Result of FASTA (omim) for pF1KB6249
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6249, 756 aa
  1>>>pF1KB6249 756 - 756 aa - 756 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.5724+/-0.000678; mu= -19.6814+/- 0.040
 mean_var=900.3757+/-199.349, 0's: 0 Z-trim(115.3): 971  B-trim: 0 in 0/57
 Lambda= 0.042743
 statistics sampled from 24432 (25667) to 24432 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.301), width:  16
 Scan time: 11.980

The best scores are:                                      opt bits E(85289)
NP_001547 (OMIM: 603258,615592) inhibitor of nucle ( 756) 5051 328.8   5e-89
XP_005273547 (OMIM: 603258,615592) PREDICTED: inhi ( 805) 4901 319.6 3.2e-86
XP_011542819 (OMIM: 603258,615592) PREDICTED: inhi ( 805) 4901 319.6 3.2e-86
NP_001177649 (OMIM: 603258,615592) inhibitor of nu ( 754) 4798 313.2 2.5e-84
XP_005273549 (OMIM: 603258,615592) PREDICTED: inhi ( 706) 4707 307.6 1.2e-82
NP_001229707 (OMIM: 603258,615592) inhibitor of nu ( 697) 4574 299.4 3.4e-80
XP_005273551 (OMIM: 603258,615592) PREDICTED: inhi ( 674) 4441 291.1 9.9e-78
XP_011542821 (OMIM: 603258,615592) PREDICTED: inhi ( 746) 4424 290.2 2.2e-77
XP_005273548 (OMIM: 603258,615592) PREDICTED: inhi ( 746) 4424 290.2 2.2e-77
XP_005273550 (OMIM: 603258,615592) PREDICTED: inhi ( 700) 3992 263.5 2.2e-69
XP_011542822 (OMIM: 603258,615592) PREDICTED: inhi ( 720) 3992 263.5 2.2e-69
XP_011542823 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_005273553 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_005273552 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_005273555 (OMIM: 603258,615592) PREDICTED: inhi ( 595) 3316 221.7 7.1e-57
XP_011542820 (OMIM: 603258,615592) PREDICTED: inhi ( 755) 3316 221.8 8.1e-57
XP_011542824 (OMIM: 603258,615592) PREDICTED: inhi ( 526) 2986 201.3 8.8e-51
XP_016868885 (OMIM: 603258,615592) PREDICTED: inhi ( 526) 2986 201.3 8.8e-51
NP_001269 (OMIM: 600664,613630) inhibitor of nucle ( 745) 2488 170.8 1.9e-41
XP_016871100 (OMIM: 600664,613630) PREDICTED: inhi ( 814) 2451 168.5 9.6e-41
NP_001307857 (OMIM: 600664,613630) inhibitor of nu ( 719) 2409 165.9 5.4e-40
XP_016871101 (OMIM: 600664,613630) PREDICTED: inhi ( 598) 2157 150.2 2.3e-35
XP_016871102 (OMIM: 600664,613630) PREDICTED: inhi ( 410)  857 69.8 2.5e-11
NP_001136082 (OMIM: 608650) serine/threonine-prote (1036)  447 45.1  0.0018
NP_055498 (OMIM: 608650) serine/threonine-protein  (1036)  447 45.1  0.0018
XP_011537101 (OMIM: 603168) PREDICTED: serine/thre (1044)  430 44.1  0.0037
NP_003556 (OMIM: 603168) serine/threonine-protein  (1050)  430 44.1  0.0037
XP_011537100 (OMIM: 603168) PREDICTED: serine/thre (1073)  430 44.1  0.0037


>>NP_001547 (OMIM: 603258,615592) inhibitor of nuclear f  (756 aa)
 initn: 5051 init1: 5051 opt: 5051  Z-score: 1719.3  bits: 328.8 E(85289): 5e-89
Smith-Waterman score: 5051; 100.0% identity (100.0% similar) in 756 aa overlap (1-756:1-756)

