Result of FASTA (omim) for pF1KB8104
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8104, 461 aa
  1>>>pF1KB8104 461 - 461 aa - 461 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.5643+/-0.000314; mu= 4.4893+/- 0.020
 mean_var=196.6873+/-39.269, 0's: 0 Z-trim(122.5): 5  B-trim: 0 in 0/60
 Lambda= 0.091451
 statistics sampled from 40778 (40783) to 40778 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.478), width:  16
 Scan time:  8.370

The best scores are:                                      opt bits E(85289)
NP_002211 (OMIM: 147521) inositol-trisphosphate 3- ( 461) 3126 424.5  3e-118
XP_011519824 (OMIM: 147521) PREDICTED: inositol-tr ( 289) 1961 270.7 3.8e-72
NP_002212 (OMIM: 147522) inositol-trisphosphate 3- ( 946) 1448 203.3 2.3e-51
NP_079470 (OMIM: 606476,611775) inositol-trisphosp ( 683) 1291 182.5   3e-45
XP_016882813 (OMIM: 606476,611775) PREDICTED: inos ( 422) 1178 167.5 6.4e-41


>>NP_002211 (OMIM: 147521) inositol-trisphosphate 3-kina  (461 aa)
 initn: 3126 init1: 3126 opt: 3126  Z-score: 2244.0  bits: 424.5 E(85289): 3e-118
Smith-Waterman score: 3126; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461)

               10        20        30        40        50        60
pF1KB8 MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 RRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 STSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 STSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVIS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 PFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVER
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKT
              370       380       390       400       410       420

              430       440       450       460 
pF1KB8 TPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
       :::::::::::::::::::::::::::::::::::::::::
NP_002 TPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
              430       440       450       460 

>>XP_011519824 (OMIM: 147521) PREDICTED: inositol-trisph  (289 aa)
 initn: 1961 init1: 1961 opt: 1961  Z-score: 1416.2  bits: 270.7 E(85289): 3.8e-72
Smith-Waterman score: 1961; 100.0% identity (100.0% similar) in 289 aa overlap (173-461:1-289)

            150       160       170       180       190       200  
pF1KB8 SDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAG
                                     ::::::::::::::::::::::::::::::
XP_011                               MVNLPVISPFKKRYAWVQLAGHTGSFKAAG
                                             10        20        30

            210       220       230       240       250       260  
pF1KB8 TSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLD
               40        50        60        70        80        90

            270       280       290       300       310       320  
pF1KB8 CKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGI
              100       110       120       130       140       150

            330       340       350       360       370       380  
pF1KB8 SSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRD
              160       170       180       190       200       210

            390       400       410       420       430       440  
pF1KB8 TLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNRED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNRED
              220       230       240       250       260       270

            450       460 
pF1KB8 GYLLGLDNLIGILASLAER
       :::::::::::::::::::
XP_011 GYLLGLDNLIGILASLAER
              280         

>>NP_002212 (OMIM: 147522) inositol-trisphosphate 3-kina  (946 aa)
 initn: 1400 init1: 1189 opt: 1448  Z-score: 1043.2  bits: 203.3 E(85289): 2.3e-51
Smith-Waterman score: 1448; 57.2% identity (76.5% similar) in 400 aa overlap (67-460:545-941)

         40        50        60        70        80        90      
pF1KB8 LFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSP
                                     :. ::. :  : . .    .. : :  :. 
NP_002 KAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDM
          520       530       540       550       560       570    

        100       110        120       130       140       150     
pF1KB8 GPPERERDCLPAAGSSHLQQP-RRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQL
       :  : .     . :: . . : :.::.::.:::: ::  ::::.:. :: :     :  .
NP_002 GTQE-DGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAF
           580       590       600       610       620       630   

         160           170        180       190       200       210
pF1KB8 EAGEDVGQK----NHWQKIRTMVNL-PVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKR
           :  ::    . :.::..::.  : .  :::.: :.:::::.::::::. .: :::.
NP_002 LHTLD-QQKPRVSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAA-NGRILKK
            640       650       660       670       680        690 

              220       230       240       250       260       270
pF1KB8 CSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTY
         : :. :: :::.:.::  :::.:: : .::: : :..:::  ::.:::.:::::.:::
NP_002 HCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTY
             700       710       720       730       740       750 

              280       290       300       310       320       330
pF1KB8 LEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGF
       :::::::::..:.::::::.::. ::::::::::.::::::::::::::: :::..::::
NP_002 LEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGF
             760       770       780       790       800       810 

              340       350       360       370       380       390
pF1KB8 RIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFF
       ::::::: ::. . ::: :..:::: ..:.::..:....:  : .::. :: ::::: ::
NP_002 RIEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFF
             820       830       840       850       860       870 

              400       410       420       430       440       450
pF1KB8 RRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDN
       . ::::::::::.::. ..: ::.::::::::::.:: :.:  ::.::::::::: ::.:
NP_002 KCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNN
             880       890       900       910       920       930 

