Result of FASTA (ccds) for pF1KB8191
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8191, 425 aa
  1>>>pF1KB8191 425 - 425 aa - 425 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.4848+/-0.000887; mu= 7.2706+/- 0.053
 mean_var=128.2560+/-25.647, 0's: 0 Z-trim(111.0): 15  B-trim: 291 in 1/51
 Lambda= 0.113249
 statistics sampled from 12010 (12024) to 12010 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.733), E-opt: 0.2 (0.369), width:  16
 Scan time:  2.160

The best scores are:                                      opt bits E(32554)
CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15         ( 425) 2990 499.7 2.3e-141
CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15         ( 381) 2544 426.8 1.8e-119
CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18         ( 467) 2342 393.8 1.8e-109
CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15         ( 320) 2261 380.5 1.3e-105
CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13          ( 430) 1893 320.4 2.1e-87
CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15         ( 230) 1615 274.9 5.7e-74
CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5          ( 465) 1218 210.2 3.5e-54
CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4           ( 465) 1192 205.9 6.6e-53
CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13         ( 467) 1153 199.5 5.5e-51
CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18         ( 552)  472 88.3   2e-17
CCDS10221.1 SMAD6 gene_id:4091|Hs108|chr15         ( 496)  386 74.2 3.1e-13


>>CCDS10222.1 SMAD3 gene_id:4088|Hs108|chr15              (425 aa)
 initn: 2990 init1: 2990 opt: 2990  Z-score: 2651.5  bits: 499.7 E(32554): 2.3e-141
Smith-Waterman score: 2990; 100.0% identity (100.0% similar) in 425 aa overlap (1-425:1-425)

               10        20        30        40        50        60
pF1KB8 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 NTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 CVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 PPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYEL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 NQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS10 EAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIR
              370       380       390       400       410       420

            
pF1KB8 CSSVS
       :::::
CCDS10 CSSVS
            

>>CCDS45288.1 SMAD3 gene_id:4088|Hs108|chr15              (381 aa)
 initn: 2540 init1: 2540 opt: 2544  Z-score: 2258.4  bits: 426.8 E(32554): 1.8e-119
Smith-Waterman score: 2544; 98.1% identity (98.6% similar) in 366 aa overlap (60-425:16-381)

      30        40        50        60        70        80         
pF1KB8 WCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYC
                                     :. :   . :::::::::::::::::::::
CCDS45                MSCLHPRQTWKGAALVHRKAWWMGRSLDGRLQVSHRKGLPHVIYC
                              10        20        30        40     

      90       100       110       120       130       140         
pF1KB8 RLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 RLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAE
          50        60        70        80        90       100     

     150       160       170       180       190       200         
pF1KB8 FPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSP
         110       120       130       140       150       160     

     210       220       230       240       250       260         
pF1KB8 NPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 NPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERF
         170       180       190       200       210       220     

     270       280       290       300       310       320         
pF1KB8 CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPA
         230       240       250       260       270       280     

     330       340       350       360       370       380         
pF1KB8 TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV
         290       300       310       320       330       340     

     390       400       410       420     
pF1KB8 TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
       ::::::::::::::::::::::::::::::::::::
CCDS45 TSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
         350       360       370       380 

>>CCDS11934.1 SMAD2 gene_id:4087|Hs108|chr18              (467 aa)
 initn: 2301 init1: 1454 opt: 2342  Z-score: 2078.7  bits: 393.8 E(32554): 1.8e-109
Smith-Waterman score: 2608; 83.6% identity (89.7% similar) in 457 aa overlap (11-425:11-467)

               10        20                  30        40        50
pF1KB8 MSSILPFTPPIVKRLLGWKK----------GEQNGQEEKWCEKAVKSLVKKLKKTGQLDE
                 .:::::::::          ::::::::::::::::::::::::::.:::
CCDS11 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
               10        20        30        40        50        60

               60                                      70        80
pF1KB8 LEKAITTQNVNTKCITIP------------------------------RSLDGRLQVSHR
       ::::::::: ::::.:::                              ::::::::::::
CCDS11 LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR
               70        80        90       100       110       120