               10        20        30        40        50        60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
              670       680       690       700       710       720

              730       740       750      
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
       ::::::::::::::::::::::::::::::::::::
NP_001 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
              730       740       750      

>>XP_005273547 (OMIM: 603258,615592) PREDICTED: inhibito  (805 aa)
 initn: 4901 init1: 4901 opt: 4901  Z-score: 1669.0  bits: 319.6 E(85289): 3.2e-86
Smith-Waterman score: 4901; 100.0% identity (100.0% similar) in 735 aa overlap (1-735:1-735)

               10        20        30        40        50        60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
              670       680       690       700       710       720

              730       740       750                              
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS                        
       :::::::::::::::                                             
XP_005 NAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEEKMEMQSGIILNLSVCLFACLFVTG
              730       740       750       760       770       780

>>XP_011542819 (OMIM: 603258,615592) PREDICTED: inhibito  (805 aa)
 initn: 4901 init1: 4901 opt: 4901  Z-score: 1669.0  bits: 319.6 E(85289): 3.2e-86
Smith-Waterman score: 4901; 100.0% identity (100.0% similar) in 735 aa overlap (1-735:1-735)

               10        20        30        40        50        60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
              670       680       690       700       710       720

              730       740       750                              
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS                        
       :::::::::::::::                                             
XP_011 NAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEEKMEMQSGIILNLSVCLFACLFVTG
              730       740       750       760       770       780

>>NP_001177649 (OMIM: 603258,615592) inhibitor of nuclea  (754 aa)
 initn: 4798 init1: 4798 opt: 4798  Z-score: 1635.0  bits: 313.2 E(85289): 2.5e-84
Smith-Waterman score: 4798; 100.0% identity (100.0% similar) in 722 aa overlap (35-756:33-754)

           10        20        30        40        50        60    
pF1KB6 PSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQI
                                     ::::::::::::::::::::::::::::::
NP_001 SGGCHSPGFGRPSPAFPAPGSPPPAPRPCRQETGEQIAIKQCRQELSPRNRERWCLEIQI
             10        20        30        40        50        60  

           70        80        90       100       110       120    
pF1KB6 MRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILT
             70        80        90       100       110       120  

          130       140       150       160       170       180    
pF1KB6 LLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVG
            130       140       150       160       170       180  

          190       200       210       220       230       240    
pF1KB6 TLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIV
            190       200       210       220       230       240  

          250       260       270       280       290       300    
pF1KB6 VSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALD
            250       260       270       280       290       300  

          310       320       330       340       350       360    
pF1KB6 DILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPD
            310       320       330       340       350       360  

          370       380       390       400       410       420    
pF1KB6 KPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFF
            370       380       390       400       410       420  

          430       440       450       460       470       480    
pF1KB6 QLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLD
            430       440       450       460       470       480  

          490       500       510       520       530       540    
pF1KB6 FFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDI
            490       500       510       520       530       540  

          550       560       570       580       590       600    
pF1KB6 VDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKK
            550       560       570       580       590       600  

          610       620       630       640       650       660    
pF1KB6 VRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSK
            610       620       630       640       650       660  

          670       680       690       700       710       720    
pF1KB6 VRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQ
            670       680       690       700       710       720  

          730       740       750      
pF1KB6 DTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
       ::::::::::::::::::::::::::::::::
NP_001 DTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
            730       740       750    

>>XP_005273549 (OMIM: 603258,615592) PREDICTED: inhibito  (706 aa)
 initn: 4707 init1: 4707 opt: 4707  Z-score: 1604.9  bits: 307.6 E(85289): 1.2e-82
Smith-Waterman score: 4707; 100.0% identity (100.0% similar) in 704 aa overlap (1-704:1-704)

               10        20        30        40        50        60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
       ::::::::::::::::::::::::::::::::::::::::::::                
XP_005 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKRP              
              670       680       690       700                    

              730       740       750      
pF1KB6 NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS

