Result of FASTA (omim) for pF1KB5832
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5832, 481 aa
  1>>>pF1KB5832 481 - 481 aa - 481 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.8232+/-0.000415; mu= -16.4884+/- 0.025
 mean_var=496.4965+/-106.239, 0's: 0 Z-trim(123.9): 34  B-trim: 799 in 1/61
 Lambda= 0.057559
 statistics sampled from 44390 (44451) to 44390 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.811), E-opt: 0.2 (0.521), width:  16
 Scan time: 11.880

The best scores are:                                      opt bits E(85289)
NP_006067 (OMIM: 604019) arf-GAP domain and FG rep ( 481) 3303 288.7 2.5e-77
XP_016867601 (OMIM: 604019) PREDICTED: arf-GAP dom ( 394) 2691 237.8 4.3e-62
XP_005250363 (OMIM: 604019) PREDICTED: arf-GAP dom ( 492) 2076 186.8 1.2e-46
XP_016867602 (OMIM: 604019) PREDICTED: arf-GAP dom ( 295) 1995 179.9 8.7e-45
XP_016867603 (OMIM: 604019) PREDICTED: arf-GAP dom ( 247) 1336 125.1 2.3e-28
NP_001128659 (OMIM: 600862) arf-GAP domain and FG  ( 584)  929 91.6 6.4e-18
XP_005246573 (OMIM: 600862) PREDICTED: arf-GAP dom ( 586)  929 91.6 6.4e-18
XP_006712542 (OMIM: 600862) PREDICTED: arf-GAP dom ( 600)  929 91.6 6.5e-18
XP_006712541 (OMIM: 600862) PREDICTED: arf-GAP dom ( 602)  929 91.6 6.5e-18
NP_001128660 (OMIM: 600862) arf-GAP domain and FG  ( 560)  908 89.8 2.1e-17
NP_004495 (OMIM: 600862) arf-GAP domain and FG rep ( 562)  908 89.8 2.1e-17
XP_006712543 (OMIM: 600862) PREDICTED: arf-GAP dom ( 578)  908 89.9 2.1e-17
NP_001128661 (OMIM: 600862) arf-GAP domain and FG  ( 522)  896 88.8 3.9e-17


>>NP_006067 (OMIM: 604019) arf-GAP domain and FG repeat-  (481 aa)
 initn: 3303 init1: 3303 opt: 3303  Z-score: 1509.3  bits: 288.7 E(85289): 2.5e-77
Smith-Waterman score: 3303; 100.0% identity (100.0% similar) in 481 aa overlap (1-481:1-481)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 FGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSFPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSFPAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB5 LFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTTNPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTTNPF
              430       440       450       460       470       480

        
pF1KB5 L
       :
NP_006 L
        

>>XP_016867601 (OMIM: 604019) PREDICTED: arf-GAP domain   (394 aa)
 initn: 2691 init1: 2691 opt: 2691  Z-score: 1235.8  bits: 237.8 E(85289): 4.3e-62
Smith-Waterman score: 2691; 100.0% identity (100.0% similar) in 394 aa overlap (88-481:1-394)

        60        70        80        90       100       110       
pF1KB5 VDITVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDA
                                     ::::::::::::::::::::::::::::::
XP_016                               MTTFTEPEVVFLQSRGNEVCRKIWLGLFDA
                                             10        20        30

       120       130       140       150       160       170       
pF1KB5 RTSLVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTSLVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRT
               40        50        60        70        80        90

       180       190       200       210       220       230       
pF1KB5 LLGDPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLGDPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAP
              100       110       120       130       140       150

       240       250       260       270       280       290       
pF1KB5 QMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQG
              160       170       180       190       200       210

       300       310       320       330       340       350       
pF1KB5 TPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSST
              220       230       240       250       260       270

       360       370       380       390       400       410       
pF1KB5 GLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPPTGAFASSF
              280       290       300       310       320       330

       420       430       440       450       460       470       
pF1KB5 PAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSPFASKPPTT
              340       350       360       370       380       390

       480 
pF1KB5 NPFL
       ::::
XP_016 NPFL
           

>>XP_005250363 (OMIM: 604019) PREDICTED: arf-GAP domain   (492 aa)
 initn: 2070 init1: 2000 opt: 2076  Z-score: 958.5  bits: 186.8 E(85289): 1.2e-46
Smith-Waterman score: 3271; 97.8% identity (97.8% similar) in 492 aa overlap (1-481:1-492)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
              190       200       210       220       230       240

              250       260       270       280       290          
pF1KB5 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPA--------
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
XP_005 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAASRMLTES
              250       260       270       280       290       300

               300       310       320       330       340         
pF1KB5 ---GSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTM
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YSFGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTM
              310       320       330       340       350       360

