Result of FASTA (omim) for pF1KB8786
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8786, 297 aa
  1>>>pF1KB8786 297 - 297 aa - 297 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8357+/-0.000578; mu= 19.1868+/- 0.036
 mean_var=167.6648+/-50.315, 0's: 0 Z-trim(107.3): 362  B-trim: 1007 in 1/50
 Lambda= 0.099050
 statistics sampled from 14863 (15396) to 14863 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.507), E-opt: 0.2 (0.181), width:  16
 Scan time:  5.800

The best scores are:                                      opt bits E(85289)
XP_016881270 (OMIM: 202200,607397) PREDICTED: adre ( 297) 1960 293.1 4.3e-79
NP_000520 (OMIM: 202200,607397) adrenocorticotropi ( 297) 1960 293.1 4.3e-79
NP_001278840 (OMIM: 202200,607397) adrenocorticotr ( 297) 1960 293.1 4.3e-79
NP_005904 (OMIM: 600042) melanocortin receptor 5 [ ( 325)  942 147.7 2.8e-35
NP_005903 (OMIM: 155541,601665) melanocortin recep ( 332)  934 146.6 6.2e-35
NP_002377 (OMIM: 155555,203200,266300,613098,61309 ( 317)  750 120.3   5e-27
NP_063941 (OMIM: 155540,602025,607948) melanocorti ( 323)  583 96.4 7.7e-20
NP_004221 (OMIM: 605111,610419,610419) sphingosine ( 353)  310 57.5 4.4e-08
NP_005217 (OMIM: 601965) sphingosine 1-phosphate r ( 378)  306 57.0 6.8e-08
NP_001391 (OMIM: 601974) sphingosine 1-phosphate r ( 382)  252 49.3 1.4e-05
NP_001307659 (OMIM: 601974) sphingosine 1-phosphat ( 382)  252 49.3 1.4e-05
XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321)  232 46.3 9.6e-05
NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415)  232 46.5 0.00011
XP_016869885 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_005251838 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869889 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_005251839 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869878 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869887 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869886 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869876 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869884 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869880 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869894 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
NP_476500 (OMIM: 602282) lysophosphatidic acid rec ( 364)  223 45.1 0.00025
XP_016869881 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869877 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869892 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869879 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869895 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
NP_001392 (OMIM: 602282) lysophosphatidic acid rec ( 364)  223 45.1 0.00025
XP_016869882 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869875 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869883 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869888 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869896 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869874 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869872 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869873 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869890 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869893 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
XP_016869891 (OMIM: 602282) PREDICTED: lysophospha ( 364)  223 45.1 0.00025
NP_004215 (OMIM: 300207) melatonin-related recepto ( 617)  219 44.9 0.00048
NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350)  212 43.5 0.00073
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328)  207 42.7  0.0012
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331)  207 42.7  0.0012
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366)  207 42.8  0.0012
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389)  207 42.8  0.0013
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402)  207 42.9  0.0013
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520)  207 43.1  0.0014


>>XP_016881270 (OMIM: 202200,607397) PREDICTED: adrenoco  (297 aa)
 initn: 1960 init1: 1960 opt: 1960  Z-score: 1541.0  bits: 293.1 E(85289): 4.3e-79
Smith-Waterman score: 1960; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297)

               10        20        30        40        50        60
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
              190       200       210       220       230       240

              250       260       270       280       290       
pF1KB8 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
              250       260       270       280       290       

>>NP_000520 (OMIM: 202200,607397) adrenocorticotropic ho  (297 aa)
 initn: 1960 init1: 1960 opt: 1960  Z-score: 1541.0  bits: 293.1 E(85289): 4.3e-79
Smith-Waterman score: 1960; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297)

               10        20        30        40        50        60
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
              190       200       210       220       230       240

              250       260       270       280       290       
pF1KB8 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
              250       260       270       280       290       

>>NP_001278840 (OMIM: 202200,607397) adrenocorticotropic  (297 aa)
 initn: 1960 init1: 1960 opt: 1960  Z-score: 1541.0  bits: 293.1 E(85289): 4.3e-79
Smith-Waterman score: 1960; 100.0% identity (100.0% similar) in 297 aa overlap (1-297:1-297)

               10        20        30        40        50        60
pF1KB8 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
              190       200       210       220       230       240