>>NP_001229707 (OMIM: 603258,615592) inhibitor of nuclea  (697 aa)
 initn: 4574 init1: 4574 opt: 4574  Z-score: 1560.7  bits: 299.4 E(85289): 3.4e-80
Smith-Waterman score: 4574; 100.0% identity (100.0% similar) in 690 aa overlap (67-756:8-697)

         40        50        60        70        80        90      
pF1KB6 TGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
                                     ::::::::::::::::::::::::::::::
NP_001                        MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
                                      10        20        30       

        100       110       120       130       140       150      
pF1KB6 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
        40        50        60        70        80        90       

        160       170       180       190       200       210      
pF1KB6 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
       100       110       120       130       140       150       

        220       230       240       250       260       270      
pF1KB6 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
       160       170       180       190       200       210       

        280       290       300       310       320       330      
pF1KB6 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
       220       230       240       250       260       270       

        340       350       360       370       380       390      
pF1KB6 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
       280       290       300       310       320       330       

        400       410       420       430       440       450      
pF1KB6 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
       340       350       360       370       380       390       

        460       470       480       490       500       510      
pF1KB6 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
       400       410       420       430       440       450       

        520       530       540       550       560       570      
pF1KB6 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
       460       470       480       490       500       510       

        580       590       600       610       620       630      
pF1KB6 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
       520       530       540       550       560       570       

        640       650       660       670       680       690      
pF1KB6 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
       580       590       600       610       620       630       

        700       710       720       730       740       750      
pF1KB6 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
       640       650       660       670       680       690       

>>XP_005273551 (OMIM: 603258,615592) PREDICTED: inhibito  (674 aa)
 initn: 4441 init1: 4441 opt: 4441  Z-score: 1516.5  bits: 291.1 E(85289): 9.9e-78
Smith-Waterman score: 4441; 99.6% identity (99.6% similar) in 667 aa overlap (1-667:1-667)

               10        20        30        40        50        60
pF1KB6 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB6 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB6 ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
       ::   ::                                                     
XP_005 ACPGHRGCKPQEFP                                              
              670                                                  

>>XP_011542821 (OMIM: 603258,615592) PREDICTED: inhibito  (746 aa)
 initn: 4424 init1: 4424 opt: 4424  Z-score: 1510.4  bits: 290.2 E(85289): 2.2e-77
Smith-Waterman score: 4424; 100.0% identity (100.0% similar) in 669 aa overlap (67-735:8-676)

         40        50        60        70        80        90      
pF1KB6 TGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
                                     ::::::::::::::::::::::::::::::
XP_011                        MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
                                      10        20        30       

        100       110       120       130       140       150      
pF1KB6 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
        40        50        60        70        80        90       

        160       170       180       190       200       210      
pF1KB6 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
       100       110       120       130       140       150       

        220       230       240       250       260       270      
pF1KB6 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
       160       170       180       190       200       210       

        280       290       300       310       320       330      
pF1KB6 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
       220       230       240       250       260       270       

        340       350       360       370       380       390      
pF1KB6 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
       280       290       300       310       320       330       

        400       410       420       430       440       450      
pF1KB6 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
       340       350       360       370       380       390       

        460       470       480       490       500       510      
pF1KB6 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
       400       410       420       430       440       450       

        520       530       540       550       560       570      
pF1KB6 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
       460       470       480       490       500       510       

        580       590       600       610       620       630      
pF1KB6 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
       520       530       540       550       560       570       

        640       650       660       670       680       690      
pF1KB6 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
       580       590       600       610       620       630       

        700       710       720       730       740       750      
pF1KB6 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
       :::::::::::::::::::::::::::::::::::::::                     
XP_011 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEE
       640       650       660       670       680       690       

XP_011 KMEMQSGIILNLSVCLFACLFVTGSLSLTQAGVQWHDLGSLQPPLPGFK
       700       710       720       730       740      

>>XP_005273548 (OMIM: 603258,615592) PREDICTED: inhibito  (746 aa)
 initn: 4424 init1: 4424 opt: 4424  Z-score: 1510.4  bits: 290.2 E(85289): 2.2e-77
Smith-Waterman score: 4424; 100.0% identity (100.0% similar) in 669 aa overlap (67-735:8-676)

