Result of FASTA (omim) for pF1KB0403
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB0403, 465 aa
  1>>>pF1KB0403 465 - 465 aa - 465 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.3224+/-0.000582; mu= -11.4256+/- 0.034
 mean_var=714.7871+/-162.000, 0's: 0 Z-trim(117.0): 640  B-trim: 555 in 1/57
 Lambda= 0.047972
 statistics sampled from 27845 (28644) to 27845 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.698), E-opt: 0.2 (0.336), width:  16
 Scan time:  9.970

The best scores are:                                      opt bits E(85289)
NP_951009 (OMIM: 605069) MAP kinase-interacting se ( 465) 3180 236.2 1.5e-61
NP_060042 (OMIM: 605069) MAP kinase-interacting se ( 414) 2669 200.7 6.1e-51
XP_006711065 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 2027 156.3 1.5e-37
XP_006711064 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 2027 156.3 1.5e-37
XP_006711066 (OMIM: 606724) PREDICTED: MAP kinase- ( 418) 2027 156.3 1.5e-37
XP_006711063 (OMIM: 606724) PREDICTED: MAP kinase- ( 424) 2018 155.7 2.3e-37
NP_001129025 (OMIM: 606724) MAP kinase-interacting ( 424) 2018 155.7 2.3e-37
XP_016858145 (OMIM: 606724) PREDICTED: MAP kinase- ( 412) 2015 155.5 2.6e-37
XP_016858144 (OMIM: 606724) PREDICTED: MAP kinase- ( 412) 2015 155.5 2.6e-37
XP_016858142 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 1787 139.7 1.5e-32
XP_016858141 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 1787 139.7 1.5e-32
XP_016858143 (OMIM: 606724) PREDICTED: MAP kinase- ( 427) 1787 139.7 1.5e-32
XP_016858151 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 1783 139.3 1.6e-32
XP_016858150 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 1783 139.3 1.6e-32
XP_016858149 (OMIM: 606724) PREDICTED: MAP kinase- ( 341) 1783 139.3 1.6e-32
XP_006711070 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
XP_006711069 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
XP_006711072 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
XP_016858146 (OMIM: 606724) PREDICTED: MAP kinase- ( 369) 1778 139.0 2.1e-32
NP_945324 (OMIM: 606724) MAP kinase-interacting se ( 347) 1774 138.7 2.4e-32
XP_016858148 (OMIM: 606724) PREDICTED: MAP kinase- ( 347) 1774 138.7 2.4e-32
XP_016858152 (OMIM: 606724) PREDICTED: MAP kinase- ( 335) 1771 138.5 2.8e-32
XP_016858147 (OMIM: 606724) PREDICTED: MAP kinase- ( 350) 1543 122.7 1.6e-27
XP_016858154 (OMIM: 606724) PREDICTED: MAP kinase- ( 292) 1534 122.0 2.2e-27
XP_006711076 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
XP_006711078 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
XP_006711077 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
XP_016858153 (OMIM: 606724) PREDICTED: MAP kinase- ( 329) 1482 118.4 2.9e-26
NP_003675 (OMIM: 606724) MAP kinase-interacting se ( 465) 1322 107.6 7.5e-23
XP_016858155 (OMIM: 606724) PREDICTED: MAP kinase- ( 252) 1238 101.4   3e-21
XP_016858156 (OMIM: 606724) PREDICTED: MAP kinase- ( 252) 1238 101.4   3e-21
XP_016858157 (OMIM: 606724) PREDICTED: MAP kinase- ( 243)  775 69.3 1.3e-11
NP_003659 (OMIM: 606723) MAP kinase-activated prot ( 471)  545 53.8 1.2e-06
NP_620777 (OMIM: 606723) MAP kinase-activated prot ( 473)  545 53.8 1.2e-06
XP_016875620 (OMIM: 606723) PREDICTED: MAP kinase- ( 378)  505 50.9   7e-06
XP_016875618 (OMIM: 606723) PREDICTED: MAP kinase- ( 380)  505 50.9 7.1e-06
XP_016875619 (OMIM: 606723) PREDICTED: MAP kinase- ( 380)  505 50.9 7.1e-06
XP_016875616 (OMIM: 606723) PREDICTED: MAP kinase- ( 386)  505 50.9 7.1e-06
XP_016875617 (OMIM: 606723) PREDICTED: MAP kinase- ( 386)  505 50.9 7.1e-06
XP_016875614 (OMIM: 606723) PREDICTED: MAP kinase- ( 405)  505 51.0 7.3e-06
NP_001287731 (OMIM: 603606) ribosomal protein S6 k ( 765)  431 46.3 0.00036
XP_016874016 (OMIM: 603606) PREDICTED: ribosomal p ( 398)  423 45.3 0.00037
NP_001006945 (OMIM: 603606) ribosomal protein S6 k ( 766)  424 45.8  0.0005
NP_001305290 (OMIM: 603606) ribosomal protein S6 k ( 709)  423 45.7 0.00051
XP_005274437 (OMIM: 603606) PREDICTED: ribosomal p ( 717)  423 45.7 0.00051
NP_003933 (OMIM: 603606) ribosomal protein S6 kina ( 772)  423 45.7 0.00053
NP_006733 (OMIM: 177015) serine/threonine-protein  ( 424)  407 44.2 0.00082
XP_016873652 (OMIM: 607670) PREDICTED: serine/thre ( 378)  403 43.9 0.00094
XP_016873653 (OMIM: 607670) PREDICTED: serine/thre ( 378)  403 43.9 0.00094
XP_016873651 (OMIM: 607670) PREDICTED: serine/thre ( 378)  403 43.9 0.00094