              250       260       270       280       290       
pF1KB8 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
              250       260       270       280       290       

>>NP_005904 (OMIM: 600042) melanocortin receptor 5 [Homo  (325 aa)
 initn: 930 init1: 559 opt: 942  Z-score: 754.4  bits: 147.7 E(85289): 2.8e-35
Smith-Waterman score: 942; 46.5% identity (77.8% similar) in 288 aa overlap (13-293:25-312)

                           10        20        30        40        
pF1KB8             MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLA
                               :.  ..: :  . .  :.:.:......:::..:. :
NP_005 MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA
               10        20        30        40        50        60

       50        60        70        80        90       100        
pF1KB8 VFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDS
       . :::::..:::::.::::..::: :. .  :.: : : :  .:    .:    :...::
NP_005 IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS
               70        80        90       100       110       120

      110       120       130       140       150       160        
pF1KB8 LFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIF
       .. .:...:. :: .::.:::.:::.::::: :.: ::. .... ::.:::: ::.....
NP_005 MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY
              130       140       150       160       170       180

      170       180       190       200       210              220 
pF1KB8 SHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLP-------RANMKGAITL
       :. . ... . :.:  :: ... ::.:::::::.:...:..::       :..:.::.:.
NP_005 SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV
              190       200       210       220       230       240

             230       240       250       260       270       280 
pF1KB8 TILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSP
       :.:::::  ::::: ::. ::  ::.: ::. .:: :..  .:::::.:.::.:::::: 
NP_005 TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ
              250       260       270       280       290       300

             290                
pF1KB8 ELRDAFKKMIFCSRYW         
       :.: .::..: :             
NP_005 EMRKTFKEIICCRGFRIACSFPRRD
              310       320     

>>NP_005903 (OMIM: 155541,601665) melanocortin receptor   (332 aa)
 initn: 950 init1: 397 opt: 934  Z-score: 748.2  bits: 146.6 E(85289): 6.2e-35
Smith-Waterman score: 934; 47.3% identity (77.7% similar) in 296 aa overlap (6-293:26-319)

                                   10        20         30         
pF1KB8                     MKHIINSYENINNTARNNSDC-PRVVLPEEIFFTISIVGV
                                :. :.... . ... :  .. .  :.: :......
NP_005 MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGK-GYSDGGCYEQLFVSPEVFVTLGVISL
               10        20        30         40        50         

      40        50        60        70        80        90         
pF1KB8 LENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFE
       :::..:..:. :::::..::::::::::..::: :. .  :.:.: : :      . :: 
NP_005 LENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQ-SFT
      60        70        80        90       100       110         

     100       110       120       130       140       150         
pF1KB8 TTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCT
       .. :..:::..  :::.:: ::  ::.:::.:::.::.::.:.:..:. .... ::. ::
NP_005 VNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACT
      120       130       140       150       160       170        

     160       170       180       190       200       210         
pF1KB8 GTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPR-------
        .:: ..:.:    ..: . ..:  ::...  :::::::.:: : ..:..::        
NP_005 VSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQG
      180       190       200       210       220       230        

            220       230       240       250       260       270  
pF1KB8 ANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVID
       ::::::::::::.:::. ::::: ::....  ::.::::.:.:: :..  .:::::..::
NP_005 ANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIID
      240       250       260       270       280       290        

            280       290                
pF1KB8 PFIYAFRSPELRDAFKKMIFCSRYW         
       :.:::.:: ::: .::..: :             
NP_005 PLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
      300       310       320       330  

>>NP_002377 (OMIM: 155555,203200,266300,613098,613099) m  (317 aa)
 initn: 773 init1: 390 opt: 750  Z-score: 606.2  bits: 120.3 E(85289): 5e-27
Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (21-297:35-317)

                         10        20        30        40        50
pF1KB8           MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF
                                     : .: . . .:.....:...:: .:. .. 
NP_002 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA
           10        20        30        40        50        60    

               60        70        80        90       100       110
pF1KB8 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF
       ::.::..::: ::: ::.::.: :  ..::. .:.: . : :  :..     :..:: . 
NP_002 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT
           70        80        90       100       110       120    

              120       130       140       150       160       170
pF1KB8 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH
         :.:.:.  :..::.::::.::.:::::::::. :.  ....::.  .  .  .. .  
NP_002 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD
          130       140       150       160       170       180    

