Result of FASTA (omim) for
pF1KB6217
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6217, 728 aa
1>>>pF1KB6217 728 - 728 aa - 728 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9772+/-0.000342; mu= 4.2180+/- 0.022
mean_var=191.2571+/-38.546, 0's: 0 Z-trim(121.8): 46 B-trim: 0 in 0/54
Lambda= 0.092740
statistics sampled from 38878 (38925) to 38878 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.772), E-opt: 0.2 (0.456), width: 16
Scan time: 12.890
The best scores are: opt bits E(85289)
NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 5094 694.1 5.3e-199
NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 4813 656.4 1.1e-187
NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 4675 638.0 3.7e-182
NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 1210 174.4 1.3e-42
XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 1210 174.4 1.3e-42
XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 1210 174.4 1.3e-42
XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 1210 174.4 1.3e-42
XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 1196 172.5 4.7e-42
XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 1196 172.5 4.7e-42
XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 1196 172.5 5.1e-42
XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 1196 172.5 5.1e-42
XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 1196 172.5 5.3e-42
XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 1196 172.5 5.3e-42
XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 1196 172.5 5.4e-42
XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 1196 172.5 5.4e-42
XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 1196 172.5 5.5e-42
XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 1196 172.5 5.5e-42
XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 1196 172.5 5.7e-42
NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 1196 172.5 5.7e-42
XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 1196 172.5 5.8e-42
XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 1196 172.5 5.8e-42
XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 1196 172.5 5.9e-42
XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 1196 172.6 6e-42
XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 1196 172.6 6e-42
XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 1196 172.6 6e-42
XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 1196 172.6 6.3e-42
XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 1196 172.6 6.3e-42
NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 1163 168.1 1e-40
XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 578 89.8 3.6e-17
NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 461 74.1 1.7e-12
NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 412 67.5 1.5e-10
NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 411 67.4 1.7e-10
NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 350 59.3 5.1e-08
NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 350 59.3 5.8e-08
NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 309 53.8 2.5e-06
NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 299 52.4 5.2e-06
NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 282 50.2 2.8e-05
XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 273 48.9 5.4e-05
NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 269 48.4 8.5e-05
XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 262 47.4 0.00011
XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 253 46.3 0.00039
NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 251 46.0 0.00049
NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 248 45.6 0.00061
XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 237 44.1 0.0018
XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 232 43.5 0.0028
>>NP_001153048 (OMIM: 264350,600228,613021) amiloride-se (728 aa)
initn: 5094 init1: 5094 opt: 5094 Z-score: 3693.7 bits: 694.1 E(85289): 5.3e-199
Smith-Waterman score: 5094; 99.9% identity (100.0% similar) in 728 aa overlap (1-728:1-728)
10 20 30 40 50 60
pF1KB6 MGMARGSLTRVPGVMGEGTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGMARGSLTRVPGVMGEGTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 EGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 SDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 GTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 SSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 YGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB6 MDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB6 QESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB6 TSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB6 VTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRG
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB6 AQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASS
670 680 690 700 710 720
pF1KB6 SACPLGGP
:.::::::
NP_001 STCPLGGP
>>NP_001153047 (OMIM: 264350,600228,613021) amiloride-se (692 aa)
initn: 4813 init1: 4813 opt: 4813 Z-score: 3490.8 bits: 656.4 E(85289): 1.1e-187
Smith-Waterman score: 4813; 99.7% identity (100.0% similar) in 689 aa overlap (40-728:4-692)
10 20 30 40 50 60
pF1KB6 RVPGVMGEGTQGPELSLDPDPCSPQSTPGLMKGNKLEEQDPRPLQPIPGLMEGNKLEEQD
.:::::::::::::::::::::::::::::
NP_001 MSSIKGNKLEEQDPRPLQPIPGLMEGNKLEEQD
10 20 30
70 80 90 100 110 120
pF1KB6 SSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHG
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB6 AIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAV
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB6 TICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQR
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB6 LRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVRE
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB6 WYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND
280 290 300 310 320 330
370 380 390 400 410 420
pF1KB6 KNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLR
340 350 360 370 380 390
