Result of FASTA (omim) for pF1KF0386
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KF0386, 674 aa
  1>>>pF1KF0386 674 - 674 aa - 674 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 19.7648+/-0.000502; mu= -47.4213+/- 0.031
 mean_var=903.3502+/-187.061, 0's: 0 Z-trim(125.7): 124  B-trim: 0 in 0/62
 Lambda= 0.042672
 statistics sampled from 49776 (49944) to 49776 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.814), E-opt: 0.2 (0.586), width:  16
 Scan time: 15.810

The best scores are:                                      opt bits E(85289)
NP_001280165 (OMIM: 607372) mediator of RNA polyme ( 677) 4579 297.3 1.2e-79
XP_016884309 (OMIM: 607372) PREDICTED: mediator of ( 667) 4081 266.6 2.1e-70
NP_001280164 (OMIM: 607372) mediator of RNA polyme ( 722) 4081 266.6 2.2e-70
NP_001280166 (OMIM: 607372) mediator of RNA polyme ( 722) 4081 266.6 2.2e-70
NP_056973 (OMIM: 607372) mediator of RNA polymeras ( 748) 4081 266.7 2.3e-70
XP_006724326 (OMIM: 607372) PREDICTED: mediator of ( 717) 2926 195.5 5.6e-49
XP_016884307 (OMIM: 607372) PREDICTED: mediator of ( 707) 2922 195.3 6.6e-49
XP_016884308 (OMIM: 607372) PREDICTED: mediator of ( 707) 2922 195.3 6.6e-49
XP_006724327 (OMIM: 607372) PREDICTED: mediator of ( 707) 2922 195.3 6.6e-49
XP_011528517 (OMIM: 607372) PREDICTED: mediator of ( 741) 2922 195.3 6.9e-49
XP_016884306 (OMIM: 607372) PREDICTED: mediator of ( 749) 2922 195.3 6.9e-49
XP_011528516 (OMIM: 607372) PREDICTED: mediator of ( 762) 2922 195.3   7e-49
NP_001003891 (OMIM: 607372) mediator of RNA polyme ( 788) 2922 195.3 7.3e-49
NP_001280163 (OMIM: 607372) mediator of RNA polyme ( 731) 2893 193.5 2.3e-48
XP_016884312 (OMIM: 607372) PREDICTED: mediator of ( 404) 2526 170.8   9e-42
XP_016884313 (OMIM: 607372) PREDICTED: mediator of ( 404) 2526 170.8   9e-42
XP_016884311 (OMIM: 607372) PREDICTED: mediator of ( 406) 1576 112.3 3.6e-24
XP_011528521 (OMIM: 607372) PREDICTED: mediator of ( 406) 1576 112.3 3.6e-24
XP_011528522 (OMIM: 607372) PREDICTED: mediator of ( 406) 1576 112.3 3.6e-24
XP_011528520 (OMIM: 607372) PREDICTED: mediator of ( 411) 1571 112.0 4.6e-24
XP_016884310 (OMIM: 607372) PREDICTED: mediator of ( 520) 1571 112.0 5.6e-24
XP_011541326 (OMIM: 607537) PREDICTED: mastermind- ( 928)  496 46.0 0.00076
XP_011541325 (OMIM: 607537) PREDICTED: mastermind- (1009)  496 46.0 0.00081
NP_115803 (OMIM: 607537) mastermind-like protein 2 (1156)  496 46.0 0.00091
XP_011537078 (OMIM: 147920,602113) PREDICTED: hist (5525)  512 47.4  0.0017
XP_006719679 (OMIM: 147920,602113) PREDICTED: hist (5536)  512 47.4  0.0017
XP_005269219 (OMIM: 147920,602113) PREDICTED: hist (5537)  512 47.4  0.0017
NP_003473 (OMIM: 147920,602113) histone-lysine N-m (5537)  512 47.4  0.0017
XP_006719677 (OMIM: 147920,602113) PREDICTED: hist (5540)  512 47.4  0.0017
XP_011537076 (OMIM: 147920,602113) PREDICTED: hist (5549)  512 47.4  0.0017
XP_011537075 (OMIM: 147920,602113) PREDICTED: hist (5552)  512 47.4  0.0017
XP_011537074 (OMIM: 147920,602113) PREDICTED: hist (5553)  512 47.4  0.0017
XP_011537073 (OMIM: 147920,602113) PREDICTED: hist (5555)  512 47.4  0.0017
XP_011537072 (OMIM: 147920,602113) PREDICTED: hist (5556)  512 47.4  0.0017


