Result of FASTA (omim) for pF1KB6620
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6620, 435 aa
  1>>>pF1KB6620 435 - 435 aa - 435 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.0811+/-0.000343; mu= 2.5063+/- 0.021
 mean_var=294.6581+/-60.279, 0's: 0 Z-trim(124.1): 67  B-trim: 808 in 1/61
 Lambda= 0.074716
 statistics sampled from 44920 (45005) to 44920 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.825), E-opt: 0.2 (0.528), width:  16
 Scan time:  9.570

The best scores are:                                      opt bits E(85289)
NP_002333 (OMIM: 600979) tumor necrosis factor rec ( 435) 3169 354.7 2.8e-97
NP_001257916 (OMIM: 600979) tumor necrosis factor  ( 416) 2956 331.7 2.2e-90
XP_005253745 (OMIM: 600979) PREDICTED: tumor necro ( 399) 1668 192.8 1.3e-48
XP_006719046 (OMIM: 600979) PREDICTED: tumor necro ( 255) 1650 190.7 3.8e-48
NP_001057 (OMIM: 191191) tumor necrosis factor rec ( 461)  451 61.7 4.5e-09
XP_011540365 (OMIM: 191191) PREDICTED: tumor necro ( 462)  451 61.7 4.5e-09
XP_011540362 (OMIM: 191191) PREDICTED: tumor necro ( 484)  451 61.7 4.7e-09
XP_016857700 (OMIM: 191191) PREDICTED: tumor necro ( 491)  451 61.7 4.7e-09
NP_003814 (OMIM: 603361) tumor necrosis factor rec ( 300)  417 57.8 4.3e-08
XP_016883626 (OMIM: 109535,606843) PREDICTED: tumo ( 222)  412 57.2 5.1e-08
NP_001241 (OMIM: 109535,606843) tumor necrosis fac ( 277)  412 57.3 5.9e-08
NP_001309350 (OMIM: 109535,606843) tumor necrosis  ( 281)  412 57.3   6e-08
NP_001257878 (OMIM: 174810,602080,603499,612301) t ( 263)  405 56.5 9.6e-08
NP_001289682 (OMIM: 109535,606843) tumor necrosis  ( 237)  403 56.2   1e-07
XP_016883624 (OMIM: 109535,606843) PREDICTED: tumo ( 323)  403 56.4 1.3e-07
NP_001257879 (OMIM: 174810,602080,603499,612301) t ( 337)  403 56.4 1.3e-07
NP_003830 (OMIM: 174810,602080,603499,612301) tumo ( 616)  405 56.9 1.7e-07
NP_001257880 (OMIM: 174810,602080,603499,612301) t ( 299)  386 54.5 4.3e-07
XP_011524546 (OMIM: 174810,602080,603499,612301) P ( 621)  386 54.8 7.1e-07
XP_016857702 (OMIM: 191191) PREDICTED: tumor necro ( 440)  377 53.7 1.1e-06
XP_016857701 (OMIM: 191191) PREDICTED: tumor necro ( 440)  377 53.7 1.1e-06
NP_690593 (OMIM: 109535,606843) tumor necrosis fac ( 203)  357 51.2 2.9e-06
XP_016883625 (OMIM: 109535,606843) PREDICTED: tumo ( 289)  357 51.4 3.7e-06
NP_003811 (OMIM: 602746) tumor necrosis factor rec ( 283)  350 50.6 6.2e-06
NP_002537 (OMIM: 239000,602643) tumor necrosis fac ( 401)  339 49.6 1.8e-05
XP_016866233 (OMIM: 605732) PREDICTED: tumor necro ( 444)  337 49.4 2.2e-05
XP_006711082 (OMIM: 602746) PREDICTED: tumor necro ( 197)  329 48.2 2.3e-05
NP_001284534 (OMIM: 602746) tumor necrosis factor  ( 184)  328 48.0 2.4e-05
NP_055267 (OMIM: 605732) tumor necrosis factor rec ( 655)  337 49.6 2.9e-05
NP_001056 (OMIM: 142680,191190,614810) tumor necro ( 455)  329 48.6 4.1e-05
XP_016881554 (OMIM: 174810,602080,603499,612301) P ( 566)  312 46.8 0.00017
XP_011540743 (OMIM: 153243) PREDICTED: tumor necro ( 594)  304 46.0 0.00032
NP_001234 (OMIM: 153243) tumor necrosis factor rec ( 595)  304 46.0 0.00032
XP_011527411 (OMIM: 109535,606843) PREDICTED: tumo ( 166)  267 41.4  0.0021
NP_001309351 (OMIM: 109535,606843) tumor necrosis  ( 225)  267 41.5  0.0026
XP_005260676 (OMIM: 109535,606843) PREDICTED: tumo ( 229)  267 41.6  0.0026
NP_001265197 (OMIM: 174810,602080,603499,612301) t ( 602)  266 41.9  0.0055
NP_690610 (OMIM: 134637,601859) tumor necrosis fac ( 314)  257 40.6  0.0069
XP_011538067 (OMIM: 134637,601859) PREDICTED: tumo ( 368)  257 40.7  0.0077
NP_001307548 (OMIM: 134637,601859) tumor necrosis  ( 197)  251 39.8  0.0079
NP_690611 (OMIM: 134637,601859) tumor necrosis fac ( 220)  251 39.8  0.0085


