Result of FASTA (omim) for pF1KB7795
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7795, 461 aa
  1>>>pF1KB7795 461 - 461 aa - 461 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.5455+/-0.00032; mu= -0.0501+/- 0.020
 mean_var=261.2431+/-55.680, 0's: 0 Z-trim(124.3): 359  B-trim: 2478 in 2/57
 Lambda= 0.079351
 statistics sampled from 45437 (45813) to 45437 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.824), E-opt: 0.2 (0.537), width:  16
 Scan time:  8.000

The best scores are:                                      opt bits E(85289)
NP_001035919 (OMIM: 602353) transforming growth fa ( 461) 3330 393.9 4.7e-109
NP_057011 (OMIM: 602353) transforming growth facto ( 444) 3227 382.1 1.6e-105
NP_001158191 (OMIM: 602353) transforming growth fa ( 444) 3227 382.1 1.6e-105
XP_005253974 (OMIM: 602505) PREDICTED: paxillin is ( 403) 1380 170.7 6.7e-42
XP_016875225 (OMIM: 602505) PREDICTED: paxillin is ( 748) 1383 171.2 8.4e-42
NP_001230685 (OMIM: 602505) paxillin isoform 3 [Ho ( 605) 1380 170.8 9.1e-42
XP_016875228 (OMIM: 602505) PREDICTED: paxillin is ( 611) 1380 170.8 9.2e-42
XP_016875227 (OMIM: 602505) PREDICTED: paxillin is ( 645) 1380 170.8 9.5e-42
XP_016875223 (OMIM: 602505) PREDICTED: paxillin is ( 888) 1383 171.3 9.6e-42
XP_006719597 (OMIM: 602505) PREDICTED: paxillin is ( 996) 1383 171.3   1e-41
XP_006719599 (OMIM: 602505) PREDICTED: paxillin is ( 996) 1383 171.3   1e-41
XP_006719598 (OMIM: 602505) PREDICTED: paxillin is ( 996) 1383 171.3   1e-41
XP_011536925 (OMIM: 602505) PREDICTED: paxillin is ( 996) 1383 171.3   1e-41
XP_016875220 (OMIM: 602505) PREDICTED: paxillin is ( 996) 1383 171.3   1e-41
XP_011536924 (OMIM: 602505) PREDICTED: paxillin is ( 996) 1383 171.3   1e-41
XP_016875232 (OMIM: 602505) PREDICTED: paxillin is ( 424) 1374 170.0 1.1e-41
NP_079433 (OMIM: 602505) paxillin isoform 4 [Homo  ( 424) 1374 170.0 1.1e-41
XP_016875217 (OMIM: 602505) PREDICTED: paxillin is (1127) 1383 171.4 1.1e-41
XP_006719595 (OMIM: 602505) PREDICTED: paxillin is (1129) 1383 171.4 1.1e-41
XP_016875216 (OMIM: 602505) PREDICTED: paxillin is (1130) 1383 171.4 1.1e-41
XP_016875215 (OMIM: 602505) PREDICTED: paxillin is (1135) 1383 171.4 1.2e-41
XP_016875222 (OMIM: 602505) PREDICTED: paxillin is ( 940) 1380 171.0 1.3e-41
NP_002850 (OMIM: 602505) paxillin isoform 1 [Homo  ( 557) 1374 170.1 1.4e-41
XP_016875231 (OMIM: 602505) PREDICTED: paxillin is ( 563) 1374 170.1 1.4e-41
XP_016875224 (OMIM: 602505) PREDICTED: paxillin is ( 858) 1370 169.8 2.6e-41
XP_016875230 (OMIM: 602505) PREDICTED: paxillin is ( 589) 1363 168.9 3.4e-41
NP_001074324 (OMIM: 602505) paxillin isoform 2 [Ho ( 591) 1363 168.9 3.4e-41
XP_016875229 (OMIM: 602505) PREDICTED: paxillin is ( 597) 1363 168.9 3.5e-41
XP_016875226 (OMIM: 602505) PREDICTED: paxillin is ( 700) 1363 168.9 3.9e-41
XP_016875218 (OMIM: 602505) PREDICTED: paxillin is (1087) 1363 169.1 5.5e-41
XP_006718813 (OMIM: 605390) PREDICTED: leupaxin is ( 290) 1266 157.5 4.4e-38
NP_001294880 (OMIM: 605390) leupaxin isoform 3 [Ho ( 366) 1266 157.6 5.3e-38
XP_011543692 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 1266 157.6 5.3e-38
XP_011543690 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 1266 157.6 5.3e-38
XP_011543693 (OMIM: 605390) PREDICTED: leupaxin is ( 366) 1266 157.6 5.3e-38
NP_004802 (OMIM: 605390) leupaxin isoform 2 [Homo  ( 386) 1266 157.6 5.5e-38
NP_001137467 (OMIM: 605390) leupaxin isoform 1 [Ho ( 391) 1266 157.6 5.5e-38
XP_016875219 (OMIM: 602505) PREDICTED: paxillin is (1057)  905 116.6 3.2e-25
XP_016871096 (OMIM: 605906,609452) PREDICTED: LIM  ( 463)  633 85.2 4.1e-16
XP_011537495 (OMIM: 605906,609452) PREDICTED: LIM  ( 463)  633 85.2 4.1e-16
XP_011537493 (OMIM: 605906,609452) PREDICTED: LIM  ( 633)  633 85.3 5.2e-16
XP_011537491 (OMIM: 605906,609452) PREDICTED: LIM  ( 696)  633 85.3 5.6e-16
XP_016871095 (OMIM: 605906,609452) PREDICTED: LIM  ( 743)  633 85.4 5.9e-16
XP_011537490 (OMIM: 605906,609452) PREDICTED: LIM  ( 743)  633 85.4 5.9e-16
XP_011537496 (OMIM: 605906,609452) PREDICTED: LIM  ( 400)  627 84.5 5.9e-16
XP_011537487 (OMIM: 605906,609452) PREDICTED: LIM  ( 811)  633 85.4 6.3e-16
XP_011537486 (OMIM: 605906,609452) PREDICTED: LIM  ( 811)  633 85.4 6.3e-16
XP_011537489 (OMIM: 605906,609452) PREDICTED: LIM  ( 748)  627 84.7 9.5e-16
XP_005262755 (OMIM: 605904) PREDICTED: PDZ and LIM ( 493)  621 83.8 1.1e-15
XP_016863147 (OMIM: 605904) PREDICTED: PDZ and LIM ( 498)  621 83.8 1.1e-15


