Result of FASTA (omim) for pF1KB6212
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6212, 698 aa
  1>>>pF1KB6212 698 - 698 aa - 698 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.2032+/-0.000395; mu= 6.3964+/- 0.025
 mean_var=166.8911+/-35.330, 0's: 0 Z-trim(117.0): 56  B-trim: 191 in 1/55
 Lambda= 0.099279
 statistics sampled from 28640 (28696) to 28640 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.336), width:  16
 Scan time:  9.510

The best scores are:                                      opt bits E(85289)
NP_602309 (OMIM: 142765) DNA-binding protein RFX2  ( 698) 4661 680.3 6.8e-195
XP_016882597 (OMIM: 142765) PREDICTED: DNA-binding ( 653) 4369 638.4 2.5e-182
XP_011526473 (OMIM: 142765) PREDICTED: DNA-binding ( 723) 3540 519.7 1.5e-146
NP_000626 (OMIM: 142765) DNA-binding protein RFX2  ( 723) 3540 519.7 1.5e-146
XP_016882596 (OMIM: 142765) PREDICTED: DNA-binding ( 678) 3528 518.0 4.7e-146
XP_011526474 (OMIM: 142765) PREDICTED: DNA-binding ( 687) 3279 482.3 2.6e-135
XP_016870490 (OMIM: 601337) PREDICTED: transcripti ( 724) 2891 426.8 1.5e-118
XP_011516302 (OMIM: 601337) PREDICTED: transcripti ( 745) 2820 416.6 1.7e-115
NP_001269045 (OMIM: 601337) transcription factor R ( 749) 2555 378.7 4.6e-104
NP_602304 (OMIM: 601337) transcription factor RFX3 ( 749) 2555 378.7 4.6e-104
XP_011516300 (OMIM: 601337) PREDICTED: transcripti ( 770) 2484 368.5 5.4e-101
XP_006716907 (OMIM: 601337) PREDICTED: transcripti ( 770) 2484 368.5 5.4e-101
XP_011516301 (OMIM: 601337) PREDICTED: transcripti ( 770) 2484 368.5 5.4e-101
XP_006716908 (OMIM: 601337) PREDICTED: transcripti ( 770) 2484 368.5 5.4e-101
XP_016870489 (OMIM: 601337) PREDICTED: transcripti ( 770) 2484 368.5 5.4e-101
XP_006716906 (OMIM: 601337) PREDICTED: transcripti ( 770) 2484 368.5 5.4e-101
XP_006716903 (OMIM: 601337) PREDICTED: transcripti ( 780) 2484 368.5 5.5e-101
NP_002910 (OMIM: 601337) transcription factor RFX3 ( 707) 2479 367.8 8.3e-101
XP_011516303 (OMIM: 601337) PREDICTED: transcripti ( 687) 2462 365.3 4.4e-100
XP_011526472 (OMIM: 600006) PREDICTED: MHC class I ( 980) 2298 341.9 6.9e-93
XP_011526471 (OMIM: 600006) PREDICTED: MHC class I ( 980) 2298 341.9 6.9e-93
XP_011526469 (OMIM: 600006) PREDICTED: MHC class I (1089) 2298 341.9 7.5e-93
XP_011526468 (OMIM: 600006) PREDICTED: MHC class I (1089) 2298 341.9 7.5e-93
XP_011526467 (OMIM: 600006) PREDICTED: MHC class I (1089) 2298 341.9 7.5e-93
NP_002909 (OMIM: 600006) MHC class II regulatory f ( 979) 2297 341.8 7.6e-93
XP_011526470 (OMIM: 600006) PREDICTED: MHC class I ( 991) 2233 332.6 4.4e-90
XP_006716910 (OMIM: 601337) PREDICTED: transcripti ( 492) 1785 268.3 5.2e-71
XP_016870491 (OMIM: 601337) PREDICTED: transcripti ( 501) 1775 266.8 1.4e-70
NP_001269046 (OMIM: 601337) transcription factor R ( 413) 1082 167.5 9.2e-41
NP_115880 (OMIM: 603958) transcription factor RFX4 ( 641)  574 94.9   1e-18
NP_998759 (OMIM: 603958) transcription factor RFX4 ( 735)  374 66.3 4.9e-10
NP_001193620 (OMIM: 603958) transcription factor R ( 744)  374 66.3   5e-10
XP_011533891 (OMIM: 612659,615710) PREDICTED: DNA- ( 892)  323 59.0 9.1e-08
NP_775831 (OMIM: 612659,615710) DNA-binding protei ( 928)  323 59.0 9.4e-08
XP_016865966 (OMIM: 612659,615710) PREDICTED: DNA- ( 802)  317 58.1 1.5e-07
XP_016877995 (OMIM: 612660) PREDICTED: DNA-binding (1460)  227 45.4  0.0019
XP_005254660 (OMIM: 612660) PREDICTED: DNA-binding (1460)  227 45.4  0.0019
NP_073752 (OMIM: 612660) DNA-binding protein RFX7  (1460)  227 45.4  0.0019
XP_016877996 (OMIM: 612660) PREDICTED: DNA-binding (1363)  219 44.2  0.0039
XP_011520227 (OMIM: 612660) PREDICTED: DNA-binding (1363)  219 44.2  0.0039
XP_016877997 (OMIM: 612660) PREDICTED: DNA-binding (1363)  219 44.2  0.0039
XP_005245463 (OMIM: 209920,601863) PREDICTED: DNA- ( 616)  204 41.9  0.0091
XP_011508149 (OMIM: 209920,601863) PREDICTED: DNA- ( 616)  204 41.9  0.0091
NP_001020774 (OMIM: 209920,601863) DNA-binding pro ( 616)  204 41.9  0.0091
NP_000440 (OMIM: 209920,601863) DNA-binding protei ( 616)  204 41.9  0.0091
XP_011508150 (OMIM: 209920,601863) PREDICTED: DNA- ( 616)  204 41.9  0.0091
XP_011508151 (OMIM: 209920,601863) PREDICTED: DNA- ( 616)  204 41.9  0.0091
XP_005245462 (OMIM: 209920,601863) PREDICTED: DNA- ( 616)  204 41.9  0.0091
XP_011508152 (OMIM: 209920,601863) PREDICTED: DNA- ( 616)  204 41.9  0.0091