     350       360       370       380       390       400         
pF1KB5 GGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGPGFPQAVPP
              370       380       390       400       410       420

     410       420       430       440       450       460         
pF1KB5 TGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPLSQPAGISTNPFMTGPSSSP
              430       440       450       460       470       480

     470       480 
pF1KB5 FASKPPTTNPFL
       ::::::::::::
XP_005 FASKPPTTNPFL
              490  

>>XP_016867602 (OMIM: 604019) PREDICTED: arf-GAP domain   (295 aa)
 initn: 1995 init1: 1995 opt: 1995  Z-score: 925.1  bits: 179.9 E(85289): 8.7e-45
Smith-Waterman score: 1995; 100.0% identity (100.0% similar) in 292 aa overlap (1-292:1-292)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGSASTPVQGSIPEGKPLRTLLG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAAPQMA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAGSSQGTPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
XP_016 PAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAVGC     
              250       260       270       280       290          

              310       320       330       340       350       360
pF1KB5 GATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVTMGGGGGSSTGLA

>>XP_016867603 (OMIM: 604019) PREDICTED: arf-GAP domain   (247 aa)
 initn: 1308 init1: 1308 opt: 1336  Z-score: 630.4  bits: 125.1 E(85289): 2.3e-28
Smith-Waterman score: 1564; 95.5% identity (95.5% similar) in 242 aa overlap (251-481:6-247)

              230       240       250       260       270       280
pF1KB5 ASTDLLADIGGDPFAAPQMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPA
                                     ::::::::::::::::::::::::::::::
XP_016                          MRRRDGQTPSQGGFANFDAFSSGPSSSVFGSLPPA
                                        10        20        30     

              290                  300       310       320         
pF1KB5 GQASFQAQPTPA-----------GSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAG
       ::::::::::::           :::::::::::::::::::::::::::::::::::::
XP_016 GQASFQAQPTPAASRMLTESYSFGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAG
          40        50        60        70        80        90     

     330       340       350       360       370       380         
pF1KB5 VPSSLFGMAGQVPPLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPSSLFGMAGQVPPLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLA
         100       110       120       130       140       150     

     390       400       410       420       430       440         
pF1KB5 PGPGFGMSSAGPGFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPGFGMSSAGPGFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRP
         160       170       180       190       200       210     

     450       460       470       480 
pF1KB5 LSQPAGISTNPFMTGPSSSPFASKPPTTNPFL
       ::::::::::::::::::::::::::::::::
XP_016 LSQPAGISTNPFMTGPSSSPFASKPPTTNPFL
         220       230       240       

>>NP_001128659 (OMIM: 600862) arf-GAP domain and FG repe  (584 aa)
 initn: 1009 init1: 635 opt: 929  Z-score: 442.7  bits: 91.6 E(85289): 6.4e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
                                     . .:.. :  .  ::.::.: ::: :::..
NP_001                 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
                               10        20          30        40  

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
NP_001 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
             50        60        70        80        90       100  

              130       140       150       160          170       
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
        .:: :::::::::::::::::::::::.:.:  . ...:   .:.   .: :: :::..
NP_001 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
            110       120       130       140       150       160  

       180       190        200       210       220       230      
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
       :::: ::.: .  .: :: ::    .  ::... .        : . :::.:.:.: :::
NP_001 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
            170       180           190               200       210

           240           250       260       270       280         
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
       :   . : :    :: : . ..:. ... :::::::... .:: ::..: :... :: : 
NP_001 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
              220       230       240       250       260       270

     290            300       310       320         330       340  
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
       :      .. : :   .: ::  :.. .: :.:.. ..   . : ..  :. ::  .   
NP_001 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
              280       290        300       310         320       

            350       360       370       380       390       400  
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
         :...  . .  ::. :    .. ..: :  . . :..    .:   : ::: .. .: 
NP_001 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
       330         340       350       360           370       380 

             410       420       430           440       450       
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
       :   .::  .. .:.  : :   .. . .  ..:    : .. .:  .:  :.     .:
NP_001 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
             390       400       410       420       430       440 

             460       470            480                          
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL                         
       ::. :.  :: . ::..:: :.  :.    ::::                          
NP_001 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTP
             450       460       470       480       490       500 

NP_001 APYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGFAAFGQTKPVVTPFGQVAAAGVSS
             510       520       530       540       550       560 

>>XP_005246573 (OMIM: 600862) PREDICTED: arf-GAP domain   (586 aa)
 initn: 1048 init1: 635 opt: 929  Z-score: 442.7  bits: 91.6 E(85289): 6.4e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
                                     . .:.. :  .  ::.::.: ::: :::..
XP_005                 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
                               10        20          30        40  

