Result of FASTA (omim) for pF1KB8767
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8767, 225 aa
  1>>>pF1KB8767 225 - 225 aa - 225 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.6284+/-0.000303; mu= -3.8376+/- 0.019
 mean_var=231.3802+/-47.160, 0's: 0 Z-trim(124.5): 31  B-trim: 0 in 0/61
 Lambda= 0.084316
 statistics sampled from 46155 (46187) to 46155 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.829), E-opt: 0.2 (0.542), width:  16
 Scan time:  7.480

The best scores are:                                      opt bits E(85289)
NP_003946 (OMIM: 604176) suppressor of cytokine si ( 225) 1521 196.5 3.1e-50
NP_659508 (OMIM: 602441,607948,611162,614383) cyto ( 258)  349 54.0 2.8e-07
XP_011531631 (OMIM: 602441,607948,611162,614383) P ( 264)  349 54.0 2.9e-07
NP_037456 (OMIM: 602441,607948,611162,614383) cyto ( 275)  349 54.0   3e-07
NP_003736 (OMIM: 603597) suppressor of cytokine si ( 211)  284 46.0 5.8e-05
NP_001257396 (OMIM: 605117) suppressor of cytokine ( 198)  244 41.1  0.0016
NP_001257398 (OMIM: 605117) suppressor of cytokine ( 198)  244 41.1  0.0016
NP_001257397 (OMIM: 605117) suppressor of cytokine ( 198)  244 41.1  0.0016
NP_001257400 (OMIM: 605117) suppressor of cytokine ( 198)  244 41.1  0.0016
XP_016875645 (OMIM: 605117) PREDICTED: suppressor  ( 198)  244 41.1  0.0016
NP_001257399 (OMIM: 605117) suppressor of cytokine ( 198)  244 41.1  0.0016
NP_003868 (OMIM: 605117) suppressor of cytokine si ( 198)  244 41.1  0.0016
XP_011537238 (OMIM: 605117) PREDICTED: suppressor  ( 204)  244 41.1  0.0016
XP_011537237 (OMIM: 605117) PREDICTED: suppressor  ( 212)  244 41.1  0.0017
XP_011537231 (OMIM: 605117) PREDICTED: suppressor  ( 220)  244 41.1  0.0017
XP_016875644 (OMIM: 605117) PREDICTED: suppressor  ( 222)  244 41.1  0.0018
XP_016875640 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019
XP_016875639 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019
XP_016875636 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019
XP_016875638 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019
XP_016875637 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019
XP_016875641 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019
XP_016875642 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019
XP_016875643 (OMIM: 605117) PREDICTED: suppressor  ( 243)  244 41.2  0.0019


>>NP_003946 (OMIM: 604176) suppressor of cytokine signal  (225 aa)
 initn: 1521 init1: 1521 opt: 1521  Z-score: 1022.9  bits: 196.5 E(85289): 3.1e-50
Smith-Waterman score: 1521; 100.0% identity (100.0% similar) in 225 aa overlap (1-225:1-225)

               10        20        30        40        50        60
pF1KB8 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
              130       140       150       160       170       180

              190       200       210       220     
pF1KB8 PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
       :::::::::::::::::::::::::::::::::::::::::::::
NP_003 PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
              190       200       210       220     

>>NP_659508 (OMIM: 602441,607948,611162,614383) cytokine  (258 aa)
 initn: 331 init1: 235 opt: 349  Z-score: 251.6  bits: 54.0 E(85289): 2.8e-07
Smith-Waterman score: 349; 33.6% identity (58.4% similar) in 214 aa overlap (15-221:51-254)

                               10        20        30        40    
pF1KB8                 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
                                     : .:  . :... . .   ....   :.::
NP_659 PLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRES
               30        40        50        60        70        80

           50        60        70        80        90       100    
pF1KB8 GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL
       :.::...:..::   :.  : ::::.:::.   ..:::::::  :  :.::.   .:: :
NP_659 GWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL
               90       100       110       120       130       140

          110       120       130          140       150           
pF1KB8 QSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSF---PSPPTEPSSEVPEQ--PSAQPLPGS
       .:.  :   .  :  :..::.::.    : .    :.:   :.  .:..  ::   ::. 
NP_659 DSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAP
              150       160       170       180       190       200

     160       170       180         190       200       210       
pF1KB8 PPRRAYYIYSGGEKIPLVLSRPL--SSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREF
       ::  :         . : : .:.   :.. .:::::: ..: .: .      ::  . ..
NP_659 PPATA---------VHLKLVQPFVRRSSARSLQHLCRLVIN-RLVADVDCLPLPRRMADY
                       210       220       230        240       250