>>NP_602309 (OMIM: 142765) DNA-binding protein RFX2 isof  (698 aa)
 initn: 4661 init1: 4661 opt: 4661  Z-score: 3619.9  bits: 680.3 E(85289): 6.8e-195
Smith-Waterman score: 4661; 99.9% identity (100.0% similar) in 698 aa overlap (1-698:1-698)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
       :::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
NP_602 VQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLQWLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLQWLLD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 NYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 NYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKY
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 HYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 HYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 TMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 TMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVM
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 NLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 NLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB6 CDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 CDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB6 AFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 AFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB6 RLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 RLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIR
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB6 DLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 DLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDK
              610       620       630       640       650       660

              670       680       690        
pF1KB6 DDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI
       ::::::::::::::::::::::::::::::::::::::
NP_602 DDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI
              670       680       690        

>>XP_016882597 (OMIM: 142765) PREDICTED: DNA-binding pro  (653 aa)
 initn: 4369 init1: 4369 opt: 4369  Z-score: 3394.3  bits: 638.4 E(85289): 2.5e-182
Smith-Waterman score: 4369; 99.8% identity (100.0% similar) in 653 aa overlap (46-698:1-653)

          20        30        40        50        60        70     
pF1KB6 LRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQVQPVQHVYPAQVQYV
                                     ::::::::::::::::::::::::::::::
XP_016                               MQPISLPRVQQVPQQVQPVQHVYPAQVQYV
                                             10        20        30

          80        90       100       110       120       130     
pF1KB6 EGGDAVYTNGTIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGI
       ::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGI
               40        50        60        70        80        90

         140       150       160       170       180       190     
pF1KB6 TMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLQWLLDNYETAEGVSLPRSSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLQWLLDNYETAEGVSLPRSSL
              100       110       120       130       140       150

         200       210       220       230       240       250     
pF1KB6 YNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNR
              160       170       180       190       200       210

         260       270       280       290       300       310     
pF1KB6 LQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDV
              220       230       240       250       260       270

         320       330       340       350       360       370     
pF1KB6 SHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFW
              280       290       300       310       320       330

         380       390       400       410       420       430     
pF1KB6 NSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIP
              340       350       360       370       380       390

         440       450       460       470       480       490     
pF1KB6 DVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHL
              400       410       420       430       440       450

         500       510       520       530       540       550     
pF1KB6 AQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSS
              460       470       480       490       500       510