>>NP_951009 (OMIM: 605069) MAP kinase-interacting serine  (465 aa)
 initn: 3180 init1: 3180 opt: 3180  Z-score: 1226.2  bits: 236.2 E(85289): 1.5e-61
Smith-Waterman score: 3180; 100.0% identity (100.0% similar) in 465 aa overlap (1-465:1-465)

               10        20        30        40        50        60
pF1KB0 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB0 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_951 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
              370       380       390       400       410       420

              430       440       450       460     
pF1KB0 QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
       :::::::::::::::::::::::::::::::::::::::::::::
NP_951 QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
              430       440       450       460     

>>NP_060042 (OMIM: 605069) MAP kinase-interacting serine  (414 aa)
 initn: 2669 init1: 2669 opt: 2669  Z-score: 1035.6  bits: 200.7 E(85289): 6.1e-51
Smith-Waterman score: 2669; 100.0% identity (100.0% similar) in 385 aa overlap (1-385:1-385)

               10        20        30        40        50        60
pF1KB0 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB0 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB0 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB0 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB0 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB0 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB0 QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
       :::::::::::::::::::::::::                                   
NP_060 QVLQHPWVQGCAPENTLPTPMVLQRWDSHFLLPPHPCRIHVRPGGLVRTVTVNE      
              370       380       390       400       410          

>>XP_006711065 (OMIM: 606724) PREDICTED: MAP kinase-inte  (418 aa)
 initn: 2033 init1: 1977 opt: 2027  Z-score: 795.4  bits: 156.3 E(85289): 1.5e-37
Smith-Waterman score: 2027; 72.6% identity (89.0% similar) in 409 aa overlap (46-451:5-404)

          20        30        40        50        60        70     
pF1KB0 FKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSF
                                     :.: .:.:. : :. .: :::.:::::::.
XP_006                           MQNIPEMGSSEPLPIADGDRRRKKKRRGRATDSL
                                         10        20        30    

          80        90       100       110       120       130     
pF1KB0 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ
        :.:::.:.:  ..:::::.:.::  ..: ...:::::::::: :: ::::::::: :::
XP_006 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ
           40        50        60        70        80        90    

         140       150       160       170       180       190     
pF1KB0 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF
       :::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::
XP_006 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF
          100       110       120       130       140       150    

         200       210       220       230       240       250     
pF1KB0 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE
       ::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::
XP_006 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE
          160       170       180       190       200       210    

         260       270       280       290       300       310     
pF1KB0 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ
       ::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::
XP_006 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ
          220       230       240       250       260       270    

         320       330       340       350       360       370     
pF1KB0 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPEN
       : :::::::::::::::::::::  :::::::::::::::::::::::::::::: :::.
XP_006 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK
          280       290       300       310       320       330    

         380       390       400       410         420       430   
pF1KB0 TLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC
        ::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:          :
XP_006 GLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------C
          340       350       360       370       380              

            440       450       460     
pF1KB0 -LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
        ..:::: .:.::.::  :              
XP_006 SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
         390       400       410        

>>XP_006711064 (OMIM: 606724) PREDICTED: MAP kinase-inte  (418 aa)
 initn: 2033 init1: 1977 opt: 2027  Z-score: 795.4  bits: 156.3 E(85289): 1.5e-37
Smith-Waterman score: 2027; 72.6% identity (89.0% similar) in 409 aa overlap (46-451:5-404)

