB7 ACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLT
: ::. ::: ::::::::.::::.::: :.: ....::.. .::..
NP_001 ALKALIRGK--------VSKDDRSDVESSSEEEDVTTCTKSPCDSSSSNGANRVNGHMGG
280 290 300 310 320
390
pF1KB7 GSCSMDD
NP_001 SYWAEE
330
>>NP_001317998 (OMIM: 615335) ceramide synthase 5 isofor (323 aa)
initn: 1465 init1: 1465 opt: 1467 Z-score: 1738.5 bits: 330.2 E(85289): 4.3e-90
Smith-Waterman score: 1467; 67.8% identity (89.0% similar) in 292 aa overlap (56-342:7-298)
30 40 50 60 70 80
pF1KB7 NTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEK
.::.:::::. ..:. .:: : :::::::
NP_001 MMKPRPKRFIAKPCALCIGIEDSGPYQAQPNAILEK
10 20 30
90 100 110 120 130 140
pF1KB7 VFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYV
:: .:::.::.::::::::::::.::.:: :::.::::.:: :::.::::::::.::: .
NP_001 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB7 FTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDF
: ::.::: ..::.:. :.::.:::.:::.. :..:::.::.::::::::::::::::::
NP_001 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB7 GIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFV
:::.::::.: ::.:::.:::.:::::..:::: .: ::::::.:::::.:..:: :::
NP_001 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB7 MFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKI
.:..::..:::::.:.:.:::::::::::.::: :::..: ::: .: :. .:::::..:
NP_001 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB7 ACKAVSRGKA---GKWNP--LHVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTN
: ::. :::. :. : ::
NP_001 ALKALIRGKVTCPGRIRPCTLHSFLTSFLFSMPGGSWTVSSLACIEG
280 290 300 310 320
>>XP_016875691 (OMIM: 615335) PREDICTED: ceramide syntha (334 aa)
initn: 1465 init1: 1465 opt: 1465 Z-score: 1735.9 bits: 329.8 E(85289): 6e-90
Smith-Waterman score: 1465; 69.5% identity (91.0% similar) in 279 aa overlap (56-334:7-285)
30 40 50 60 70 80
pF1KB7 NTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPNAILEK
.::.:::::. ..:. .:: : :::::::
XP_016 MMKPRPKRFIAKPCALCIGIEDSGPYQAQPNAILEK
10 20 30
90 100 110 120 130 140
pF1KB7 VFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYV
:: .:::.::.::::::::::::.::.:: :::.::::.:: :::.::::::::.::: .
XP_016 VFISITKYPDKKRLEGLSKQLDWNVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYLCI
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB7 FTYGVRFLKKTPWLWNTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDF
: ::.::: ..::.:. :.::.:::.:::.. :..:::.::.::::::::::::::::::
XP_016 FCYGIRFLWSSPWFWDIRQCWHNYPFQPLSSGLYHYYIMELAFYWSLMFSQFTDIKRKDF
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB7 GIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFV
:::.::::.: ::.:::.:::.:::::..:::: .: ::::::.:::::.:..:: :::
XP_016 LIMFVHHLVTIGLISFSYINNMVRVGTLIMCLHDVSDFLLEAAKLANYAKYQRLCDTLFV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB7 MFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLVQGLNCFWSYLIVKI
.:..::..:::::.:.:.:::::::::::.::: :::..: ::: .: :. .:::::..:
XP_016 IFSAVFMVTRLGIYPFWILNTTLFESWEIIGPYASWWLLNGLLLTLQLLHVIWSYLIARI
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB7 ACKAVSRGKAGKWNPLHVSKDDRSDIESSSDEEDSEPPGKNPHTATTTNGTSGTNGYLLT
: ::. :::
XP_016 ALKALIRGKMESRSVAQAGVQCHDLGSPQPPPPGFKRFSCLSLPSSWDYRRMPPGIEG
280 290 300 310 320 330
392 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 17:48:03 2016 done: Sat Nov 5 17:48:05 2016
Total Scan time: 7.730 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]