         560       570       580       590       600       610     
pF1KB6 LDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHL
              520       530       540       550       560       570

         620       630       640       650       660       670     
pF1KB6 IRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPD
              580       590       600       610       620       630

         680       690        
pF1KB6 ARSLGEPLVKRERSDPNHSLQGI
       :::::::::::::::::::::::
XP_016 ARSLGEPLVKRERSDPNHSLQGI
              640       650   

>>XP_011526473 (OMIM: 142765) PREDICTED: DNA-binding pro  (723 aa)
 initn: 3518 init1: 3518 opt: 3540  Z-score: 2752.0  bits: 519.7 E(85289): 1.5e-146
Smith-Waterman score: 4601; 96.4% identity (96.5% similar) in 723 aa overlap (1-698:1-723)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
       :::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
XP_011 VQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
               70        80        90       100       110       120

              130       140       150       160       170          
pF1KB6 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATL-----
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
XP_011 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIE
              130       140       150       160       170       180

                             180       190       200       210     
pF1KB6 --------------------QWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAAS
                           ::::::::::::::::::::::::::::::::::::::::
XP_011 NLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAAS
              190       200       210       220       230       240

         220       230       240       250       260       270     
pF1KB6 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPR
              250       260       270       280       290       300

         280       290       300       310       320       330     
pF1KB6 YRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDG
              310       320       330       340       350       360

         340       350       360       370       380       390     
pF1KB6 VTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDP
              370       380       390       400       410       420

         400       410       420       430       440       450     
pF1KB6 EGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKS
              430       440       450       460       470       480

         460       470       480       490       500       510     
pF1KB6 LEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD
              490       500       510       520       530       540

         520       530       540       550       560       570     
pF1KB6 LNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHA
              550       560       570       580       590       600

         580       590       600       610       620       630     
pF1KB6 GSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEA
              610       620       630       640       650       660

         640       650       660       670       680       690     
pF1KB6 TGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSL
              670       680       690       700       710       720

          
pF1KB6 QGI
       :::
XP_011 QGI
          

>>NP_000626 (OMIM: 142765) DNA-binding protein RFX2 isof  (723 aa)
 initn: 3518 init1: 3518 opt: 3540  Z-score: 2752.0  bits: 519.7 E(85289): 1.5e-146
Smith-Waterman score: 4601; 96.4% identity (96.5% similar) in 723 aa overlap (1-698:1-723)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
       :::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
NP_000 VQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
               70        80        90       100       110       120

              130       140       150       160       170          
pF1KB6 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATL-----
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
NP_000 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIE
              130       140       150       160       170       180

                             180       190       200       210     
pF1KB6 --------------------QWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAAS
                           ::::::::::::::::::::::::::::::::::::::::
NP_000 NLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAAS
              190       200       210       220       230       240

         220       230       240       250       260       270     
pF1KB6 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPR
              250       260       270       280       290       300

         280       290       300       310       320       330     
pF1KB6 YRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDG
              310       320       330       340       350       360

         340       350       360       370       380       390     
pF1KB6 VTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDP
              370       380       390       400       410       420

         400       410       420       430       440       450     
pF1KB6 EGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKS
              430       440       450       460       470       480

         460       470       480       490       500       510     
pF1KB6 LEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD
              490       500       510       520       530       540

         520       530       540       550       560       570     
pF1KB6 LNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHA
              550       560       570       580       590       600

         580       590       600       610       620       630     
pF1KB6 GSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEA
              610       620       630       640       650       660

         640       650       660       670       680       690     
pF1KB6 TGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSL
              670       680       690       700       710       720

          
pF1KB6 QGI
       :::
NP_000 QGI
          

>>XP_016882596 (OMIM: 142765) PREDICTED: DNA-binding pro  (678 aa)
 initn: 3518 init1: 3518 opt: 3528  Z-score: 2743.1  bits: 518.0 E(85289): 4.7e-146
Smith-Waterman score: 4309; 96.2% identity (96.3% similar) in 678 aa overlap (46-698:1-678)

          20        30        40        50        60        70     
pF1KB6 LRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQVQPVQHVYPAQVQYV
                                     ::::::::::::::::::::::::::::::
XP_016                               MQPISLPRVQQVPQQVQPVQHVYPAQVQYV
                                             10        20        30

          80        90       100       110       120       130     
pF1KB6 EGGDAVYTNGTIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGI
       ::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGI
               40        50        60        70        80        90