       220     
pF1KB8 LDQYDAPL
       : ::    
NP_659 LRQYPFQL
               

>>XP_011531631 (OMIM: 602441,607948,611162,614383) PREDI  (264 aa)
 initn: 331 init1: 235 opt: 349  Z-score: 251.4  bits: 54.0 E(85289): 2.9e-07
Smith-Waterman score: 349; 33.6% identity (58.4% similar) in 214 aa overlap (15-221:57-260)

                               10        20        30        40    
pF1KB8                 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
                                     : .:  . :... . .   ....   :.::
XP_011 PLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRES
         30        40        50        60        70        80      

           50        60        70        80        90       100    
pF1KB8 GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL
       :.::...:..::   :.  : ::::.:::.   ..:::::::  :  :.::.   .:: :
XP_011 GWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL
         90       100       110       120       130       140      

          110       120       130          140       150           
pF1KB8 QSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSF---PSPPTEPSSEVPEQ--PSAQPLPGS
       .:.  :   .  :  :..::.::.    : .    :.:   :.  .:..  ::   ::. 
XP_011 DSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAP
        150       160       170       180       190       200      

     160       170       180         190       200       210       
pF1KB8 PPRRAYYIYSGGEKIPLVLSRPL--SSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREF
       ::  :         . : : .:.   :.. .:::::: ..: .: .      ::  . ..
XP_011 PPATA---------VHLKLVQPFVRRSSARSLQHLCRLVIN-RLVADVDCLPLPRRMADY
        210                220       230        240       250      

       220     
pF1KB8 LDQYDAPL
       : ::    
XP_011 LRQYPFQL
        260    

>>NP_037456 (OMIM: 602441,607948,611162,614383) cytokine  (275 aa)
 initn: 331 init1: 235 opt: 349  Z-score: 251.2  bits: 54.0 E(85289): 3e-07
Smith-Waterman score: 349; 33.6% identity (58.4% similar) in 214 aa overlap (15-221:68-271)

                               10        20        30        40    
pF1KB8                 MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQES
                                     : .:  . :... . .   ....   :.::
NP_037 PLWAPSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRES
        40        50        60        70        80        90       

           50        60        70        80        90       100    
pF1KB8 GFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSL
       :.::...:..::   :.  : ::::.:::.   ..:::::::  :  :.::.   .:: :
NP_037 GWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRL
       100       110       120       130       140       150       

          110       120       130          140       150           
pF1KB8 QSDPRSTQPVPRFDCVLKLVHHYMPPPGAPSF---PSPPTEPSSEVPEQ--PSAQPLPGS
       .:.  :   .  :  :..::.::.    : .    :.:   :.  .:..  ::   ::. 
NP_037 DSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPMPKEDAPSDPALPAP
       160       170       180       190       200       210       

     160       170       180         190       200       210       
pF1KB8 PPRRAYYIYSGGEKIPLVLSRPL--SSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREF
       ::  :         . : : .:.   :.. .:::::: ..: .: .      ::  . ..
NP_037 PPATA---------VHLKLVQPFVRRSSARSLQHLCRLVIN-RLVADVDCLPLPRRMADY
       220                230       240        250       260       

       220     
pF1KB8 LDQYDAPL
       : ::    
NP_037 LRQYPFQL
       270     

>>NP_003736 (OMIM: 603597) suppressor of cytokine signal  (211 aa)
 initn: 294 init1: 215 opt: 284  Z-score: 210.1  bits: 46.0 E(85289): 5.8e-05
Smith-Waterman score: 284; 38.9% identity (64.9% similar) in 131 aa overlap (8-134:43-165)

                                      10        20        30       
pF1KB8                        MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNA
                                     ::.    : :: .:  :: :...:. .. :
NP_003 VSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFR--TFRSHADYRRITRA
             20        30        40        50          60        70

        40        50        60        70        80        90       
pF1KB8 VRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQC
          :.  ::::. ..   :.  : :::.::::.::: ..  ::.::::  ::  ..:.. 
NP_003 SALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHF
               80        90       100       110       120       130

       100       110       120       130           140       150   
pF1KB8 EGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPP----GAPSFPSPPTEPSSEVPEQPSA
       ..: : :... .:      :::...:..::.  :    :::                   
NP_003 QAGRFHLDGSRES------FDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVA
              140             150       160       170       180    

           160       170       180       190       200       210   
pF1KB8 QPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGP
                                                                   
