Result of FASTA (ccds) for pF1KB8196
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8196, 458 aa
  1>>>pF1KB8196 458 - 458 aa - 458 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.5151+/-0.000754; mu= 12.9258+/- 0.046
 mean_var=99.2538+/-20.138, 0's: 0 Z-trim(111.6): 14  B-trim: 0 in 0/51
 Lambda= 0.128736
 statistics sampled from 12461 (12469) to 12461 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.383), width:  16
 Scan time:  2.930

The best scores are:                                      opt bits E(32554)
CCDS1951.1 HTRA2 gene_id:27429|Hs108|chr2          ( 458) 2982 563.9 1.2e-160
CCDS1952.1 HTRA2 gene_id:27429|Hs108|chr2          ( 361) 1569 301.4 9.8e-82
CCDS3400.1 HTRA3 gene_id:94031|Hs108|chr4          ( 453) 1133 220.5 2.8e-57
CCDS7630.1 HTRA1 gene_id:5654|Hs108|chr10          ( 480) 1107 215.7 8.4e-56
CCDS6110.1 HTRA4 gene_id:203100|Hs108|chr8         ( 476) 1001 196.0 7.1e-50
CCDS75105.1 HTRA3 gene_id:94031|Hs108|chr4         ( 357)  884 174.2 1.9e-43


>>CCDS1951.1 HTRA2 gene_id:27429|Hs108|chr2               (458 aa)
 initn: 2982 init1: 2982 opt: 2982  Z-score: 2997.6  bits: 563.9 E(32554): 1.2e-160
Smith-Waterman score: 2982; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458)

               10        20        30        40        50        60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
              370       380       390       400       410       420

              430       440       450        
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       ::::::::::::::::::::::::::::::::::::::
CCDS19 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
              430       440       450        

>>CCDS1952.1 HTRA2 gene_id:27429|Hs108|chr2               (361 aa)
 initn: 2325 init1: 1567 opt: 1569  Z-score: 1580.9  bits: 301.4 E(32554): 9.8e-82
Smith-Waterman score: 2139; 78.8% identity (78.8% similar) in 458 aa overlap (1-458:1-361)

               10        20        30        40        50        60
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::   
CCDS19 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTK---
              190       200       210       220       230          

              250       260       270       280       290       300
pF1KB8 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
                                                                   
CCDS19 ------------------------------------------------------------
                                                                   

              310       320       330       340       350       360
pF1KB8 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS19 --FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
         240       250       260       270       280       290     

              370       380       390       400       410       420
pF1KB8 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
       :::::::::::                                :::::::::::::::::
CCDS19 YIGVMMLTLSP--------------------------------RAGLRPGDVILAIGEQM
         300                                       310       320   

              430       440       450        
pF1KB8 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       ::::::::::::::::::::::::::::::::::::::
CCDS19 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
           330       340       350       360 

>>CCDS3400.1 HTRA3 gene_id:94031|Hs108|chr4               (453 aa)
 initn: 885 init1: 634 opt: 1133  Z-score: 1141.8  bits: 220.5 E(32554): 2.8e-57
Smith-Waterman score: 1138; 45.2% identity (71.6% similar) in 454 aa overlap (19-456:10-451)

               10        20        30        40        50          
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
                         ::...  .:.:  .:      .:   .::    : .:.:   
CCDS34          MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
                        10        20        30        40         50

      60        70          80         90       100        110     
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
        :  ...: . :   : :  .: .. :  :    : : .    :: ....  : :: :..
CCDS34 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
               60           70        80        90       100       

         120       130           140       150       160       170 
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
          : : :    :   :     :      .::: ..::::::::: :::::.::.. :::
CCDS34 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
       110          120       130       140       150       160    

             180       190       200             210       220     
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
       ..::.::.:.::::...  :::.::::::..      :....:.: .::.:::..  .: 
CCDS34 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
          170       180       190       200       210       220    

         230       240       250       260       270       280     
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
        .::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
CCDS34 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
          230       240       250       260       270       280    

         290       300       310       320       330       340     
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
       :: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: . 
CCDS34 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
          290       300       310       320       330       340    

         350       360       370       380       390       400     
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
       . :.    :.  ..:.::. : :..::.. ::.  .:.::.:. :. ...:  .::..:.
CCDS34 QDKQ----IKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG
              350       360       370       380       390       400

         410        420       430       440       450        
pF1KB8 GLRPGDVILAI-GEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
       :.. ::.:. . :. .:...: . ::: :.: : ...::: . : . ..:::  
CCDS34 GIQDGDIIVKVNGRPLVDSSE-LQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM
              410       420        430       440       450   

>>CCDS7630.1 HTRA1 gene_id:5654|Hs108|chr10               (480 aa)
 initn: 1103 init1: 869 opt: 1107  Z-score: 1115.3  bits: 215.7 E(32554): 8.4e-56
Smith-Waterman score: 1107; 53.8% identity (81.6% similar) in 316 aa overlap (140-455:162-476)

     110       120       130       140       150       160         
pF1KB8 ALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDR
                                     : : : .:::::::::: :::::.::.. .
CCDS76 LRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRK
             140       150       160       170       180       190 

     170       180       190       200       210       220         
pF1KB8 HPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADI
        ::  ::::...::::.:. :::::::::::....::.:.: .: :::: .  ::  :::
CCDS76 LPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADI
             200       210       220       230       240       250 

