Result of FASTA (omim) for pF1KB5654
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5654, 331 aa
  1>>>pF1KB5654 331 - 331 aa - 331 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2812+/-0.000427; mu= 16.1503+/- 0.026
 mean_var=70.0546+/-13.938, 0's: 0 Z-trim(111.4): 60  B-trim: 152 in 1/49
 Lambda= 0.153234
 statistics sampled from 19878 (19938) to 19878 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.612), E-opt: 0.2 (0.234), width:  16
 Scan time:  6.890

The best scores are:                                      opt bits E(85289)
NP_004070 (OMIM: 116845) cathepsin S isoform 1 pre ( 331) 2292 516.0 4.3e-146
NP_001186668 (OMIM: 116845) cathepsin S isoform 2  ( 281) 1378 313.9 2.5e-85
NP_000387 (OMIM: 265800,601105) cathepsin K prepro ( 329) 1241 283.7 3.7e-76
NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 1119 256.7   5e-68
NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 1119 256.7   5e-68
XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 1101 252.7 7.8e-67
NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 1101 252.7 7.8e-67
NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 1101 252.7 7.8e-67
NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 1101 252.7 7.8e-67
NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 1101 252.7 7.8e-67
XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272)  815 189.4 7.2e-48
XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272)  815 189.4 7.2e-48
NP_004381 (OMIM: 116820) pro-cathepsin H isoform a ( 335)  723 169.2 1.1e-41
XP_016877440 (OMIM: 116820) PREDICTED: pro-catheps ( 317)  713 166.9   5e-41
XP_005254238 (OMIM: 116820) PREDICTED: pro-catheps ( 297)  702 164.5 2.6e-40
XP_016877441 (OMIM: 116820) PREDICTED: pro-catheps ( 297)  702 164.5 2.6e-40
XP_011543630 (OMIM: 603539,615362) PREDICTED: cath ( 424)  561 133.4 8.2e-31
NP_003784 (OMIM: 603539,615362) cathepsin F precur ( 484)  561 133.5 9.2e-31
NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151)  543 129.2 5.6e-30
NP_001325 (OMIM: 600550) cathepsin O preproprotein ( 321)  502 120.3 5.6e-27
NP_001306066 (OMIM: 116820) pro-cathepsin H isofor ( 201)  451 108.9 9.4e-24
NP_001326 (OMIM: 602364) cathepsin W preproprotein ( 376)  399 97.6 4.5e-20
XP_011519578 (OMIM: 116820) PREDICTED: pro-catheps ( 169)  272 69.3 6.7e-12
NP_001327 (OMIM: 603169) cathepsin Z preproprotein ( 303)  272 69.4 1.1e-11
NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463)  239 62.3 2.4e-09
NP_001304166 (OMIM: 116810) cathepsin B isoform 2  ( 215)  228 59.6 6.9e-09
XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245)  228 59.6 7.7e-09
XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339)  228 59.7   1e-08
XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339)  228 59.7   1e-08
XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339)  228 59.7   1e-08
NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339)  228 59.7   1e-08
NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339)  228 59.7   1e-08
XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339)  228 59.7   1e-08
NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339)  228 59.7   1e-08
NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339)  228 59.7   1e-08
NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339)  228 59.7   1e-08
XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339)  228 59.7   1e-08
XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339)  228 59.7   1e-08
XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339)  228 59.7   1e-08
XP_005271163 (OMIM: 616064) PREDICTED: tubulointer ( 440)  194 52.3 2.3e-06
XP_016866234 (OMIM: 606749) PREDICTED: tubulointer ( 438)  150 42.6  0.0019


>>NP_004070 (OMIM: 116845) cathepsin S isoform 1 preprop  (331 aa)
 initn: 2292 init1: 2292 opt: 2292  Z-score: 2743.8  bits: 516.0 E(85289): 4.3e-146
Smith-Waterman score: 2292; 99.7% identity (99.7% similar) in 331 aa overlap (1-331:1-331)