>>NP_001035919 (OMIM: 602353) transforming growth factor  (461 aa)
 initn: 3330 init1: 3330 opt: 3330  Z-score: 2078.9  bits: 393.9 E(85289): 4.7e-109
Smith-Waterman score: 3330; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461)

               10        20        30        40        50        60
pF1KB7 MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB7 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB7 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB7 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB7 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
              370       380       390       400       410       420

              430       440       450       460 
pF1KB7 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
       :::::::::::::::::::::::::::::::::::::::::
NP_001 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
              430       440       450       460 

>>NP_057011 (OMIM: 602353) transforming growth factor be  (444 aa)
 initn: 3227 init1: 3227 opt: 3227  Z-score: 2015.4  bits: 382.1 E(85289): 1.6e-105
Smith-Waterman score: 3227; 100.0% identity (100.0% similar) in 444 aa overlap (18-461:1-444)

               10        20        30        40        50        60
pF1KB7 MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY
                        :::::::::::::::::::::::::::::::::::::::::::
NP_057                  MPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY
                                10        20        30        40   

               70        80        90       100       110       120
pF1KB7 STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV
            50        60        70        80        90       100   

              130       140       150       160       170       180
pF1KB7 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT
           110       120       130       140       150       160   

              190       200       210       220       230       240
pF1KB7 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
           170       180       190       200       210       220   

              250       260       270       280       290       300
pF1KB7 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
           230       240       250       260       270       280   

              310       320       330       340       350       360
pF1KB7 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
           290       300       310       320       330       340   

              370       380       390       400       410       420
pF1KB7 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
           350       360       370       380       390       400   

              430       440       450       460 
pF1KB7 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
       :::::::::::::::::::::::::::::::::::::::::
NP_057 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
           410       420       430       440    