              460     
pF1KB8 LIGILASLAER    
       :. ::. ...     
NP_002 LVDILTEMSQDAPLA
             940      

>>NP_079470 (OMIM: 606476,611775) inositol-trisphosphate  (683 aa)
 initn: 1253 init1: 1145 opt: 1291  Z-score: 933.2  bits: 182.5 E(85289): 3e-45
Smith-Waterman score: 1311; 53.1% identity (75.4% similar) in 390 aa overlap (73-460:322-682)

             50        60        70        80        90        100 
pF1KB8 AAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSP-GPPER
                                     .:  :: :.: .: : :. : ..: ::: :
NP_079 DCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPV-PRLIITPETPE-PEAQPVGPPSR
             300       310       320        330        340         

             110       120       130       140       150       160 
pF1KB8 ERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDV
        .     .::. .        ::.::      ...::::... . . :         :: 
NP_079 VE-----GGSGGF--------SSASS------FDESEDDVVAGGGGASD-------PEDR
     350                    360             370              380   

             170        180       190       200       210       220
pF1KB8 GQKNHWQKIRTMVNL-PVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLA
       . .. :.:..:...  : .  :.:.: ::::.::.:.:.: : .: ::::  . :.  : 
NP_079 SGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQA-GEDGRILKRFCQCEQRSLE
           390       400       410       420        430       440  

              230       240       250       260       270       280
pF1KB8 RLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARE
       .:: : ::  :::..:.: .::... :..:::  :.:: ..::::: ::::::::.::::
NP_079 QLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARE
            450       460       470       480       490       500  

              290       300       310       320       330       340
pF1KB8 RPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADG
       ::. :::::.::.:::: ::: ::::: :::::::::::: .::..::::::::::::::
NP_079 RPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADG
            510       520       530       540       550       560  

              350       360       370       380       390       400
pF1KB8 SCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSL
       .:.:.:: :.. ::: .:.:.::.::. .:..:.  :...:..::.: ::. :::.::::
NP_079 TCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSL
            570       580       590       600       610       620  

              410       420       430       440       450       460
pF1KB8 LFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAE
       ::::::   : ::.::::::. ::: : :.:: :: ::::::::: ::::.: .: .::.
NP_079 LFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQ
            630       640       650       660       670       680  

        
pF1KB8 R
        
NP_079 S
        

>>XP_016882813 (OMIM: 606476,611775) PREDICTED: inositol  (422 aa)
 initn: 1229 init1: 1145 opt: 1178  Z-score: 855.6  bits: 167.5 E(85289): 6.4e-41
Smith-Waterman score: 1261; 50.5% identity (71.4% similar) in 412 aa overlap (73-460:39-421)

             50        60        70        80        90        100 
pF1KB8 AAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSP-GPPER
                                     .:  :: :.: .: : :. : ..: ::: :
XP_016 LKQPGNSLALVVSKYNRILMAPGHNLALTCSPLCPV-PRLIITPETPE-PEAQPVGPPSR
       10        20        30        40         50         60      

             110       120       130       140       150       160 
pF1KB8 ERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDV
        .     .::. .        ::.::      ...::::... . . :         :: 
XP_016 VE-----GGSGGF--------SSASS------FDESEDDVVAGGGGASD-------PEDR
              70                      80        90              100

             170        180       190                              
pF1KB8 GQKNHWQKIRTMVNL-PVISPFKKRYAWVQLAGHTGS----------------------F
       . .. :.:..:...  : .  :.:.: ::::.::.::                      :
XP_016 SGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGSCGEVLFLIQFLILSFILPPLGNF
              110       120       130       140       150       160

      200       210       220       230       240       250        
pF1KB8 KAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGP
       .: : .: ::::  . :.  : .:: : ::  :::..:.: .::... :..:::  :.::
XP_016 QA-GEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGP
               170       180       190       200       210         

      260       270       280       290       300       310        
pF1KB8 CVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQW
        ..::::: ::::::::.::::::. :::::.::.:::: ::: ::::: ::::::::::
XP_016 SIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQW
     220       230       240       250       260       270         

      320       330       340       350       360       370        
pF1KB8 REGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQ
       :: .::..::::::::::::::.:.:.:: :.. ::: .:.:.::.::. .:..:.  :.
XP_016 RETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLE
     280       290       300       310       320       330         

      380       390       400       410       420       430        
pF1KB8 QIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEG
       ..:..::.: ::. :::.::::::::::   : ::.::::::. ::: : :.:: :: ::
XP_016 ELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEG
     340       350       360       370       380       390         

      440       450       460 
pF1KB8 NREDGYLLGLDNLIGILASLAER
       ::::::: ::::.: .: .::. 
XP_016 NREDGYLWGLDNMICLLQGLAQS
     400       410       420  




461 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 09:30:09 2016 done: Fri Nov  4 09:30:10 2016
 Total Scan time:  8.370 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
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