430 440 450 460 470 480
pF1KB6 PGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECG
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB6 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB6 SRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSN
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB6 LGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLA
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB6 SSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSACPLGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_001 SSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP
640 650 660 670 680 690
>>NP_001029 (OMIM: 264350,600228,613021) amiloride-sensi (669 aa)
initn: 4675 init1: 4675 opt: 4675 Z-score: 3391.3 bits: 638.0 E(85289): 3.7e-182
Smith-Waterman score: 4675; 99.9% identity (100.0% similar) in 669 aa overlap (60-728:1-669)
30 40 50 60 70 80
pF1KB6 PCSPQSTPGLMKGNKLEEQDPRPLQPIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQG
::::::::::::::::::::::::::::::
NP_001 MEGNKLEEQDSSPPQSTPGLMKGNKREEQG
10 20 30
90 100 110 120 130 140
pF1KB6 LGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KB6 WLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEEL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KB6 DRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSL
160 170 180 190 200 210
270 280 290 300 310 320
pF1KB6 RDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSL
220 230 240 250 260 270
330 340 350 360 370 380
pF1KB6 EEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSL
280 290 300 310 320 330
390 400 410 420 430 440
pF1KB6 MLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGD
340 350 360 370 380 390
450 460 470 480 490 500
pF1KB6 YGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKH
400 410 420 430 440 450
510 520 530 540 550 560
pF1KB6 SSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN
460 470 480 490 500 510
570 580 590 600 610 620
pF1KB6 NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMA
520 530 540 550 560 570
630 640 650 660 670 680
pF1KB6 ELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPG
580 590 600 610 620 630
690 700 710 720
pF1KB6 PAPSPALTAPPPAYATLGPRPSPGGSAGASSSACPLGGP
::::::::::::::::::::::::::::::::.::::::
NP_001 PAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP
640 650 660
>>NP_000327 (OMIM: 177200,211400,264350,600760) amilorid (640 aa)
initn: 1125 init1: 448 opt: 1210 Z-score: 886.1 bits: 174.4 E(85289): 1.3e-42
Smith-Waterman score: 1230; 32.4% identity (65.8% similar) in 620 aa overlap (113-710:21-627)
90 100 110 120 130 140
pF1KB6 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK
.:.::. ..:.::. :: :..: . :
NP_000 MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPK--K
10 20 30 40
150 160 170 180 190 200
pF1KB6 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI
:.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .:
NP_000 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
50 60 70 80 90 100
210 220 230 240 250
pF1KB6 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPPH-
:. :..::.. : .: . .. .. . . :.: .. : : : : :
NP_000 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV
110 120 130 140 150 160
260 270 280 290 300 310
pF1KB6 ----GARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF
: . ..:: .. . . :....::. :...: .....:...:. ::: .
NP_000 LDLFGDNHNGLTSSSASEK--ICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
170 180 190 200 210 220
320 330 340 350 360 370
pF1KB6 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN
. ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: .
NP_000 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB6 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV
. :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :.
NP_000 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT
290 300 310 320 330 340
440 450 460 470 480
pF1KB6 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG
::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:.
NP_000 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
350 360 370 380 390 400
490 500 510 520 530 540
pF1KB6 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
:.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... ..
NP_000 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM
410 420 430 440 450
550 560 570 580 590 600
pF1KB6 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL
. ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: ::
NP_000 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL
460 470 480 490 500 510
610 620 630 640 650 660
pF1KB6 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV
::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: :
NP_000 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV
520 530 540 550 560 570
670 680 690 700 710 720
pF1KB6 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS
: . . : : : . :: :: : .::: : .: .:
NP_000 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG
580 590 600 610 620 630
pF1KB6 SACPLGGP
NP_000 DAI
640
>>XP_011544216 (OMIM: 177200,211400,264350,600760) PREDI (646 aa)
initn: 1125 init1: 448 opt: 1210 Z-score: 886.0 bits: 174.4 E(85289): 1.3e-42
Smith-Waterman score: 1230; 32.4% identity (65.8% similar) in 620 aa overlap (113-710:27-633)
90 100 110 120 130 140
pF1KB6 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK
.:.::. ..:.::. :: :..: . :
XP_011 MTVGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPK--K
10 20 30 40 50
150 160 170 180 190 200
pF1KB6 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI
:.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .:
XP_011 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
60 70 80 90 100 110
210 220 230 240 250
pF1KB6 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPPH-
:. :..::.. : .: . .. .. . . :.: .. : : : : :
XP_011 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV
120 130 140 150 160
260 270 280 290 300 310
pF1KB6 ----GARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF
: . ..:: .. . . :....::. :...: .....:...:. ::: .
