Result of FASTA (omim) for pF1KB5718
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5718, 724 aa
  1>>>pF1KB5718 724 - 724 aa - 724 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.5937+/-0.000373; mu= -10.1522+/- 0.023
 mean_var=295.2716+/-61.997, 0's: 0 Z-trim(122.2): 36  B-trim: 1059 in 2/54
 Lambda= 0.074639
 statistics sampled from 39822 (39861) to 39822 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.771), E-opt: 0.2 (0.467), width:  16
 Scan time:  9.980

The best scores are:                                      opt bits E(85289)
NP_997006 (OMIM: 604439) GRB2-associated-binding p ( 724) 4965 548.4 3.6e-155
XP_016863457 (OMIM: 604439) PREDICTED: GRB2-associ ( 711) 4804 531.1 5.8e-150
XP_016863460 (OMIM: 604439) PREDICTED: GRB2-associ ( 621) 4257 472.2 2.8e-132
NP_002030 (OMIM: 604439) GRB2-associated-binding p ( 694) 3711 413.4 1.5e-114
XP_016863458 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_006714230 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_016863459 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_006714231 (OMIM: 604439) PREDICTED: GRB2-associ ( 648) 3631 404.8 5.7e-112
XP_016863456 (OMIM: 604439) PREDICTED: GRB2-associ ( 734) 3631 404.8 6.3e-112
XP_016863455 (OMIM: 604439) PREDICTED: GRB2-associ ( 738) 3631 404.8 6.4e-112
NP_536739 (OMIM: 606203) GRB2-associated-binding p ( 676) 1166 139.3 4.7e-32
NP_036428 (OMIM: 606203) GRB2-associated-binding p ( 638)  921 113.0 3.9e-24
XP_006718816 (OMIM: 606203) PREDICTED: GRB2-associ ( 638)  921 113.0 3.9e-24
NP_001269212 (OMIM: 300482) GRB2-associated-bindin ( 548)  580 76.2 3.9e-13
XP_011529408 (OMIM: 300482) PREDICTED: GRB2-associ ( 572)  580 76.2   4e-13
NP_001075042 (OMIM: 300482) GRB2-associated-bindin ( 587)  580 76.2 4.1e-13
XP_011529407 (OMIM: 300482) PREDICTED: GRB2-associ ( 587)  580 76.2 4.1e-13
XP_005274705 (OMIM: 300482) PREDICTED: GRB2-associ ( 587)  580 76.2 4.1e-13
XP_006724867 (OMIM: 300482) PREDICTED: GRB2-associ ( 587)  580 76.2 4.1e-13
XP_016884765 (OMIM: 300482) PREDICTED: GRB2-associ ( 609)  580 76.2 4.3e-13
XP_011529405 (OMIM: 300482) PREDICTED: GRB2-associ ( 611)  580 76.2 4.3e-13
NP_542179 (OMIM: 300482) GRB2-associated-binding p ( 586)  576 75.8 5.6e-13


>>NP_997006 (OMIM: 604439) GRB2-associated-binding prote  (724 aa)
 initn: 4965 init1: 4965 opt: 4965  Z-score: 2906.8  bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4965; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724)

               10        20        30        40        50        60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB5 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB5 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB5 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
              670       680       690       700       710       720

           
pF1KB5 KSVK
       ::::
NP_997 KSVK
           

>>XP_016863457 (OMIM: 604439) PREDICTED: GRB2-associated  (711 aa)
 initn: 4800 init1: 4800 opt: 4804  Z-score: 2813.2  bits: 531.1 E(85289): 5.8e-150
Smith-Waterman score: 4804; 98.7% identity (99.2% similar) in 713 aa overlap (12-724:1-711)

               10        20        30        40        50        60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
                  .::  :.   :. ::::::::::::::::::::::::::::::::::::
XP_016            MRK--PHLYKKKKAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
                            10        20        30        40       

               70        80        90       100       110       120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
        50        60        70        80        90       100       

              130       140       150       160       170       180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
       110       120       130       140       150       160       

              190       200       210       220       230       240
pF1KB5 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
       170       180       190       200       210       220       

              250       260       270       280       290       300
pF1KB5 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
       230       240       250       260       270       280       

              310       320       330       340       350       360
pF1KB5 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
       290       300       310       320       330       340       

              370       380       390       400       410       420
pF1KB5 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
       350       360       370       380       390       400       

