Result of FASTA (omim) for pF1KB9581
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9581, 354 aa
  1>>>pF1KB9581 354 - 354 aa - 354 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.3733+/-0.000314; mu= 6.1964+/- 0.020
 mean_var=224.2021+/-46.580, 0's: 0 Z-trim(124.6): 49  B-trim: 3989 in 2/59
 Lambda= 0.085655
 statistics sampled from 46433 (46491) to 46433 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.816), E-opt: 0.2 (0.545), width:  16
 Scan time: 10.110

The best scores are:                                      opt bits E(85289)
NP_005163 (OMIM: 601461) protein atonal homolog 1  ( 354) 2412 309.9 5.6e-84
NP_660161 (OMIM: 609875) protein atonal homolog 7  ( 152)  259 43.5 0.00038
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272)  262 44.1 0.00044
NP_803238 (OMIM: 608606) class A basic helix-loop- ( 189)  256 43.2 0.00057
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337)  249 42.6  0.0016
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214)  245 41.9  0.0016
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214)  245 41.9  0.0016
NP_002491 (OMIM: 125853,601724,606394) neurogenic  ( 356)  247 42.3  0.0019
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331)  246 42.2   0.002
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237)  242 41.5  0.0022
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382)  232 40.5  0.0074


>>NP_005163 (OMIM: 601461) protein atonal homolog 1 [Hom  (354 aa)
 initn: 2412 init1: 2412 opt: 2412  Z-score: 1628.6  bits: 309.9 E(85289): 5.6e-84
Smith-Waterman score: 2412; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354)

               10        20        30        40        50        60
pF1KB9 MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 PRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 PVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFD
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 QLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB9 AASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDS
              250       260       270       280       290       300

              310       320       330       340       350    
pF1KB9 ALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
              310       320       330       340       350    

>>NP_660161 (OMIM: 609875) protein atonal homolog 7 [Hom  (152 aa)
 initn: 279 init1: 258 opt: 259  Z-score: 195.5  bits: 43.5 E(85289): 0.00038
Smith-Waterman score: 259; 71.9% identity (91.2% similar) in 57 aa overlap (159-215:40-96)

      130       140       150       160       170       180        
pF1KB9 CKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPS
                                     .:::::::::::::.::: :::.:: :.:.
NP_660 PAGARVAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQ
      10        20        30        40        50        60         

      190       200       210       220       230       240        
pF1KB9 FNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGA
       ...:::::::::::::  :: ::...:                                 
NP_660 WGQDKKLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKL
      70        80        90       100       110       120         

>>NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapiens]    (272 aa)
 initn: 288 init1: 209 opt: 262  Z-score: 194.2  bits: 44.1 E(85289): 0.00044
Smith-Waterman score: 276; 35.9% identity (55.8% similar) in 217 aa overlap (84-282:24-225)

            60        70        80             90       100        
pF1KB9 SLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGA-----SEAAAPRDEVDGRGELVRR
                                     :: :.:     : :   ..:  : .  .::
NP_076        MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARR
                      10        20        30        40        50   

      110       120       130         140                150       
pF1KB9 SSGGASSSKSPGPVKVREQLCKLKG--GVVVDELGC----SRQRAPS-----SKQVNGVQ
       . :. ... . : : .  . :.     :.: :   :    :: :: :     .. :. ..
NP_076 QRGAEAGQGARGGVAAGAEGCRPARLLGLVHD---CKRRPSRARAVSRGAKTAETVQRIK
            60        70        80           90       100       110

       160       170       180       190       200       210       
pF1KB9 KQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQT
       : ::: :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: ::.: :. 
NP_076 KTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRL
              120       130       140       150       160       170

         220       230       240       250       260       270     
pF1KB9 PS--GGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTR
        .  ::     : :        : . :   . .:   :..: ..:: :  :.   :: : 
NP_076 ADHCGGGGGGLPGA--------LFSEAVLLSPGG---ASAALSSSGDSPSPASTWSC-TN
              180               190          200       210         

         280       290       300       310       320       330     
pF1KB9 FSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSH
         ::.:.                                                     
NP_076 SPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI      
      220       230       240       250       260       270        

>>NP_803238 (OMIM: 608606) class A basic helix-loop-heli  (189 aa)
 initn: 262 init1: 219 opt: 256  Z-score: 192.3  bits: 43.2 E(85289): 0.00057
Smith-Waterman score: 256; 37.6% identity (59.2% similar) in 157 aa overlap (115-265:29-177)