XP_011 LDLFGDNHNGLTSSSASEK--ICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
170 180 190 200 210 220
320 330 340 350 360 370
pF1KB6 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN
. ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: .
XP_011 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB6 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV
. :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :.
XP_011 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT
290 300 310 320 330 340
440 450 460 470 480
pF1KB6 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG
::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:.
XP_011 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
350 360 370 380 390 400
490 500 510 520 530 540
pF1KB6 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
:.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... ..
XP_011 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM
410 420 430 440 450 460
550 560 570 580 590 600
pF1KB6 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL
. ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: ::
XP_011 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL
470 480 490 500 510 520
610 620 630 640 650 660
pF1KB6 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV
::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: :
XP_011 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV
530 540 550 560 570 580
670 680 690 700 710 720
pF1KB6 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS
: . . : : : . :: :: : .::: : .: .:
XP_011 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG
590 600 610 620 630 640
pF1KB6 SACPLGGP
XP_011 DAI
>>XP_011544215 (OMIM: 177200,211400,264350,600760) PREDI (651 aa)
initn: 1125 init1: 448 opt: 1210 Z-score: 885.9 bits: 174.4 E(85289): 1.3e-42
Smith-Waterman score: 1230; 32.4% identity (65.8% similar) in 620 aa overlap (113-710:32-638)
90 100 110 120 130 140
pF1KB6 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK
.:.::. ..:.::. :: :..: . :
XP_011 GKPGHREGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPK--K
10 20 30 40 50
150 160 170 180 190 200
pF1KB6 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI
:.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .:
XP_011 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
60 70 80 90 100 110
210 220 230 240 250
pF1KB6 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPPH-
:. :..::.. : .: . .. .. . . :.: .. : : : : :
XP_011 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV
120 130 140 150 160 170
260 270 280 290 300 310
pF1KB6 ----GARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF
: . ..:: .. . . :....::. :...: .....:...:. ::: .
XP_011 LDLFGDNHNGLTSSSASEK--ICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
180 190 200 210 220 230
320 330 340 350 360 370
pF1KB6 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN
. ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: .
XP_011 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT
240 250 260 270 280 290
380 390 400 410 420 430
pF1KB6 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV
. :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :.
XP_011 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT
300 310 320 330 340 350
440 450 460 470 480
pF1KB6 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG
::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:.
XP_011 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
360 370 380 390 400 410
490 500 510 520 530 540
pF1KB6 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
:.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... ..
XP_011 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM
420 430 440 450 460 470
550 560 570 580 590 600
pF1KB6 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL
. ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: ::
XP_011 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL
480 490 500 510 520 530
610 620 630 640 650 660
pF1KB6 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV
::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: :
XP_011 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV
540 550 560 570 580
670 680 690 700 710 720
pF1KB6 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS
: . . : : : . :: :: : .::: : .: .:
XP_011 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG
590 600 610 620 630 640
pF1KB6 SACPLGGP
XP_011 DAI
650
>>XP_016879014 (OMIM: 177200,211400,264350,600760) PREDI (659 aa)
initn: 1125 init1: 448 opt: 1210 Z-score: 885.9 bits: 174.4 E(85289): 1.3e-42
Smith-Waterman score: 1230; 32.4% identity (65.8% similar) in 620 aa overlap (113-710:40-646)
90 100 110 120 130 140
pF1KB6 NKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMK
.:.::. ..:.::. :: :..: . :
XP_016 HQETTLTGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPK--K
10 20 30 40 50 60
150 160 170 180 190 200
pF1KB6 TAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEI
:.: .: : ... ::.:... :.:. ::...... . :::::::. .:..: .:
XP_016 KAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFKTMDFPAVTICNASPFKYSKI
70 80 90 100 110 120
210 220 230 240 250
pF1KB6 KEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTL----PHPLQRLRVPPPPH-
:. :..::.. : .: . .. .. . . :.: .. : : : : :
XP_016 KHLLKDLDELMEAVLERI-----LAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMV
130 140 150 160 170 180
260 270 280 290 300 310
pF1KB6 ----GARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRF
: . ..:: .. . . :....::. :...: .....:...:. ::: .
