Result of FASTA (omim) for pF1KB0477
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB0477, 518 aa
  1>>>pF1KB0477 518 - 518 aa - 518 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.1242+/-0.000342; mu= 14.6822+/- 0.021
 mean_var=89.1123+/-17.974, 0's: 0 Z-trim(115.8): 15  B-trim: 154 in 1/54
 Lambda= 0.135864
 statistics sampled from 26576 (26588) to 26576 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.312), width:  16
 Scan time:  9.860

The best scores are:                                      opt bits E(85289)
NP_060297 (OMIM: 612804,613845) serine--tRNA ligas ( 518) 3480 692.3 9.1e-199
NP_001139373 (OMIM: 612804,613845) serine--tRNA li ( 520) 3275 652.1 1.1e-186
NP_006504 (OMIM: 607529) serine--tRNA ligase, cyto ( 514)  590 125.8   3e-28
NP_001317598 (OMIM: 607529) serine--tRNA ligase, c ( 536)  497 107.6 9.7e-23


>>NP_060297 (OMIM: 612804,613845) serine--tRNA ligase, m  (518 aa)
 initn: 3480 init1: 3480 opt: 3480  Z-score: 3689.5  bits: 692.3 E(85289): 9.1e-199
Smith-Waterman score: 3480; 100.0% identity (100.0% similar) in 518 aa overlap (1-518:1-518)

               10        20        30        40        50        60
pF1KB0 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB0 LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB0 SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
              430       440       450       460       470       480

              490       500       510        
pF1KB0 LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
       ::::::::::::::::::::::::::::::::::::::
NP_060 LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
              490       500       510        

>>NP_001139373 (OMIM: 612804,613845) serine--tRNA ligase  (520 aa)
 initn: 3300 init1: 2452 opt: 3275  Z-score: 3472.3  bits: 652.1 E(85289): 1.1e-186
Smith-Waterman score: 3275; 95.4% identity (96.2% similar) in 521 aa overlap (1-518:1-520)

               10        20        30        40        50        60
pF1KB0 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
               70        80        90       100       110       120

              130          140       150       160       170       
pF1KB0 LANQDSGEVQQ---DPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPD
       :::::::::::   ::   .. .         . :   ::::::::::::::::::::::
NP_001 LANQDSGEVQQVRLDPGAGSIFGPTFLPFPGQLSLLV-EAQLEEQFYLQALKLPNQTHPD
              130       140       150        160       170         

       180       190       200       210       220       230       
pF1KB0 VPVGDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPVGDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGAL
     180       190       200       210       220       230         

       240       250       260       270       280       290       
pF1KB0 LQHGLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQHGLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLA
     240       250       260       270       280       290         

       300       310       320       330       340       350       
pF1KB0 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVT
     300       310       320       330       340       350         

       360       370       380       390       400       410       
pF1KB0 GPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFG
     360       370       380       390       400       410         

       420       430       440       450       460       470       
pF1KB0 EVTSASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVTSASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLV
     420       430       440       450       460       470         

       480       490       500       510        
pF1KB0 PPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
       :::::::::::::::::::::::::::::::::::::::::
NP_001 PPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
     480       490       500       510       520

>>NP_006504 (OMIM: 607529) serine--tRNA ligase, cytoplas  (514 aa)
 initn: 433 init1: 287 opt: 590  Z-score: 628.0  bits: 125.8 E(85289): 3e-28
Smith-Waterman score: 596; 29.5% identity (66.4% similar) in 342 aa overlap (158-485:123-460)

       130       140       150       160       170       180       
pF1KB0 EVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPVGDESQA-
                                     .:: . . .  .. :  ::.::.... .. 
NP_006 DALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVD
            100       110       120       130       140       150  

         190       200       210       220       230       240     
pF1KB0 -RVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNF
        .: .. ::  :   .  .:...   .: .. .. . :.: :.:.:.:. ..:...:...
NP_006 NKVERIWGDCTVR--KKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQY
            160         170       180       190       200       210