         40        50        60        70        80        90      
pF1KB6 TGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
                                     ::::::::::::::::::::::::::::::
XP_005                        MSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAM
                                      10        20        30       

        100       110       120       130       140       150      
pF1KB6 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQG
        40        50        60        70        80        90       

        160       170       180       190       200       210      
pF1KB6 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECI
       100       110       120       130       140       150       

        220       230       240       250       260       270      
pF1KB6 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKW
       160       170       180       190       200       210       

        280       290       300       310       320       330      
pF1KB6 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSL
       220       230       240       250       260       270       

        340       350       360       370       380       390      
pF1KB6 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKIT
       280       290       300       310       320       330       

        400       410       420       430       440       450      
pF1KB6 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMM
       340       350       360       370       380       390       

        460       470       480       490       500       510      
pF1KB6 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE
       400       410       420       430       440       450       

        520       530       540       550       560       570      
pF1KB6 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLRE
       460       470       480       490       500       510       

        580       590       600       610       620       630      
pF1KB6 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLM
       520       530       540       550       560       570       

        640       650       660       670       680       690      
pF1KB6 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASN
       580       590       600       610       620       630       

        700       710       720       730       740       750      
pF1KB6 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
       :::::::::::::::::::::::::::::::::::::::                     
XP_005 SLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIEE
       640       650       660       670       680       690       

XP_005 KMEMQSGIILNLSVCLFACLFVTGSLSLTQAGVQWHDLGSLQPPLPGFK
       700       710       720       730       740      

>>XP_005273550 (OMIM: 603258,615592) PREDICTED: inhibito  (700 aa)
 initn: 3992 init1: 3992 opt: 3992  Z-score: 1366.7  bits: 263.5 E(85289): 2.2e-69
Smith-Waterman score: 3992; 99.3% identity (99.8% similar) in 610 aa overlap (126-735:21-630)

         100       110       120       130       140       150     
pF1KB6 MEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQ
                                     ... ::::::::::::::::::::::::::
XP_005           MWGLGNERAPWDRGIWKCHPMAQSASALRYLHENRIIHRDLKPENIVLQQ
                         10        20        30        40        50

         160       170       180       190       200       210     
pF1KB6 GEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFEC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFEC
               60        70        80        90       100       110

         220       230       240       250       260       270     
pF1KB6 ITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEK
              120       130       140       150       160       170

         280       290       300       310       320       330     
pF1KB6 WLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQS
              180       190       200       210       220       230

         340       350       360       370       380       390     
pF1KB6 LKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKI
              240       250       260       270       280       290

         400       410       420       430       440       450     
pF1KB6 TYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAM
              300       310       320       330       340       350

         460       470       480       490       500       510     
pF1KB6 MNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWR
              360       370       380       390       400       410

         520       530       540       550       560       570     
pF1KB6 EMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLR
              420       430       440       450       460       470

         580       590       600       610       620       630     
pF1KB6 EKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSL
              480       490       500       510       520       530

         640       650       660       670       680       690     
pF1KB6 MNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTAS
              540       550       560       570       580       590

         700       710       720       730       740       750     
pF1KB6 NSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQA
       ::::::::::::::::::::::::::::::::::::::::                    
XP_005 NSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTVTACVRLLRFHVLSFYGKIE
              600       610       620       630       640       650

                                                         
pF1KB6 S                                                 
                                                         
XP_005 EKMEMQSGIILNLSVCLFACLFVTGSLSLTQAGVQWHDLGSLQPPLPGFK
              660       670       680       690       700




756 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 14:28:13 2016 done: Sat Nov  5 14:28:15 2016
 Total Scan time: 11.980 Total Display time:  0.200

Function used was FASTA [36.3.4 Apr, 2011]
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