               90       100       110       120       130       140
pF1KB8 KGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLV
       :::::::::::::::::::::::.:.: ::.:::.:::::::::::::::::::::::::
CCDS11 KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV
              130       140       150       160       170       180

              150       160       170        180       190         
pF1KB8 PRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSN-IPETPPPGYLSEDGETSDHQMNHS
       :::::: .:.::::::.:::::::::::::::::: :::::::::.::::::::.:.:.:
CCDS11 PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS
              190       200       210       220       230       240

     200        210       220       230       240       250        
pF1KB8 MDAGSP-NLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVD
       ::.::: .:::. .::....:::::::: ::::::::.::::::::::::::::::.:::
CCDS11 MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD
              250       260       270       280       290       300

      260       270       280       290       300       310        
pF1KB8 GFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
       :::::::::::::::::::::::.::.:::::::::::::::::::::::::::::::::
CCDS11 GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
              310       320       330       340       350       360

      320       330       340       350       360       370        
pF1KB8 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS11 NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
              370       380       390       400       410       420

      380       390       400       410       420     
pF1KB8 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
       ::::::::::::::::::::::::::::::::::::::::.::::.:
CCDS11 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
              430       440       450       460       

>>CCDS53950.1 SMAD3 gene_id:4088|Hs108|chr15              (320 aa)
 initn: 2261 init1: 2261 opt: 2261  Z-score: 2009.7  bits: 380.5 E(32554): 1.3e-105
Smith-Waterman score: 2261; 100.0% identity (100.0% similar) in 320 aa overlap (106-425:1-320)

          80        90       100       110       120       130     
pF1KB8 QVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVL
                                     ::::::::::::::::::::::::::::::
CCDS53                               MELCEFAFNMKKDEVCVNPYHYQRVETPVL
                                             10        20        30

         140       150       160       170       180       190     
pF1KB8 PPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 PPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQ
               40        50        60        70        80        90

         200       210       220       230       240       250     
pF1KB8 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
              100       110       120       130       140       150

         260       270       280       290       300       310     
pF1KB8 TVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 TVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFV
              160       170       180       190       200       210

         320       330       340       350       360       370     
pF1KB8 QSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 QSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMS
              220       230       240       250       260       270

         380       390       400       410       420     
pF1KB8 FVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 FVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
              280       290       300       310       320

>>CCDS9360.1 SMAD9 gene_id:4093|Hs108|chr13               (430 aa)
 initn: 990 init1: 898 opt: 1893  Z-score: 1682.8  bits: 320.4 E(32554): 2.1e-87
Smith-Waterman score: 1893; 64.2% identity (82.6% similar) in 436 aa overlap (1-425:7-430)

                     10        20        30        40         50   
pF1KB8       MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEK
             .::.. :: : ::::::::.:..   :::: :::: ::::::::  : .::::.
CCDS93 MHSTTPISSLFSFTSPAVKRLLGWKQGDE---EEKWAEKAVDSLVKKLKKKKGAMDELER
               10        20           30        40        50       

            60        70        80        90       100       110   
pF1KB8 AITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAF
       :..  .  .::.:::::::::::::::::::::::::.::::::.:::::. .: ::: :
CCDS93 ALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
        60        70        80        90       100       110       

           120       130       140       150              160      
pF1KB8 NMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNF
       . :. :::.:::::.:::::::::::::::.:   ..  :  .     ::   .:.:...
CCDS93 GSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATY
       120       130       140       150       160       170       

        170         180       190       200       210       220    
pF1KB8 PAGIE--PQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPV
       : ...  : : .: .:  .. :..  :...   ::   :::.   .: :: ... :..::
CCDS93 PDSFQQPPCSALPPSPSHAF-SQSPCTASYP--HS--PGSPS---EPESPYQHS-DFRPV
       180       190        200           210          220         