         140       150       160       170                         
pF1KB6 TMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATL--------------------
       ::::::::::::::::::::::::::::::::::::::::                    
XP_016 TMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGL
              100       110       120       130       140       150

              180       190       200       210       220       230
pF1KB6 -----QWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTR
            :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTR
              160       170       180       190       200       210

              240       250       260       270       280       290
pF1KB6 RLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGS
              220       230       240       250       260       270

              300       310       320       330       340       350
pF1KB6 HSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRR
              280       290       300       310       320       330

              360       370       380       390       400       410
pF1KB6 HCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQ
              340       350       360       370       380       390

              420       430       440       450       460       470
pF1KB6 CDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQ
              400       410       420       430       440       450

              480       490       500       510       520       530
pF1KB6 VIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASW
              460       470       480       490       500       510

              540       550       560       570       580       590
pF1KB6 VCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLK
              520       530       540       550       560       570

              600       610       620       630       640       650
pF1KB6 WSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDL
              580       590       600       610       620       630

              660       670       680       690        
pF1KB6 ASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI
       ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI
              640       650       660       670        

>>XP_011526474 (OMIM: 142765) PREDICTED: DNA-binding pro  (687 aa)
 initn: 3257 init1: 3257 opt: 3279  Z-score: 2550.3  bits: 482.3 E(85289): 2.6e-135
Smith-Waterman score: 4340; 96.2% identity (96.4% similar) in 685 aa overlap (1-660:1-685)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
       :::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::
XP_011 VQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVA
               70        80        90       100       110       120

              130       140       150       160       170          
pF1KB6 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATL-----
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
XP_011 ASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIE
              130       140       150       160       170       180

                             180       190       200       210     
pF1KB6 --------------------QWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAAS
                           ::::::::::::::::::::::::::::::::::::::::
XP_011 NLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAAS
              190       200       210       220       230       240

         220       230       240       250       260       270     
pF1KB6 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPR
              250       260       270       280       290       300

         280       290       300       310       320       330     
pF1KB6 YRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDG
              310       320       330       340       350       360

         340       350       360       370       380       390     
pF1KB6 VTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDP
              370       380       390       400       410       420

         400       410       420       430       440       450     
pF1KB6 EGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKS
              430       440       450       460       470       480

         460       470       480       490       500       510     
pF1KB6 LEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD
              490       500       510       520       530       540

         520       530       540       550       560       570     
pF1KB6 LNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHA
              550       560       570       580       590       600

         580       590       600       610       620       630     
pF1KB6 GSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEA
              610       620       630       640       650       660

         640       650       660       670       680       690     
pF1KB6 TGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSL
       :::::::::::::::::::::::::                                   
XP_011 TGETPIAVMGEFNDLASLSLTLLDKGR                                 
              670       680                                        

>>XP_016870490 (OMIM: 601337) PREDICTED: transcription f  (724 aa)
 initn: 2615 init1: 1472 opt: 2891  Z-score: 2249.6  bits: 426.8 E(85289): 1.5e-118
Smith-Waterman score: 2923; 66.7% identity (84.7% similar) in 699 aa overlap (1-690:1-673)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::.:: :.:. ..:.:. :.:.    : : .:. :.    :  .:.:      :::: : 
XP_016 MQTSETGSDTGSTVTLQTSVASQA--AVPTQVVQQV----P--VQQQ------VQQV-QT
               10        20          30                    40      

               70        80        90        100       110         
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTA-YTYNPEPQMYAPSSTASYFEAPGG-AQVT
       :: ::::::::::::::.:.:::::.:::. : :. : :::. .. ..::.. :. ::::
XP_016 VQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYT-ETQMYSQNTGGNYFDTQGSSAQVT
          50        60        70        80         90       100    

      120       130           140       150       160       170    
pF1KB6 VAASSPPAVPSHSMVG---ITMDV-GGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPAT
       ...::      :::::   : : : ::. : ::.:.::: ..:... ::..::.:.::::
XP_016 TVVSS------HSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPAT
                110       120       130       140       150        

          180       190       200       210       220       230    
pF1KB6 LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGT
       :::::::::::::::::::.::::::::::::::::::::::::::::.:::::::::::
XP_016 LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGT
      160       170       180       190       200       210        