>>NP_001280165 (OMIM: 607372) mediator of RNA polymerase  (677 aa)
 initn: 3858 init1: 3858 opt: 4579  Z-score: 1550.6  bits: 297.3 E(85289): 1.2e-79
Smith-Waterman score: 4579; 99.6% identity (99.6% similar) in 677 aa overlap (1-674:1-677)

               10        20        30        40        50        60
pF1KF0 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KF0 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQA
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::  :::
NP_001 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA
               70        80        90       100       110       120

      120       130       140        150       160       170       
pF1KF0 QQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
       :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
              130       140       150       160       170       180

       180       190       200       210       220       230       
pF1KF0 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
              190       200       210       220       230       240

       240       250       260       270       280       290       
pF1KF0 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
              250       260       270       280       290       300

       300       310       320       330       340       350       
pF1KF0 TAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSS
              310       320       330       340       350       360

       360       370       380       390       400       410       
pF1KF0 GPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQ
              370       380       390       400       410       420

       420       430       440       450       460       470       
pF1KF0 YLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIA
              430       440       450       460       470       480

       480       490       500       510       520       530       
pF1KF0 LEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHG
              490       500       510       520       530       540

       540       550       560       570       580       590       
pF1KF0 PPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLD
              550       560       570       580       590       600

       600       610       620       630       640       650       
pF1KF0 DKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTA
              610       620       630       640       650       660

       660       670    
pF1KF0 LLNTWAQSVHQACLSAA
       :::::::::::::::::
NP_001 LLNTWAQSVHQACLSAA
              670       

>>XP_016884309 (OMIM: 607372) PREDICTED: mediator of RNA  (667 aa)
 initn: 3858 init1: 3858 opt: 4081  Z-score: 1385.0  bits: 266.6 E(85289): 2.1e-70
Smith-Waterman score: 4081; 98.7% identity (99.2% similar) in 604 aa overlap (74-674:64-667)

            50        60        70        80        90       100   
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
                                     : :. ..:::::::::::::::::::::::
XP_016 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
            40        50        60        70        80        90   

           110         120       130       140        150       160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
       ::::::::::::  ::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
           100       110       120       130       140       150   

              170       180       190       200       210       220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
           160       170       180       190       200       210   

              230       240       250       260       270       280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
           220       230       240       250       260       270   

              290       300       310       320       330       340
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQP
           280       290       300       310       320       330   

              350       360       370       380       390       400
pF1KF0 SPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVN
           340       350       360       370       380       390   

              410       420       430       440       450       460
pF1KF0 PSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILT
           400       410       420       430       440       450   

              470       480       490       500       510       520
pF1KF0 DPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVF
           460       470       480       490       500       510   

              530       540       550       560       570       580
pF1KF0 NHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLD
           520       530       540       550       560       570   

              590       600       610       620       630       640
pF1KF0 PSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHR
           580       590       600       610       620       630   

              650       660       670    
pF1KF0 CMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
       ::::::::::::::::::::::::::::::::::
XP_016 CMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
           640       650       660       

>>NP_001280164 (OMIM: 607372) mediator of RNA polymerase  (722 aa)
 initn: 3858 init1: 3858 opt: 4081  Z-score: 1384.5  bits: 266.6 E(85289): 2.2e-70
Smith-Waterman score: 4151; 89.4% identity (89.5% similar) in 706 aa overlap (43-674:17-722)

             20        30        40        50        60        70  
pF1KF0 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
                                     ::::::::::::::::::::::::::::::
NP_001               MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
                             10        20        30        40      

                                                                   
pF1KF0 KSQASVS-----------------------------------------------------
       :::::::                                                     
NP_001 KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPG
         50        60        70        80        90       100      

                        80        90       100       110           
pF1KF0 ------------------AQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQAQ
                         .:::::::::::::::::::::::::::::::::::  ::::
NP_001 TSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQ
        110       120       130       140       150       160      

     120       130       140        150       160       170        
pF1KF0 QSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
       ::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
        170       180       190       200       210       220      