>>NP_002333 (OMIM: 600979) tumor necrosis factor recepto  (435 aa)
 initn: 3169 init1: 3169 opt: 3169  Z-score: 1867.5  bits: 354.7 E(85289): 2.8e-97
Smith-Waterman score: 3169; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)

               10        20        30        40        50        60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB6 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB6 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
              370       380       390       400       410       420

              430     
pF1KB6 TPSNRGPRNQFITHD
       :::::::::::::::
NP_002 TPSNRGPRNQFITHD
              430     

>>NP_001257916 (OMIM: 600979) tumor necrosis factor rece  (416 aa)
 initn: 2948 init1: 2948 opt: 2956  Z-score: 1743.7  bits: 331.7 E(85289): 2.2e-90
Smith-Waterman score: 2956; 98.5% identity (99.0% similar) in 413 aa overlap (23-435:5-416)

               10        20        30        40        50        60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
                             :.  ::: . ::::::::::::::::::::::::::::
NP_001                   MEATGISLASQLK-VPPYASENQTCRDQEKEYYEPQHRICCS
                                 10         20        30        40 

               70        80        90       100       110       120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
              50        60        70        80        90       100 

              130       140       150       160       170       180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
             110       120       130       140       150       160 

              190       200       210       220       230       240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
             170       180       190       200       210       220 

              250       260       270       280       290       300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
             230       240       250       260       270       280 

              310       320       330       340       350       360
pF1KB6 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
             290       300       310       320       330       340 

              370       380       390       400       410       420
pF1KB6 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
             350       360       370       380       390       400 

              430     
pF1KB6 TPSNRGPRNQFITHD
       :::::::::::::::
NP_001 TPSNRGPRNQFITHD
             410      

>>XP_005253745 (OMIM: 600979) PREDICTED: tumor necrosis   (399 aa)
 initn: 1734 init1: 1668 opt: 1668  Z-score: 993.6  bits: 192.8 E(85289): 1.3e-48
Smith-Waterman score: 2846; 91.7% identity (91.7% similar) in 435 aa overlap (1-435:1-399)

               10        20        30        40        50        60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
       :::::::::::::::::::::::::::::::::::::::::::                 
XP_005 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSG-----------------
              190       200       210       220                    

              250       260       270       280       290       300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
                          :::::::::::::::::::::::::::::::::::::::::
XP_005 -------------------SLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
                              230       240       250       260    

              310       320       330       340       350       360
pF1KB6 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTITGN
          270       280       290       300       310       320    

              370       380       390       400       410       420
pF1KB6 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGPPGLSTPHQEDGKAWHLAETEHCGA
          330       340       350       360       370       380    

              430     
pF1KB6 TPSNRGPRNQFITHD
       :::::::::::::::
XP_005 TPSNRGPRNQFITHD
          390         

>>XP_006719046 (OMIM: 600979) PREDICTED: tumor necrosis   (255 aa)
 initn: 1650 init1: 1650 opt: 1650  Z-score: 985.4  bits: 190.7 E(85289): 3.8e-48
Smith-Waterman score: 1650; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222)

               10        20        30        40        50        60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLLL
       ::::::::::::::::::::::::::::::::::::::::::                  
XP_006 PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSEPALSKGVENLQALLYQA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 ATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISGD
                                                                   