           90       100       110       120       130       140    
pF1KB9 PELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSR
                                     :  .:::  ..  : .  . ...   : .:
NP_803   MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAK-GLRSRPARAAARAPGEGR
                 10        20        30         40        50       

          150          160       170       180       190       200 
pF1KB9 QRAPSSKQVNGVQK---QRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETL
       .: :. .  .: .    :::: .: :::.::: ::.::. ::.:::    :::::: :::
NP_803 RRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETL
        60        70        80        90       100       110       

             210       220          230       240       250        
pF1KB9 QMAQIYINALSELLQTPSGGEQPP---PPPASCKSDHHHLRTAASYEGGAGNATAAGAQQ
        .:. ::..:.  . : :... :    : :      ..: .   .  ::: .:: :   :
NP_803 TLAKNYIKSLTATILTMSSSRLPGLEGPGPKL----YQHYQQQQQVAGGALGATEA---Q
       120       130       140           150       160          170

      260       270       280       290       300       310        
pF1KB9 ASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGS
        .:  ::                                                     
NP_803 PQGHLQRYSTQIHSFREGT                                         
              180                                                  

>>NP_073565 (OMIM: 611513) neurogenic differentiation fa  (337 aa)
 initn: 251 init1: 225 opt: 249  Z-score: 184.3  bits: 42.6 E(85289): 0.0016
Smith-Waterman score: 249; 41.9% identity (67.5% similar) in 117 aa overlap (112-224:45-156)

              90       100       110       120       130       140 
pF1KB9 LHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELG
                                     : : ...::    .:.  . .     :: :
NP_073 SQMCRKFSRECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEE--EEEDREEEDENG
           20        30        40        50        60          70  

             150           160       170       180       190       
pF1KB9 CSRQRAPSSKQVNGVQ----KQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSK
         :.:.  .:... ..    : ::  :::::: :::::: :.:.::.:.: ... .::::
NP_073 LPRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSK
             80        90       100       110       120       130  

       200       210       220       230       240       250       
pF1KB9 YETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQ
        :::..:. :: ::::.:.    :..:                                 
NP_073 IETLRLAKNYIWALSEILRI---GKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFL
            140       150          160       170       180         

>>NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo sap  (214 aa)
 initn: 261 init1: 214 opt: 245  Z-score: 184.2  bits: 41.9 E(85289): 0.0016
Smith-Waterman score: 254; 30.3% identity (52.2% similar) in 228 aa overlap (61-283:3-206)

               40        50        60        70        80        90
pF1KB9 PPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGAS
                                     :.   :::.: .      ..   : .  . 
NP_066                             MTPQPSGAPTVQ-VTRETERSFPRASEDEVTC
                                           10         20        30 

              100       110       120       130       140       150
pF1KB9 EAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSS
        ..:: . .  ::. ..   ::  ..    : :.: .    .::         :.:  : 
NP_066 PTSAPPSPTRTRGNCAEAEEGGCRGA----PRKLRAR----RGG---------RSRPKSE
              40        50            60                     70    

              160       170       180       190       200       210
pF1KB9 KQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINA
         ..  ...::  :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: :
NP_066 LALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWA
           80        90       100       110       120       130    

              220       230       240       250       260          
pF1KB9 LSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTP--
       :.. :.  . .     :::       :    .:  :. :.  .  .  ...::  :.   
NP_066 LTQTLRIADHSLYALEPPAP------HCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASL
          140       150             160       170       180        

         270       280       290       300       310       320     
pF1KB9 ---PGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQE
          ::   . :::  : :                                          
NP_066 EERPGLLGATFSACLSPGSLAFSDFL                                  
      190       200       210                                      

>>XP_016871769 (OMIM: 604882,610370) PREDICTED: neurogen  (214 aa)
 initn: 261 init1: 214 opt: 245  Z-score: 184.2  bits: 41.9 E(85289): 0.0016
Smith-Waterman score: 254; 30.3% identity (52.2% similar) in 228 aa overlap (61-283:3-206)

               40        50        60        70        80        90
pF1KB9 PPPPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTARAAQYLLHSPELGAS
                                     :.   :::.: .      ..   : .  . 
XP_016                             MTPQPSGAPTVQ-VTRETERSFPRASEDEVTC
                                           10         20        30 