>>NP_001158191 (OMIM: 602353) transforming growth factor  (444 aa)
 initn: 3227 init1: 3227 opt: 3227  Z-score: 2015.4  bits: 382.1 E(85289): 1.6e-105
Smith-Waterman score: 3227; 100.0% identity (100.0% similar) in 444 aa overlap (18-461:1-444)

               10        20        30        40        50        60
pF1KB7 MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY
                        :::::::::::::::::::::::::::::::::::::::::::
NP_001                  MPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLY
                                10        20        30        40   

               70        80        90       100       110       120
pF1KB7 STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKV
            50        60        70        80        90       100   

              130       140       150       160       170       180
pF1KB7 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPT
           110       120       130       140       150       160   

              190       200       210       220       230       240
pF1KB7 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
           170       180       190       200       210       220   

              250       260       270       280       290       300
pF1KB7 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
           230       240       250       260       270       280   

              310       320       330       340       350       360
pF1KB7 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
           290       300       310       320       330       340   

              370       380       390       400       410       420
pF1KB7 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
           350       360       370       380       390       400   

              430       440       450       460 
pF1KB7 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
       :::::::::::::::::::::::::::::::::::::::::
NP_001 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
           410       420       430       440    

>>XP_005253974 (OMIM: 602505) PREDICTED: paxillin isofor  (403 aa)
 initn: 1350 init1: 1350 opt: 1380  Z-score: 873.2  bits: 170.7 E(85289): 6.7e-42
Smith-Waterman score: 1384; 52.4% identity (71.8% similar) in 372 aa overlap (115-460:32-402)

           90       100       110       120        130             
pF1KB7 VLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGE-QKEDQSEDKKR------PS
                                     .:::  :.   :  .:  : .:      : 
XP_005 SAPSSTGPQYCPGLPSRKEATPEGRPETCLLPSSPQAQRPIQGLEQRADGERCWAAGWPR
              10        20        30        40        50        60 

       140       150       160       170                    180    
pF1KB7 LPSSPSPGLPKASATSATLELDRLMASLSDFRVQN-----------HLPAS--GPTQPP-
         .  :::    .. :  ::   :..:.:.  ::.           :   :  .: ::: 
XP_005 DGGRSSPGGQDEGGGSWPLEEVVLLVSISS-SVQEGEKYPHPCAARHRTPSLRSPDQPPP
              70        80        90        100       110       120

              190        200        210       220       230        
pF1KB7 ---VVSSTNEGSPSPPE-PTGKGS-LDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQ
           ... . :: :::  :   :: ::.::: :::::.. :: : :::.::.:.::::::
XP_005 CPQFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQ
              130       140       150       160       170       180

      240       250       260       270       280       290        
pF1KB7 VVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKM
       ::::.:..::::::::  :.  .:. .:::.:: :.: . : . ::::: .:: ::  :.
XP_005 VVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKV
              190       200       210       220       230       240

      300       310       320       330       340       350        
pF1KB7 VTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYI
       ::::   :::::: :..::  :: :::::..:. :::.:....:::.: ::   ::.:::
XP_005 VTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYI
              250       260       270       280       290       300

      360       370       380       390       400       410        
pF1KB7 SALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVS
       :::..::::.::::::::.:: .::::::.:.: :: :.: ::::::. :  :.::::..
XP_005 SALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCIT
              310       320       330       340       350       360

      420       430       440       450       460 
pF1KB7 ALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
       :....:::.::.:.:::. :.::.:.:.  ::::: :::::: 
XP_005 AMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
              370       380       390       400   

>>XP_016875225 (OMIM: 602505) PREDICTED: paxillin isofor  (748 aa)
 initn: 1571 init1: 1350 opt: 1383  Z-score: 871.5  bits: 171.2 E(85289): 8.4e-42
Smith-Waterman score: 1412; 45.7% identity (66.3% similar) in 490 aa overlap (1-460:272-747)

                                             10        20        30
pF1KB7                               MEDLDALLSDLETTTSHMPRSGAPKERPAE
                                     ...: : :::....    : :  : .:   
XP_016 TVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKVVFP--PGSPIPLRRTIS
             250       260       270       280         290         