               10        20        30        40        50        60
pF1KB5 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNWILPDSVD
       :::::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
NP_004 LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
              250       260       270       280       290       300

              310       320       330 
pF1KB5 GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       :::::::::::::::::::::::::::::::
NP_004 GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
              310       320       330 

>>NP_001186668 (OMIM: 116845) cathepsin S isoform 2 prep  (281 aa)
 initn: 1377 init1: 1377 opt: 1378  Z-score: 1652.8  bits: 313.9 E(85289): 2.5e-85
Smith-Waterman score: 1853; 84.9% identity (84.9% similar) in 331 aa overlap (1-331:1-281)

               10        20        30        40        50        60
pF1KB5 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNWILPDSVD
       :::::::::::::::::::::::                                     
NP_001 LHNLEHSMGMHSYDLGMNHLGDM-------------------------------------
               70        80                                        

              130       140       150       160       170       180
pF1KB5 WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
                    :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------------GSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
                         90       100       110       120       130

              190       200       210       220       230       240
pF1KB5 NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
              140       150       160       170       180       190

              250       260       270       280       290       300
pF1KB5 AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
              200       210       220       230       240       250

              310       320       330 
pF1KB5 GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       :::::::::::::::::::::::::::::::
NP_001 GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
              260       270       280 

>>NP_000387 (OMIM: 265800,601105) cathepsin K preproprot  (329 aa)
 initn: 1097 init1: 467 opt: 1241  Z-score: 1488.2  bits: 283.7 E(85289): 3.7e-76
Smith-Waterman score: 1241; 55.8% identity (79.9% similar) in 328 aa overlap (7-331:6-329)

               10        20        30        40        50        60
pF1KB5 MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
             :::.   . : :. .  :: ::.:::::. :::..: .:  ::::::::::.. 
NP_000  MWGLKVLLLPVVSFA-LYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYIS
                10         20        30        40        50        

               70        80        90       100       110          
pF1KB5 LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNWI--LPDS
       .:::: :.:.:.:.:.::::::::::::.. :..:.:: . .:.      :.:    :::
NP_000 IHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDS
       60        70        80        90       100       110        

      120       130       140       150       160       170        
pF1KB5 VDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNK
       ::.:.:: :: :: ::.::.:::::.:::::.::: :::::..:: :::::: .:   : 
NP_000 VDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE---ND
      120       130       140       150       160       170        

      180       190       200       210       220       230        
pF1KB5 GCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVL
       ::.::.::.::::.  :.::::. .::: .....:.:.   .:: :  : :.: : : .:
NP_000 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
         180       190       200       210       220       230     

      240       250       260       270        280       290       
pF1KB5 KEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSC-TQNVNHGVLVVGYGDLNGKEYWLVK
       :.:::  :::::..::   :: .: .::::. :: ..:.::.::.::::  .:...:..:
NP_000 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIK
         240       250       260       270       280       290     

       300       310       320       330 
pF1KB5 NSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       ::::.:.:..::: :::::.: ::::.. :.:..
NP_000 NSWGENWGNKGYILMARNKNNACGIANLASFPKM
         300       310       320         

>>NP_001188504 (OMIM: 603308) cathepsin L2 preproprotein  (334 aa)
 initn: 1056 init1: 363 opt: 1119  Z-score: 1342.3  bits: 256.7 E(85289): 5e-68
Smith-Waterman score: 1119; 50.6% identity (78.5% similar) in 326 aa overlap (12-331:15-334)

                  10        20        30        40        50       
pF1KB5    MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLK
                     .::: ..  : .:: .:. :: :. . :   :::. :: .::::.:
NP_001 MNLSLVLAAFCLGIASAVPKF--DQNLDTKWYQWKATHRRLYGA-NEEGWRRAVWEKNMK
               10        20          30        40         50       