XP_016 LDLFGDNHNGLTSSSASEK--ICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYIL
190 200 210 220 230 240
320 330 340 350 360 370
pF1KB6 HYINILSRLPETLPSLEEDTLGN-FIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNN
. ::....:. .: . :. .:.:: :. :: :.. . .: ::::: :: .
XP_016 QATNIFAQVPQQ-ELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT
250 260 270 280 290
380 390 400 410 420 430
pF1KB6 SNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV
. :. :: . ::.:.: :.:..:.:....:.:.:.: : :. : :. :.
XP_016 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGT
300 310 320 330 340 350
440 450 460 470 480
pF1KB6 ETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYP---SKYTQQVCIHSCFQESMIKECG
::::.. . :.:.: :. :: :::.:::.:.: . :. :.:..::::. ::..:.
XP_016 ETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCN
360 370 380 390 400 410
490 500 510 520 530 540
pF1KB6 CAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGY
:.. .:: :.. .::. : .:..:: ::.. .. . :. :.. :. :.:... ..
XP_016 CGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKESCNDTQYKMTISM
420 430 440 450 460 470
550 560 570 580 590 600
pF1KB6 SRWPSVTSQEWVFQMLSRQNNYTVNN--KRNGVAKVNIFFKELNYKTNSESPSVTMVTLL
. ::: .:..:.:..::.. . ..: .:.:..:.::.:.:.::.: :: . ..: ::
XP_016 ADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLL
480 490 500 510 520 530
610 620 630 640 650 660
pF1KB6 SNLGSQWSLWFGSSVLSVVEMAELVFDLL---VIMFLMLLRRFRSRYWSPGRGGRGAQEV
::::.:...:.:.::: ..:..:...:.. .: .. : . .:.: . . .: :
XP_016 SNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSLRQRRAQASYAG-PPPTV
540 550 560 570 580 590
670 680 690 700 710 720
pF1KB6 ASTLASSPPSHFCPHPMSLSLSQPGPAPS----PALTAPPPAYATLGPRPSPGGSAGASS
: . . : : : . :: :: : .::: : .: .:
XP_016 AELVEAHTNFGFQPDTAPRS-PNTGPYPSEQALPIPGTPPPNYDSLRLQPLDVIESDSEG
600 610 620 630 640 650
pF1KB6 SACPLGGP
XP_016 DAI
>>XP_011540234 (OMIM: 601328) PREDICTED: amiloride-sensi (638 aa)
initn: 1521 init1: 675 opt: 1196 Z-score: 876.0 bits: 172.5 E(85289): 4.7e-42
Smith-Waterman score: 1570; 38.2% identity (68.6% similar) in 631 aa overlap (91-710:32-632)
70 80 90 100 110
pF1KB6 EGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAE--EEALIEFHRSYRELF
:: :.:: : : .:.:.:. :.:::.
XP_011 AEHRSMDGRMEAATRGGSHLQAAAQTPPRPGP-PSAPPPPPKEGHQEGLVELPASFRELL
10 20 30 40 50 60
120 130 140 150 160 170
pF1KB6 EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN
:::.:.:::::::::::. ::.::. :..: : .. . ::.:::: ... :: . ..
XP_011 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS
70 80 90 100 110 120
180 190 200 210 220 230
pF1KB6 LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRD
..:.. ..: ::.: :: : . ..:: ::....... .::. : :..:
XP_011 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYN-------VNLSKGRAA
130 140 150 160 170
240 250 260 270 280 290
pF1KB6 LRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQ
: .:.: : :: : :. : . : .. .: ..::.:::.. .::::.
XP_011 LSATVP------RHEPPFHLDREIR--LQRLSHSGSRV-----RVGFRLCNSTGGDCFYR
180 190 200 210 220
300 310 320 330 340 350
pF1KB6 TYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHH
:.::: ::..::.:::..::. :: . . . . :.:...: .. ..:. .. :::
XP_011 GYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHH
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB6 PMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEP
: ::.::: . ..: .. :::..:..:.::.::. .:::::..: ::::::...
