Result of FASTA (omim) for pF1KB8244
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8244, 334 aa
  1>>>pF1KB8244 334 - 334 aa - 334 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.4090+/-0.000389; mu= 15.4936+/- 0.024
 mean_var=61.6539+/-12.415, 0's: 0 Z-trim(111.4): 44  B-trim: 1120 in 2/54
 Lambda= 0.163340
 statistics sampled from 19962 (20005) to 19962 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.235), width:  16
 Scan time:  6.090

The best scores are:                                      opt bits E(85289)
NP_006828 (OMIM: 604850) COP9 signalosome complex  ( 334) 2209 529.2 4.8e-150
NP_005796 (OMIM: 607173) 26S proteasome non-ATPase ( 310)  474 120.3 5.3e-27
NP_077308 (OMIM: 300617) lys-63-specific deubiquit ( 316)  157 45.6 0.00017
XP_005274808 (OMIM: 300617) PREDICTED: lys-63-spec ( 317)  157 45.6 0.00017
XP_016885327 (OMIM: 300617) PREDICTED: lys-63-spec ( 291)  153 44.7  0.0003
NP_001018065 (OMIM: 300617) lys-63-specific deubiq ( 291)  153 44.7  0.0003
NP_001229569 (OMIM: 300617) lys-63-specific deubiq ( 292)  153 44.7  0.0003
NP_002802 (OMIM: 157970) 26S proteasome non-ATPase ( 324)  147 43.3 0.00087


>>NP_006828 (OMIM: 604850) COP9 signalosome complex subu  (334 aa)
 initn: 2209 init1: 2209 opt: 2209  Z-score: 2814.8  bits: 529.2 E(85289): 4.8e-150
Smith-Waterman score: 2209; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334)

               10        20        30        40        50        60
pF1KB8 MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
              250       260       270       280       290       300

              310       320       330    
pF1KB8 AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
       ::::::::::::::::::::::::::::::::::
NP_006 AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
              310       320       330    

>>NP_005796 (OMIM: 607173) 26S proteasome non-ATPase reg  (310 aa)
 initn: 414 init1: 236 opt: 474  Z-score: 605.7  bits: 120.3 E(85289): 5.3e-27
Smith-Waterman score: 474; 35.7% identity (66.3% similar) in 252 aa overlap (57-301:33-271)

         30        40        50        60        70        80      
pF1KB8 EIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGK-V
                                     ::.::::::. :.:.:  .::::::::. :
NP_005 RLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFV
             10        20        30        40        50        60  

          90       100       110       120       130       140     
pF1KB8 DGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGC
       :  :. ..: ::.:  ::   :...:.   ..: ...  ::.:: : ..::::::::.::
NP_005 DDYTVRVIDVFAMPQSGT--GVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
             70        80          90       100       110       120

         150       160       170       180       190           200 
pF1KB8 WLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGY----KPPDEGPS
       ::::.:..::.  . ..:  ::::.:: .... ::: . :::    ..    . : .  :
NP_005 WLSGVDINTQQSFEALSERAVAVVVDPIQSVK-GKVVIDAFRLINANMMVLGHEPRQTTS
              130       140       150        160       170         

             210         220       230       240       250         
pF1KB8 EYQTIPLNKIEDFGVH--CKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNA
       .   .   .:. . .:   ..::.. ..: :. :..:.:  : .: :.. :      :  
NP_005 NLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGL------TLQ
     180       190        200       210       220             230  

     260       270       280       290       300       310         
pF1KB8 DYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLM
       ::.  .    .:.. .   .:.. ..  ..: .:. . ..::                  
NP_005 DYS--EHCKHNESVVKEMLELAK-NYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVD
              240       250        260       270       280         

     320       330          
pF1KB8 SQVIKDKLFNQINIS      
                            
NP_005 VLMTSNIVQCLAAMLDTVVFK
     290       300       310

>>NP_077308 (OMIM: 300617) lys-63-specific deubiquitinas  (316 aa)
 initn: 202 init1: 139 opt: 157  Z-score: 201.9  bits: 45.6 E(85289): 0.00017
Smith-Waterman score: 157; 24.6% identity (56.9% similar) in 130 aa overlap (84-205:65-193)

            60        70        80        90       100       110   
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
                                     :::.  .. . :  .  .. . .  .. . 
NP_077 MGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
           40        50        60        70        80        90    

           120          130       140       150       160       170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
        .  ::  :    :. .::   ..:::::::    : : .:: :: . :.... ::....
NP_077 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
          100       110       120       130       140       150    

                 180       190         200       210       220     
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPD--EGPSEYQTIPLNKIEDFGVHCKQYYALE
       .     .. ..:.:    :..  .. :  .  .:: .. .                    
NP_077 SCFIEDKNTKTGRVLYTCFQSI-QAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIE
          160       170        180       190       200       210   

         230       240       250       260       270       280     
pF1KB8 VSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSF
                                                                   
NP_077 IPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLC
           220       230       240       250       260       270   

>>XP_005274808 (OMIM: 300617) PREDICTED: lys-63-specific  (317 aa)
 initn: 202 init1: 139 opt: 157  Z-score: 201.9  bits: 45.6 E(85289): 0.00017
Smith-Waterman score: 157; 24.6% identity (56.9% similar) in 130 aa overlap (84-205:66-194)

            60        70        80        90       100       110   
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
                                     :::.  .. . :  .  .. . .  .. . 
XP_005 GLCIGELNDDTSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
          40        50        60        70        80        90     