XP_006 ATGSSEASFPTLSPL                                             
              250                                                  

>>NP_001057 (OMIM: 191191) tumor necrosis factor recepto  (461 aa)
 initn: 341 init1: 199 opt: 451  Z-score: 283.8  bits: 61.7 E(85289): 4.5e-09
Smith-Waterman score: 472; 29.8% identity (53.3% similar) in 392 aa overlap (9-376:2-352)

               10        20          30           40        50     
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
               ::  .:. :..::  : ::..  :  :   ::: : ..:::   .:::.   
NP_001        MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
                      10         20        30        40          50

          60        70        80        90       100          110  
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
       ..:::.: :: .... :..  :::: .: ...:.. ::..  :  :   :  : :    :
NP_001 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
               60        70        80        90       100          

            120       130        140       150       160       170 
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
          :: ...  : :.:: .::    : :  :  :  : ::  .  .  .  ..  : :: 
NP_001 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
        110       120       130       140       150        160     

             180       190       200       210         220         
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
        : :.::.: .  :.::  :.    : : ::.:. :..: .  : . . :   :     :
NP_001 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAP---G-----A
         170       180           190       200       210           

     230       240       250        260       270       280        
pF1KB6 VLLPLAFFLLLATVFSCIWKS-HPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFP
       : ::      ..:  .    . .::   . . ::   :.: .: :. ::           
NP_001 VHLPQP----VSTRSQHTQPTPEPSTAPSTSFLL---PMGPSP-PAEGS---------TG
               220       230       240           250               

      290       300       310       320         330          340   
pF1KB6 DLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQ--QSPLDLTRE---PQLEPGEQSQVAH
       :..   ::..  :. .. ::    :..  .  :  ..:: : ::   :.: :..... ..
NP_001 DFA---LPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHL-PADKARGTQ
           260       270       280       290       300        310  

           350              360       370       380       390      
pF1KB6 GTNGIHV-------TGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGP
       : .  :.       ...:.  ...     .:. . : .::                    
NP_001 GPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSP
            320       330       340       350       360       370  

        400       410       420       430                          
pF1KB6 PGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD                     
                                                                   
NP_001 GGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRS
            380       390       400       410       420       430  

>>XP_011540365 (OMIM: 191191) PREDICTED: tumor necrosis   (462 aa)
 initn: 341 init1: 199 opt: 451  Z-score: 283.8  bits: 61.7 E(85289): 4.5e-09
Smith-Waterman score: 476; 29.2% identity (52.6% similar) in 418 aa overlap (9-401:2-378)

               10        20          30           40        50     
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
               ::  .:. :..::  : ::..  :  :   ::: : ..:::   .:::.   
XP_011        MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
                      10         20        30        40          50

          60        70        80        90       100          110  
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
       ..:::.: :: .... :..  :::: .: ...:.. ::..  :  :   :  : :    :
XP_011 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
               60        70        80        90       100          

            120       130        140       150       160       170 
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
          :: ...  : :.:: .::    : :  :  :  : ::  .  .  .  ..  : :: 
XP_011 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
        110       120       130       140       150        160     

             180       190       200       210         220         
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
        : :.::.: .  :.::  :.    : : ::.:. :..: .  : . . :   :     :
XP_011 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAP---G-----A
         170       180           190       200       210           

     230       240       250        260       270       280        
pF1KB6 VLLPLAFFLLLATVFSCIWKS-HPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFP
       : ::      ..:  .    . .::   . . ::   :.: .: :. ::           
XP_011 VHLPQP----VSTRSQHTQPTPEPSTAPSTSFLL---PMGPSP-PAEGS---------TG
               220       230       240           250               

      290       300       310       320         330          340   
pF1KB6 DLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQ--QSPLDLTRE---PQLEPGEQSQVAH
       :..   ::..  :. .. ::    :..  .  :  ..:: : ::   :.: :..... ..
XP_011 DFA---LPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHL-PADKARGTQ
           260       270       280       290       300        310  

           350              360       370        380       390     
pF1KB6 GTNGIHV-------TGGSMTITGNIYIYNGPVLGGPPGPG-DLPATPEPPYPIPEEGDPG
       : .  :.       ...:.  ...     .:. . : .:: .  .. :        .: .
XP_011 GPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSADSS
            320       330       340       350       360       370  

         400       410       420       430                         
pF1KB6 PPGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD                    
       : : .:                                                      
XP_011 PGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFR
            380       390       400       410       420       430  