NP_003 TVGRENLARIPLNPVLRDYLSSFPFQI                                 
          190       200       210                                  

>>NP_001257396 (OMIM: 605117) suppressor of cytokine sig  (198 aa)
 initn: 300 init1: 210 opt: 244  Z-score: 184.2  bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)

            10        20        30        40        50        60   
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
                                     ...:.:.: ..:.::...: .::.  :.  
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
          10        20        30        40        50        60     

            70        80        90       100       110       120   
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
       : ::::::::: . ...:.::::..:  ::::. . :.: :.:     . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
          70        80        90       100       110       120     

           130       140       150       160       170       180   
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
       . .:.             . .   :: :      :.              . : :..:: 
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
         130                 140                         150       

           190       200       210       220     
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
       ... .:::::: :.:    .   .  ::  ....:..:    
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
       160       170       180        190        

>>NP_001257398 (OMIM: 605117) suppressor of cytokine sig  (198 aa)
 initn: 300 init1: 210 opt: 244  Z-score: 184.2  bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)

            10        20        30        40        50        60   
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
                                     ...:.:.: ..:.::...: .::.  :.  
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
          10        20        30        40        50        60     

            70        80        90       100       110       120   
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
       : ::::::::: . ...:.::::..:  ::::. . :.: :.:     . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
          70        80        90       100       110       120     

           130       140       150       160       170       180   
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
       . .:.             . .   :: :      :.              . : :..:: 
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
         130                 140                         150       

           190       200       210       220     
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
       ... .:::::: :.:    .   .  ::  ....:..:    
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
       160       170       180        190        

>>NP_001257397 (OMIM: 605117) suppressor of cytokine sig  (198 aa)
 initn: 300 init1: 210 opt: 244  Z-score: 184.2  bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)

            10        20        30        40        50        60   
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
                                     ...:.:.: ..:.::...: .::.  :.  
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
          10        20        30        40        50        60     

            70        80        90       100       110       120   
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
       : ::::::::: . ...:.::::..:  ::::. . :.: :.:     . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
          70        80        90       100       110       120     

           130       140       150       160       170       180   
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
       . .:.             . .   :: :      :.              . : :..:: 
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
         130                 140                         150       

           190       200       210       220     
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
       ... .:::::: :.:    .   .  ::  ....:..:    
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
       160       170       180        190        

>>NP_001257400 (OMIM: 605117) suppressor of cytokine sig  (198 aa)
 initn: 300 init1: 210 opt: 244  Z-score: 184.2  bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)

            10        20        30        40        50        60   
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
                                     ...:.:.: ..:.::...: .::.  :.  
NP_001 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
          10        20        30        40        50        60     

            70        80        90       100       110       120   
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
       : ::::::::: . ...:.::::..:  ::::. . :.: :.:     . . .:: :..:
NP_001 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
          70        80        90       100       110       120     

           130       140       150       160       170       180   
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
       . .:.             . .   :: :      :.              . : :..:: 
NP_001 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
         130                 140                         150       

           190       200       210       220     
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
       ... .:::::: :.:    .   .  ::  ....:..:    
NP_001 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
       160       170       180        190        

>>XP_016875645 (OMIM: 605117) PREDICTED: suppressor of c  (198 aa)
 initn: 300 init1: 210 opt: 244  Z-score: 184.2  bits: 41.1 E(85289): 0.0016
Smith-Waterman score: 284; 31.4% identity (59.0% similar) in 188 aa overlap (34-221:36-194)

            10        20        30        40        50        60   
pF1KB8 HSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAE
                                     ...:.:.: ..:.::...: .::.  :.  
XP_016 LEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA
          10        20        30        40        50        60     

            70        80        90       100       110       120   
pF1KB8 PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKL
       : ::::::::: . ...:.::::..:  ::::. . :.: :.:     . . .:: :..:
XP_016 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL
          70        80        90       100       110       120     

           130       140       150       160       170       180   
pF1KB8 VHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLS
       . .:.             . .   :: :      :.              . : :..:: 
XP_016 IDYYV----------QMCKDKRTGPEAPRN----GT--------------VHLYLTKPLY
         130                 140                         150       

           190       200       210       220     
pF1KB8 SNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
       ... .:::::: :.:    .   .  ::  ....:..:    
XP_016 TSAPSLQHLCRLTINKCTGAIWGLP-LPTRLKDYLEEYKFQV
       160       170       180        190        




225 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 15:24:56 2016 done: Fri Nov  4 15:24:57 2016
 Total Scan time:  7.480 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com