Result of FASTA (omim) for pF1KB6635
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6635, 418 aa
  1>>>pF1KB6635 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5877+/-0.000351; mu= 17.4947+/- 0.022
 mean_var=99.4985+/-19.650, 0's: 0 Z-trim(116.0): 67  B-trim: 579 in 3/53
 Lambda= 0.128578
 statistics sampled from 26697 (26766) to 26697 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.314), width:  16
 Scan time:  9.200

The best scores are:                                      opt bits E(85289)
NP_689419 (OMIM: 606098) sorting nexin-6 isoform b ( 418) 2711 513.3 4.5e-145
XP_006720287 (OMIM: 606098) PREDICTED: sorting nex ( 381) 2032 387.3 3.5e-107
NP_067072 (OMIM: 606098) sorting nexin-6 isoform a ( 290) 1848 353.1 5.4e-97
NP_689413 (OMIM: 605937) sorting nexin-5 isoform a ( 404) 1772 339.1 1.2e-92
NP_055241 (OMIM: 605937) sorting nexin-5 isoform a ( 404) 1772 339.1 1.2e-92
NP_001269383 (OMIM: 605937) sorting nexin-5 isofor ( 299) 1315 254.2 3.2e-67
NP_001265128 (OMIM: 605929) sorting nexin-2 isofor ( 402)  219 51.0 6.2e-06
NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 ( 519)  219 51.1 7.5e-06
NP_683758 (OMIM: 601272) sorting nexin-1 isoform b ( 457)  188 45.3 0.00037
XP_005254668 (OMIM: 601272) PREDICTED: sorting nex ( 399)  187 45.1 0.00038
NP_001229862 (OMIM: 601272) sorting nexin-1 isofor ( 557)  188 45.4 0.00043
NP_003090 (OMIM: 601272) sorting nexin-1 isoform a ( 522)  185 44.8  0.0006


>>NP_689419 (OMIM: 606098) sorting nexin-6 isoform b [Ho  (418 aa)
 initn: 2711 init1: 2711 opt: 2711  Z-score: 2725.5  bits: 513.3 E(85289): 4.5e-145
Smith-Waterman score: 2711; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418)

               10        20        30        40        50        60
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 TVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 TVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
              310       320       330       340       350       360

              370       380       390       400       410        
pF1KB6 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
              370       380       390       400       410        

>>XP_006720287 (OMIM: 606098) PREDICTED: sorting nexin-6  (381 aa)
 initn: 2442 init1: 2032 opt: 2032  Z-score: 2045.3  bits: 387.3 E(85289): 3.5e-107
Smith-Waterman score: 2372; 91.1% identity (91.1% similar) in 418 aa overlap (1-418:1-381)

               10        20        30        40        50        60
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 TVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQ
       :::::                                     ::::::::::::::::::
XP_006 TVHTK-------------------------------------IPPAPPRPDFDASREKLQ
                                                    70        80   

              130       140       150       160       170       180
pF1KB6 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLE
            90       100       110       120       130       140   

              190       200       210       220       230       240
pF1KB6 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDAS
           150       160       170       180       190       200   

              250       260       270       280       290       300
pF1KB6 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADE
           210       220       230       240       250       260   

              310       320       330       340       350       360
pF1KB6 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCC
           270       280       290       300       310       320   

              370       380       390       400       410        
pF1KB6 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
           330       340       350       360       370       380 

>>NP_067072 (OMIM: 606098) sorting nexin-6 isoform a [Ho  (290 aa)
 initn: 1848 init1: 1848 opt: 1848  Z-score: 1862.4  bits: 353.1 E(85289): 5.4e-97
Smith-Waterman score: 1848; 100.0% identity (100.0% similar) in 290 aa overlap (129-418:1-290)

      100       110       120       130       140       150        
pF1KB6 AGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEV
                                     ::::::::::::::::::::::::::::::
NP_067                               MTKEEFTKMKQELEAEYLAIFKKTVAMHEV
                                             10        20        30