              100       110       120       130       140       150
pF1KB9 EAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSS
        ..:: . .  ::. ..   ::  ..    : :.: .    .::         :.:  : 
XP_016 PTSAPPSPTRTRGNCAEAEEGGCRGA----PRKLRAR----RGG---------RSRPKSE
              40        50            60                     70    

              160       170       180       190       200       210
pF1KB9 KQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINA
         ..  ...::  :: ::: :::.:: :.: ::.:.:.: .: ::.: :::..:. :: :
XP_016 LALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWA
           80        90       100       110       120       130    

              220       230       240       250       260          
pF1KB9 LSELLQTPSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTP--
       :.. :.  . .     :::       :    .:  :. :.  .  .  ...::  :.   
XP_016 LTQTLRIADHSLYALEPPAP------HCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASL
          140       150             160       170       180        

         270       280       290       300       310       320     
pF1KB9 ---PGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQE
          ::   . :::  : :                                          
XP_016 EERPGLLGATFSACLSPGSLAFSDFL                                  
      190       200       210                                      

>>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff  (356 aa)
 initn: 263 init1: 233 opt: 247  Z-score: 182.7  bits: 42.3 E(85289): 0.0019
Smith-Waterman score: 247; 48.2% identity (80.0% similar) in 85 aa overlap (144-224:82-163)

           120       130       140       150           160         
pF1KB9 SSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQ----KQRRLAANARER
                                     ..:.:..:... ..    : ::. ::::::
NP_002 SLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARER
              60        70        80        90       100       110 

     170       180       190       200       210       220         
pF1KB9 RRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPA
        :::::: :.:.::.:.: ... .:::: :::..:. :: ::::.:..   :..:     
NP_002 NRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRS---GKSPDLVSF
             120       130       140       150          160        

     230       240       250       260       270       280         
pF1KB9 SCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQL
                                                                   
NP_002 VQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQSPGLPS
      170       180       190       200       210       220        

>>NP_067014 (OMIM: 611635) neurogenic differentiation fa  (331 aa)
 initn: 275 init1: 231 opt: 246  Z-score: 182.4  bits: 42.2 E(85289): 0.002
Smith-Waterman score: 246; 50.0% identity (77.4% similar) in 84 aa overlap (144-220:68-151)

           120       130       140       150           160         
pF1KB9 SSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQ----KQRRLAANARER
                                     ..:.:..:... ..    . ::. ::::::
NP_067 PGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKANARER
        40        50        60        70        80        90       

     170       180       190       200       210          220      
pF1KB9 RRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELL---QTPSGGEQPPP
        :::::: :.:.:: :.: ... .:::: :::..:. :: ::::.:   ::: :      
NP_067 TRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEM
       100       110       120       130       140       150       

        230       240       250       260       270       280      
pF1KB9 PPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYS
                                                                   
NP_067 LCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHM
       160       170       180       190       200       210       

>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens]    (237 aa)
 initn: 258 init1: 211 opt: 242  Z-score: 181.6  bits: 41.5 E(85289): 0.0022
Smith-Waterman score: 252; 38.6% identity (60.0% similar) in 145 aa overlap (144-269:77-215)

           120       130       140       150       160       170   
pF1KB9 SSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMH
                                     : :. :   .......::. :: ::: :::
NP_006 PARRGAPNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMH
         50        60        70        80        90       100      

           180       190       200       210            220        
pF1KB9 GLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQT-----PSGGEQ----P
       .:: :.: ::.:.::: .: ::.: :::..:  :: ::.: :.      :.:: .    :
NP_006 NLNAALDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLP
        110       120       130       140       150       160      

                230       240       250       260           270    
pF1KB9 P------PPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQ----RPTPPGSCRT
       :      : : :  ::      : :. .::. :.  .  .. ..:.    ::  :     
NP_006 PQCVPCLPGPPSPASD------AESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFP
        170       180             190       200       210       220

          280       290       300       310       320       330    
pF1KB9 RFSAPASAGGYSVQLDALHFSTFEDSALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRS
                                                                   
NP_006 SLPKDLLHTTPCFIPYH                                           
              230                                                  




354 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 17:29:06 2016 done: Fri Nov  4 17:29:07 2016
 Total Scan time: 10.110 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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