      180       190       200       210       220       230        
pF1KF0 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
        230       240       250       260       270       280      

      240       250       260       270       280       290        
pF1KF0 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
        290       300       310       320       330       340      

      300       310       320       330       340       350        
pF1KF0 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
        350       360       370       380       390       400      

      360       370       380       390       400       410        
pF1KF0 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
        410       420       430       440       450       460      

      420       430       440       450       460       470        
pF1KF0 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
        470       480       490       500       510       520      

      480       490       500       510       520       530        
pF1KF0 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
        530       540       550       560       570       580      

      540       550       560       570       580       590        
pF1KF0 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
        590       600       610       620       630       640      

      600       610       620       630       640       650        
pF1KF0 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
        650       660       670       680       690       700      

      660       670    
pF1KF0 LNTWAQSVHQACLSAA
       ::::::::::::::::
NP_001 LNTWAQSVHQACLSAA
        710       720  

>>NP_001280166 (OMIM: 607372) mediator of RNA polymerase  (722 aa)
 initn: 3858 init1: 3858 opt: 4081  Z-score: 1384.5  bits: 266.6 E(85289): 2.2e-70
Smith-Waterman score: 4151; 89.4% identity (89.5% similar) in 706 aa overlap (43-674:17-722)

             20        30        40        50        60        70  
pF1KF0 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
                                     ::::::::::::::::::::::::::::::
NP_001               MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
                             10        20        30        40      

                                                                   
pF1KF0 KSQASVS-----------------------------------------------------
       :::::::                                                     
NP_001 KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPG
         50        60        70        80        90       100      

                        80        90       100       110           
pF1KF0 ------------------AQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQAQ
                         .:::::::::::::::::::::::::::::::::::  ::::
NP_001 TSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQ
        110       120       130       140       150       160      

     120       130       140        150       160       170        
pF1KF0 QSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
       ::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
        170       180       190       200       210       220      

      180       190       200       210       220       230        
pF1KF0 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
        230       240       250       260       270       280      

      240       250       260       270       280       290        
pF1KF0 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
        290       300       310       320       330       340      

      300       310       320       330       340       350        
pF1KF0 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
        350       360       370       380       390       400      

      360       370       380       390       400       410        
pF1KF0 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
        410       420       430       440       450       460      

      420       430       440       450       460       470        
pF1KF0 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
        470       480       490       500       510       520      

      480       490       500       510       520       530        
pF1KF0 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
        530       540       550       560       570       580      

      540       550       560       570       580       590        
pF1KF0 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
        590       600       610       620       630       640      

      600       610       620       630       640       650        
pF1KF0 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
        650       660       670       680       690       700      

      660       670    
pF1KF0 LNTWAQSVHQACLSAA
       ::::::::::::::::
NP_001 LNTWAQSVHQACLSAA
        710       720  

>>NP_056973 (OMIM: 607372) mediator of RNA polymerase II  (748 aa)
 initn: 3858 init1: 3858 opt: 4081  Z-score: 1384.2  bits: 266.7 E(85289): 2.3e-70
Smith-Waterman score: 4151; 89.4% identity (89.5% similar) in 706 aa overlap (43-674:43-748)

             20        30        40        50        60        70  
pF1KF0 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
                                     ::::::::::::::::::::::::::::::
NP_056 TAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNK
             20        30        40        50        60        70  

                                                                   
pF1KF0 KSQASVS-----------------------------------------------------
       :::::::                                                     
NP_056 KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPG
             80        90       100       110       120       130  

                        80        90       100       110           
pF1KF0 ------------------AQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQAQ
                         .:::::::::::::::::::::::::::::::::::  ::::
NP_056 TSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQ
            140       150       160       170       180       190  

     120       130       140        150       160       170        
pF1KF0 QSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
       ::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_056 QSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQ
            200       210       220       230       240       250  

      180       190       200       210       220       230        
pF1KF0 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQ
            260       270       280       290       300       310  

      240       250       260       270       280       290        
pF1KF0 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 NQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQT
            320       330       340       350       360       370  

      300       310       320       330       340       350        
pF1KF0 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSG
            380       390       400       410       420       430  

      360       370       380       390       400       410        
pF1KF0 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQY
            440       450       460       470       480       490  