           120          130       140       150       160       170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
        .  ::  :    :. .::   ..:::::::    : : .:: :: . :.... ::....
XP_005 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
         100       110       120       130       140       150     

                 180       190         200       210       220     
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPD--EGPSEYQTIPLNKIEDFGVHCKQYYALE
       .     .. ..:.:    :..  .. :  .  .:: .. .                    
XP_005 SCFIEDKNTKTGRVLYTCFQSI-QAQKSSESLHGPRDFWSSSQHISIEGQKEEERYERIE
         160       170        180       190       200       210    

         230       240       250       260       270       280     
pF1KB8 VSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSF
                                                                   
XP_005 IPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLC
          220       230       240       250       260       270    

>>XP_016885327 (OMIM: 300617) PREDICTED: lys-63-specific  (291 aa)
 initn: 202 init1: 139 opt: 153  Z-score: 197.3  bits: 44.7 E(85289): 0.0003
Smith-Waterman score: 153; 26.1% identity (57.7% similar) in 111 aa overlap (84-188:65-175)

            60        70        80        90       100       110   
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
                                     :::.  .. . :  .  .. . .  .. . 
XP_016 MGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
           40        50        60        70        80        90    

           120          130       140       150       160       170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
        .  ::  :    :. .::   ..:::::::    : : .:: :: . :.... ::....
XP_016 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
          100       110       120       130       140       150    

                 180       190       200       210       220       
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVS
       .     .. ..:.:    :..                                       
XP_016 SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKIL
          160       170       180       190       200       210    

>>NP_001018065 (OMIM: 300617) lys-63-specific deubiquiti  (291 aa)
 initn: 202 init1: 139 opt: 153  Z-score: 197.3  bits: 44.7 E(85289): 0.0003
Smith-Waterman score: 153; 26.1% identity (57.7% similar) in 111 aa overlap (84-188:65-175)

            60        70        80        90       100       110   
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
                                     :::.  .. . :  .  .. . .  .. . 
NP_001 MGLCIGELNDDTRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
           40        50        60        70        80        90    

           120          130       140       150       160       170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
        .  ::  :    :. .::   ..:::::::    : : .:: :: . :.... ::....
NP_001 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
          100       110       120       130       140       150    

                 180       190       200       210       220       
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVS
       .     .. ..:.:    :..                                       
NP_001 SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKIL
          160       170       180       190       200       210    

>>NP_001229569 (OMIM: 300617) lys-63-specific deubiquiti  (292 aa)
 initn: 202 init1: 139 opt: 153  Z-score: 197.3  bits: 44.7 E(85289): 0.0003
Smith-Waterman score: 153; 26.1% identity (57.7% similar) in 111 aa overlap (84-188:66-176)

            60        70        80        90       100       110   
pF1KB8 YCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAA
                                     :::.  .. . :  .  .. . .  .. . 
NP_001 GLCIGELNDDTSRSDSKFAYTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISP
          40        50        60        70        80        90     

           120          130       140       150       160       170
pF1KB8 YEYMAAYIEN---AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVI
        .  ::  :    :. .::   ..:::::::    : : .:: :: . :.... ::....
NP_001 EQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIF
         100       110       120       130       140       150     

                 180       190       200       210       220       
pF1KB8 D---PTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVS
       .     .. ..:.:    :..                                       
NP_001 SCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKIL
         160       170       180       190       200       210     

>>NP_002802 (OMIM: 157970) 26S proteasome non-ATPase reg  (324 aa)
 initn:  97 init1:  97 opt: 147  Z-score: 189.0  bits: 43.3 E(85289): 0.00087
Smith-Waterman score: 154; 23.0% identity (53.3% similar) in 291 aa overlap (57-326:11-283)

         30        40        50        60            70        80  
pF1KB8 EIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMH----ARSGGNLEVMGLML
                                     .  :.::..: :    .. :.. .:.:..:
NP_002                     MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLL
                                   10        20        30        40

             90       100       110       120       130       140  
pF1KB8 GKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPG
       :. . ... . .:::.: .  .   ..    ..:.  .    :.:.  :  .::::. : 
NP_002 GSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPK
               50        60        70        80        90       100

            150       160       170                180       190   
pF1KB8 YGCWLSGIDVSTQMLNQQFQEPFVAVVID--------PTRT-ISAGKVNLGAFRTYPKGY
           :   :.. . : ...    : :.::        ::.. ::. .:.  .  :     
NP_002 ----LHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFE
                  110       120       130       140       150      

            200           210        220       230       240       
pF1KB8 KPPDE-GPSEYQTIP----LNKIEDFGVHC-KQYYALEVSYFKSSLDRKLLELLWNKYWV
       .  .: :  : . .     :  :.:  :   .:  . .:  .:. :. :::..   . ..
NP_002 HVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKG-LNSKLLDI---RSYL
        160       170       180       190       200           210  

       250       260         270       280       290       300     
pF1KB8 NTLSSSSLLTNAD--YTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATR
       . .....:  : .  :   .::.:   : .   :    .:.:       :..:... .  
NP_002 EKVATGKLPINHQIIYQLQDVFNL---LPDVSLQEFVKAFYL-------KTNDQMVVVYL
            220       230          240       250              260  

         310       320       330                                   
pF1KB8 DSCKTTIEAIHGLMSQVIKDKLFNQINIS                               
        :   .. :.:.:... : ..                                       
NP_002 ASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKE
            270       280       290       300       310       320  




334 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:56:23 2016 done: Fri Nov  4 10:56:24 2016
 Total Scan time:  6.090 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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