         250       260       270       280               290       
pF1KB0 TFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNI--------DPARFKDLNLA
       ..  :  ::. :. .: ..:  :..  ..  . .  ..:..        :   . .  : 
NP_006 ALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDNSYDEKYLI
              220       230       240        250       260         

       300       310       320       330        340       350      
pF1KB0 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNT-GQEPRGLYRVHHFTKVEMFGV
       .:.:  .:.   :. .  .:::....  :::.: :... :.. ::..:::.: :.:.:  
NP_006 ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVY
     270       280       290       300       310       320         

        360       370       380       390       400       410      
pF1KB0 TGPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRF
       ..:  ..: ...::...   :.   ::. ...... .  :.  : .:.:.:::.:: : :
NP_006 SSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAF
     330       340       350       360       370       380         

        420       430        440         450       460       470   
pF1KB0 GEVTSASNCTDFQSRRLHIMF-QTEA--GELQFAHTVNATACAVPRLLIALLESNQQKDG
        :..: :::::.:.:::.: . ::.    ...:.: .::: ::. : . :.::. : . :
NP_006 RELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG
     390       400       410       420       430       440         

           480       490       500       510                       
pF1KB0 SVLVPPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS               
        . ::  :. ..                                                
NP_006 -ITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQN
      450       460       470       480       490       500        

>>NP_001317598 (OMIM: 607529) serine--tRNA ligase, cytop  (536 aa)
 initn: 433 init1: 287 opt: 497  Z-score: 529.3  bits: 107.6 E(85289): 9.7e-23
Smith-Waterman score: 554; 28.3% identity (62.9% similar) in 364 aa overlap (158-485:123-482)

       130       140       150       160       170       180       
pF1KB0 EVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPVGDESQA-
                                     .:: . . .  .. :  ::.::.... .. 
NP_001 DALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVD
            100       110       120       130       140       150  

         190       200       210       220       230       240     
pF1KB0 -RVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNF
        .: .. ::  :   .  .:...   .: .. .. . :.: :.:.:.:. ..:...:...
NP_001 NKVERIWGDCTVR--KKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQY
            160         170       180       190       200       210

         250       260       270       280               290       
pF1KB0 TFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNI--------DPARFKDLNLA
       ..  :  ::. :. .: ..:  :..  ..  . .  ..:..        :   . .  : 
NP_001 ALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDNSYDEKYLI
              220       230       240        250       260         

       300       310       320       330        340       350      
pF1KB0 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNT-GQEPRGLYRVHHFTKVEMFGV
       .:.:  .:.   :. .  .:::....  :::.: :... :.. ::..:::.: :.:.:  
NP_001 ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVY
     270       280       290       300       310       320         

        360       370       380       390       400       410      
pF1KB0 TGPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRF
       ..:  ..: ...::...   :.   ::. ...... .  :.  : .:.:.:::.:: : :
NP_001 SSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAF
     330       340       350       360       370       380         

        420       430                           440            450 
pF1KB0 GEVTSASNCTDFQSRRLHIMF-QT-------------------EAG-----ELQFAHTVN
        :..: :::::.:.:::.: . ::                   ::.     ...:.: .:
NP_001 RELVSCSNCTDYQARRLRIRYGQTKKMMDKRKNNLHLSTQNKLEASLFSPKKVEFVHMLN
     390       400       410       420       430       440         

             460       470       480       490       500       510 
pF1KB0 ATACAVPRLLIALLESNQQKDGSVLVPPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGL
       :: ::. : . :.::. : . : . ::  :. ..                          
NP_001 ATMCATTRTICAILENYQTEKG-ITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKK
     450       460       470        480       490       500        

                                   
pF1KB0 PGQPAVS                     
                                   
NP_001 QHEGSKKKAAARDVTLENRLQNMEVTDA
      510       520       530      




518 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 17:04:56 2016 done: Sat Nov  5 17:04:57 2016
 Total Scan time:  9.860 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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