          230       240       250       260        270       280   
pF1KB8 TYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSE-RFCLGLLSNVNRNAAV
        : ::  :::..:::::.::::::.::. :. .::::::::.. :::::::::::::...
CCDS93 CYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTI
      230       240       250       260       270       280        

           290       300       310       320       330       340   
pF1KB8 ELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIF
       : ::::::.::.:::.::::.:::.:::.::::: ::: ..:.::::::::: ::.::.:
CCDS93 ENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVF
      290       300       310       320       330       340        

           350       360       370       380       390       400   
pF1KB8 NNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGP
       ::: :: ::::::..:::.::.::.::::::::::::::::.:: :::::::::.::.::
CCDS93 NNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGP
      350       360       370       380       390       400        

           410       420     
pF1KB8 LQWLDKVLTQMGSPSIRCSSVS
       ::::::::::::::    ::::
CCDS93 LQWLDKVLTQMGSPHNPISSVS
      410       420       430

>>CCDS53951.1 SMAD3 gene_id:4088|Hs108|chr15              (230 aa)
 initn: 1615 init1: 1615 opt: 1615  Z-score: 1441.5  bits: 274.9 E(32554): 5.7e-74
Smith-Waterman score: 1615; 100.0% identity (100.0% similar) in 230 aa overlap (196-425:1-230)

         170       180       190       200       210       220     
pF1KB8 FPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVT
                                     ::::::::::::::::::::::::::::::
CCDS53                               MNHSMDAGSPNLSPNPMSPAHNNLDLQPVT
                                             10        20        30

         230       240       250       260       270       280     
pF1KB8 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVEL
               40        50        60        70        80        90

         290       300       310       320       330       340     
pF1KB8 TRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 TRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNN
              100       110       120       130       140       150

         350       360       370       380       390       400     
pF1KB8 QEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 QEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQ
              160       170       180       190       200       210

         410       420     
pF1KB8 WLDKVLTQMGSPSIRCSSVS
       ::::::::::::::::::::
CCDS53 WLDKVLTQMGSPSIRCSSVS
              220       230

>>CCDS75308.1 SMAD5 gene_id:4090|Hs108|chr5               (465 aa)
 initn: 1508 init1: 904 opt: 1218  Z-score: 1086.2  bits: 210.2 E(32554): 3.5e-54
Smith-Waterman score: 1870; 61.3% identity (78.6% similar) in 462 aa overlap (7-425:10-465)

                  10        20        30        40         50      
pF1KB8    MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAIT
                :: : ::::::::.:.   .:::: :::: .:::::::  : ..:::::..
CCDS75 MTSMASLFSFTSPAVKRLLGWKQGD---EEEKWAEKAVDALVKKLKKKKGAMEELEKALS
               10        20           30        40        50       

         60        70        80        90       100       110      
pF1KB8 TQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMK
       . .  .::.:::::::::::::::::::::::::.::::::.:::::. ...::: :. :
CCDS75 SPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSK
        60        70        80        90       100       110       

        120       130       140       150             160       170
pF1KB8 KDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDY---SHS---IPENTNFPAGI
       . :::.:::::.:::.:::::::::::.:.  .   : ..   ::.   .:.:..:: ..
CCDS75 QKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSF
       120       130       140       150       160       170       

                                                 180       190     
pF1KB8 EPQSNIP-----------------------------------ETPPPGYLSEDGETSDHQ
       .  .: :                                   .::::.:.  : . . ..
CCDS75 HQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMG-QD
       180       190       200       210       220       230       

         200       210       220       230       240       250     
pF1KB8 MNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
        .. ::. : :. :. : :. .. :.:::.: ::  :::: :::::.::::.::::. :.
CCDS75 NSQPMDT-SNNMIPQIM-PSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSV
        240        250        260       270       280       290    

         260        270       280       290       300       310    
pF1KB8 TVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIF
        :::::::::.. :::::::::::::...: ::::::.::.:::.::::.:::::::.::
CCDS75 LVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIF
          300       310       320       330       340       350    