        60        70        80        90       100       110       
pF1KB5 FVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNWI-LP
       .. ::: :.:.: :.. ..:: .::::.::  ..:. .:  ...... ... .: .. ::
NP_001 MIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFR-NQKFRKGKVFR-EPLFLDLP
        60        70        80        90        100        110     

        120       130       140       150       160       170      
pF1KB5 DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG
        :::::.:: :: :: : .::.::::::.::::.:.  ::::::::: :::::::  . :
NP_001 KSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ-G
         120       130       140       150       160       170     

        180       190       200       210       220       230      
pF1KB5 NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGRED
       :.:::::::. ::::. .: :.::. :::: :.:. :.:  .  .:. . .: .  :.: 
NP_001 NQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEK
          180       190       200       210       220       230    

        240       250       260       270        280           290 
pF1KB5 VLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYG----DLNGK
       .: .:::. ::.::..:: : :: .:.::.:.::.:. .:..:::::::::    . :..
NP_001 ALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNS
          240       250       260       270       280       290    

             300       310       320       330 
pF1KB5 EYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       .::::::::: ..: .::...:..:.::::::.  :::..
NP_001 KYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
          300       310       320       330    

>>NP_001324 (OMIM: 603308) cathepsin L2 preproprotein [H  (334 aa)
 initn: 1056 init1: 363 opt: 1119  Z-score: 1342.3  bits: 256.7 E(85289): 5e-68
Smith-Waterman score: 1119; 50.6% identity (78.5% similar) in 326 aa overlap (12-331:15-334)

                  10        20        30        40        50       
pF1KB5    MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLK
                     .::: ..  : .:: .:. :: :. . :   :::. :: .::::.:
NP_001 MNLSLVLAAFCLGIASAVPKF--DQNLDTKWYQWKATHRRLYGA-NEEGWRRAVWEKNMK
               10        20          30        40         50       

        60        70        80        90       100       110       
pF1KB5 FVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNWI-LP
       .. ::: :.:.: :.. ..:: .::::.::  ..:. .:  ...... ... .: .. ::
NP_001 MIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFR-NQKFRKGKVFR-EPLFLDLP
        60        70        80        90        100        110     

        120       130       140       150       160       170      
pF1KB5 DSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYG
        :::::.:: :: :: : .::.::::::.::::.:.  ::::::::: :::::::  . :
NP_001 KSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQ-G
         120       130       140       150       160       170     

        180       190       200       210       220       230      
pF1KB5 NKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGRED
       :.:::::::. ::::. .: :.::. :::: :.:. :.:  .  .:. . .: .  :.: 
NP_001 NQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEK
          180       190       200       210       220       230    

        240       250       260       270        280           290 
pF1KB5 VLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYG----DLNGK
       .: .:::. ::.::..:: : :: .:.::.:.::.:. .:..:::::::::    . :..
NP_001 ALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNS
          240       250       260       270       280       290    

             300       310       320       330 
pF1KB5 EYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       .::::::::: ..: .::...:..:.::::::.  :::..
NP_001 KYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
          300       310       320       330    

>>XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L1 is  (333 aa)
 initn: 937 init1: 293 opt: 1101  Z-score: 1320.8  bits: 252.7 E(85289): 7.8e-67
Smith-Waterman score: 1101; 49.7% identity (75.6% similar) in 328 aa overlap (14-331:15-333)

                10        20        30        40        50         
pF1KB5  MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFV
                     : : :  : .:. .:  ::  ... :   :::. :: .::::.:..
XP_005 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGM-NEEGWRRAVWEKNMKMI
               10        20        30        40         50         

      60        70        80        90         100          110    
pF1KB5 MLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSL--RVPSQ---WQRNITYKSNPNWI
        ::: :.  : ::. ..:: .:::::::  ..:...  : : .   .:. . :..     
XP_005 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-----
      60        70        80        90       100       110         