      160       170       180       190       200       210        
pF1KB6 FLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 FLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDV
               40        50        60        70        80        90

      220       230       240       250       260       270        
pF1KB6 DDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 DDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKF
              100       110       120       130       140       150

      280       290       300       310       320       330        
pF1KB6 FLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 FLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKA
              160       170       180       190       200       210

      340       350       360       370       380       390        
pF1KB6 LDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELK
              220       230       240       250       260       270

      400       410        
pF1KB6 HAKGNLQLLQNCLAVLNGDT
       ::::::::::::::::::::
NP_067 HAKGNLQLLQNCLAVLNGDT
              280       290

>>NP_689413 (OMIM: 605937) sorting nexin-5 isoform a [Ho  (404 aa)
 initn: 1767 init1: 1739 opt: 1772  Z-score: 1784.3  bits: 339.1 E(85289): 1.2e-92
Smith-Waterman score: 1772; 64.5% identity (90.0% similar) in 400 aa overlap (21-417:5-404)

               10        20          30         40        50       
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLS--EEDRG-LKAINVDLQSDAALQVDISDALSERDK
                           :..:.  ::::. :....:::. : .::.:: ::::::::
NP_689                 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
                               10        20        30        40    

        60        70        80        90       100       110       
pF1KB6 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE
       ::::::::..::.:.. ::::.::::.:.::::...:. :::: :::::: .::::. ::
NP_689 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE
           50        60        70        80        90       100    

       120       130       140       150       160       170       
pF1KB6 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
       :.:::::::::::::::.::::::::::::.:::::. ::::: :...::.: .: ::::
NP_689 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV
          110       120       130       140       150       160    

       180       190       200       210       220       230       
pF1KB6 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVK
       ::::.:::::: :: :: .  :::..::::: :. .:::.::::::.:..::..:.::.:
NP_689 FLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIK
          170       180       190       200       210       220    

       240       250       260       270       280       290       
pF1KB6 DASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVS
       :. .:.:.::::::..:::: . .. :..:. .. : : :..:::.:::.: ::.:.:::
NP_689 DSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVS
          230       240       250       260       270       280    

       300       310       320       330       340       350       
pF1KB6 ADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQ
       .::::::..::.::. . .:::::::::...:.::::.:::::::: :.:::  ::. ::
NP_689 SDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQ
          290       300       310       320       330       340    

       360       370       380       390       400       410       
pF1KB6 LCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGD
        ::::::..:::::.:::.:: .:::::::::.:..:::.:::..:..:::.:. .....
NP_689 ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
          350       360       370       380       390       400    

        
pF1KB6 T

>>NP_055241 (OMIM: 605937) sorting nexin-5 isoform a [Ho  (404 aa)
 initn: 1767 init1: 1739 opt: 1772  Z-score: 1784.3  bits: 339.1 E(85289): 1.2e-92
Smith-Waterman score: 1772; 64.5% identity (90.0% similar) in 400 aa overlap (21-417:5-404)

               10        20          30         40        50       
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLS--EEDRG-LKAINVDLQSDAALQVDISDALSERDK
                           :..:.  ::::. :....:::. : .::.:: ::::::::
NP_055                 MAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDK
                               10        20        30        40    

        60        70        80        90       100       110       
pF1KB6 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE
       ::::::::..::.:.. ::::.::::.:.::::...:. :::: :::::: .::::. ::
NP_055 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE
           50        60        70        80        90       100    

       120       130       140       150       160       170       
pF1KB6 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
       :.:::::::::::::::.::::::::::::.:::::. ::::: :...::.: .: ::::
NP_055 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV
          110       120       130       140       150       160    

       180       190       200       210       220       230       
pF1KB6 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVK
       ::::.:::::: :: :: .  :::..::::: :. .:::.::::::.:..::..:.::.:
NP_055 FLEYDQDLSVRRKNTKEMFGGFFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIK
          170       180       190       200       210       220    