              430       440       450       460       470       480
pF1KB5 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
       410       420       430       440       450       460       

              490       500       510       520       530       540
pF1KB5 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
       470       480       490       500       510       520       

              550       560       570       580       590       600
pF1KB5 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
       530       540       550       560       570       580       

              610       620       630       640       650       660
pF1KB5 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
       590       600       610       620       630       640       

              670       680       690       700       710       720
pF1KB5 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
       650       660       670       680       690       700       

           
pF1KB5 KSVK
       ::::
XP_016 KSVK
       710 

>>XP_016863460 (OMIM: 604439) PREDICTED: GRB2-associated  (621 aa)
 initn: 4257 init1: 4257 opt: 4257  Z-score: 2495.8  bits: 472.2 E(85289): 2.8e-132
Smith-Waterman score: 4257; 100.0% identity (100.0% similar) in 621 aa overlap (104-724:1-621)

            80        90       100       110       120       130   
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                     ::::::::::::::::::::::::::::::
XP_016                               MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                             10        20        30

           140       150       160       170       180       190   
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
               40        50        60        70        80        90

           200       210       220       230       240       250   
pF1KB5 PEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSAS
              100       110       120       130       140       150

           260       270       280       290       300       310   
pF1KB5 VDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTP
              160       170       180       190       200       210

           320       330       340       350       360       370   
pF1KB5 GNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSY
              220       230       240       250       260       270

           380       390       400       410       420       430   
pF1KB5 CIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVL
              280       290       300       310       320       330

           440       450       460       470       480       490   
pF1KB5 TVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPA
              340       350       360       370       380       390

           500       510       520       530       540       550   
pF1KB5 HMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDF
              400       410       420       430       440       450

           560       570       580       590       600       610   
pF1KB5 ATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSH
              460       470       480       490       500       510

           620       630       640       650       660       670   
pF1KB5 DSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQ
              520       530       540       550       560       570

           680       690       700       710       720    
pF1KB5 KSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
       :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
              580       590       600       610       620 

>>NP_002030 (OMIM: 604439) GRB2-associated-binding prote  (694 aa)
 initn: 3667 init1: 3667 opt: 3711  Z-score: 2177.3  bits: 413.4 E(85289): 1.5e-114
Smith-Waterman score: 4696; 95.9% identity (95.9% similar) in 724 aa overlap (1-724:1-694)

               10        20        30        40        50        60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQM
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETC
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB5 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKGQSPKILRLKPH
       ::::::::::::::::::::::::::::::::::::::::::::::::            
NP_002 DFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRK------------
              490       500       510       520                    

              550       560       570       580       590       600
pF1KB5 GLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
                         ::::::::::::::::::::::::::::::::::::::::::
NP_002 ------------------VKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRP
                        530       540       550       560       570

              610       620       630       640       650       660
pF1KB5 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDL
              580       590       600       610       620       630

              670       680       690       700       710       720
pF1KB5 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPA
              640       650       660       670       680       690

           
pF1KB5 KSVK
       ::::
NP_002 KSVK
           

>>XP_016863458 (OMIM: 604439) PREDICTED: GRB2-associated  (648 aa)
 initn: 3596 init1: 3596 opt: 3631  Z-score: 2131.2  bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)

            80        90       100       110       120       130   
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                     ::::::::::::::::::::::::::::::
XP_016                               MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                             10        20        30

           140       150       160       170       180       190   
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
               40        50        60        70        80        90

                                      200       210       220      
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
       ::::                           .::::::::::::::::::::::::::::
XP_016 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
              100       110       120       130       140       150

        230       240       250       260       270       280      
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
              160       170       180       190       200       210

        290       300       310       320       330       340      
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
              220       230       240       250       260       270

        350       360       370       380       390       400      
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
              280       290       300       310       320       330

        410       420       430       440       450       460      
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
              340       350       360       370       380       390

        470       480       490       500       510       520      
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
              400       410       420       430       440       450

        530       540       550       560       570       580      
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
              460       470       480       490       500       510

        590       600       610       620       630       640      
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
              520       530       540       550       560       570

        650       660       670       680       690       700      
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
              580       590       600       610       620       630

        710       720    
pF1KB5 WTDGRQSTESETPAKSVK
       ::::::::::::::::::
XP_016 WTDGRQSTESETPAKSVK
              640        

>>XP_006714230 (OMIM: 604439) PREDICTED: GRB2-associated  (648 aa)
 initn: 3596 init1: 3596 opt: 3631  Z-score: 2131.2  bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)