      420       430       440       450       460       470        
pF1KF0 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIAL
            500       510       520       530       540       550  

      480       490       500       510       520       530        
pF1KF0 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGP
            560       570       580       590       600       610  

      540       550       560       570       580       590        
pF1KF0 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDD
            620       630       640       650       660       670  

      600       610       620       630       640       650        
pF1KF0 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTAL
            680       690       700       710       720       730  

      660       670    
pF1KF0 LNTWAQSVHQACLSAA
       ::::::::::::::::
NP_056 LNTWAQSVHQACLSAA
            740        

>>XP_006724326 (OMIM: 607372) PREDICTED: mediator of RNA  (717 aa)
 initn: 2710 init1: 2710 opt: 2926  Z-score: 1000.2  bits: 195.5 E(85289): 5.6e-49
Smith-Waterman score: 4408; 93.9% identity (93.9% similar) in 706 aa overlap (12-674:12-717)

               10        20        30        40        50        60
pF1KF0 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
                  :::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVA
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KF0 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQ--FQA
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::  :::
XP_006 RLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQA
               70        80        90       100       110       120

      120       130       140        150       160       170       
pF1KF0 QQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
       :::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_006 QQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQ
              130       140       150       160       170       180

       180       190       200       210       220       230       
pF1KF0 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVA
              190       200       210       220       230       240

       240       250       260       270       280       290       
pF1KF0 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQ
              250       260       270       280       290       300

       300       310                                               
pF1KF0 TAQAAQMVAPGVQ----------------------------------------VSQSSLP
       :::::::::::::                                        :::::::
XP_006 TAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLP
              310       320       330       340       350       360

       320       330       340       350       360       370       
pF1KF0 MLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQS
              370       380       390       400       410       420

       380       390       400       410       420       430       
pF1KF0 PVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMIN
              430       440       450       460       470       480

       440       450       460       470       480       490       
pF1KF0 KIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPP
              490       500       510       520       530       540

       500       510       520       530       540       550       
pF1KF0 TKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDER
              550       560       570       580       590       600

       560       570       580       590       600       610       
pF1KF0 QSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPA
              610       620       630       640       650       660

       620       630       640       650       660       670    
pF1KF0 QSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
              670       680       690       700       710       

>>XP_016884307 (OMIM: 607372) PREDICTED: mediator of RNA  (707 aa)
 initn: 2710 init1: 2710 opt: 2922  Z-score: 999.0  bits: 195.3 E(85289): 6.6e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:64-707)

            50        60        70        80        90       100   
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
                                     : :. ..:::::::::::::::::::::::
XP_016 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
            40        50        60        70        80        90   

           110         120       130       140        150       160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
       ::::::::::::  ::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
           100       110       120       130       140       150   

              170       180       190       200       210       220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
           160       170       180       190       200       210   

              230       240       250       260       270       280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
           220       230       240       250       260       270   

              290       300       310                              
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
       ::::::::::::::::::::::::::::::                              
XP_016 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
           280       290       300       310       320       330   

                        320       330       340       350       360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
           340       350       360       370       380       390   

              370       380       390       400       410       420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
           400       410       420       430       440       450   

              430       440       450       460       470       480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
           460       470       480       490       500       510   

              490       500       510       520       530       540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
           520       530       540       550       560       570   

              550       560       570       580       590       600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
           580       590       600       610       620       630   

              610       620       630       640       650       660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
           640       650       660       670       680       690   

              670    
pF1KF0 TWAQSVHQACLSAA
       ::::::::::::::
XP_016 TWAQSVHQACLSAA
           700       

>>XP_016884308 (OMIM: 607372) PREDICTED: mediator of RNA  (707 aa)
 initn: 2710 init1: 2710 opt: 2922  Z-score: 999.0  bits: 195.3 E(85289): 6.6e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:64-707)

            50        60        70        80        90       100   
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
                                     : :. ..:::::::::::::::::::::::
XP_016 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
            40        50        60        70        80        90   

           110         120       130       140        150       160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
       ::::::::::::  ::::::::::::::::::::::::::::: ::::::::::::::::
XP_016 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
           100       110       120       130       140       150   

              170       180       190       200       210       220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
           160       170       180       190       200       210   

              230       240       250       260       270       280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
           220       230       240       250       260       270   