          320       330       340       350       360       370    
pF1KB8 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRM
       ::: ::: ..:.::.:::::: .:.:::::::::: :::::::.::::::.::.::::::
CCDS75 VQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRM
          360       370       380       390       400       410    

          380       390       400       410       420     
pF1KB8 SFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
       ::::::::::.:: :::::::::.::.::::::::::::::::    ::::
CCDS75 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
          420       430       440       450       460     

>>CCDS3765.1 SMAD1 gene_id:4086|Hs108|chr4                (465 aa)
 initn: 1611 init1: 913 opt: 1192  Z-score: 1063.3  bits: 205.9 E(32554): 6.6e-53
Smith-Waterman score: 1856; 62.0% identity (77.6% similar) in 460 aa overlap (7-425:9-465)

                 10        20        30        40         50       
pF1KB8   MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEKAITT
               :: : ::::::::.:.   .:::: :::: .:::::::  : ..:::::.. 
CCDS37 MNVTSLFSFTSPAVKRLLGWKQGD---EEEKWAEKAVDALVKKLKKKKGAMEELEKALSC
               10        20           30        40        50       

        60        70        80        90       100       110       
pF1KB8 QNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKK
        .  ..:.:::::::::::::::::::::::::.::::::.:::::. .: ::: :. :.
CCDS37 PGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQ
        60        70        80        90       100       110       

       120       130       140             150       160       170 
pF1KB8 DEVCVNPYHYQRVETPVLPPVLVPRHTEI-P-----AEFPPLDDYSHSIPENTNFPAGIE
        :::.:::::.:::.:::::::::::.:  :     :.:  : .    .: :..:: ...
CCDS37 KEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQ
       120       130       140       150       160       170       

               180       190         200                   210     
pF1KB8 -PQSN-IPETPPPGYLSEDGETSDHQMNH--SMDAGSPNLSP------------NPMS--
        :.:. .:..:  .: .  : .:.   .   : : :::   :            .::.  
CCDS37 QPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQD
       180       190       200       210       220       230       

                          220       230       240       250        
pF1KB8 ---PAHNNL------------DLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVD
          :  .:.            :.: :.: ::  :::: :::::.::::.::::. :. ::
CCDS37 GSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVD
       240       250       260       270       280       290       

      260        270       280       290       300       310       
pF1KB8 GFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQS
       :::::::.. :::::::::::::...: ::::::.::.:::.::::.:::::::.:::::
CCDS37 GFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQS
       300       310       320       330       340       350       

       320       330       340       350       360       370       
pF1KB8 PNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFV
        ::: ..:.::.:::::: ::.:::::::::: :::::::.:::.::.::.:::::::::
CCDS37 RNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFV
       360       370       380       390       400       410       

       380       390       400       410       420     
pF1KB8 KGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
       :::::::.:: :::::::::.::.::::::::::::::::    ::::
CCDS37 KGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
       420       430       440       450       460     

>>CCDS45032.1 SMAD9 gene_id:4093|Hs108|chr13              (467 aa)
 initn: 1559 init1: 898 opt: 1153  Z-score: 1028.8  bits: 199.5 E(32554): 5.5e-51
Smith-Waterman score: 1838; 61.0% identity (77.8% similar) in 459 aa overlap (7-425:13-467)

                     10        20        30        40         50   
pF1KB8       MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKT-GQLDELEK
                   :: : ::::::::.:.   .:::: :::: ::::::::  : .::::.
CCDS45 MHSTTPISSLFSFTSPAVKRLLGWKQGD---EEEKWAEKAVDSLVKKLKKKKGAMDELER
               10        20           30        40        50       

            60        70        80        90       100       110   
pF1KB8 AITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAF
       :..  .  .::.:::::::::::::::::::::::::.::::::.:::::. .: ::: :
CCDS45 ALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPF
        60        70        80        90       100       110       

           120       130       140       150              160      
pF1KB8 NMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYS----HS---IPENTNF
       . :. :::.:::::.:::::::::::::::.:   ..  :  .     ::   .:.:...
CCDS45 GSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATY
       120       130       140       150       160       170       