          240       250       260       270       280       290    
pF1KB6 RGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGL
       ::::::::::::.:::::::::::: ::::::::::.:: ::.: ::.:...:. . :: 
XP_016 RGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQ
      220       230       240       250       260       270        

            300       310       320       330       340       350  
pF1KB6 HS--TPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHC
       ..  . :::. .:::::::..:.:...:::   ...:  : ::.:..:.:.:: .::.::
XP_016 QTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISS--LPDGTTFEDIKSLQSLYREHC
      280       290       300       310         320       330      

            360       370        380       390       400       410 
pF1KB6 EATVDVVMNLQFHYIEKLWLSFWN-SKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQC
       :: .:::.::::  ::::: .::  : .. .:: :   .:. .   . ::: :::.::. 
XP_016 EAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTITESSNLSEIESRLPKAKLITLCKH
        340       350       360       370       380       390      

             420       430       440       450       460       470 
pF1KB6 DPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQV
       . ::.:: .::: .:::::::::::::::.::.::::::::::::::::.:::...::..
XP_016 ESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRM
        400       410       420       430       440       450      

             480       490       500       510       520       530 
pF1KB6 IQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWV
       :::::..:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWV
        460       470       480       490       500       510      

             540       550       560       570       580       590 
pF1KB6 CQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKW
       :::....::::: :::.::::::.:.:::.:::.:. :.:: . : ::::::::::::::
XP_016 CQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKW
        520       530       540       550       560       570      

             600       610       620       630       640       650 
pF1KB6 SFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLA
       ::::::::::::::::::::::::::::::::::::::::::.:::::::::::::.:: 
XP_016 SFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLN
        580       590       600       610       620       630      

             660       670       680       690                     
pF1KB6 SLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI             
       ..:   ::::. :.: . ::   .  . .:: .:::...                     
XP_016 AVSPGNLDKDE-GSEVE-SEMDEELDDSSEPQAKREKTELSQAFPVGCMQPVLETGVQPS
        640        650        660       670       680       690    

XP_016 LLNPIHSEHIVTSTQTIRQCSATGNTYTAV
          700       710       720    

>>XP_011516302 (OMIM: 601337) PREDICTED: transcription f  (745 aa)
 initn: 2574 init1: 1431 opt: 2820  Z-score: 2194.4  bits: 416.6 E(85289): 1.7e-115
Smith-Waterman score: 2871; 64.7% identity (82.2% similar) in 720 aa overlap (1-690:1-694)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::.:: :.:. ..:.:. :.:.    : : .:. :.    :  .:.:      :::: : 
XP_011 MQTSETGSDTGSTVTLQTSVASQA--AVPTQVVQQV----P--VQQQ------VQQV-QT
               10        20          30                    40      

               70        80        90        100       110         
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTA-YTYNPEPQMYAPSSTASYFEAPGG-AQVT
       :: ::::::::::::::.:.:::::.:::. : :. : :::. .. ..::.. :. ::::
XP_011 VQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYT-ETQMYSQNTGGNYFDTQGSSAQVT
          50        60        70        80         90       100    

      120       130           140       150       160       170    
pF1KB6 VAASSPPAVPSHSMVG---ITMDV-GGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPAT
       ...::      :::::   : : : ::. : ::.:.::: ..:... ::..::.:.::::
XP_011 TVVSS------HSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPAT
                110       120       130       140       150        

          180       190       200       210       220       230    
pF1KB6 LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGT
       :::::::::::::::::::.::::::::::::::::::::::::::::.:::::::::::
XP_011 LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGT
      160       170       180       190       200       210        

          240       250       260       270       280       290    
pF1KB6 RGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGL
       ::::::::::::.:::::::::::: ::::::::::.:: ::.: ::.:...:. . :: 
XP_011 RGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQ
      220       230       240       250       260       270        

            300       310       320       330       340       350  
pF1KB6 HS--TPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHC
       ..  . :::. .:::::::..:.:...:::   ...:  : ::.:..:.:.:: .::.::
XP_011 QTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISS--LPDGTTFEDIKSLQSLYREHC
      280       290       300       310         320       330      

            360       370        380       390       400       410 
pF1KB6 EATVDVVMNLQFHYIEKLWLSFWN-SKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQC
       :: .:::.::::  ::::: .::  : .. .:: :   .:. .   . ::: :::.::. 
XP_011 EAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTITESSNLSEIESRLPKAKLITLCKH
        340       350       360       370       380       390      