          120       130       140       150       160       170    
pF1KB5 LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEK
        : :::::::: :: :: ::.::.::::::.::::.:.  :::.:.::: :::::::  .
XP_005 -PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQ
           120       130       140       150       160       170   

          180       190       200       210       220       230    
pF1KB5 YGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGR
        ::.:::::.:  ::::. :: :.::. ::::.: ...:.:. :: .:. . ....:  .
XP_005 -GNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-Q
            180       190       200       210       220       230  

          240       250       260       270        280             
pF1KB5 EDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYG----DLN
       : .: .:::. ::.::..:: : ::..:. :.:.::.:. ....:::::::::    . .
XP_005 EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESD
             240       250       260       270       280       290 

     290       300       310       320       330 
pF1KB5 GKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       ...:::::::::...:  ::..::... :::::::  ::: .
XP_005 NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
             300       310       320       330   

>>NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 prepro  (333 aa)
 initn: 937 init1: 293 opt: 1101  Z-score: 1320.8  bits: 252.7 E(85289): 7.8e-67
Smith-Waterman score: 1101; 49.7% identity (75.6% similar) in 328 aa overlap (14-331:15-333)

                10        20        30        40        50         
pF1KB5  MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFV
                     : : :  : .:. .:  ::  ... :   :::. :: .::::.:..
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGM-NEEGWRRAVWEKNMKMI
               10        20        30        40         50         

      60        70        80        90         100          110    
pF1KB5 MLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSL--RVPSQ---WQRNITYKSNPNWI
        ::: :.  : ::. ..:: .:::::::  ..:...  : : .   .:. . :..     
NP_001 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-----
      60        70        80        90       100       110         

          120       130       140       150       160       170    
pF1KB5 LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEK
        : :::::::: :: :: ::.::.::::::.::::.:.  :::.:.::: :::::::  .
NP_001 -PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQ
           120       130       140       150       160       170   

          180       190       200       210       220       230    
pF1KB5 YGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGR
        ::.:::::.:  ::::. :: :.::. ::::.: ...:.:. :: .:. . ....:  .
NP_001 -GNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-Q
            180       190       200       210       220       230  

          240       250       260       270        280             
pF1KB5 EDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYG----DLN
       : .: .:::. ::.::..:: : ::..:. :.:.::.:. ....:::::::::    . .
NP_001 EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESD
             240       250       260       270       280       290 

     290       300       310       320       330 
pF1KB5 GKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       ...:::::::::...:  ::..::... :::::::  ::: .
NP_001 NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
             300       310       320       330   

>>NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 pre  (333 aa)
 initn: 937 init1: 293 opt: 1101  Z-score: 1320.8  bits: 252.7 E(85289): 7.8e-67
Smith-Waterman score: 1101; 49.7% identity (75.6% similar) in 328 aa overlap (14-331:15-333)

                10        20        30        40        50         
pF1KB5  MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFV
                     : : :  : .:. .:  ::  ... :   :::. :: .::::.:..
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGM-NEEGWRRAVWEKNMKMI
               10        20        30        40         50         

      60        70        80        90         100          110    
pF1KB5 MLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSL--RVPSQ---WQRNITYKSNPNWI
        ::: :.  : ::. ..:: .:::::::  ..:...  : : .   .:. . :..     
NP_001 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-----
      60        70        80        90       100       110         

          120       130       140       150       160       170    
pF1KB5 LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEK
        : :::::::: :: :: ::.::.::::::.::::.:.  :::.:.::: :::::::  .
NP_001 -PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQ
           120       130       140       150       160       170   

          180       190       200       210       220       230    
pF1KB5 YGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGR
        ::.:::::.:  ::::. :: :.::. ::::.: ...:.:. :: .:. . ....:  .
NP_001 -GNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-Q
            180       190       200       210       220       230  