>>XP_011540362 (OMIM: 191191) PREDICTED: tumor necrosis   (484 aa)
 initn: 341 init1: 199 opt: 451  Z-score: 283.6  bits: 61.7 E(85289): 4.7e-09
Smith-Waterman score: 482; 29.1% identity (51.9% similar) in 443 aa overlap (9-427:2-395)

               10        20          30           40        50     
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
               ::  .:. :..::  : ::..  :  :   ::: : ..:::   .:::.   
XP_011        MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
                      10         20        30        40          50

          60        70        80        90       100          110  
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
       ..:::.: :: .... :..  :::: .: ...:.. ::..  :  :   :  : :    :
XP_011 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
               60        70        80        90       100          

            120       130        140       150       160       170 
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
          :: ...  : :.:: .::    : :  :  :  : ::  .  .  .  ..  : :: 
XP_011 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
        110       120       130       140       150        160     

             180       190       200       210         220         
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
        : :.::.: .  :.::  :.    : : ::.:. :..: .  : . . :   :     :
XP_011 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAP---G-----A
         170       180           190       200       210           

     230       240       250        260       270       280        
pF1KB6 VLLPLAFFLLLATVFSCIWKS-HPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFP
       : ::      ..:  .    . .::   . . ::   :.: .: :. ::           
XP_011 VHLPQP----VSTRSQHTQPTPEPSTAPSTSFLL---PMGPSP-PAEGS---------TG
               220       230       240           250               

      290       300       310       320         330          340   
pF1KB6 DLVQPLLPISGDVSPVSTGLPAAPVLEAGVPQQ--QSPLDLTRE---PQLEPGEQSQVAH
       :..   ::..  :. .. ::    :..  .  :  ..:: : ::   :.: :..... ..
XP_011 DFA---LPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHL-PADKARGTQ
           260       270       280       290       300        310  

           350              360       370       380       390      
pF1KB6 GTNGIHV-------TGGSMTITGNIYIYNGPVLGGPPGPGDLPATPEPPYPIPEEGDPGP
       : .  :.       ...:.  ...     .:. . : .::      :       ... : 
XP_011 GPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPG-----VEASGAGEARASTGS
            320       330       340       350            360       

        400       410       420       430                          
pF1KB6 PGLSTPHQEDGKAWHLAETEHCGATPSNRGPRNQFITHD                     
        :::    .  .   :. :  :: ::.. .:                             
XP_011 SGLSDCMYR--HCLLLSPTPGCG-TPADSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQA
       370         380        390       400       410       420    

XP_011 SSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
          430       440       450       460       470       480    

>>XP_016857700 (OMIM: 191191) PREDICTED: tumor necrosis   (491 aa)
 initn: 341 init1: 199 opt: 451  Z-score: 283.5  bits: 61.7 E(85289): 4.7e-09
Smith-Waterman score: 451; 35.1% identity (57.2% similar) in 222 aa overlap (9-219:2-211)

               10        20          30           40        50     
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQ--PQAVP--PYASE-NQTCRDQEKEYYEPQH
               ::  .:. :..::  : ::..  :  :   ::: : ..:::   .:::.   
XP_016        MAPVAVWAALAVGLE-LWAAAHALPAQVAFTPYAPEPGSTCR--LREYYDQTA
                      10         20        30        40          50

          60        70        80        90       100          110  
pF1KB6 RICCSRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRP-C--DPVMGLEE
       ..:::.: :: .... :..  :::: .: ...:.. ::..  :  :   :  : :    :
XP_016 QMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQV----E
               60        70        80        90       100          

            120       130        140       150       160       170 
pF1KB6 IAPCTSKRKTQCRCQPGMFCAAWALE-CTHCELLSDCPPGTEAELKDEVGKGNNHCVPCK
          :: ...  : :.:: .::    : :  :  :  : ::  .  .  .  ..  : :: 
XP_016 TQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVA-RPGTETSDVVCKPCA
        110       120       130       140       150        160     

             180       190       200       210         220         
pF1KB6 AGHFQNTSSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKN--PLEPLPPEMSGTMLMLA
        : :.::.: .  :.::  :.    : : ::.:. :..: .  : . . :          
XP_016 PGTFSNTTSSTDICRPHQICN----VVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVS
         170       180           190       200       210       220 

     230       240       250       260       270       280         
pF1KB6 VLLPLAFFLLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPD
                                                                   
XP_016 TRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNC
             230       240       250       260       270       280 