     230       240       250       260       270       280         
pF1KB8 ATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQ
       : ..:. .  ::.: ::::...: ::::::.::::.::::.:.::::..:: ...::: .
CCDS76 ALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRN
             260       270       280       290       300       310 

     290       300       310       320       330       340         
pF1KB8 TNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKN
       ....:::::: :..::::::::::::::::.::.:::::::::::::....:: ... ..
CCDS76 SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQ
             320       330       340       350       360       370 

     350       360       370       380       390       400         
pF1KB8 SSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRP
       .. : . ....:::. :..:. :   ::. :. .::::  :. : .::  .::. .::. 
CCDS76 AK-GKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKE
              380       390       400       410       420       430

     410       420       430       440       450         
pF1KB8 GDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 
       .:::..:. : : .:.:: .... .: : . .::: : . . : ::    
CCDS76 NDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
              440       450       460       470       480

>>CCDS6110.1 HTRA4 gene_id:203100|Hs108|chr8              (476 aa)
 initn: 926 init1: 769 opt: 1001  Z-score: 1008.9  bits: 196.0 E(32554): 7.1e-50
Smith-Waterman score: 1002; 44.1% identity (71.2% similar) in 392 aa overlap (71-455:94-473)

               50        60        70               80        90   
pF1KB8 SGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPG-------PRAQLTAVTPDTRTR
                                     ::    ::       :    ..   : :: 
CCDS61 DLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTY
            70        80        90       100       110       120   

           100       110       120       130       140       150   
pF1KB8 EASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADV
        .     ...::  :  ::   :: .  ::.  :  .. .: :       : .::::: :
CCDS61 PSMCALRAENRA--ARRLGKVPAVPVQ-WGNC-GDTGTRSAGPL------RRNYNFIAAV
           130         140        150        160             170   

           160       170       180       190       200       210   
pF1KB8 VEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSG
       :::.::.::....  :    .: ::. .::::.:. ::::.:::::: ... ..: : .:
CCDS61 VEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNG
           180       190       200       210       220       230   

           220       230       240       250       260       270   
pF1KB8 DTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSG
         :::::  .:   :.:...:...  ::.: ::::.:.: ::::::.::::.:::: :.:
CCDS61 ARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAG
           240       250       260       270       280       290   

           280       290       300       310       320       330   
pF1KB8 IVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAI
       :::. :: ...::. .....:.: ::.:..::::::::::::.:::::...:: ::::::
CCDS61 IVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAI
           300       310       320       330       340       350   

           340       350       360       370       380       390   
pF1KB8 PSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLI
       ::::.:.:: .  .... .: . :...:.:..::.:.  .  ::... :.::::. :: .
CCDS61 PSDRVRQFLAE-YHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYV
           360        370       380       390       400       410  

           400       410       420       430       440       450   
pF1KB8 HKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVT
        ::. :. :. .:::  :::. :. . . .. :: .:. ..: :.. . ::...: : : 
CCDS61 CKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVI
            420       430       440       450        460       470 

            
pF1KB8 PEVTE
       ::   
CCDS61 PETIN
            

>>CCDS75105.1 HTRA3 gene_id:94031|Hs108|chr4              (357 aa)
 initn: 678 init1: 634 opt: 884  Z-score: 893.4  bits: 174.2 E(32554): 1.9e-43
Smith-Waterman score: 889; 48.1% identity (70.7% similar) in 345 aa overlap (19-348:10-347)

               10        20        30        40        50          
pF1KB8 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSL-WA
                         ::...  .:.:  .:      .:   .::    : .:.:   
CCDS75          MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGY-VPDLCNC
                        10        20        30        40         50

      60        70          80         90       100        110     
pF1KB8 RLSVGVTEPRACLTSGTP--GPRAQ-LTAVTPDTRTREASENSGTRSRAWLAV-ALGAGG
        :  ...: . :   : :  .: .. :  :    : : .    :: ....  : :: :..
CCDS75 CLVCAASEGEPC---GGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAAS
               60           70        80        90       100       

         120       130           140       150       160       170 
pF1KB8 AVLLLLWGGGRGPPAVLAAVPSP----PPASPRSQYNFIADVVEKTAPAVVYIEILDRHP
          : : :    :   :     :      .::: ..::::::::: :::::.::.. :::
CCDS75 RRALQLSGT---PVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHP
       110          120       130       140       150       160    

             180       190       200             210       220     
pF1KB8 FLGREVPISNGSGFVVAADGLIVTNAHVVAD------RRRVRVRLLSGDTYEAVVTAVDP
       ..::.::.:.::::...  :::.::::::..      :....:.: .::.:::..  .: 
CCDS75 LFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDK
          170       180       190       200       210       220    

         230       240       250       260       270       280     
pF1KB8 VADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDL
        .::::..:. :. ::.: ::.:::.: ::::::.:::::::::.:.::::.::: .:.:
CCDS75 KSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGREL
          230       240       250       260       270       280    

         290       300       310       320       330       340     
pF1KB8 GLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG
       :: .....:::::: :..::::::::::::::::.::.::::::::::::::. .:: . 
CCDS75 GLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEF
          290       300       310       320       330       340    

         350       360       370       380       390       400     
pF1KB8 EKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRA
       . :                                                         
CCDS75 QDKQIKAPSLAVH                                               
          350                                                      




458 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:26:33 2016 done: Fri Nov  4 10:26:34 2016
 Total Scan time:  2.930 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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