               40        50        60        70        80        90
pF1KB7 PLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLGTGL
        :. :     : .: .. ::..      : : .    . .: .:.:    .:::: ..: 
XP_016 VLASPSVPLLQHRTDAAASSSSP-----LPSLL----ASSPLGPSAYT-CGSSGVQSAGE
     300       310       320                330        340         

                  100            110       120       130           
pF1KB7 CELDRLLQ----ELNA--TQFNI---TDEIMSQFPSSKVASGEQKEDQSE--DKKRPSLP
          :. .:     . :  :. ..   :::    ::  .. . ::. :  .      :   
XP_016 EPHDEGVQGPALPIPAPHTMRSVGCQTDED-PLFPPMQIQGLEQRADGERCWAAGWPRDG
     350       360       370        380       390       400        

     140       150       160       170                    180      
pF1KB7 SSPSPGLPKASATSATLELDRLMASLSDFRVQN-----------HLPAS--GPTQPP---
       .  :::    .. :  ::   :..:.:.  ::.           :   :  .: :::   
XP_016 GRSSPGGQDEGGGSWPLEEVVLLVSISS-SVQEGEKYPHPCAARHRTPSLRSPDQPPPCP
      410       420       430        440       450       460       

            190        200        210       220       230       240
pF1KB7 -VVSSTNEGSPSPPE-PTGKGS-LDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVV
         ... . :: :::  :   :: ::.::: :::::.. :: : :::.::.:.::::::::
XP_016 QFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVV
       470       480       490       500       510       520       

              250       260       270       280       290       300
pF1KB7 TALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVT
       ::.:..::::::::  :.  .:. .:::.:: :.: . : . ::::: .:: ::  :.::
XP_016 TAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVT
       530       540       550       560       570       580       

              310       320       330       340       350       360
pF1KB7 ALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISA
       ::   :::::: :..::  :: :::::..:. :::.:....:::.: ::   ::.:::::
XP_016 ALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISA
       590       600       610       620       630       640       

              370       380       390       400       410       420
pF1KB7 LSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSAL
       :..::::.::::::::.:: .::::::.:.: :: :.: ::::::. :  :.::::..:.
XP_016 LNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAM
       650       660       670       680       690       700       

              430       440       450       460 
pF1KB7 GRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
       ...:::.::.:.:::. :.::.:.:.  ::::: :::::: 
XP_016 AKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
       710       720       730       740        

>>NP_001230685 (OMIM: 602505) paxillin isoform 3 [Homo s  (605 aa)
 initn: 1588 init1: 1350 opt: 1380  Z-score: 870.8  bits: 170.8 E(85289): 9.1e-42
Smith-Waterman score: 1443; 46.4% identity (63.9% similar) in 498 aa overlap (55-460:113-604)

           30        40        50        60        70        80    
pF1KB7 KERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSG
                                     ...:.::   : .: .:.    :   :.: 
NP_001 SSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSFPNKQKSAEPS----PTVMSTS-
             90       100       110       120       130            

           90       100           110                   120        
pF1KB7 VLGTGLCELDRLLQELNATQFNI----TDEIMSQ------------FPSSKVASGEQKED
        ::..: :::::: ::::.: :     .::  :.             : ..   : .   
NP_001 -LGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGP
        140       150       160       170       180       190      

      130                  140                                     
pF1KB7 QSEDKK-----------RPSLPS----------SPSPGL---------P----------K
        ...:            :::. :          :: :..         :          .
NP_001 LTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTR
        200       210       220       230       240       250      

      150       160                        170                     
pF1KB7 ASATSATLELDRLMASLSDFR-----------------VQN-----------HLPAS--G
        ::.::: :::.::::::::.                 ::.           :   :  .
NP_001 ISASSATRELDELMASLSDFKGSWPLEEVVLLVSISSSVQEGEKYPHPCAARHRTPSLRS
        260       270       280       290       300       310      

      180           190        200        210       220       230  
pF1KB7 PTQPP----VVSSTNEGSPSPPE-PTGKGS-LDTMLGLLQSDLSRRGVPTQAKGLCGSCN
       : :::     ... . :: :::  :   :: ::.::: :::::.. :: : :::.::.:.
NP_001 PDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACK
        320       330       340       350       360       370      

            240       250       260       270       280       290  
pF1KB7 KPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQ
       ::::::::::.:..::::::::  :.  .:. .:::.:: :.: . : . ::::: .:: 
NP_001 KPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNG
        380       390       400       410       420       430      