XP_011 PTYGSCYTVD-----GVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHT
290 300 310 320 330
420 430 440 450 460 470
pF1KB6 AFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHS
:. .:..:::.:..::.:.. . :::. :: :: .: : :: :. ..::.:.:. :
XP_011 PFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVS
340 350 360 370 380 390
480 490 500 510 520 530
pF1KB6 CFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPC
:::. :.. :.:.: ..: : ..:::. .: .::.:.:.: :. . .: : ..: .::
XP_011 CFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPC
400 410 420 430 440 450
540 550 560 570 580 590
pF1KB6 SVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN-NYTVNNKRNGVAKVNIFFKELNYKTNSE
....::.: :::::. : :.. :..:. . . .:...::.:: ..::::.. :
XP_011 RESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEE
460 470 480 490 500 510
600 610 620 630 640 650
pF1KB6 SPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRY--WSPG
.: .. ::: .:: :::::.::::..:. ::..: .. ... ::.: . : .
XP_011 APVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRA
520 530 540 550 560 570
660 670 680 690 700
pF1KB6 RGGRGAQEVASTLASSPPSHFCPHPMSLSLSQP-GPA-PS---PALTAPPPAYATL-GPR
. ::. . .. :: : . . .: :: : :.. : : . ::.
XP_011 SPASGASSIKPEASQMPP----PAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQ
580 590 600 610 620 630
710 720
pF1KB6 PSPGGSAGASSSACPLGGP
:
XP_011 PLETLDT
>>XP_011540235 (OMIM: 601328) PREDICTED: amiloride-sensi (638 aa)
initn: 1521 init1: 675 opt: 1196 Z-score: 876.0 bits: 172.5 E(85289): 4.7e-42
Smith-Waterman score: 1570; 38.2% identity (68.6% similar) in 631 aa overlap (91-710:32-632)
70 80 90 100 110
pF1KB6 EGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAE--EEALIEFHRSYRELF
:: :.:: : : .:.:.:. :.:::.
XP_011 AEHRSMDGRMEAATRGGSHLQAAAQTPPRPGP-PSAPPPPPKEGHQEGLVELPASFRELL
10 20 30 40 50 60
120 130 140 150 160 170
pF1KB6 EFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN
:::.:.:::::::::::. ::.::. :..: : .. . ::.:::: ... :: . ..
XP_011 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS
70 80 90 100 110 120
180 190 200 210 220 230
pF1KB6 LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRD
..:.. ..: ::.: :: : . ..:: ::....... .::. : :..:
XP_011 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYN-------VNLSKGRAA
130 140 150 160 170
240 250 260 270 280 290
pF1KB6 LRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQ
: .:.: : :: : :. : . : .. .: ..::.:::.. .::::.
XP_011 LSATVP------RHEPPFHLDREIR--LQRLSHSGSRV-----RVGFRLCNSTGGDCFYR
180 190 200 210 220
300 310 320 330 340 350
pF1KB6 TYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHH
:.::: ::..::.:::..::. :: . . . . :.:...: .. ..:. .. :::
XP_011 GYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHH
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB6 PMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEP
: ::.::: . ..: .. :::..:..:.::.::. .:::::..: ::::::...
XP_011 PTYGSCYTVD-----GVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHT
290 300 310 320 330
420 430 440 450 460 470
pF1KB6 AFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHS
:. .:..:::.:..::.:.. . :::. :: :: .: : :: :. ..::.:.:. :
XP_011 PFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVS
340 350 360 370 380 390
480 490 500 510 520 530
pF1KB6 CFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPC
:::. :.. :.:.: ..: : ..:::. .: .::.:.:.: :. . .: : ..: .::
XP_011 CFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPC
400 410 420 430 440 450
540 550 560 570 580 590
pF1KB6 SVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN-NYTVNNKRNGVAKVNIFFKELNYKTNSE
....::.: :::::. : :.. :..:. . . .:...::.:: ..::::.. :
XP_011 RESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEE
460 470 480 490 500 510
600 610 620 630 640 650
pF1KB6 SPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRY--WSPG
.: .. ::: .:: :::::.::::..:. ::..: .. ... ::.: . : .
