Result of FASTA (omim) for pF1KB8196
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8196, 458 aa
  1>>>pF1KB8196 458 - 458 aa - 458 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.5003+/-0.000316; mu= 12.8616+/- 0.020
 mean_var=105.3776+/-21.425, 0's: 0 Z-trim(118.7): 23  B-trim: 0 in 0/53
 Lambda= 0.124940
 statistics sampled from 31904 (31927) to 31904 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.374), width:  16
 Scan time:  7.240

The best scores are:                                      opt bits E(85289)
NP_037379 (OMIM: 606441,610297) serine protease HT ( 458) 2982 547.9  2e-155
NP_001308657 (OMIM: 606441,610297) serine protease ( 426) 2430 448.4 1.7e-125
NP_001308656 (OMIM: 606441,610297) serine protease ( 436) 2065 382.6 1.1e-105
NP_659540 (OMIM: 606441,610297) serine protease HT ( 361) 1569 293.2 7.8e-79
NP_444272 (OMIM: 608785) serine protease HTRA3 iso ( 453) 1133 214.7 4.3e-55
NP_002766 (OMIM: 600142,602194,610149,616779) seri ( 480) 1107 210.0 1.2e-53
NP_710159 (OMIM: 610700) serine protease HTRA4 pre ( 476) 1001 190.9 6.5e-48
NP_001284488 (OMIM: 608785) serine protease HTRA3  ( 357)  884 169.7 1.1e-41
XP_011511898 (OMIM: 608785) PREDICTED: serine prot ( 373)  884 169.7 1.2e-41
XP_011542733 (OMIM: 610700) PREDICTED: serine prot ( 380)  773 149.7 1.3e-35
XP_011542734 (OMIM: 610700) PREDICTED: serine prot ( 343)  619 121.9 2.6e-27


>>NP_037379 (OMIM: 606441,610297) serine protease HTRA2,  (458 aa)
 initn: 2982 init1: 2982 opt: 2982  Z-score: 2911.3  bits: 547.9 E(85289): 2e-155
Smith-Waterman score: 2982; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458)

               10        20        30        40        50        60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
              370       380       390       400       410       420

              430       440       450        
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       ::::::::::::::::::::::::::::::::::::::
NP_037 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
              430       440       450        

>>NP_001308657 (OMIM: 606441,610297) serine protease HTR  (426 aa)
 initn: 2757 init1: 2430 opt: 2430  Z-score: 2374.0  bits: 448.4 E(85289): 1.7e-125
Smith-Waterman score: 2697; 93.0% identity (93.0% similar) in 458 aa overlap (1-458:1-426)

               10        20        30        40        50        60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
       :::::::::::                                :::::::::::::::::
NP_001 YIGVMMLTLSP--------------------------------RAGLRPGDVILAIGEQM
              370                                       380        

              430       440       450        
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       ::::::::::::::::::::::::::::::::::::::
NP_001 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
      390       400       410       420      

>>NP_001308656 (OMIM: 606441,610297) serine protease HTR  (436 aa)
 initn: 2743 init1: 2061 opt: 2065  Z-score: 2018.3  bits: 382.6 E(85289): 1.1e-105
Smith-Waterman score: 2667; 91.0% identity (91.0% similar) in 468 aa overlap (1-458:1-436)

               10        20        30        40        50        60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
              250       260       270       280       290       300

              310                 320       330       340       350
pF1KB8 IDFGNSGGPLVNL----------DGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNS
       :::::::::::::          :::::::::::::::::::::::::::::::::::::
NP_001 IDFGNSGGPLVNLARELGAVSLQDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNS
              310       320       330       340       350       360

              360       370       380       390       400       410
pF1KB8 SSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPG
       :::::::::::::::::::::                                :::::::
NP_001 SSGISGSQRRYIGVMMLTLSP--------------------------------RAGLRPG
              370       380                                        

              420       430       440       450        
pF1KB8 DVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
      390       400       410       420       430      

>>NP_659540 (OMIM: 606441,610297) serine protease HTRA2,  (361 aa)
 initn: 2325 init1: 1567 opt: 1569  Z-score: 1536.3  bits: 293.2 E(85289): 7.8e-79
Smith-Waterman score: 2139; 78.8% identity (78.8% similar) in 458 aa overlap (1-458:1-361)

               10        20        30        40        50        60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::   
NP_659 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTK---
              190       200       210       220       230          

              250       260       270       280       290       300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
                                                                   
NP_659 ------------------------------------------------------------
                                                                   

              310       320       330       340       350       360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_659 --FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
         240       250       260       270       280       290     

              370       380       390       400       410       420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
       :::::::::::                                :::::::::::::::::
NP_659 YIGVMMLTLSP--------------------------------RAGLRPGDVILAIGEQM
         300                                       310       320   

              430       440       450        
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       ::::::::::::::::::::::::::::::::::::::
NP_659 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
           330       340       350       360 