        170         180                      190             200   
pF1KB8 PAGIE--PQSNIPETP-------P--------PGYLSEDGETSDHQMN------HSMDAG
       : ...  : : .: .:       :        ::  ::     .:...      :. .: 
CCDS45 PDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEA-
       180       190       200       210       220       230       

           210               220       230       240       250     
pF1KB8 SPNLSPNPMSPAHN--------NLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSM
       : . : .:.. . .        : :..:: : ::  :::..:::::.::::::.::. :.
CCDS45 SETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSV
        240       250       260       270       280       290      

         260        270       280       290       300       310    
pF1KB8 TVDGFTDPSNSE-RFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIF
        .::::::::.. :::::::::::::...: ::::::.::.:::.::::.:::.:::.::
CCDS45 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIF
        300       310       320       330       340       350      

          320       330       340       350       360       370    
pF1KB8 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRM
       ::: ::: ..:.::::::::: ::.::.:::: :: ::::::..:::.::.::.::::::
CCDS45 VQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRM
        360       370       380       390       400       410      

          380       390       400       410       420     
pF1KB8 SFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
       ::::::::::.:: :::::::::.::.::::::::::::::::    ::::
CCDS45 SFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
        420       430       440       450       460       

>>CCDS11950.1 SMAD4 gene_id:4089|Hs108|chr18              (552 aa)
 initn: 766 init1: 229 opt: 472  Z-score: 426.4  bits: 88.3 E(32554): 2e-17
Smith-Waterman score: 782; 39.1% identity (60.5% similar) in 425 aa overlap (11-344:19-439)

                       10        20        30        40         50 
pF1KB8         MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLK-KTGQLDEL
                         ::. :.  ..:   :. : . ..:..::::::: :  .:: :
CCDS11 MDNMSITNTPTSNDACLSIVHSLMCHRQG---GESETFAKRAIESLVKKLKEKKDELDSL
               10        20           30        40        50       

              60         70        80        90       100       110
pF1KB8 EKAITTQNVN-TKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCE
         ::::.... .::.:: :.:::::::. :::.::::: :::::::::.. ::. .. :.
CCDS11 ITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQ
        60        70        80        90       100        110      

              120       130       140             150              
pF1KB8 FAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPA------EF-------PPLDDYS
       .::..: : ::::::::.:: .: .    .  ... :.      :.       : :.  .
CCDS11 YAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEG
        120       130       140       150       160       170      

       160                   170              180                  
pF1KB8 HSI------PENT------NFPAGIEPQ-------SNIPETP------PPGYL----SE-
       :::      : :       . :: . :.       .:.:. :      : . :    :: 
CCDS11 HSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEG
        180       190       200       210       220       230      

            190                 200                                
pF1KB8 -----DGETSDHQMN----------HSMDA---GS------PNLS--------------P
            .:    .:.:          :.  .   ::      :::               :
CCDS11 LLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP
        240       250       260       270       280       290      

     210         220       230         240         250       260   
pF1KB8 NPMS--PAHNNLDLQPVTYCEPA--FWCSISYYELNQRVGETFH--ASQPSMTVDGFTDP
       .:    :.::.: .::    .::  .::::.:.:.. .:::::.  .: : .::::..::
CCDS11 HPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDP
        300       310       320       330       340       350      

           270       280       290       300        310       320  
pF1KB8 SNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG-GEVFAECLSDSAIFVQSPNCNQ
       :...::::: ::::.:. :.: .: :::.::.:   : :.:...:::: :.::::   ..
CCDS11 SGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDR
        360       370       380       390       400       410      

             330       340       350       360       370       380 
pF1KB8 RYGWHPA-TVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWG
       . :  :. .: :: :.  .:.:.                                     
CCDS11 EAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVG
        420       430       440       450       460       470      




425 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 10:22:46 2016 done: Fri Nov  4 10:22:47 2016
 Total Scan time:  2.160 Total Display time:  0.040

Function used was FASTA [36.3.4 Apr, 2011]
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