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
XP_005 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
             50        60        70        80        90       100  

              130       140       150       160          170       
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
        .:: :::::::::::::::::::::::.:.:  . ...:   .:.   .: :: :::..
XP_005 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
            110       120       130       140       150       160  

       180       190        200       210       220       230      
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
       :::: ::.: .  .: :: ::    .  ::... .        : . :::.:.:.: :::
XP_005 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
            170       180           190               200       210

           240           250       260       270       280         
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
       :   . : :    :: : . ..:. ... :::::::... .:: ::..: :... :: : 
XP_005 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
              220       230       240       250       260       270

     290            300       310       320         330       340  
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
       :      .. : :   .: ::  :.. .: :.:.. ..   . : ..  :. ::  .   
XP_005 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
              280       290        300       310         320       

            350       360       370       380       390       400  
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
         :...  . .  ::. :    .. ..: :  . . :..    .:   : ::: .. .: 
XP_005 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
       330         340       350       360           370       380 

             410       420       430           440       450       
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
       :   .::  .. .:.  : :   .. . .  ..:    : .. .:  .:  :.     .:
XP_005 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
             390       400       410       420       430       440 

             460       470            480                          
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL                         
       ::. :.  :: . ::..:: :.  :.    ::::                          
XP_005 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTP
             450       460       470       480       490       500 

XP_005 APYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGAGFAAFGQTKPVVTPFGQVAAAGV
             510       520       530       540       550       560 

>>XP_006712542 (OMIM: 600862) PREDICTED: arf-GAP domain   (600 aa)
 initn: 1009 init1: 635 opt: 929  Z-score: 442.6  bits: 91.6 E(85289): 6.5e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
                                     . .:.. :  .  ::.::.: ::: :::..
XP_006                 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
                               10        20          30        40  

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
XP_006 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
             50        60        70        80        90       100  

              130       140       150       160          170       
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
        .:: :::::::::::::::::::::::.:.:  . ...:   .:.   .: :: :::..
XP_006 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
            110       120       130       140       150       160  

       180       190        200       210       220       230      
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
       :::: ::.: .  .: :: ::    .  ::... .        : . :::.:.:.: :::
XP_006 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
            170       180           190               200       210

           240           250       260       270       280         
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
       :   . : :    :: : . ..:. ... :::::::... .:: ::..: :... :: : 
XP_006 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
              220       230       240       250       260       270

     290            300       310       320         330       340  
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
       :      .. : :   .: ::  :.. .: :.:.. ..   . : ..  :. ::  .   
XP_006 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
              280       290        300       310         320       

            350       360       370       380       390       400  
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
         :...  . .  ::. :    .. ..: :  . . :..    .:   : ::: .. .: 
XP_006 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
       330         340       350       360           370       380 

             410       420       430           440       450       
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
       :   .::  .. .:.  : :   .. . .  ..:    : .. .:  .:  :.     .:
XP_006 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
             390       400       410       420       430       440 

             460       470            480                          
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL                         
       ::. :.  :: . ::..:: :.  :.    ::::                          
XP_006 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATGLSGAMHSQVFPHAHFAA
             450       460       470       480       490       500 

XP_006 TFGTASMSMPTGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGFAAFGQTK
             510       520       530       540       550       560 

>>XP_006712541 (OMIM: 600862) PREDICTED: arf-GAP domain   (602 aa)
 initn: 1048 init1: 635 opt: 929  Z-score: 442.6  bits: 91.6 E(85289): 6.5e-18
Smith-Waterman score: 943; 40.7% identity (64.7% similar) in 484 aa overlap (31-480:15-475)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
                                     . .:.. :  .  ::.::.: ::: :::..
XP_006                 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
                               10        20          30        40  

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
XP_006 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
             50        60        70        80        90       100  

              130       140       150       160          170       
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
        .:: :::::::::::::::::::::::.:.:  . ...:   .:.   .: :: :::..
XP_006 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
            110       120       130       140       150       160  

       180       190        200       210       220       230      
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
       :::: ::.: .  .: :: ::    .  ::... .        : . :::.:.:.: :::
XP_006 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
            170       180           190               200       210

           240           250       260       270       280         
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
       :   . : :    :: : . ..:. ... :::::::... .:: ::..: :... :: : 
XP_006 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
              220       230       240       250       260       270

     290            300       310       320         330       340  
pF1KB5 TP-----AGSSQGTPFGATPLAPASQPNSLADVGSFLG--PGVPAAGVPSSLFGMAGQVP
       :      .. : :   .: ::  :.. .: :.:.. ..   . : ..  :. ::  .   
XP_006 TAFRMLSSSCSFGEFTSAFPLQ-ATHSGSAASVNANFAHFDNFPKSS--SADFGTFNTSQ
              280       290        300       310         320       