            80        90       100       110       120       130   
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                     ::::::::::::::::::::::::::::::
XP_006                               MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                             10        20        30

           140       150       160       170       180       190   
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
               40        50        60        70        80        90

                                      200       210       220      
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
       ::::                           .::::::::::::::::::::::::::::
XP_006 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
              100       110       120       130       140       150

        230       240       250       260       270       280      
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
              160       170       180       190       200       210

        290       300       310       320       330       340      
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
              220       230       240       250       260       270

        350       360       370       380       390       400      
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
              280       290       300       310       320       330

        410       420       430       440       450       460      
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
              340       350       360       370       380       390

        470       480       490       500       510       520      
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
              400       410       420       430       440       450

        530       540       550       560       570       580      
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
              460       470       480       490       500       510

        590       600       610       620       630       640      
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
              520       530       540       550       560       570

        650       660       670       680       690       700      
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
              580       590       600       610       620       630

        710       720    
pF1KB5 WTDGRQSTESETPAKSVK
       ::::::::::::::::::
XP_006 WTDGRQSTESETPAKSVK
              640        

>>XP_016863459 (OMIM: 604439) PREDICTED: GRB2-associated  (648 aa)
 initn: 3596 init1: 3596 opt: 3631  Z-score: 2131.2  bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)

            80        90       100       110       120       130   
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                     ::::::::::::::::::::::::::::::
XP_016                               MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                             10        20        30

           140       150       160       170       180       190   
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
               40        50        60        70        80        90

                                      200       210       220      
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
       ::::                           .::::::::::::::::::::::::::::
XP_016 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
              100       110       120       130       140       150

        230       240       250       260       270       280      
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
              160       170       180       190       200       210

        290       300       310       320       330       340      
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
              220       230       240       250       260       270

        350       360       370       380       390       400      
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
              280       290       300       310       320       330

        410       420       430       440       450       460      
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
              340       350       360       370       380       390

        470       480       490       500       510       520      
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
              400       410       420       430       440       450

        530       540       550       560       570       580      
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
              460       470       480       490       500       510

        590       600       610       620       630       640      
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
              520       530       540       550       560       570

        650       660       670       680       690       700      
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
              580       590       600       610       620       630

        710       720    
pF1KB5 WTDGRQSTESETPAKSVK
       ::::::::::::::::::
XP_016 WTDGRQSTESETPAKSVK
              640        

>>XP_006714231 (OMIM: 604439) PREDICTED: GRB2-associated  (648 aa)
 initn: 3596 init1: 3596 opt: 3631  Z-score: 2131.2  bits: 404.8 E(85289): 5.7e-112
Smith-Waterman score: 4187; 95.7% identity (95.8% similar) in 648 aa overlap (104-724:1-648)

            80        90       100       110       120       130   
pF1KB5 FNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                     ::::::::::::::::::::::::::::::
XP_006                               MNKWVRCICDICGFNPTEEDPVKPPGSSLQ
                                             10        20        30

           140       150       160       170       180       190   
pF1KB5 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKK
               40        50        60        70        80        90

                                      200       210       220      
pF1KB5 PEPT---------------------------RTHADSAKSTSSETDCNDNVPSHKNPASS
       ::::                           .::::::::::::::::::::::::::::
XP_006 PEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDCNDNVPSHKNPASS
              100       110       120       130       140       150

        230       240       250       260       270       280      
pF1KB5 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYV
              160       170       180       190       200       210

        290       300       310       320       330       340      
pF1KB5 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPP
              220       230       240       250       260       270

        350       360       370       380       390       400      
pF1KB5 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCY
              280       290       300       310       320       330

        410       420       430       440       450       460      
pF1KB5 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEP
              340       350       360       370       380       390

        470       480       490       500       510       520      
pF1KB5 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPD
              400       410       420       430       440       450

        530       540       550       560       570       580      
pF1KB5 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWEELQAPVRSPITRS
              460       470       480       490       500       510

        590       600       610       620       630       640      
pF1KB5 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPM
              520       530       540       550       560       570

        650       660       670       680       690       700      
pF1KB5 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREA
              580       590       600       610       620       630