              180       190       200       210               220  
pF1KB8 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT
       :: ... .. .:  :::..  :::::.  : .:.. :. : . .        .:::.:::
NP_002 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT
          190       200       210       220       230       240    

            230       240       250       260       270       280  
pF1KB8 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE
       ::::.:..::.:: ::. :...:: .: :.: .. :..   ::.:::.:::.::::.: :
NP_002 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE
          250       260       270       280       290       300    

            290       
pF1KB8 LRDAFKKMIFCSRYW
       :: ..:... ::  :
NP_002 LRRTLKEVLTCS--W
          310         

>>NP_063941 (OMIM: 155540,602025,607948) melanocortin re  (323 aa)
 initn: 951 init1: 583 opt: 583  Z-score: 477.2  bits: 96.4 E(85289): 7.7e-20
Smith-Waterman score: 940; 47.9% identity (79.8% similar) in 282 aa overlap (21-293:35-315)

                         10        20        30        40        50
pF1KB8           MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF
                                     : .: .  :.:....::..:::..:.::: 
NP_063 CCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVV
           10        20        30        40        50        60    

               60        70        80        90       100       110
pF1KB8 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF
       .: ::..:::::.::::..::: :. . ::.:.: . .  ::  . .:    :.:.::..
NP_063 RNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMI
           70        80        90       100       110       120    

              120       130       140       150       160       170
pF1KB8 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH
        .::..:: .: .::.:::.:::.:::::::.:.:........::. :   :......:.
NP_063 CISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSE
          130       140       150       160       170       180    

              180       190       200       210                220 
pF1KB8 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN---------MKGAITL
          ... . ..:  :....  :::::::.:: :...:..:: :.         ::::.:.
NP_063 SKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTI
          190       200       210       220       230       240    

             230       240       250       260       270       280 
pF1KB8 TILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSP
       :::::::::::::: ::..:.  ::.:::: :: . :..  .:::::.::::.:::::: 
NP_063 TILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSL
          250       260       270       280       290       300    

             290           
pF1KB8 ELRDAFKKMIFCSRYW    
       :::..:.. :.:        
NP_063 ELRNTFRE-ILCGCNGMNLG
          310        320   

>>NP_004221 (OMIM: 605111,610419,610419) sphingosine 1-p  (353 aa)
 initn: 322 init1: 115 opt: 310  Z-score: 266.0  bits: 57.5 E(85289): 4.4e-08
Smith-Waterman score: 315; 30.4% identity (59.4% similar) in 283 aa overlap (39-295:48-307)

       10        20        30        40        50        60        
pF1KB8 ENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAI
                                     :.:::.::.:: .:..... ::.:. .:: 
NP_004 YNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAA
        20        30        40        50        60        70       

       70        80           90       100       110       120     
pF1KB8 SDMLGSLYKILENIL---IILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIA
       ::.:...  . ...:   . ::    : :   :   .     : :. .: .:.::: .::
NP_004 SDLLAGVAFVANTLLSGSVTLR----LTPVQWFAREG-----SAFI-TLSASVFSLLAIA
        80        90           100       110             120       

         130       140       150                    160            
pF1KB8 ADRYITIFHALRYHSIVTMRRTVVV------------LTVI-WTFCTG----TGITMVIF
        .:...: ..  : :  . :  ...            : .. :. : :     . .. ..
NP_004 IERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWN-CLGHLEACSTVLPLY
       130       140       150       160       170        180      

      170       180       190       200        210       220       
pF1KB8 SHHVPTVITFTSLFPLMLVFILCLYVHMFLLARS-HTRKISTLPRANMKGAITLTILLGV
       ..:   :.  ...: ..:. :. :::... ..:: :.   .    : .:   :.::.:::
NP_004 AKHY--VLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLK---TVTIVLGV
        190         200       210       220       230          240 

       230       240            250       260       270       280  
pF1KB8 FIFCWAPFVLHVLLMTF-CP--SNP--YCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE
       :: :: : .. .::. . ::  : :  : : :  .: :. .    :....: ::..:: .
NP_004 FIVCWLP-AFSILLLDYACPVHSCPILYKAHY--FFAVSTL----NSLLNPVIYTWRSRD
              250       260       270             280       290    

