Result of FASTA (ccds) for pF1KB8353
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8353, 347 aa
  1>>>pF1KB8353 347 - 347 aa - 347 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4038+/-0.000771; mu= 15.2934+/- 0.047
 mean_var=59.2119+/-11.919, 0's: 0 Z-trim(107.1): 27  B-trim: 0 in 0/50
 Lambda= 0.166675
 statistics sampled from 9326 (9344) to 9326 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.287), width:  16
 Scan time:  1.710

The best scores are:                                      opt bits E(32554)
CCDS2615.1 HDAC11 gene_id:79885|Hs108|chr3         ( 347) 2316 565.1 2.9e-161
CCDS46760.1 HDAC11 gene_id:79885|Hs108|chr3        ( 296) 1605 394.1 7.5e-110
CCDS82738.1 HDAC11 gene_id:79885|Hs108|chr3        ( 268) 1224 302.5 2.6e-82
CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6          ( 488)  305 81.6 1.5e-15
CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1            ( 482)  292 78.5 1.3e-14
CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX         ( 377)  278 75.1 1.1e-13
CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5           ( 428)  241 66.2 5.6e-11


>>CCDS2615.1 HDAC11 gene_id:79885|Hs108|chr3              (347 aa)
 initn: 2316 init1: 2316 opt: 2316  Z-score: 3008.6  bits: 565.1 E(32554): 2.9e-161
Smith-Waterman score: 2316; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347)

               10        20        30        40        50        60
pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
              250       260       270       280       290       300

              310       320       330       340       
pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
       :::::::::::::::::::::::::::::::::::::::::::::::
CCDS26 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
              310       320       330       340       

>>CCDS46760.1 HDAC11 gene_id:79885|Hs108|chr3             (296 aa)
 initn: 1605 init1: 1605 opt: 1605  Z-score: 2085.7  bits: 394.1 E(32554): 7.5e-110
Smith-Waterman score: 1906; 92.8% identity (92.8% similar) in 319 aa overlap (29-347:1-296)

               10        20        30        40        50        60
pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
                                   ::::::::::::::::::::::::::::::::
CCDS46                             MGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
                                           10        20        30  

               70        80        90       100       110       120
pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
       ::::::::::::::::::::::::                       :::::::::::::
CCDS46 VEAREASEEDLLVVHTRRYLNELK-----------------------RKVLRPLRTQTGG
             40        50                               60         

              130       140       150       160       170       180
pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
      70        80        90       100       110       120         

              190       200       210       220       230       240
pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
     130       140       150       160       170       180         

              250       260       270       280       290       300
pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
     190       200       210       220       230       240         

              310       320       330       340       
pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
       :::::::::::::::::::::::::::::::::::::::::::::::
CCDS46 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
     250       260       270       280       290      

>>CCDS82738.1 HDAC11 gene_id:79885|Hs108|chr3             (268 aa)
 initn: 1224 init1: 1224 opt: 1224  Z-score: 1591.3  bits: 302.5 E(32554): 2.6e-82
Smith-Waterman score: 1608; 77.2% identity (77.2% similar) in 347 aa overlap (1-347:1-268)

               10        20        30        40        50        60
pF1KB8 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
       ::::::::::::::::::::::::                                    
CCDS82 VEAREASEEDLLVVHTRRYLNELK------------------------------------
               70        80                                        

              130       140       150       160       170       180
pF1KB8 TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
                                                  :::::::::::::::::
CCDS82 -------------------------------------------FLFERVEGISRATIIDL
                                                      90       100 

              190       200       210       220       230       240
pF1KB8 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
             110       120       130       140       150       160 

              250       260       270       280       290       300
pF1KB8 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
             170       180       190       200       210       220 

              310       320       330       340       
pF1KB8 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
       :::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
             230       240       250       260        