          20        30        40        50        60        70     
pF1KB0 FKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSF
                                     :.: .:.:. : :. .: :::.:::::::.
XP_006                           MQNIPEMGSSEPLPIADGDRRRKKKRRGRATDSL
                                         10        20        30    

          80        90       100       110       120       130     
pF1KB0 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ
        :.:::.:.:  ..:::::.:.::  ..: ...:::::::::: :: ::::::::: :::
XP_006 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ
           40        50        60        70        80        90    

         140       150       160       170       180       190     
pF1KB0 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF
       :::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::
XP_006 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF
          100       110       120       130       140       150    

         200       210       220       230       240       250     
pF1KB0 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE
       ::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::
XP_006 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE
          160       170       180       190       200       210    

         260       270       280       290       300       310     
pF1KB0 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ
       ::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::
XP_006 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ
          220       230       240       250       260       270    

         320       330       340       350       360       370     
pF1KB0 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPEN
       : :::::::::::::::::::::  :::::::::::::::::::::::::::::: :::.
XP_006 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK
          280       290       300       310       320       330    

         380       390       400       410         420       430   
pF1KB0 TLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC
        ::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:          :
XP_006 GLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------C
          340       350       360       370       380              

            440       450       460     
pF1KB0 -LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
        ..:::: .:.::.::  :              
XP_006 SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
         390       400       410        

>>XP_006711066 (OMIM: 606724) PREDICTED: MAP kinase-inte  (418 aa)
 initn: 2033 init1: 1977 opt: 2027  Z-score: 795.4  bits: 156.3 E(85289): 1.5e-37
Smith-Waterman score: 2027; 72.6% identity (89.0% similar) in 409 aa overlap (46-451:5-404)

          20        30        40        50        60        70     
pF1KB0 FKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSF
                                     :.: .:.:. : :. .: :::.:::::::.
XP_006                           MQNIPEMGSSEPLPIADGDRRRKKKRRGRATDSL
                                         10        20        30    

          80        90       100       110       120       130     
pF1KB0 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ
        :.:::.:.:  ..:::::.:.::  ..: ...:::::::::: :: ::::::::: :::
XP_006 PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ
           40        50        60        70        80        90    

         140       150       160       170       180       190     
pF1KB0 CQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDF
       :::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::
XP_006 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF
          100       110       120       130       140       150    

         200       210       220       230       240       250     
pF1KB0 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAE
       ::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::
XP_006 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE
          160       170       180       190       200       210    

         260       270       280       290       300       310     
pF1KB0 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ
       ::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::
XP_006 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ
          220       230       240       250       260       270    

         320       330       340       350       360       370     
pF1KB0 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPEN
       : :::::::::::::::::::::  :::::::::::::::::::::::::::::: :::.
XP_006 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEK
          280       290       300       310       320       330    

         380       390       400       410         420       430   
pF1KB0 TLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC
        ::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:          :
XP_006 GLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------C
          340       350       360       370       380              

            440       450       460     
pF1KB0 -LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
        ..:::: .:.::.::  :              
XP_006 SMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
         390       400       410        

>>XP_006711063 (OMIM: 606724) PREDICTED: MAP kinase-inte  (424 aa)
 initn: 2023 init1: 1967 opt: 2018  Z-score: 792.0  bits: 155.7 E(85289): 2.3e-37
Smith-Waterman score: 2018; 72.3% identity (88.8% similar) in 411 aa overlap (45-451:9-410)

           20        30        40         50        60        70   
pF1KB0 SFKGQNPFELAFSLDQPDHGDSDFGLQCSARP-DMPASQPIDIPDAKKRGKKKKRGRATD
                                     .: .: .:.:. : :. .: :::.::::::
XP_006                       MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATD
                                     10        20        30        

            80        90       100       110       120       130   
pF1KB0 SFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEML
       :. :.:::.:.:  ..:::::.:.::  ..: ...:::::::::: :: ::::::::: :
XP_006 SLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETL
       40        50        60        70        80        90        

           140       150       160       170       180       190   
pF1KB0 YQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASAL
       :::::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::
XP_006 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL
      100       110       120       130       140       150        

           200       210       220       230       240       250   
pF1KB0 DFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGS
       ::::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::
XP_006 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS
      160       170       180       190       200       210        