          240       250       260       270        280             
pF1KB5 EDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYG----DLN
       : .: .:::. ::.::..:: : ::..:. :.:.::.:. ....:::::::::    . .
NP_001 EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESD
             240       250       260       270       280       290 

     290       300       310       320       330 
pF1KB5 GKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       ...:::::::::...:  ::..::... :::::::  ::: .
NP_001 NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
             300       310       320       330   

>>NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 pre  (333 aa)
 initn: 937 init1: 293 opt: 1101  Z-score: 1320.8  bits: 252.7 E(85289): 7.8e-67
Smith-Waterman score: 1101; 49.7% identity (75.6% similar) in 328 aa overlap (14-331:15-333)

                10        20        30        40        50         
pF1KB5  MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFV
                     : : :  : .:. .:  ::  ... :   :::. :: .::::.:..
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGM-NEEGWRRAVWEKNMKMI
               10        20        30        40         50         

      60        70        80        90         100          110    
pF1KB5 MLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSL--RVPSQ---WQRNITYKSNPNWI
        ::: :.  : ::. ..:: .:::::::  ..:...  : : .   .:. . :..     
NP_001 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-----
      60        70        80        90       100       110         

          120       130       140       150       160       170    
pF1KB5 LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEK
        : :::::::: :: :: ::.::.::::::.::::.:.  :::.:.::: :::::::  .
NP_001 -PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQ
           120       130       140       150       160       170   

          180       190       200       210       220       230    
pF1KB5 YGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGR
        ::.:::::.:  ::::. :: :.::. ::::.: ...:.:. :: .:. . ....:  .
NP_001 -GNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-Q
            180       190       200       210       220       230  

          240       250       260       270        280             
pF1KB5 EDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYG----DLN
       : .: .:::. ::.::..:: : ::..:. :.:.::.:. ....:::::::::    . .
NP_001 EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESD
             240       250       260       270       280       290 

     290       300       310       320       330 
pF1KB5 GKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       ...:::::::::...:  ::..::... :::::::  ::: .
NP_001 NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
             300       310       320       330   

>>NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 prepro  (333 aa)
 initn: 937 init1: 293 opt: 1101  Z-score: 1320.8  bits: 252.7 E(85289): 7.8e-67
Smith-Waterman score: 1101; 49.7% identity (75.6% similar) in 328 aa overlap (14-331:15-333)

                10        20        30        40        50         
pF1KB5  MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFV
                     : : :  : .:. .:  ::  ... :   :::. :: .::::.:..
NP_666 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGM-NEEGWRRAVWEKNMKMI
               10        20        30        40         50         

      60        70        80        90         100          110    
pF1KB5 MLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSL--RVPSQ---WQRNITYKSNPNWI
        ::: :.  : ::. ..:: .:::::::  ..:...  : : .   .:. . :..     
NP_666 ELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-----
      60        70        80        90       100       110         

          120       130       140       150       160       170    
pF1KB5 LPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEK
        : :::::::: :: :: ::.::.::::::.::::.:.  :::.:.::: :::::::  .
NP_666 -PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQ
           120       130       140       150       160       170   

          180       190       200       210       220       230    
pF1KB5 YGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGR
        ::.:::::.:  ::::. :: :.::. ::::.: ...:.:. :: .:. . ....:  .
NP_666 -GNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-Q
            180       190       200       210       220       230  

          240       250       260       270        280             
pF1KB5 EDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCT-QNVNHGVLVVGYG----DLN
       : .: .:::. ::.::..:: : ::..:. :.:.::.:. ....:::::::::    . .
NP_666 EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESD
             240       250       260       270       280       290 

     290       300       310       320       330 
pF1KB5 GKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
       ...:::::::::...:  ::..::... :::::::  ::: .
NP_666 NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
             300       310       320       330   




331 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 13:10:24 2016 done: Sat Nov  5 13:10:25 2016
 Total Scan time:  6.890 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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