>>NP_444272 (OMIM: 608785) serine protease HTRA3 isoform  (453 aa)
 initn: 885 init1: 634 opt: 1133  Z-score: 1110.1  bits: 214.7 E(85289): 4.3e-55
Smith-Waterman score: 1138; 45.2% identity (71.6% similar) in 454 aa overlap (19-456:10-451)

               10        20        30        40        50          
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
                         ::...  .:.:  .:      .:   .::    : .:.:   
NP_444          MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
                        10        20        30        40         50

      60        70          80         90       100        110     
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
        :  ...: . :   : :  .: .. :  :    : : .    :: ....  : :: :..
NP_444 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
               60           70        80        90       100       

         120       130           140       150       160       170 
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
          : : :    :   :     :      .::: ..::::::::: :::::.::.. :::
NP_444 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
       110          120       130       140       150       160    

             180       190       200             210       220     
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
       ..::.::.:.::::...  :::.::::::..      :....:.: .::.:::..  .: 
NP_444 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
          170       180       190       200       210       220    

         230       240       250       260       270       280     
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
        .::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
NP_444 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
          230       240       250       260       270       280    

         290       300       310       320       330       340     
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
       :: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: . 
NP_444 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
          290       300       310       320       330       340    

         350       360       370       380       390       400     
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
       . :.    :.  ..:.::. : :..::.. ::.  .:.::.:. :. ...:  .::..:.
NP_444 QDKQ----IKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG
              350       360       370       380       390       400

         410        420       430       440       450        
pF1KB8 GLRPGDVILAI-GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       :.. ::.:. . :. .:...: . ::: :.: : ...::: . : . ..:::  
NP_444 GIQDGDIIVKVNGRPLVDSSE-LQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
              410       420        430       440       450   

>>NP_002766 (OMIM: 600142,602194,610149,616779) serine p  (480 aa)
 initn: 1103 init1: 869 opt: 1107  Z-score: 1084.4  bits: 210.0 E(85289): 1.2e-53
Smith-Waterman score: 1107; 53.8% identity (81.6% similar) in 316 aa overlap (140-455:162-476)

     110       120       130       140       150       160         
pF1KB8 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR
                                     : : : .:::::::::: :::::.::.. .
NP_002 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK
             140       150       160       170       180       190 

     170       180       190       200       210       220         
pF1KB8 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI
        ::  ::::...::::.:. :::::::::::....::.:.: .: :::: .  ::  :::
NP_002 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI
             200       210       220       230       240       250 

     230       240       250       260       270       280         
pF1KB8 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ
       : ..:. .  ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: .
NP_002 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN
             260       270       280       290       300       310 

     290       300       310       320       330       340         
pF1KB8 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN
       ....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... ..
NP_002 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ
             320       330       340       350       360       370 

     350       360       370       380       390       400         
pF1KB8 SSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRP
       .. : . ....:::. :..:. :   ::. :. .::::  :. : .::  .::. .::. 
NP_002 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE
              380       390       400       410       420       430

     410       420       430       440       450         
pF1KB8 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 
       .:::..:. : : .:.:: .... .: : . .::: : . . : ::    
NP_002 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
              440       450       460       470       480

>>NP_710159 (OMIM: 610700) serine protease HTRA4 precurs  (476 aa)
 initn: 926 init1: 769 opt: 1001  Z-score: 981.2  bits: 190.9 E(85289): 6.5e-48
Smith-Waterman score: 1002; 44.1% identity (71.2% similar) in 392 aa overlap (71-455:94-473)

               50        60        70               80        90   
pF1KB8 SGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPG-------PRAQLTAVTPDTRTR
                                     ::    ::       :    ..   : :: 
NP_710 DLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTY
            70        80        90       100       110       120   

           100       110       120       130       140       150   
pF1KB8 EASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADV
        .     ...::  :  ::   :: .  ::.  :  .. .: :       : .::::: :
NP_710 PSMCALRAENRA--ARRLGKVPAVPVQ-WGNC-GDTGTRSAGPL------RRNYNFIAAV
           130         140        150        160             170   

           160       170       180       190       200       210   
pF1KB8 VEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSG
       :::.::.::....  :    .: ::. .::::.:. ::::.:::::: ... ..: : .:
NP_710 VEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNG
           180       190       200       210       220       230   

           220       230       240       250       260       270   
pF1KB8 DTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSG
         :::::  .:   :.:...:...  ::.: ::::.:.: ::::::.::::.:::: :.:
NP_710 ARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAG
           240       250       260       270       280       290   

           280       290       300       310       320       330   
pF1KB8 IVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAI
       :::. :: ...::. .....:.: ::.:..::::::::::::.:::::...:: ::::::
NP_710 IVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAI
           300       310       320       330       340       350   

           340       350       360       370       380       390   
pF1KB8 PSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLI
       ::::.:.:: .  .... .: . :...:.:..::.:.  .  ::... :.::::. :: .
NP_710 PSDRVRQFLAE-YHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYV
           360        370       380       390       400       410  