           260       270       280       290       300       310   
pF1KB0 AEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPA
       ::::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .
XP_006 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV
      220       230       240       250       260       270        

           320       330       340       350       360       370   
pF1KB0 CQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAP
       ::: :::::::::::::::::::::  :::::::::::::::::::::::::::::: ::
XP_006 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP
      280       290       300       310       320       330        

           380       390       400       410         420       430 
pF1KB0 ENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATS
       :. ::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:         
XP_006 EKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL--------
      340       350       360       370       380       390        

              440       450       460     
pF1KB0 RC-LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
        : ..:::: .:.::.::  :              
XP_006 -CSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
               400       410       420    

>>NP_001129025 (OMIM: 606724) MAP kinase-interacting ser  (424 aa)
 initn: 2023 init1: 1967 opt: 2018  Z-score: 792.0  bits: 155.7 E(85289): 2.3e-37
Smith-Waterman score: 2018; 72.3% identity (88.8% similar) in 411 aa overlap (45-451:9-410)

           20        30        40         50        60        70   
pF1KB0 SFKGQNPFELAFSLDQPDHGDSDFGLQCSARP-DMPASQPIDIPDAKKRGKKKKRGRATD
                                     .: .: .:.:. : :. .: :::.::::::
NP_001                       MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATD
                                     10        20        30        

            80        90       100       110       120       130   
pF1KB0 SFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEML
       :. :.:::.:.:  ..:::::.:.::  ..: ...:::::::::: :: ::::::::: :
NP_001 SLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETL
       40        50        60        70        80        90        

           140       150       160       170       180       190   
pF1KB0 YQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASAL
       :::::..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::
NP_001 YQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAAL
      100       110       120       130       140       150        

           200       210       220       230       240       250   
pF1KB0 DFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGS
       ::::.:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::
NP_001 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS
      160       170       180       190       200       210        

           260       270       280       290       300       310   
pF1KB0 AEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPA
       ::::::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .
NP_001 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV
      220       230       240       250       260       270        

           320       330       340       350       360       370   
pF1KB0 CQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAP
       ::: :::::::::::::::::::::  :::::::::::::::::::::::::::::: ::
NP_001 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP
      280       290       300       310       320       330        

           380       390       400       410         420       430 
pF1KB0 ENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATS
       :. ::::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:         
NP_001 EKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL--------
      340       350       360       370       380       390        

              440       450       460     
pF1KB0 RC-LQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
        : ..:::: .:.::.::  :              
NP_001 -CSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
               400       410       420    

>>XP_016858145 (OMIM: 606724) PREDICTED: MAP kinase-inte  (412 aa)
 initn: 2021 init1: 1965 opt: 2015  Z-score: 791.0  bits: 155.5 E(85289): 2.6e-37
Smith-Waterman score: 2015; 72.7% identity (88.9% similar) in 407 aa overlap (48-451:1-398)

        20        30        40        50        60        70       
pF1KB0 GQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSG
                                     : .:.:. : :. .: :::.:::::::. :
XP_016                               MGSSEPLPIADGDRRRKKKRRGRATDSLPG
                                             10        20        30

        80        90       100       110       120       130       
pF1KB0 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ
       .:::.:.:  ..:::::.:.::  ..: ...:::::::::: :: ::::::::: :::::
XP_016 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ
               40        50        60        70        80        90

       140       150       160       170       180       190       
pF1KB0 GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH
       :..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::::
XP_016 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH
              100       110       120       130       140       150

       200       210       220       230       240       250       
pF1KB0 NKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYM
       .:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::::
XP_016 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM
              160       170       180       190       200       210

       260       270       280       290       300       310       
pF1KB0 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNM
       ::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::: 
XP_016 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNK
              220       230       240       250       260       270

       320       330       340       350       360       370       
pF1KB0 LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL
       :::::::::::::::::::::  :::::::::::::::::::::::::::::: :::. :
XP_016 LFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGL
              280       290       300       310       320       330

       380       390       400       410         420       430     
pF1KB0 PTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC-L
       :::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:          : .
XP_016 PTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------CSM
              340       350       360       370                380 

          440       450       460     
pF1KB0 QLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
       .:::: .:.::.::  :              
XP_016 KLSPPCKSRLARRRALAQAGRGEDRSPPTAL
             390       400       410  

>>XP_016858144 (OMIM: 606724) PREDICTED: MAP kinase-inte  (412 aa)
 initn: 2021 init1: 1965 opt: 2015  Z-score: 791.0  bits: 155.5 E(85289): 2.6e-37
Smith-Waterman score: 2015; 72.7% identity (88.9% similar) in 407 aa overlap (48-451:1-398)