            300       310       320       330       340       350  
pF1KB7 PIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGP
       ::  :.::::   :::::: :..::  :: :::::..:. :::.:....:::.: ::   
NP_001 PILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARA
        440       450       460       470       480       490      

            360       370       380       390       400       410  
pF1KB7 ILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPV
       ::.::::::..::::.::::::::.:: .::::::.:.: :: :.: ::::::. :  :.
NP_001 ILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPI
        500       510       520       530       540       550      

            420       430       440       450       460 
pF1KB7 TGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
       ::::..:....:::.::.:.:::. :.::.:.:.  ::::: :::::: 
NP_001 TGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
        560       570       580       590       600     

>>XP_016875228 (OMIM: 602505) PREDICTED: paxillin isofor  (611 aa)
 initn: 1566 init1: 1350 opt: 1380  Z-score: 870.8  bits: 170.8 E(85289): 9.2e-42
Smith-Waterman score: 1443; 46.4% identity (63.9% similar) in 498 aa overlap (55-460:119-610)

           30        40        50        60        70        80    
pF1KB7 KERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSG
                                     ...:.::   : .: .:.    :   :.: 
XP_016 SSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSFPNKQKSAEPS----PTVMSTS-
       90       100       110       120       130           140    

           90       100           110                   120        
pF1KB7 VLGTGLCELDRLLQELNATQFNI----TDEIMSQ------------FPSSKVASGEQKED
        ::..: :::::: ::::.: :     .::  :.             : ..   : .   
XP_016 -LGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGP
            150       160       170       180       190       200  

      130                  140                                     
pF1KB7 QSEDKK-----------RPSLPS----------SPSPGL---------P----------K
        ...:            :::. :          :: :..         :          .
XP_016 LTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTR
            210       220       230       240       250       260  

      150       160                        170                     
pF1KB7 ASATSATLELDRLMASLSDFR-----------------VQN-----------HLPAS--G
        ::.::: :::.::::::::.                 ::.           :   :  .
XP_016 ISASSATRELDELMASLSDFKGSWPLEEVVLLVSISSSVQEGEKYPHPCAARHRTPSLRS
            270       280       290       300       310       320  

      180           190        200        210       220       230  
pF1KB7 PTQPP----VVSSTNEGSPSPPE-PTGKGS-LDTMLGLLQSDLSRRGVPTQAKGLCGSCN
       : :::     ... . :: :::  :   :: ::.::: :::::.. :: : :::.::.:.
XP_016 PDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACK
            330       340       350       360       370       380  

            240       250       260       270       280       290  
pF1KB7 KPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQ
       ::::::::::.:..::::::::  :.  .:. .:::.:: :.: . : . ::::: .:: 
XP_016 KPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNG
            390       400       410       420       430       440  

            300       310       320       330       340       350  
pF1KB7 PIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGP
       ::  :.::::   :::::: :..::  :: :::::..:. :::.:....:::.: ::   
XP_016 PILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARA
            450       460       470       480       490       500  

            360       370       380       390       400       410  
pF1KB7 ILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPV
       ::.::::::..::::.::::::::.:: .::::::.:.: :: :.: ::::::. :  :.
XP_016 ILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPI
            510       520       530       540       550       560  

            420       430       440       450       460 
pF1KB7 TGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
       ::::..:....:::.::.:.:::. :.::.:.:.  ::::: :::::: 
XP_016 TGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC
            570       580       590       600       610 

>>XP_016875227 (OMIM: 602505) PREDICTED: paxillin isofor  (645 aa)
 initn: 1577 init1: 1350 opt: 1380  Z-score: 870.5  bits: 170.8 E(85289): 9.5e-42
Smith-Waterman score: 1414; 46.6% identity (68.3% similar) in 470 aa overlap (18-460:189-644)

                            10        20        30        40       
pF1KB7              MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSG
                                     .:....:    : :::      ..:. ..:
XP_016 NAVQHNPPGFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTK-----EKPKRNGG
      160       170       180       190       200            210   