       240       250       260       270       280       290       
pF1KB6 DASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVS
       :. .:.:.::::::..:::: . .. :..:. .. : : :..:::.:::.: ::.:.:::
NP_055 DSCVKADKMTRSHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVS
          230       240       250       260       270       280    

       300       310       320       330       340       350       
pF1KB6 ADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQ
       .::::::..::.::. . .:::::::::...:.::::.:::::::: :.:::  ::. ::
NP_055 SDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQ
          290       300       310       320       330       340    

       360       370       380       390       400       410       
pF1KB6 LCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGD
        ::::::..:::::.:::.:: .:::::::::.:..:::.:::..:..:::.:. .....
NP_055 ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIKHARNNVSLLQSCIDLFKNN
          350       360       370       380       390       400    

        
pF1KB6 T

>>NP_001269383 (OMIM: 605937) sorting nexin-5 isoform b   (299 aa)
 initn: 1312 init1: 1312 opt: 1315  Z-score: 1327.9  bits: 254.2 E(85289): 3.2e-67
Smith-Waterman score: 1315; 64.5% identity (90.3% similar) in 299 aa overlap (119-417:1-299)

       90       100       110       120       130       140        
pF1KB6 HDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAI
                                     .:::::::::::::::.::::::::::::.
NP_001                               MQKLGEGEGSMTKEEFAKMKQELEAEYLAV
                                             10        20        30

      150       160       170       180       190       200        
pF1KB6 FKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSAD
       :::::. ::::: :...::.: .: ::::::::.:::::: :: :: .  :::..:::::
NP_001 FKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGGFFKSVVKSAD
               40        50        60        70        80        90

      210       220       230       240       250       260        
pF1KB6 GVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG
        :. .:::.::::::.:..::..:.::.::. .:.:.::::::..:::: . .. :..:.
NP_001 EVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVADDYIHTAACLHSLA
              100       110       120       130       140       150

      270       280       290       300       310       320        
pF1KB6 TQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRS
        .. : : :..:::.:::.: ::.:.:::.::::::..::.::. . .:::::::::...
NP_001 LEEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKA
              160       170       180       190       200       210

      330       340       350       360       370       380        
pF1KB6 LVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKN
       :.::::.:::::::: :.:::  ::. :: ::::::..:::::.:::.:: .::::::::
NP_001 LIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKN
              220       230       240       250       260       270

      390       400       410        
pF1KB6 LVELAELELKHAKGNLQLLQNCLAVLNGDT
       :.:..:::.:::..:..:::.:. ..... 
NP_001 LIEMSELEIKHARNNVSLLQSCIDLFKNN 
              280       290          

>>NP_001265128 (OMIM: 605929) sorting nexin-2 isoform 2   (402 aa)
 initn: 280 init1: 151 opt: 219  Z-score: 227.5  bits: 51.0 E(85289): 6.2e-06
Smith-Waterman score: 297; 24.0% identity (57.0% similar) in 391 aa overlap (28-394:8-378)

               10        20        30        40         50         
pF1KB6 MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDA-ALQVDISDALSERDKVK
                                  ::. . :. . ..:   ... .::  .  : ..
NP_001                     MSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMN
                                   10        20        30        40

          60        70        80        90       100       110     
pF1KB6 ----FTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDAS
           . : ::.::  :...:::: :.  .:. ::.... .  ..:::.:::: .     .
NP_001 AYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMT
               50        60        70        80        90       100

         120       130       140       150       160       170     
pF1KB6 REKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNF
       . :.   :. ..: :  ::..             :. .:. : .: :.. :: : .: ..
NP_001 KVKV---GKEDSSST--EFVE-------------KRRAAL-ERYLQRTVKHPTLLQDPDL
                 110                      120        130       140 

         180       190       200       210         220       230   
pF1KB6 HVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLLEYH
       . ::: ...:    ...  .   ... . :.::.:    .:  . : .::...  . .  
NP_001 RQFLE-SSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLD
              150       160       170       180       190       200