>>CCDS43493.2 HDAC2 gene_id:3066|Hs108|chr6               (488 aa)
 initn: 200 init1: 103 opt: 305  Z-score: 392.8  bits: 81.6 E(32554): 1.5e-15
Smith-Waterman score: 305; 27.4% identity (56.9% similar) in 288 aa overlap (35-307:29-307)

           10        20        30        40        50        60    
pF1KB8 TQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAR
                                     ::.   .   . :.: .  :     . . .
CCDS43   MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
                 10        20        30        40        50        

           70        80        90       100       110           120
pF1KB8 EASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPL----RTQTGG
       .:. :..   :. .:.. :. :.   ...:    .   :   .  :.  :    . .:::
CCDS43 KATAEEMTKYHSDEYIKFLR-SIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG
       60        70         80        90       100       110       

              130          140       150       160       170       
pF1KB8 TIMAGKLAVER---GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATI
       .. :: . ..:     :.: .::.:: ......:::   ::.:::   .: ..  .:.  
CCDS43 SV-AGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRVLY
        120       130       140       150       160          170   

       180       190       200        210            220           
pF1KB8 IDLDAHQGNGHERDFMDDKRVYIMDVYNR-HIYPG-----DRFAKQAIRRKVELEW--GT
       ::.: :.:.: :. :.   ::. .. ..  . .::     :  : ..    :..    : 
CCDS43 IDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGI
           180       190       200       210       220       230   

     230       240       250       260       270       280         
pF1KB8 EDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMV
       .:. : .  .  :.: .. . :..:: . :.: : ::::: ....  : .:  :.:    
CCDS43 DDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVV----
           240       250       260       270       280             

     290       300       310       320       330       340         
pF1KB8 RGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP  
       .   .:.::. .:::  :                                          
CCDS43 KTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPS
     290       300       310       320       330       340         

>>CCDS360.1 HDAC1 gene_id:3065|Hs108|chr1                 (482 aa)
 initn: 185 init1: 103 opt: 292  Z-score: 375.9  bits: 78.5 E(32554): 1.3e-14
Smith-Waterman score: 292; 27.2% identity (56.8% similar) in 287 aa overlap (35-307:28-306)

           10        20        30        40        50        60    
pF1KB8 TQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAR
                                     ::.   .   . :.: .  :     . . .
CCDS36    MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
                  10        20        30        40        50       

           70        80        90       100       110           120
pF1KB8 EASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPL----RTQTGG
       .:. :..   :.  :.. :. :.   ...:    .   :   .  :.  :    . .:::
CCDS36 KANAEEMTKYHSDDYIKFLR-SIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGG
        60        70         80        90       100       110      

               130        140       150       160       170        
pF1KB8 TIMAG-KLAVER-GWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATII
       .. .. ::  ..   :.: .::.:: ......:::   ::.:::   .: ..  .:.  :
CCDS36 SVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI---LELLKYHQRVLYI
        120       130       140       150       160          170   

      180       190       200        210            220         230
pF1KB8 DLDAHQGNGHERDFMDDKRVYIMDVYNR-HIYPG-----DRFAKQAIRRKVE--LEWGTE
       :.: :.:.: :. :.   ::. .. ..  . .::     :  : ..    :.  :. : .
CCDS36 DIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID
           180       190       200       210       220       230   

              240       250       260       270       280       290
pF1KB8 DDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVR
       :. :    .  ..: ..   :..:: . :.: : ::::: ....  : .:  :.:    .
CCDS36 DESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFV----K
           240       250       260       270       280             

              300       310       320       330       340          
pF1KB8 GRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP   
       .  .:.::. .:::  :                                           
CCDS36 SFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSN
     290       300       310       320       330       340         

>>CCDS14420.1 HDAC8 gene_id:55869|Hs108|chrX              (377 aa)
 initn: 186 init1: 100 opt: 278  Z-score: 359.5  bits: 75.1 E(32554): 1.1e-13
Smith-Waterman score: 278; 26.6% identity (55.8% similar) in 312 aa overlap (17-310:16-313)

