Result of FASTA (omim) for pF1KB8880
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8880, 175 aa
  1>>>pF1KB8880 175 - 175 aa - 175 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8759+/-0.00033; mu= 14.3319+/- 0.020
 mean_var=55.9055+/-11.079, 0's: 0 Z-trim(114.7): 46  B-trim: 644 in 1/52
 Lambda= 0.171533
 statistics sampled from 24691 (24737) to 24691 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.29), width:  16
 Scan time:  5.090

The best scores are:                                      opt bits E(85289)
NP_004040 (OMIM: 601056) bcl-2-related protein A1  ( 175) 1179 299.5 1.8e-81
NP_001108207 (OMIM: 601056) bcl-2-related protein  ( 163)  935 239.1 2.6e-63
NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239)  204 58.3   1e-08
XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173)  195 56.0 3.6e-08
NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192)  195 56.0 3.9e-08
XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224)  194 55.8 5.3e-08
XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198)  192 55.3 6.7e-08
NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205)  192 55.3 6.9e-08
NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114)  183 52.9   2e-07
NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143)  183 53.0 2.4e-07
NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197)  178 51.8 7.4e-07
NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179)  175 51.1 1.1e-06
NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181)  175 51.1 1.2e-06
NP_068779 (OMIM: 159552) induced myeloid leukemia  ( 350)  178 52.0 1.2e-06
NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218)  175 51.1 1.3e-06
NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221)  175 51.1 1.4e-06
NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233)  172 50.4 2.4e-06
NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233)  172 50.4 2.4e-06
NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233)  172 50.4 2.4e-06
NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233)  172 50.4 2.4e-06
NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233)  172 50.4 2.4e-06
NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233)  172 50.4 2.4e-06
XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like  ( 233)  172 50.4 2.4e-06
NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233)  172 50.4 2.4e-06
XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like  ( 233)  172 50.4 2.4e-06
NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193)  166 48.8 5.7e-06
NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193)  166 48.8 5.7e-06
XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152)  164 48.3 6.6e-06
NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140)  163 48.0 7.3e-06
XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211)  164 48.4 8.7e-06
NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211)  164 48.4 8.7e-06


>>NP_004040 (OMIM: 601056) bcl-2-related protein A1 isof  (175 aa)
 initn: 1179 init1: 1179 opt: 1179  Z-score: 1583.6  bits: 299.5 E(85289): 1.8e-81
Smith-Waterman score: 1179; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175)

               10        20        30        40        50        60
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
               70        80        90       100       110       120

              130       140       150       160       170     
pF1KB8 FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
              130       140       150       160       170     

>>NP_001108207 (OMIM: 601056) bcl-2-related protein A1 i  (163 aa)
 initn: 935 init1: 935 opt: 935  Z-score: 1257.8  bits: 239.1 E(85289): 2.6e-63
Smith-Waterman score: 935; 100.0% identity (100.0% similar) in 140 aa overlap (1-140:1-140)

               10        20        30        40        50        60
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISY
               70        80        90       100       110       120

              130       140       150       160       170     
pF1KB8 FVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
       ::::::::::::::::::::                                   
NP_001 FVAEFIMNNTGEWIRQNGGWGKWHNHTPMLVESVAHKKRKMAL            
              130       140       150       160               

>>NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 alp  (239 aa)
 initn: 230 init1:  96 opt: 204  Z-score: 277.6  bits: 58.3 E(85289): 1e-08
Smith-Waterman score: 204; 37.6% identity (70.6% similar) in 85 aa overlap (66-150:125-204)

          40        50        60        70        80        90     
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
                                     :::  :  :.:. :.::. ::::::..: :
NP_000 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
          100       110       120       130       140        150   

         100       110       120       130       140       150     
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
        :..  . . ....: ::.   :. ...:..  .   ::..::::. .::. . :     
NP_000 GGVMCVESVNREMSPLVDN---IALWMTEYLNRHLHTWIQDNGGWD-AFVELYGPSMRPL
           160       170          180       190        200         