XP_011 APVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRA
520 530 540 550 560 570
660 670 680 690 700
pF1KB6 RGGRGAQEVASTLASSPPSHFCPHPMSLSLSQP-GPA-PS---PALTAPPPAYATL-GPR
. ::. . .. :: : . . .: :: : :.. : : . ::.
XP_011 SPASGASSIKPEASQMPP----PAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQ
580 590 600 610 620 630
710 720
pF1KB6 PSPGGSAGASSSACPLGGP
:
XP_011 PLETLDT
>>XP_011540231 (OMIM: 601328) PREDICTED: amiloride-sensi (696 aa)
initn: 1521 init1: 675 opt: 1196 Z-score: 875.4 bits: 172.5 E(85289): 5.1e-42
Smith-Waterman score: 1600; 35.9% identity (65.5% similar) in 728 aa overlap (1-710:1-690)
10 20 30 40 50
pF1KB6 MGMARGSLTRVPGVMG----EGTQGPELSLDPDPCSPQ--STPGLMKGNKLEEQDPRPLQ
::.:.. :.: .: :.. : :.: : . . . : : : ..: :.
XP_011 MGLAQSVLSRPHWGLGWVQPSGARRASLPLSPRPHAGRMDTLPYLPLG-----RSPGPVA
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 PIPGLMEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGP-EPAAPQQPTAE--EEALIEFH
: .. .:. . : : . . .:. . : :.:: : : .:.:.:.
XP_011 P----QRPCHLKGWQHRPTQHNAACKQGQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 RSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSY
:.:::. :::.:.:::::::::::. ::.::. :..: : .. . ::.:::: ...
XP_011 ASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 PVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVA
:: . ....:.. ..: ::.: :: : . ..:: ::....... .::. :
XP_011 PVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYN-------VN
180 190 200 210 220
240 250 260 270 280 290
pF1KB6 GSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQN
:..: : .:.: : :: : :. : . : .. .: ..::.:::..
XP_011 LSKGRAALSATVP------RHEPPFHLDREIR--LQRLSHSGSRV-----RVGFRLCNST
230 240 250 260 270
300 310 320 330 340 350
pF1KB6 KSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQA
.::::. :.::: ::..::.:::..::. :: . . . . :.:...: .. ..:.
XP_011 GGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQAR
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB6 NYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVM
.. :::: ::.::: . ..: .. :::..:..:.::.::. .:::::..: :::
XP_011 QFRTFHHPTYGSCYTVD-----GVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVM
340 350 360 370 380
420 430 440 450 460 470
pF1KB6 VHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYT
:::... :. .:..:::.:..::.:.. . :::. :: :: .: : :: :. ..::
XP_011 VHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYT
390 400 410 420 430 440
480 490 500 510 520 530
pF1KB6 QQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCF
.:.:. ::::. :.. :.:.: ..: : ..:::. .: .::.:.:.: :. . .: :
XP_011 RQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCT
450 460 470 480 490 500
540 550 560 570 580 590
pF1KB6 TKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN-NYTVNNKRNGVAKVNIFFKEL
..: .:: ....::.: :::::. : :.. :..:. . . .:...::.:: ..::
XP_011 SRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQEL
510 520 530 540 550 560
600 610 620 630 640 650
pF1KB6 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSR
::.. :.: .. ::: .:: :::::.::::..:. ::..: .. ... ::.:
XP_011 NYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRA
570 580 590 600 610 620
660 670 680 690 700
pF1KB6 Y--WSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQP-GPA-PS---PALTAPPPAY
. : . . ::. . .. :: : . . .: :: : :.. : :
XP_011 WFSWPRASPASGASSIKPEASQMPP----PAGGTSDDPEPSGPHLPRVMLPGVLAGVSAE
630 640 650 660 670 680
710 720
pF1KB6 ATL-GPRPSPGGSAGASSSACPLGGP
. ::.:
XP_011 ESWAGPQPLETLDT
690
728 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 14:14:40 2016 done: Sat Nov 5 14:14:42 2016
Total Scan time: 12.890 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]