           240       250       260        270       280       290  
pF1KB6 NRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG-TQDSTDICKFFLKVSELFDKTRKI
       ....   .. . ..  .:  . .   ...:   :: ..: : . . . ...:. .:  ..
NP_001 QQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQL
              210       220       230       240       250       260

            300       310       320       330       340            
pF1KB6 EARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKAR---AK----
       . . .  .   .:.::. :.:   :.: .. .: .    .:.:. .: : :   ::    
NP_001 HQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVA
              270       280       290       300       310       320

           350              360       370       380       390      
pF1KB6 NKD--VLQA-------ETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELE
       ::   . ::       :.. :   . ::.::.. ..:.  :. .::  :.  ...  :  
NP_001 NKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESL
              330       340       350       360       370       380

        400       410        
pF1KB6 LKHAKGNLQLLQNCLAVLNGDT
                             
NP_001 VQTQQQLIKYWEAFLPEAKAIA
              390       400  

>>NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 [Ho  (519 aa)
 initn: 253 init1: 151 opt: 219  Z-score: 226.0  bits: 51.1 E(85289): 7.5e-06
Smith-Waterman score: 297; 24.0% identity (57.0% similar) in 391 aa overlap (28-394:125-495)

                  10        20        30        40         50      
pF1KB6    MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDA-ALQVDISDALSERD
                                     ::. . :. . ..:   ... .::  .  :
NP_003 EPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGD
          100       110       120       130       140       150    

             60        70        80        90       100       110  
pF1KB6 KVK----FTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDF
        ..    . : ::.::  :...:::: :.  .:. ::.... .  ..:::.:::: .   
NP_003 GMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIV
          160       170       180       190       200       210    

            120       130       140       150       160       170  
pF1KB6 DASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRD
         .. :.   :. ..: :  ::..             :. .:. : .: :.. :: : .:
NP_003 GMTKVKV---GKEDSSST--EFVE-------------KRRAAL-ERYLQRTVKHPTLLQD
          220            230                     240       250     

            180       190       200       210         220       230
pF1KB6 LNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLL
        ... ::: ...:    ...  .   ... . :.::.:    .:  . : .::...  . 
NP_003 PDLRQFLE-SSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFE
         260        270       280       290       300       310    

              240       250       260        270       280         
pF1KB6 EYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG-TQDSTDICKFFLKVSELFDKT
       .  ....   .. . ..  .:  . .   ...:   :: ..: : . . . ...:. .: 
NP_003 NLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTALSRALSQLAEVEEKI
          320       330       340       350       360       370    

     290       300       310       320       330       340         
pF1KB6 RKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKAR---AK-
        ... . .  .   .:.::. :.:   :.: .. .: .    .:.:. .: : :   :: 
NP_003 DQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDAQITLLKKREAEAKM
          380       390       400       410       420       430    

              350              360       370       380       390   
pF1KB6 ---NKD--VLQA-------ETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELA
          ::   . ::       :.. :   . ::.::.. ..:.  :. .::  :.  ...  
NP_003 MVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYL
          440       450       460       470       480       490    

           400       410        
pF1KB6 ELELKHAKGNLQLLQNCLAVLNGDT
       :                        
NP_003 ESLVQTQQQLIKYWEAFLPEAKAIA
          500       510         

>>NP_683758 (OMIM: 601272) sorting nexin-1 isoform b [Ho  (457 aa)
 initn: 116 init1:  65 opt: 188  Z-score: 195.7  bits: 45.3 E(85289): 0.00037
Smith-Waterman score: 298; 22.1% identity (55.8% similar) in 389 aa overlap (28-397:69-436)

                  10        20        30        40        50       
pF1KB6    MRACAGPRLGAAMMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDK
                                     . : :  ..  ..:   : :.  . .    
NP_683 SDTEGEDIFTGAAVVSKHQSPKITTSLLPINNGSKENGIHEEQDQEPQ-DLFAGDGMNAY
       40        50        60        70        80         90       

        60        70        80        90       100       110       
pF1KB6 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE
       : . : :..::: :....:.: :.  .:. :.... :...  :.:.:: : .  .  .. 
NP_683 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKV
       100       110       120       130       140       150       