         160       170               
pF1KB8 TFLEVTGKICEMLSLLKQYC          
                                     
NP_000 FDFSWLSLKTLLSLALVGACITLGAYLGHK
     210       220       230         

>>XP_016882566 (OMIM: 600040) PREDICTED: apoptosis regul  (173 aa)
 initn: 144 init1:  86 opt: 195  Z-score: 267.7  bits: 56.0 E(85289): 3.6e-08
Smith-Waterman score: 195; 27.6% identity (60.5% similar) in 152 aa overlap (23-173:31-171)

                       10        20        30        40        50  
pF1KB8         MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNL
                                     .:: .:  .: :. :. ..     :...:.
XP_016 MKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDAS-TKKLSECLKRIG----DELDSNM
               10        20        30         40            50     

             60        70        80        90       100       110  
pF1KB8 KSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDV
       .     . .:..:. : .: .:    : :: .::::.:..: : . :. : :  .. :..
XP_016 E-LQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKV-PEL
           60        70        80        90       100       110    

            120       130       140       150        160       170 
pF1KB8 DTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTF-LEVTGKICEMLSLL
          . :  .. .:. .    ::...:::. :... :   . :.:  . :.: .   :.. 
XP_016 --IRTIMGWTLDFLRERLLGWIQDQGGWD-GLLSYFGTPT-WQTVTIFVAGVLTASLTIW
             120       130       140        150        160         

           
pF1KB8 KQYC
       :.  
XP_016 KKMG
     170   

>>NP_620116 (OMIM: 600040) apoptosis regulator BAX isofo  (192 aa)
 initn: 144 init1:  86 opt: 195  Z-score: 267.0  bits: 56.0 E(85289): 3.9e-08
Smith-Waterman score: 195; 27.6% identity (60.5% similar) in 152 aa overlap (23-173:50-190)

                       10        20        30        40        50  
pF1KB8         MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNL
                                     .:: .:  .: :. :. ..     :...:.
NP_620 MKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDAS-TKKLSECLKRIG----DELDSNM
      20        30        40        50         60            70    

             60        70        80        90       100       110  
pF1KB8 KSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDV
       .     . .:..:. : .: .:    : :: .::::.:..: : . :. : :  .. :..
NP_620 E-LQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKV-PEL
            80        90       100       110       120        130  

            120       130       140       150        160       170 
pF1KB8 DTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTF-LEVTGKICEMLSLL
          . :  .. .:. .    ::...:::. :... :   . :.:  . :.: .   :.. 
NP_620 --IRTIMGWTLDFLRERLLGWIQDQGGWD-GLLSYFGTPT-WQTVTIFVAGVLTASLTIW
              140       150        160        170       180        

           
pF1KB8 KQYC
       :.  
NP_620 KKMG
      190  

>>XP_011524437 (OMIM: 151430) PREDICTED: apoptosis regul  (224 aa)
 initn: 203 init1:  96 opt: 194  Z-score: 264.7  bits: 55.8 E(85289): 5.3e-08
Smith-Waterman score: 194; 38.2% identity (71.1% similar) in 76 aa overlap (66-141:125-196)

          40        50        60        70        80        90     
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
                                     :::  :  :.:. :.::. ::::::..: :
XP_011 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
          100       110       120       130       140        150   

         100       110       120       130       140       150     
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
        :..  . . ....: ::.   :. ...:..  .   ::..::::.              
XP_011 GGVMCVESVNREMSPLVDN---IALWMTEYLNRHLHTWIQDNGGWDALVLFAGLREFQHG
           160       170          180       190       200       210

         160       170     
pF1KB8 TFLEVTGKICEMLSLLKQYC
                           
XP_011 PGNYFLKRNLNAKF      
              220          

>>XP_016881406 (OMIM: 151430) PREDICTED: apoptosis regul  (198 aa)
 initn: 159 init1:  96 opt: 192  Z-score: 262.8  bits: 55.3 E(85289): 6.7e-08
Smith-Waterman score: 192; 38.7% identity (70.7% similar) in 75 aa overlap (66-140:125-195)