            350       360       370       380       390       400  
pF1KB5 PLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-
         :...  . .  ::. :    .. ..: :  . . :..    .:   : ::: .. .: 
XP_006 SHQTAS--AVSKVSTNKAGLQTADKYAALANLDNIFSAG----QGGDQGSGFGTTGKAPV
       330         340       350       360           370       380 

             410       420       430           440       450       
pF1KB5 GFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQ
       :   .::  .. .:.  : :   .. . .  ..:    : .. .:  .:  :.     .:
XP_006 GSVVSVPSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQ
             390       400       410       420       430       440 

             460       470            480                          
pF1KB5 PAGIST-NPFMTGPSSSPF-ASKPPT----TNPFL                         
       ::. :.  :: . ::..:: :.  :.    ::::                          
XP_006 PASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATGLSGAMHSQVFPHAHFAA
             450       460       470       480       490       500 

XP_006 TFGTASMSMPTGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGAGFAAFGQ
             510       520       530       540       550       560 

>>NP_001128660 (OMIM: 600862) arf-GAP domain and FG repe  (560 aa)
 initn: 988 init1: 635 opt: 908  Z-score: 433.6  bits: 89.8 E(85289): 2.1e-17
Smith-Waterman score: 930; 40.8% identity (62.8% similar) in 478 aa overlap (31-480:15-451)

               10        20        30        40        50        60
pF1KB5 MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDI
                                     . .:.. :  .  ::.::.: ::: :::..
NP_001                 MAASAKRKQEEKHLKMLRDMTGLPH--NRKCFDCDQRGPTYVNM
                               10        20          30        40  

               70        80        90       100       110       120
pF1KB5 TVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSRGNEVCRKIWLGLFDARTS
       ::::::::.::: :::::::::::::::::::. :. :::..:::::..::::::: :.:
NP_001 TVGSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
             50        60        70        80        90       100  

              130       140       150       160          170       
pF1KB5 LVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS---ASTPVQGSIPEGKPLRT
        .:: :::::::::::::::::::::::.:.:  . ...:   .:.   .: :: :::..
NP_001 AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPLKS
            110       120       130       140       150       160  

       180       190        200       210       220       230      
pF1KB5 LLGDPAPSLSVAASTSSQ-PVSQSHARTSQARSTQPPPHSSVKKASTDLLADIGGDPFAA
       :::: ::.: .  .: :: ::    .  ::... .        : . :::.:.:.: :::
NP_001 LLGDSAPTLHLNKGTPSQSPV----VGRSQGQQQE--------KKQFDLLSDLGSDIFAA
            170       180           190               200       210

           240           250       260       270       280         
pF1KB5 P---QMAPA----FAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGSLPPAGQASFQAQP
       :   . : :    :: : . ..:. ... :::::::... .:: ::..: :... :: : 
NP_001 PAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQT
              220       230       240       250       260       270

     290        300       310       320       330       340        
pF1KB5 TP-AGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSLFGMAGQVPPLQSVT
       :  ...: .. :.     : :   : :: :.:           :.    :. :  . :..
NP_001 TGGSAASVNANFAHFDNFPKS---SSADFGTF---------NTSQSHQTASAVSKV-STN
              280       290                   300       310        

      350       360       370       380       390       400        
pF1KB5 MGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGPGFGMSSAGP-GFPQAV
        .:   ..   :.. . : :.:               .:   : ::: .. .: :   .:
NP_001 KAGLQTADKYAALANLDNIFSAG--------------QGGDQGSGFGTTGKAPVGSVVSV
       320       330       340                     350       360   

       410       420       430           440       450             
pF1KB5 PPTGAFASSFPAPLFPPQTPLVQQQNGS----SFGDLGSAKLGQRPL-----SQPAGIST
       :  .. .:.  : :   .. . .  ..:    : .. .:  .:  :.     .:::. :.
NP_001 PSQSSASSDKYAALAELDSVFSSAATSSNAYTSTSNASSNVFGTVPVVASAQTQPASSSV
           370       380       390       400       410       420   

       460       470            480                                
pF1KB5 -NPFMTGPSSSPF-ASKPPT----TNPFL                               
         :: . ::..:: :.  :.    ::::                                
NP_001 PAPFGATPSTNPFVAAAGPSVASSTNPFQTNARGATAATFGTASMSMPTGFGTPAPYSLP
           430       440       450       460       470       480   




481 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 15:05:20 2016 done: Sat Nov  5 15:05:21 2016
 Total Scan time: 11.880 Total Display time:  0.070

Function used was FASTA [36.3.4 Apr, 2011]
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