             420       430       440       450       460       470 
pF1KB6 DPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQV
       . ::.:: .::: .:::::::::::::::.::.::::::::::::::::.:::...::..
XP_011 ESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRM
        400       410       420       430       440       450      

             480       490       500       510       520       530 
pF1KB6 IQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWV
       :::::..:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWV
        460       470       480       490       500       510      

             540       550       560       570       580       590 
pF1KB6 CQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKW
       :::....::::: :::.::::::.:.:::.:::.:. :.:: . : ::::::::::::::
XP_011 CQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKW
        520       530       540       550       560       570      

             600       610       620       630       640           
pF1KB6 SFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGE-----
       ::::::::::::::::::::::::::::::::::::::::::.::::::::::::     
XP_011 SFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGETNLVD
        580       590       600       610       620       630      

                        650       660       670       680       690
pF1KB6 ----------------FNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSD
                       :.:: ..:   ::::. :.: . ::   .  . .:: .:::...
XP_011 EKNTPIMELFISKLLNFGDLNAVSPGNLDKDE-GSEVE-SEMDEELDDSSEPQAKREKTE
        640       650       660        670        680       690    

                                                          
pF1KB6 PNHSLQGI                                           
                                                          
XP_011 LSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV
          700       710       720       730       740     

>>NP_001269045 (OMIM: 601337) transcription factor RFX3   (749 aa)
 initn: 2618 init1: 1464 opt: 2555  Z-score: 1989.3  bits: 378.7 E(85289): 4.6e-104
Smith-Waterman score: 2863; 64.4% identity (81.8% similar) in 724 aa overlap (1-690:1-698)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::.:: :.:. ..:.:. :.:.    : : .:. :.    :  .:.:      :::: : 
NP_001 MQTSETGSDTGSTVTLQTSVASQA--AVPTQVVQQV----P--VQQQ------VQQV-QT
               10        20          30                    40      

               70        80        90        100       110         
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTA-YTYNPEPQMYAPSSTASYFEAPGG-AQVT
       :: ::::::::::::::.:.:::::.:::. : :. : :::. .. ..::.. :. ::::
NP_001 VQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYT-ETQMYSQNTGGNYFDTQGSSAQVT
          50        60        70        80         90       100    

      120       130           140       150       160       170    
pF1KB6 VAASSPPAVPSHSMVG---ITMDV-GGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPAT
       ...::      :::::   : : : ::. : ::.:.::: ..:... ::..::.:.::::
NP_001 TVVSS------HSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPAT
                110       120       130       140       150        

                                   180       190       200         
pF1KB6 -------------------------LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLD
                                :::::::::::::::::::.:::::::::::::::
NP_001 IEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLD
      160       170       180       190       200       210        

     210       220       230       240       250       260         
pF1KB6 PVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQP
       :::::::::::::.:::::::::::::::::::::::.:::::::::::: :::::::::
NP_001 PVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQP
      220       230       240       250       260       270        

     270       280       290         300       310       320       
pF1KB6 MHQKPRYRPAQKTDSLGDSGSHSGLHS--TPEQTMAVQSQHHQQYIDVSHVFPEFPAPDL
       :.:: ::.: ::.:...:. . :: ..  . :::. .:::::::..:.:...:::   ..
NP_001 MQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEI
      280       290       300       310       320       330        

       330       340       350       360       370        380      
pF1KB6 GSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWN-SKASSSDGPT
       .:  : ::.:..:.:.:: .::.:::: .:::.::::  ::::: .::  : .. .:: :
NP_001 SS--LPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTT
      340         350       360       370       380       390      

        390       400       410       420       430       440      
pF1KB6 SLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLT
          .:. .   . ::: :::.::. . ::.:: .::: .:::::::::::::::.::.::
NP_001 ITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALT
        400       410       420       430       440       450      

        450       460       470       480       490       500      
pF1KB6 QAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNT
       ::::::::::::::.:::...::..:::::..::::::::::::::::::::::::::::
NP_001 QAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNT
        460       470       480       490       500       510      

        510       520       530       540       550       560      
pF1KB6 SQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSV
       ::::::::::::::::::::::::::::....::::: :::.::::::.:.:::.:::.:
NP_001 SQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNV
        520       530       540       550       560       570      

        570       580       590       600       610       620      
pF1KB6 VTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFY
       . :.:: . : :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFY
        580       590       600       610       620       630      