        710       720    
pF1KB5 WTDGRQSTESETPAKSVK
       ::::::::::::::::::
XP_006 WTDGRQSTESETPAKSVK
              640        

>>XP_016863456 (OMIM: 604439) PREDICTED: GRB2-associated  (734 aa)
 initn: 3596 init1: 3596 opt: 3631  Z-score: 2130.4  bits: 404.8 E(85289): 6.3e-112
Smith-Waterman score: 4723; 96.1% identity (96.3% similar) in 727 aa overlap (25-724:8-734)

               10        20        30        40        50        60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
                               ::::::::::::::::::::::::::::::::::::
XP_016                  MLKADECAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
                                10        20        30        40   

               70        80        90       100       110       120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
            50        60        70        80        90       100   

              130       140       150       160       170       180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
           110       120       130       140       150       160   

              190                                  200       210   
pF1KB5 QDYLLLINCQSKKPEPT---------------------------RTHADSAKSTSSETDC
       :::::::::::::::::                           .:::::::::::::::
XP_016 QDYLLLINCQSKKPEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDC
           170       180       190       200       210       220   

           220       230       240       250       260       270   
pF1KB5 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
           230       240       250       260       270       280   

           280       290       300       310       320       330   
pF1KB5 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
           290       300       310       320       330       340   

           340       350       360       370       380       390   
pF1KB5 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
           350       360       370       380       390       400   

           400       410       420       430       440       450   
pF1KB5 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
           410       420       430       440       450       460   

           460       470       480       490       500       510   
pF1KB5 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
           470       480       490       500       510       520   

           520       530       540       550       560       570   
pF1KB5 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
           530       540       550       560       570       580   

           580       590       600       610       620       630   
pF1KB5 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
           590       600       610       620       630       640   

           640       650       660       670       680       690   
pF1KB5 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
           650       660       670       680       690       700   

           700       710       720    
pF1KB5 QQKTLALKSTREAWTDGRQSTESETPAKSVK
       :::::::::::::::::::::::::::::::
XP_016 QQKTLALKSTREAWTDGRQSTESETPAKSVK
           710       720       730    

>>XP_016863455 (OMIM: 604439) PREDICTED: GRB2-associated  (738 aa)
 initn: 3596 init1: 3596 opt: 3631  Z-score: 2130.4  bits: 404.8 E(85289): 6.4e-112
Smith-Waterman score: 4734; 95.0% identity (95.5% similar) in 740 aa overlap (12-724:1-738)

               10        20        30        40        50        60
pF1KB5 MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
                  .::  :.   :. ::::::::::::::::::::::::::::::::::::
XP_016            MRK--PHLYKKKKAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRII
                            10        20        30        40       

               70        80        90       100       110       120
pF1KB5 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPT
        50        60        70        80        90       100       

              130       140       150       160       170       180
pF1KB5 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDP
       110       120       130       140       150       160       

              190                                  200       210   
pF1KB5 QDYLLLINCQSKKPEPT---------------------------RTHADSAKSTSSETDC
       :::::::::::::::::                           .:::::::::::::::
XP_016 QDYLLLINCQSKKPEPTSQGSSFVSEEGEEYLLLEDFESKTIPLQTHADSAKSTSSETDC
       170       180       190       200       210       220       

           220       230       240       250       260       270   
pF1KB5 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKV
       230       240       250       260       270       280       

           280       290       300       310       320       330   
pF1KB5 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSK
       290       300       310       320       330       340       

           340       350       360       370       380       390   
pF1KB5 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDL
       350       360       370       380       390       400       

           400       410       420       430       440       450   
pF1KB5 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPN
       410       420       430       440       450       460       

           460       470       480       490       500       510   
pF1KB5 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVAD
       470       480       490       500       510       520       

           520       530       540       550       560       570   
pF1KB5 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPPPVDRNLKPDRKGQSPKILRLKPHGLERTDSQTIGDFATRRKVKPAPLEIKPLPEWE
       530       540       550       560       570       580       

           580       590       600       610       620       630   
pF1KB5 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNL
       590       600       610       620       630       640       

           640       650       660       670       680       690   
pF1KB5 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVD
       650       660       670       680       690       700       

           700       710       720    
pF1KB5 QQKTLALKSTREAWTDGRQSTESETPAKSVK
       :::::::::::::::::::::::::::::::
XP_016 QQKTLALKSTREAWTDGRQSTESETPAKSVK
       710       720       730        




724 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 16:11:38 2016 done: Sat Nov  5 16:11:40 2016
 Total Scan time:  9.980 Total Display time:  0.170

Function used was FASTA [36.3.4 Apr, 2011]
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