        20        30        40        50        60        70       
pF1KB0 GQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSG
                                     : .:.:. : :. .: :::.:::::::. :
XP_016                               MGSSEPLPIADGDRRRKKKRRGRATDSLPG
                                             10        20        30

        80        90       100       110       120       130       
pF1KB0 RFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ
       .:::.:.:  ..:::::.:.::  ..: ...:::::::::: :: ::::::::: :::::
XP_016 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ
               40        50        60        70        80        90

       140       150       160       170       180       190       
pF1KB0 GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLH
       :..:.::::::::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::::
XP_016 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH
              100       110       120       130       140       150

       200       210       220       230       240       250       
pF1KB0 NKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYM
       .:::::::::::::::: :..::::::::::::::.:::..:.::.:::: :::::::::
XP_016 TKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYM
              160       170       180       190       200       210

       260       270       280       290       300       310       
pF1KB0 APEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNM
       ::::::.:...:..::::::::::::.:::.:::::::::.::.::::::::.: .::: 
XP_016 APEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNK
              220       230       240       250       260       270

       320       330       340       350       360       370       
pF1KB0 LFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTL
       :::::::::::::::::::::  :::::::::::::::::::::::::::::: :::. :
XP_016 LFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGL
              280       290       300       310       320       330

       380       390       400       410         420       430     
pF1KB0 PTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC-L
       :::.:::::: . ::: :::::::.::::.::.:. :::: :: ..:          : .
XP_016 PTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------CSM
              340       350       360       370                380 

          440       450       460     
pF1KB0 QLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
       .:::: .:.::.::  :              
XP_016 KLSPPCKSRLARRRALAQAGRGEDRSPPTAL
             390       400       410  

>>XP_016858142 (OMIM: 606724) PREDICTED: MAP kinase-inte  (427 aa)
 initn: 1806 init1: 1728 opt: 1787  Z-score: 705.5  bits: 139.7 E(85289): 1.5e-32
Smith-Waterman score: 1787; 69.0% identity (84.6% similar) in 397 aa overlap (60-451:28-413)

      30        40        50        60        70          80       
pF1KB0 QPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFS--GRFEDVYQLQE
                                     ::. .:::.  .: :.    :.  .  .  
XP_016    MPPDPLRREWAFPLNGQRTSFHFKSSQKKKKEKKKKTPTTKSLCLLKRWAVANPFPS
                  10        20        30        40        50       

        90       100       110       120       130       140       
pF1KB0 DVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIE
       ...  :.. :      :   :: ..:::::: :: ::::::::: ::::::..:.:::::
XP_016 QMVTGGGR-RSGGAGPLTPCQE-SLKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE
        60         70         80        90       100       110     

       150       160       170       180       190       200       
pF1KB0 FFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLK
       :::.. ::::::::..:::::.::.:..:::: ::: ::.:::.::::::.:::::::::
XP_016 FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLK
         120       130       140       150       160       170     

       210       220       230       240       250       260       
pF1KB0 PENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSE
       ::::::: :..::::::::::::::.:::..:.::.:::: :::::::::::::::.:..
XP_016 PENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTD
         180       190       200       210       220       230     

       270       280       290       300       310       320       
pF1KB0 EASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKY
       .:..::::::::::::.:::.:::::::::.::.::::::::.: .::: ::::::::::
XP_016 QATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKY
         240       250       260       270       280       290     

       330       340       350       360       370       380       
pF1KB0 EFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNS
       :::::::::::  :::::::::::::::::::::::::::::: :::. ::::.::::::
XP_016 EFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNS
         300       310       320       330       340       350     

       390       400       410         420       430        440    
pF1KB0 CAKDLTSFAAEAIAMNRQLAQHDED-LAEE-EAAGQGQPVLVRATSRC-LQLSPPSQSKL
        . ::: :::::::.::::.::.:. :::: :: ..:          : ..:::: .:.:
XP_016 STMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGL---------CSMKLSPPCKSRL
         360       370       380       390                400      

          450       460     
pF1KB0 AQRRQRASLSSAPVVLVGDHA
       :.::  :              
XP_016 ARRRALAQAGRGEDRSPPTAL
        410       420       




465 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 16:45:33 2016 done: Sat Nov  5 16:45:35 2016
 Total Scan time:  9.970 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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