        630       640       650       660       670       680      
pF1KB6 LVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKR
       :::::::.:::::::::::::.:: ..:   ::::. :.: . ::   .  . .:: .::
NP_001 LVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDE-GSEVE-SEMDEELDDSSEPQAKR
        640       650       660       670         680       690    

        690                                                   
pF1KB6 ERSDPNHSLQGI                                           
       :...                                                   
NP_001 EKTELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV
          700       710       720       730       740         

>>NP_602304 (OMIM: 601337) transcription factor RFX3 iso  (749 aa)
 initn: 2618 init1: 1464 opt: 2555  Z-score: 1989.3  bits: 378.7 E(85289): 4.6e-104
Smith-Waterman score: 2863; 64.4% identity (81.8% similar) in 724 aa overlap (1-690:1-698)

               10        20        30        40        50        60
pF1KB6 MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQ
       ::.:: :.:. ..:.:. :.:.    : : .:. :.    :  .:.:      :::: : 
NP_602 MQTSETGSDTGSTVTLQTSVASQA--AVPTQVVQQV----P--VQQQ------VQQV-QT
               10        20          30                    40      

               70        80        90        100       110         
pF1KB6 VQPVQHVYPAQVQYVEGGDAVYTNGTIRTA-YTYNPEPQMYAPSSTASYFEAPGG-AQVT
       :: ::::::::::::::.:.:::::.:::. : :. : :::. .. ..::.. :. ::::
NP_602 VQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYT-ETQMYSQNTGGNYFDTQGSSAQVT
          50        60        70        80         90       100    

      120       130           140       150       160       170    
pF1KB6 VAASSPPAVPSHSMVG---ITMDV-GGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPAT
       ...::      :::::   : : : ::. : ::.:.::: ..:... ::..::.:.::::
NP_602 TVVSS------HSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPAT
                110       120       130       140       150        

                                   180       190       200         
pF1KB6 -------------------------LQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLD
                                :::::::::::::::::::.:::::::::::::::
NP_602 IEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLD
      160       170       180       190       200       210        

     210       220       230       240       250       260         
pF1KB6 PVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQP
       :::::::::::::.:::::::::::::::::::::::.:::::::::::: :::::::::
NP_602 PVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQP
      220       230       240       250       260       270        

     270       280       290         300       310       320       
pF1KB6 MHQKPRYRPAQKTDSLGDSGSHSGLHS--TPEQTMAVQSQHHQQYIDVSHVFPEFPAPDL
       :.:: ::.: ::.:...:. . :: ..  . :::. .:::::::..:.:...:::   ..
NP_602 MQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEI
      280       290       300       310       320       330        

       330       340       350       360       370        380      
pF1KB6 GSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWN-SKASSSDGPT
       .:  : ::.:..:.:.:: .::.:::: .:::.::::  ::::: .::  : .. .:: :
NP_602 SS--LPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTT
      340         350       360       370       380       390      

        390       400       410       420       430       440      
pF1KB6 SLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLT
          .:. .   . ::: :::.::. . ::.:: .::: .:::::::::::::::.::.::
NP_602 ITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALT
        400       410       420       430       440       450      

        450       460       470       480       490       500      
pF1KB6 QAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNT
       ::::::::::::::.:::...::..:::::..::::::::::::::::::::::::::::
NP_602 QAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNT
        460       470       480       490       500       510      

        510       520       530       540       550       560      
pF1KB6 SQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSV
       ::::::::::::::::::::::::::::....::::: :::.::::::.:.:::.:::.:
NP_602 SQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNV
        520       530       540       550       560       570      

        570       580       590       600       610       620      
pF1KB6 VTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFY
       . :.:: . : :::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 MMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFY
        580       590       600       610       620       630      

        630       640       650       660       670       680      
pF1KB6 LVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKR
       :::::::.:::::::::::::.:: ..:   ::::. :.: . ::   .  . .:: .::
NP_602 LVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDE-GSEVE-SEMDEELDDSSEPQAKR
        640       650       660       670         680       690    

        690                                                   
pF1KB6 ERSDPNHSLQGI                                           
       :...                                                   
NP_602 EKTELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV
          700       710       720       730       740         




698 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 13:51:11 2016 done: Sat Nov  5 13:51:12 2016
 Total Scan time:  9.510 Total Display time:  0.190

Function used was FASTA [36.3.4 Apr, 2011]
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