       120       130       140       150       160       170       
pF1KB6 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV
       :. :    : : .            ::.:   :. .:. : .: :.. :: . .: . . 
NP_683 KVGK----EDSSS------------AEFLE--KRRAAL-ERYLQRIVNHPTMLQDPDVRE
       160                       170          180       190        

       180       190       200       210         220       230     
pF1KB6 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLLEYHNR
       ::: ...:     ..  .   ..: . :..:.:    .:  . : .::..   .   ..:
NP_683 FLE-KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQR
      200        210       220       230       240       250       

         240       250       260        270       280       290    
pF1KB6 VKDASAKSDRMTRSHKSAADDYNRIGSSLYALGT-QDSTDICKFFLKVSELFDKTRKIEA
       ..   :  . ..  .:  : .  ....::  ::. .:.: . . . ...:. .: .... 
NP_683 LRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQ
       260       270       280       290       300       310       

          300       310       320       330       340       350    
pF1KB6 RVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAET
       . . .. . :..::. :.:    ..  . .: ..   ...:. .:.: :  .  .: :. 
NP_683 EQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANK
       320       330       340       350       360       370       

          360                       370       380       390        
pF1KB6 SQQLCCQK----------------FEKISESAKQELIDFKTRRVAAFRKNLVELAELELK
        ..:   :                ::.::  ...:.: :. ..   :......  :  : 
NP_683 PDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLY
       380       390       400       410       420       430       

      400       410        
pF1KB6 HAKGNLQLLQNCLAVLNGDT
                           
NP_683 SQQQLAKYWEAFLPEAKAIS
       440       450       

>>XP_005254668 (OMIM: 601272) PREDICTED: sorting nexin-1  (399 aa)
 initn: 116 init1:  65 opt: 187  Z-score: 195.4  bits: 45.1 E(85289): 0.00038
Smith-Waterman score: 297; 22.6% identity (56.8% similar) in 359 aa overlap (58-397:5-343)

        30        40        50        60        70        80       
pF1KB6 DRGLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIW
                                     : . : :..::: :....:.: :.  .:. 
XP_005                           MNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLG
                                         10        20        30    

        90       100       110       120       130       140       
pF1KB6 LHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLA
       :.... :...  :.:.:: : .  .  .. :. :    : : .            ::.: 
XP_005 LYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGK----EDSSS------------AEFLE
           40        50        60            70                    

       150       160       170       180       190       200       
pF1KB6 IFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSA
         :. .:. : .: :.. :: . .: . . ::: ...:     ..  .   ..: . :..
XP_005 --KRRAAL-ERYLQRIVNHPTMLQDPDVREFLE-KEELPRAVGTQTLSGAGLLKMFNKAT
         80         90       100        110       120       130    

       210         220       230       240       250       260     
pF1KB6 DGVIVSGVK--DVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLY
       :.:    .:  . : .::..   .   ..:..   :  . ..  .:  : .  ....:: 
XP_005 DAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLA
          140       150       160       170       180       190    

          270       280       290       300       310       320    
pF1KB6 ALGT-QDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYR
        ::. .:.: . . . ...:. .: .... . . .. . :..::. :.:    ..  . .
XP_005 MLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQ
          200       210       220       230       240       250    

          330       340       350       360                        
pF1KB6 RSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQK----------------FEKISE
       : ..   ...:. .:.: :  .  .: :.  ..:   :                ::.:: 
XP_005 RMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERIST
          260       270       280       290       300       310    

      370       380       390       400       410                  
pF1KB6 SAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT          
        ...:.: :. ..   :......  :  :                               
XP_005 VVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQAGEQLGIRSGILLTKKLPRYSKFFST
          320       330       340       350       360       370    




418 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 11:11:37 2016 done: Sat Nov  5 11:11:39 2016
 Total Scan time:  9.200 Total Display time:  0.040

Function used was FASTA [36.3.4 Apr, 2011]
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