           50          60        70         80        90       100 
pF1KB7 ---ESSGASGDK--DHLYSTVCKPRSPKPAAPAAP-PFSSSSGVLGTGLCELDRLLQELN
          :.   : ..  :.: :.:  : :: ::  .    .:: . : .:   . .  ..  .
XP_016 RGLEDVRPSVESLLDELESSV--P-SPVPAITVNQGEMSSPQRVTST---QQQTRISASS
           220       230          240       250          260       

             110       120       130         140       150         
pF1KB7 ATQFNITDEIMSQFPSSKVASGEQKEDQSE--DKKRPSLPSSPSPGLPKASATSATLELD
       ::.    ::.:... . :. . ::. :  .      :   .  :::    .. :  ::  
XP_016 ATRE--LDELMASLSDFKIQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGGGSWPLEEV
       270         280       290       300       310       320     

     160       170                    180           190        200 
pF1KB7 RLMASLSDFRVQN-----------HLPAS--GPTQPP----VVSSTNEGSPSPPE-PTGK
        :..:.:.  ::.           :   :  .: :::     ... . :: :::  :   
XP_016 VLLVSISS-SVQEGEKYPHPCAARHRTPSLRSPDQPPPCPQFMAQGKTGSSSPPGGPPKP
         330        340       350       360       370       380    

              210       220       230       240       250       260
pF1KB7 GS-LDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTA
       :: ::.::: :::::.. :: : :::.::.:.::::::::::.:..::::::::  :.  
XP_016 GSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEE
          390       400       410       420       430       440    

              270       280       290       300       310       320
pF1KB7 LGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPF
       .:. .:::.:: :.: . : . ::::: .:: ::  :.::::   :::::: :..::  :
XP_016 IGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFF
          450       460       470       480       490       500    

              330       340       350       360       370       380
pF1KB7 GDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS
       : :::::..:. :::.:....:::.: ::   ::.::::::..::::.::::::::.:: 
XP_016 GPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFV
          510       520       530       540       550       560    

              390       400       410       420       430       440
pF1KB7 GGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTK
       .::::::.:.: :: :.: ::::::. :  :.::::..:....:::.::.:.:::. :.:
XP_016 NGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNK
          570       580       590       600       610       620    

              450       460 
pF1KB7 GSFQERAGKPYCQPCFLKLFG
       :.:.:.  ::::: :::::: 
XP_016 GTFKEQNDKPYCQNCFLKLFC
          630       640     

>>XP_016875223 (OMIM: 602505) PREDICTED: paxillin isofor  (888 aa)
 initn: 1431 init1: 1350 opt: 1383  Z-score: 870.4  bits: 171.3 E(85289): 9.6e-42
Smith-Waterman score: 1401; 46.7% identity (67.0% similar) in 463 aa overlap (34-460:427-887)

            10        20        30        40        50        60   
pF1KB7 LDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTV
                                     :: :     .: :  .: .    .:  ...
XP_016 AQDWLTEGVIITVQPRGKRAGGQLVEKVVFPPGSPIPLRRTISVLASPSVPLLQHRTDAA
        400       410       420       430       440       450      

            70        80              90           100             
pF1KB7 CKPRSPKPAAPAAPPFS------SSSGVLGTGLCELDRLLQ----ELNA--TQFNI---T
        .  :: :.  :. :..      .:::: ..:    :. .:     . :  :. ..   :
XP_016 ASSSSPLPSLLASSPLGPSAYTCGSSGVQSAGEEPHDEGVQGPALPIPAPHTMRSVGCQT
        460       470       480       490       500       510      

      110       120       130         140       150       160      
pF1KB7 DEIMSQFPSSKVASGEQKEDQSE--DKKRPSLPSSPSPGLPKASATSATLELDRLMASLS
       ::    ::  .. . ::. :  .      :   .  :::    .. :  ::   :..:.:
XP_016 DED-PLFPPMQIQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGGGSWPLEEVVLLVSIS
         520       530       540       550       560       570     

        170                    180           190        200        
pF1KB7 DFRVQN-----------HLPAS--GPTQPP----VVSSTNEGSPSPPE-PTGKGS-LDTM
       .  ::.           :   :  .: :::     ... . :: :::  :   :: ::.:
XP_016 S-SVQEGEKYPHPCAARHRTPSLRSPDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQLDSM
          580       590       600       610       620       630    