           400       410       420       430       440       450   
pF1KB8 HKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVT
        ::. :. :. .:::  :::. :. . . .. :: .:. ..: :.. . ::...: : : 
NP_710 CKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVI
            420       430       440       450        460       470 

            
pF1KB8 PEVTE
       ::   
NP_710 PETIN
            

>>NP_001284488 (OMIM: 608785) serine protease HTRA3 isof  (357 aa)
 initn: 678 init1: 634 opt: 884  Z-score: 869.1  bits: 169.7 E(85289): 1.1e-41
Smith-Waterman score: 889; 48.1% identity (70.7% similar) in 345 aa overlap (19-348:10-347)

               10        20        30        40        50          
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
                         ::...  .:.:  .:      .:   .::    : .:.:   
NP_001          MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
                        10        20        30        40         50

      60        70          80         90       100        110     
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
        :  ...: . :   : :  .: .. :  :    : : .    :: ....  : :: :..
NP_001 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
               60           70        80        90       100       

         120       130           140       150       160       170 
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
          : : :    :   :     :      .::: ..::::::::: :::::.::.. :::
NP_001 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
       110          120       130       140       150       160    

             180       190       200             210       220     
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
       ..::.::.:.::::...  :::.::::::..      :....:.: .::.:::..  .: 
NP_001 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
          170       180       190       200       210       220    

         230       240       250       260       270       280     
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
        .::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
NP_001 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
          230       240       250       260       270       280    

         290       300       310       320       330       340     
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
       :: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: . 
NP_001 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
          290       300       310       320       330       340    

         350       360       370       380       390       400     
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
       . :                                                         
NP_001 QDKQIKAPSLAVH                                               
          350                                                      

>>XP_011511898 (OMIM: 608785) PREDICTED: serine protease  (373 aa)
 initn: 634 init1: 634 opt: 884  Z-score: 868.8  bits: 169.7 E(85289): 1.2e-41
Smith-Waterman score: 889; 48.1% identity (70.7% similar) in 345 aa overlap (19-348:10-347)

               10        20        30        40        50          
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
                         ::...  .:.:  .:      .:   .::    : .:.:   
XP_011          MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
                        10        20        30        40         50

      60        70          80         90       100        110     
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
        :  ...: . :   : :  .: .. :  :    : : .    :: ....  : :: :..
XP_011 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
               60           70        80        90       100       

         120       130           140       150       160       170 
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
          : : :    :   :     :      .::: ..::::::::: :::::.::.. :::
XP_011 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
       110          120       130       140       150       160    

             180       190       200             210       220     
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
       ..::.::.:.::::...  :::.::::::..      :....:.: .::.:::..  .: 
XP_011 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
          170       180       190       200       210       220    

         230       240       250       260       270       280     
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
        .::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
XP_011 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
          230       240       250       260       270       280    

         290       300       310       320       330       340     
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
       :: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: . 
XP_011 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
          290       300       310       320       330       340    

         350       360       370       380       390       400     
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
       . :                                                         
XP_011 QDKQIKAKHMDPSAAKAGAMRAGHMKSCC                               
          350       360       370                                  

>>XP_011542733 (OMIM: 610700) PREDICTED: serine protease  (380 aa)
 initn: 769 init1: 769 opt: 773  Z-score: 760.5  bits: 149.7 E(85289): 1.3e-35
Smith-Waterman score: 774; 46.6% identity (70.5% similar) in 292 aa overlap (71-352:94-375)

               50        60        70               80        90   
pF1KB8 SGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPG-------PRAQLTAVTPDTRTR
                                     ::    ::       :    ..   : :: 
XP_011 DLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTY
            70        80        90       100       110       120   

           100       110       120       130       140       150   
pF1KB8 EASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADV
        .     ...::  :  ::   :: .  ::.  :  .. .: :       : .::::: :
XP_011 PSMCALRAENRA--ARRLGKVPAVPVQ-WGNC-GDTGTRSAGPL------RRNYNFIAAV
           130         140        150        160             170   

           160       170       180       190       200       210   
pF1KB8 VEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSG
       :::.::.::....  :    .: ::. .::::.:. ::::.:::::: ... ..: : .:
XP_011 VEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNG
           180       190       200       210       220       230   

           220       230       240       250       260       270   
pF1KB8 DTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSG
         :::::  .:   :.:...:...  ::.: ::::.:.: ::::::.::::.:::: :.:
XP_011 ARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAG
           240       250       260       270       280       290   

           280       290       300       310       320       330   
pF1KB8 IVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAI
       :::. :: ...::. .....:.: ::.:..::::::::::::.:::::...:: ::::::
XP_011 IVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAI
           300       310       320       330       340       350   

           340          350       360       370       380       390
pF1KB8 PSDRLREFL---HRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHG
       ::::.:.::   :. . :....                                      
XP_011 PSDRVRQFLAEYHEHQMKEAKTIAAQS                                 
           360       370       380                                 




458 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:26:34 2016 done: Fri Nov  4 10:26:35 2016
 Total Scan time:  7.240 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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