            290                                                   
pF1KB8 LRDAFKKMIFCSRYW                                            
       ::    . . : :                                              
NP_004 LRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
          300       310       320       330       340       350   

>>NP_005217 (OMIM: 601965) sphingosine 1-phosphate recep  (378 aa)
 initn: 221 init1: 126 opt: 306  Z-score: 262.7  bits: 57.0 E(85289): 6.8e-08
Smith-Waterman score: 355; 30.2% identity (63.2% similar) in 285 aa overlap (30-294:45-315)

                10        20        30        40        50         
pF1KB8  MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPM
                                     .:..:    :::::.::.:..::....  :
NP_005 NETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRM
           20        30        40        50        60        70    

      60        70         80        90       100       110        
pF1KB8 YFFICSLAISDML-GSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSI
       :::: .::. :.: :  ::.  :::.  ..   :.:   :   .     :.:: .: .: 
NP_005 YFFIGNLALCDLLAGIAYKV--NILMSGKKTFSLSPTVWFLREG-----SMFV-ALGAST
           80        90         100       110            120       

      120       130       140       150       160          170     
pF1KB8 FSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVI---FSHHVP--
        :: .:: .:..:... .: ..    .:. ... . : .    :   ..     :..:  
NP_005 CSLLAIAIERHLTMIK-MRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDC
        130       140        150       160       170       180     

                     180       190       200       210         220 
pF1KB8 -TV--------ITFT-SLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAI--TL
        :.        :.:  :.:  .:: :. ::.....:..: .::...   .. . :.  :.
NP_005 STILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTV
         190       200       210       220       230       240     

             230       240       250       260         270         
pF1KB8 TILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMC--NAVIDPFIYAFR
       .:...::: ::.:. .  :. . :  .   :: . ::... ....   :....: ::.. 
NP_005 VIVVSVFIACWSPLFILFLIDVACRVQ---ACPI-LFKAQWFIVLAVLNSAMNPVIYTLA
         250       260       270           280       290       300 

     280       290                                                 
pF1KB8 SPELRDAFKKMIFCSRYW                                          
       : :.: :: ... :.                                             
NP_005 SKEMRRAFFRLV-CNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
             310        320       330       340       350       360

>>NP_001391 (OMIM: 601974) sphingosine 1-phosphate recep  (382 aa)
 initn: 253 init1: 130 opt: 252  Z-score: 220.9  bits: 49.3 E(85289): 1.4e-05
Smith-Waterman score: 373; 28.9% identity (60.7% similar) in 298 aa overlap (24-295:45-330)

                      10        20        30        40        50   
pF1KB8        MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNK
                                     . :   .:. :    .:::..:::...:.:
NP_001 SVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTK
           20        30        40        50        60        70    

            60        70        80        90       100       110   
pF1KB8 NLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLS
       ... :::.:: .::.::.:...     :.:.   .   : :   :   .     :.:: .
NP_001 KFHRPMYYFIGNLALSDLLAGV-AYTANLLLSGATTYKLTPAQWFLREG-----SMFV-A
           80        90        100       110       120             

           120       130       140       150                    160
pF1KB8 LLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTF-------------CTG
       : .:.::: .:: .::::... .. :.  .  :  ..... :..             : .
NP_001 LSASVFSLLAIAIERYITMLK-MKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCIS
       130       140        150       160       170       180      

                170       180       190       200             210  
pF1KB8 --TGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRK------ISTLPR
         .. . :.  .:   ..  :..: :.:. :. :: ... :.:...:.      ::   :
NP_001 ALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASR
        190       200       210       220       230       240      

               220       230       240       250       260         
pF1KB8 ANMKGAI---TLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMC--
       .. :.     :. :.:.::: ::::. . .:: . :  .   .: . ::... .:..   
NP_001 SSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVK---TCDI-LFRAEYFLVLAVL
        250       260       270       280           290       300  

       270       280       290                                     
pF1KB8 NAVIDPFIYAFRSPELRDAFKKMIFCSRYW                              
       :.  .:.::.. . :.: :: ... : .                                
NP_001 NSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQ
            310       320       330       340       350       360  




297 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 15:36:44 2016 done: Fri Nov  4 15:36:45 2016
 Total Scan time:  5.800 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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