       210       220       230       240       250       260       
pF1KB7 LGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFF
       :: :::::.. :: : :::.::.:.::::::::::.:..::::::::  :.  .:. .::
XP_016 LGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFF
          640       650       660       670       680       690    

       270       280       290       300       310       320       
pF1KB7 EKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHE
       :.:: :.: . : . ::::: .:: ::  :.::::   :::::: :..::  :: :::::
XP_016 ERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHE
          700       710       720       730       740       750    

       330       340       350       360       370       380       
pF1KB7 REGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEH
       ..:. :::.:....:::.: ::   ::.::::::..::::.::::::::.:: .::::::
XP_016 KDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEH
          760       770       780       790       800       810    

       390       400       410       420       430       440       
pF1KB7 EGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERA
       .:.: :: :.: ::::::. :  :.::::..:....:::.::.:.:::. :.::.:.:. 
XP_016 DGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQN
          820       830       840       850       860       870    

       450       460 
pF1KB7 GKPYCQPCFLKLFG
        ::::: :::::: 
XP_016 DKPYCQNCFLKLFC
          880        

>>XP_006719597 (OMIM: 602505) PREDICTED: paxillin isofor  (996 aa)
 initn: 1507 init1: 1350 opt: 1383  Z-score: 869.8  bits: 171.3 E(85289): 1e-41
Smith-Waterman score: 1401; 46.7% identity (67.0% similar) in 463 aa overlap (34-460:535-995)

            10        20        30        40        50        60   
pF1KB7 LDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTV
                                     :: :     .: :  .: .    .:  ...
XP_006 AQDWLTEGVIITVQPRGKRAGGQLVEKVVFPPGSPIPLRRTISVLASPSVPLLQHRTDAA
          510       520       530       540       550       560    

            70        80              90           100             
pF1KB7 CKPRSPKPAAPAAPPFS------SSSGVLGTGLCELDRLLQ----ELNA--TQFNI---T
        .  :: :.  :. :..      .:::: ..:    :. .:     . :  :. ..   :
XP_006 ASSSSPLPSLLASSPLGPSAYTCGSSGVQSAGEEPHDEGVQGPALPIPAPHTMRSVGCQT
          570       580       590       600       610       620    

      110       120       130         140       150       160      
pF1KB7 DEIMSQFPSSKVASGEQKEDQSE--DKKRPSLPSSPSPGLPKASATSATLELDRLMASLS
       ::    ::  .. . ::. :  .      :   .  :::    .. :  ::   :..:.:
XP_006 DED-PLFPPMQIQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGGGSWPLEEVVLLVSIS
           630       640       650       660       670       680   

        170                    180           190        200        
pF1KB7 DFRVQN-----------HLPAS--GPTQPP----VVSSTNEGSPSPPE-PTGKGS-LDTM
       .  ::.           :   :  .: :::     ... . :: :::  :   :: ::.:
XP_006 S-SVQEGEKYPHPCAARHRTPSLRSPDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQLDSM
            690       700       710       720       730       740  

       210       220       230       240       250       260       
pF1KB7 LGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFF
       :: :::::.. :: : :::.::.:.::::::::::.:..::::::::  :.  .:. .::
XP_006 LGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFF
            750       760       770       780       790       800  

       270       280       290       300       310       320       
pF1KB7 EKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHE
       :.:: :.: . : . ::::: .:: ::  :.::::   :::::: :..::  :: :::::
XP_006 ERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHE
            810       820       830       840       850       860  

       330       340       350       360       370       380       
pF1KB7 REGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEH
       ..:. :::.:....:::.: ::   ::.::::::..::::.::::::::.:: .::::::
XP_006 KDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEH
            870       880       890       900       910       920  

       390       400       410       420       430       440       
pF1KB7 EGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERA
       .:.: :: :.: ::::::. :  :.::::..:....:::.::.:.:::. :.::.:.:. 
XP_006 DGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQN
            930       940       950       960       970       980  

       450       460 
pF1KB7 GKPYCQPCFLKLFG
        ::::: :::::: 
XP_006 DKPYCQNCFLKLFC
            990      




461 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 09:26:57 2016 done: Fri Nov  4 09:26:59 2016
 Total Scan time:  8.000 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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