          40        50        60        70        80        90     
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
                                     :::  :  :.:. :.::. ::::::..: :
XP_016 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
          100       110       120       130       140        150   

         100       110       120       130       140       150     
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
        :..  . . ....: ::   .:. ...:..  .   ::..::::               
XP_016 GGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWLYM            
           160       170          180       190                    

         160       170     
pF1KB8 TFLEVTGKICEMLSLLKQYC

>>NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 bet  (205 aa)
 initn: 159 init1:  96 opt: 192  Z-score: 262.6  bits: 55.3 E(85289): 6.9e-08
Smith-Waterman score: 192; 38.7% identity (70.7% similar) in 75 aa overlap (66-140:125-195)

          40        50        60        70        80        90     
pF1KB8 VLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAF
                                     :::  :  :.:. :.::. ::::::..: :
NP_000 LTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV-NWGRIVAFFEF
          100       110       120       130       140        150   

         100       110       120       130       140       150     
pF1KB8 EGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWM
        :..  . . ....: ::   .:. ...:..  .   ::..::::               
NP_000 GGVMCVESVNREMSPLVD---NIALWMTEYLNRHLHTWIQDNGGWVGALGDVSLG     
           160       170          180       190       200          

         160       170     
pF1KB8 TFLEVTGKICEMLSLLKQYC

>>NP_001278360 (OMIM: 600040) apoptosis regulator BAX is  (114 aa)
 initn: 144 init1:  86 opt: 183  Z-score: 254.3  bits: 52.9 E(85289): 2e-07
Smith-Waterman score: 183; 29.3% identity (62.1% similar) in 116 aa overlap (59-173:2-112)

       30        40        50        60        70        80        
pF1KB8 GPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGR
                                     . .:..:. : .: .:    : :: .::::
NP_001                              MIAAVDTDSPREVFFRVAADMFSDGNFNWGR
                                            10        20        30 

       90       100       110       120       130       140        
pF1KB8 IVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKF
       .:..: : . :. : :  .. :..   . :  .. .:. .    ::...:::. :... :
NP_001 VVALFYFASKLVLKALCTKV-PEL--IRTIMGWTLDFLRERLLGWIQDQGGWD-GLLSYF
              40        50           60        70        80        

      150        160       170     
pF1KB8 EPKSGWMTF-LEVTGKICEMLSLLKQYC
          . :.:  . :.: .   :.. :.  
NP_001 GTPT-WQTVTIFVAGVLTASLTIWKKMG
        90        100       110    

>>NP_620118 (OMIM: 600040) apoptosis regulator BAX isofo  (143 aa)
 initn: 144 init1:  86 opt: 183  Z-score: 252.9  bits: 53.0 E(85289): 2.4e-07
Smith-Waterman score: 199; 27.2% identity (59.6% similar) in 151 aa overlap (25-173:7-141)

               10        20         30        40        50         
pF1KB8 MTDCEFGYIYRLAQDYLQCVLQIPQP-GSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNV
                               :: :.::... ..... :. .:             .
NP_620                   MDGSGEQPRGGGPTSSEQIMKTGALLLQ-----------GMI
                                 10        20                   30 

      60        70        80        90       100       110         
pF1KB8 NVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEIS
        .:..:. : .: .:    : :: .::::.:..: : . :. : :  .. :..   . : 
NP_620 AAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKV-PEL--IRTIM
              40        50        60        70        80           

     120       130       140       150        160       170     
pF1KB8 YFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTF-LEVTGKICEMLSLLKQYC
        .. .:. .    ::...:::. :... :   . :.:  . :.: .   :.. :.  
NP_620 GWTLDFLRERLLGWIQDQGGWD-GLLSYFGTPT-WQTVTIFVAGVLTASLTIWKKMG
       90       100       110        120        130       140   




175 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 16:18:38 2016 done: Fri Nov  4 16:18:39 2016
 Total Scan time:  5.090 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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