               10         20        30        40        50         
pF1KB8 MLHTTQLYQHVPETRWPI-VYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSM
                       :. .:::.:     .: :. :    : ..... : :   :  .:
CCDS14  MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKI-P----KRASMVHSLIEAYALHKQM
                10        20        30             40        50    

       60        70        80        90       100          110     
pF1KB8 -LVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLP---NFLVQRKVLRPLR
        .:. . :: :.. . ::  ::..:. . .     . :  :      .  . . ..    
CCDS14 RIVKPKVASMEEMATFHTDAYLQHLQ-KVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAA
           60        70        80         90       100       110   

         120       130          140       150       160       170  
pF1KB8 TQTGGTIMAGKLAVERGW---AINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGI
       .  :.:: :..  .. :    ::: .::.:: ..:...:::   : .:.:  : .. :  
CCDS14 AIGGATITAAQCLID-GMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFE--
           120        130       140       150       160       170  

            180       190       200         210       220          
pF1KB8 SRATIIDLDAHQGNGHERDFMDDKRVYIMDV--YNRHIYPGDRFAKQAIRRK-------V
        :   .::: :.:.: :  :   ..:. ...  ..  ..::   ....   :       :
CCDS14 -RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNV
               180       190       200       210       220         

           230       240       250       260       270       280   
pF1KB8 ELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDE
        .. : .:..: .  :  .:.  :   : .:: . :.: . :: . .....:.:: :   
CCDS14 PIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGK---
     230       240       250       260       270       280         

           290       300        310       320       330       340  
pF1KB8 LVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLL
         ....   ..  :.. .:::.   :::                                
CCDS14 -CLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYV
         290       300       310       320       330       340     

>>CCDS4264.1 HDAC3 gene_id:8841|Hs108|chr5                (428 aa)
 initn:  91 init1:  91 opt: 241  Z-score: 310.5  bits: 66.2 E(32554): 5.6e-11
Smith-Waterman score: 241; 24.6% identity (54.9% similar) in 293 aa overlap (35-307:22-301)

           10        20        30        40        50        60    
pF1KB8 TQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAR
                                     ::.   . . . ... .  : .  .. .  
CCDS42          MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPY
                        10        20        30        40        50 

           70        80                   90       100       110   
pF1KB8 EASEEDLLVVHTRRYLNELKW-----------SFAVATITEIPPVIFLPNFLVQRKVLRP
       .::..:.   :.. :.. :.            :. . .. .  ::  .:...   .    
CCDS42 QASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPV--FPGLFEFCSRYTG
              60        70        80        90         100         

           120       130       140       150       160       170   
pF1KB8 LRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGIS
          : :.: . .:.      ::: .::.:: .. ...:::   ::...:   .: ..   
CCDS42 ASLQ-GATQLNNKIC---DIAINWAGGLHHAKKFEASGFCYVNDIVIGI---LELLKYHP
     110        120          130       140       150          160  

           180       190       200         210         220         
pF1KB8 RATIIDLDAHQGNGHERDFMDDKRVYIMDV--YNRHIYPG--DRFAKQAIRRK-----VE
       :.  ::.: :.:.: .. :.   ::. ..   :. ...::  : .   :   .     : 
CCDS42 RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVP
            170       180       190       200       210       220  

          230       240       250       260       270       280    
pF1KB8 LEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDEL
       :. : .:. :    .  :.. .. . :  .: . :.: :  :::: ...:  :   . : 
CCDS42 LRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRG---HGEC
            230       240       250       260       270            

          290       300       310       320       330       340    
pF1KB8 VFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPP
       : ..:..  .:.:.. .:::  :                                     
CCDS42 V-EYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTL
     280        290       300       310       320       330        




347 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 12:00:54 2016 done: Fri Nov  4 12:00:54 2016
 Total Scan time:  1.710 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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