>>NP_003814 (OMIM: 603361) tumor necrosis factor recepto  (300 aa)
 initn: 366 init1: 182 opt: 417  Z-score: 266.3  bits: 57.8 E(85289): 4.3e-08
Smith-Waterman score: 434; 32.1% identity (53.6% similar) in 274 aa overlap (6-276:3-249)

               10        20        30        40        50        60
pF1KB6 MLLPWATSAPGLAWGPLVLGLFGLLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICCS
            :  .:::.   :::.: .:: .   ..:    .:. :   .. :  :   :. :.
NP_003    MRALEGPGLSLLCLVLALPALLPVPAVRGV----AETPTYPWRDAETGE---RLVCA
                  10        20        30            40           50

               70        80        90       100       110          
pF1KB6 RCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGL--EEIAPCTS
       .:::::.:.  : :   :.:. :    :.. ::::   . :: :. . :   ::   : .
NP_003 QCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYL---ERCRYCNVLCGEREEEARACHA
               60        70        80           90       100       

      120       130       140       150       160       170        
pF1KB6 KRKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNT
        ..  :::. :.:  :       :   ..::::. . .   . . :..: ::  : :. .
NP_003 THNRACRCRTGFFAHA-----GFCLEHASCPPGAGV-IAPGTPSQNTQCQPCPPGTFSAS
       110       120            130        140       150       160 

      180       190       200       210        220       230       
pF1KB6 SSPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLE-PLPPEMSGTMLMLAVLLPLAFF
       :: : .::::  :   ::.  .::... :: : .    ::  .. :.     ... .. :
NP_003 SSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAF
             170       180       190       200       210       220 

       240       250       260       270       280       290       
pF1KB6 LLLATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPI
         .         :   : : : .:  . :.: ::.: ::                     
NP_003 QDI---------SIKRLQRLLQAL--EAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDG
                      230         240       250       260       270

       300       310       320       330       340       350       
pF1KB6 SGDVSPVSTGLPAAPVLEAGVPQQQSPLDLTREPQLEPGEQSQVAHGTNGIHVTGGSMTI
                                                                   
NP_003 ALLVRLLQALRVARMPGLERSVRERFLPVH                              
              280       290       300                              

>>XP_016883626 (OMIM: 109535,606843) PREDICTED: tumor ne  (222 aa)
 initn: 330 init1: 173 opt: 412  Z-score: 265.0  bits: 57.2 E(85289): 5.1e-08
Smith-Waterman score: 441; 33.0% identity (57.4% similar) in 230 aa overlap (16-244:5-214)

               10        20         30        40        50         
pF1KB6 MLLPWATSAPGLAWGPLVLGLFG-LLAASQPQAVPPYASENQTCRDQEKEYYEPQHRICC
                      ::   :.: ::.: .:.  :: :     ::  ::.:   ..  ::
XP_016            MVRLPLQCVLWGCLLTAVHPE--PPTA-----CR--EKQYLINSQ--CC
                          10        20                 30          

      60        70        80        90       100       110         
pF1KB6 SRCPPGTYVSAKCSRIRDTVCATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSK
       : : ::  . . :... .: :  :.:. . . ::  : :.  . ::: .::.     ::.
XP_016 SLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSE
       40        50        60        70        80        90        

     120       130       140       150       160       170         
pF1KB6 RKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTS
         : : :. :  :.. :  :  : :  .: ::  .. .  .: ... : :: .: :.:.:
XP_016 TDTICTCEEGWHCTSEA--CESCVLHRSCSPGFGVK-QIATGVSDTICEPCPVGFFSNVS
      100       110         120       130        140       150     

     180       190       200       210       220       230         
pF1KB6 SPSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTMLMLAVLLPLAFFLL
       :   .:.: : ::.. ::    :: ..:..:       : .   ..... ... . : .:
XP_016 SAFEKCHPWTSCETKDLVVQQAGTNKTDVVCG------PQDRLRALVVIPIIFGILFAIL
         160       170       180             190       200         

     240       250       260       270       280       290         
pF1KB6 LATVFSCIWKSHPSLCRKLGSLLKRRPQGEGPNPVAGSWEPPKAHPYFPDLVQPLLPISG
       :. ::                                                       
XP_016 LVLVFISGQEANQ                                               
     210       220                                                 




435 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 11:08:46 2016 done: Sat Nov  5 11:08:47 2016
 Total Scan time:  9.570 Total Display time:  0.040

Function used was FASTA [36.3.4 Apr, 2011]
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