              290       300       310                              
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
       ::::::::::::::::::::::::::::::                              
XP_016 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
           280       290       300       310       320       330   

                        320       330       340       350       360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
           340       350       360       370       380       390   

              370       380       390       400       410       420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
           400       410       420       430       440       450   

              430       440       450       460       470       480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
           460       470       480       490       500       510   

              490       500       510       520       530       540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
           520       530       540       550       560       570   

              550       560       570       580       590       600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
           580       590       600       610       620       630   

              610       620       630       640       650       660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
           640       650       660       670       680       690   

              670    
pF1KF0 TWAQSVHQACLSAA
       ::::::::::::::
XP_016 TWAQSVHQACLSAA
           700       

>>XP_006724327 (OMIM: 607372) PREDICTED: mediator of RNA  (707 aa)
 initn: 2710 init1: 2710 opt: 2922  Z-score: 999.0  bits: 195.3 E(85289): 6.6e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:64-707)

            50        60        70        80        90       100   
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
                                     : :. ..:::::::::::::::::::::::
XP_006 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
            40        50        60        70        80        90   

           110         120       130       140        150       160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
       ::::::::::::  ::::::::::::::::::::::::::::: ::::::::::::::::
XP_006 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
           100       110       120       130       140       150   

              170       180       190       200       210       220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
           160       170       180       190       200       210   

              230       240       250       260       270       280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
           220       230       240       250       260       270   

              290       300       310                              
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
       ::::::::::::::::::::::::::::::                              
XP_006 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
           280       290       300       310       320       330   

                        320       330       340       350       360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
           340       350       360       370       380       390   

              370       380       390       400       410       420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
           400       410       420       430       440       450   

              430       440       450       460       470       480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
           460       470       480       490       500       510   

              490       500       510       520       530       540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
           520       530       540       550       560       570   

              550       560       570       580       590       600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
           580       590       600       610       620       630   

              610       620       630       640       650       660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
           640       650       660       670       680       690   

              670    
pF1KF0 TWAQSVHQACLSAA
       ::::::::::::::
XP_006 TWAQSVHQACLSAA
           700       

>>XP_011528517 (OMIM: 607372) PREDICTED: mediator of RNA  (741 aa)
 initn: 2710 init1: 2710 opt: 2922  Z-score: 998.7  bits: 195.3 E(85289): 6.9e-49
Smith-Waterman score: 3991; 92.5% identity (93.0% similar) in 644 aa overlap (74-674:98-741)

            50        60        70        80        90       100   
pF1KF0 HVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQ
                                     : :. ..:::::::::::::::::::::::
XP_011 SLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQ
        70        80        90       100       110       120       

           110         120       130       140        150       160
pF1KF0 AALQQQQQQQQQ--FQAQQSAMQQQFQAVVQQQQQLQQQQQQQ-HLIKLHHQNQQQIQQQ
       ::::::::::::  ::::::::::::::::::::::::::::: ::::::::::::::::
XP_011 AALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQ
       130       140       150       160       170       180       

              170       180       190       200       210       220
pF1KF0 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMH
       190       200       210       220       230       240       

              230       240       250       260       270       280
pF1KF0 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVV
       250       260       270       280       290       300       

              290       300       310                              
pF1KF0 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQ------------------------------
       ::::::::::::::::::::::::::::::                              
XP_011 QQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSS
       310       320       330       340       350       360       

                        320       330       340       350       360
pF1KF0 ----------VSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPA
       370       380       390       400       410       420       

              370       380       390       400       410       420
pF1KF0 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLD
       430       440       450       460       470       480       

              430       440       450       460       470       480
pF1KF0 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEK
       490       500       510       520       530       540       

              490       500       510       520       530       540
pF1KF0 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPI
       550       560       570       580       590       600       

              550       560       570       580       590       600
pF1KF0 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKD
       610       620       630       640       650       660       

              610       620       630       640       650       660
pF1KF0 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLN
       670       680       690       700       710       720       

              670    
pF1KF0 TWAQSVHQACLSAA
       ::::::::::::::
XP_011 TWAQSVHQACLSAA
       730       740 




674 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 20:11:37 2016 done: Fri Nov  4 20:11:39 2016
 Total Scan time: 15.810 Total Display time:  0.160

Function used was FASTA [36.3.4 Apr, 2011]
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