Result of FASTA (omim) for pF1KB7236
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7236, 311 aa
  1>>>pF1KB7236 311 - 311 aa - 311 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.1696+/-0.000369; mu= 16.1683+/- 0.023
 mean_var=63.9609+/-12.166, 0's: 0 Z-trim(113.7): 142  B-trim: 0 in 0/51
 Lambda= 0.160368
 statistics sampled from 23006 (23163) to 23006 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.272), width:  16
 Scan time:  7.840

The best scores are:                                      opt bits E(85289)
NP_056540 (OMIM: 608575) retinol dehydrogenase 8 [ ( 331) 2024 477.0 2.3e-134
NP_000404 (OMIM: 109684) estradiol 17-beta-dehydro ( 328)  748 181.7 1.7e-45
NP_001317148 (OMIM: 109684) estradiol 17-beta-dehy ( 329)  736 179.0 1.2e-44
XP_011523032 (OMIM: 109684) PREDICTED: estradiol 1 ( 383)  649 158.9 1.5e-38
XP_011523031 (OMIM: 109684) PREDICTED: estradiol 1 ( 384)  644 157.7 3.4e-38
XP_005257349 (OMIM: 109684) PREDICTED: estradiol 1 ( 359)  628 154.0 4.2e-37
XP_006721922 (OMIM: 109684) PREDICTED: estradiol 1 ( 360)  616 151.2 2.9e-36
XP_006721921 (OMIM: 109684) PREDICTED: estradiol 1 ( 414)  529 131.1 3.7e-30
XP_006721920 (OMIM: 109684) PREDICTED: estradiol 1 ( 415)  524 130.0 8.2e-30
NP_001317088 (OMIM: 616160) dehydrogenase/reductas ( 310)  356 91.0 3.2e-18
XP_016879915 (OMIM: 616160) PREDICTED: dehydrogena ( 325)  356 91.0 3.4e-18
NP_056325 (OMIM: 616160) dehydrogenase/reductase S ( 325)  356 91.0 3.4e-18
XP_016879914 (OMIM: 616160) PREDICTED: dehydrogena ( 372)  356 91.1 3.8e-18
XP_005256652 (OMIM: 616160) PREDICTED: dehydrogena ( 372)  356 91.1 3.8e-18
XP_011522088 (OMIM: 616160) PREDICTED: dehydrogena ( 334)  351 89.9 7.7e-18
XP_016862498 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324)  333 85.7 1.3e-16
XP_016862499 (OMIM: 603063) PREDICTED: D-beta-hydr ( 324)  333 85.7 1.3e-16
XP_016862501 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330)  333 85.7 1.4e-16
XP_016862497 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330)  333 85.7 1.4e-16
XP_016862500 (OMIM: 603063) PREDICTED: D-beta-hydr ( 330)  333 85.7 1.4e-16
NP_976059 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343)  333 85.7 1.4e-16
XP_005269409 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343)  333 85.7 1.4e-16
XP_016862496 (OMIM: 603063) PREDICTED: D-beta-hydr ( 343)  333 85.7 1.4e-16
NP_004042 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343)  333 85.7 1.4e-16
NP_976060 (OMIM: 603063) D-beta-hydroxybutyrate de ( 343)  333 85.7 1.4e-16
XP_011511369 (OMIM: 603063) PREDICTED: D-beta-hydr ( 347)  333 85.7 1.4e-16
NP_001207422 (OMIM: 616161) dehydrogenase/reductas ( 312)  324 83.6 5.5e-16
NP_001309209 (OMIM: 612833) dehydrogenase/reductas ( 289)  322 83.1 7.1e-16
NP_057113 (OMIM: 612833) dehydrogenase/reductase S ( 339)  322 83.2 8.2e-16
XP_016876857 (OMIM: 612833) PREDICTED: dehydrogena ( 404)  322 83.2 9.4e-16
NP_001099041 (OMIM: 616161) dehydrogenase/reductas ( 311)  317 82.0 1.7e-15
NP_001186700 (OMIM: 136880,601617) 11-cis retinol  ( 318)  299 77.9 3.1e-14
NP_002896 (OMIM: 136880,601617) 11-cis retinol deh ( 318)  299 77.9 3.1e-14
XP_005266734 (OMIM: 136440) PREDICTED: 3-ketodihyd ( 298)  292 76.2   9e-14
NP_002026 (OMIM: 136440) 3-ketodihydrosphingosine  ( 332)  292 76.2 9.8e-14
NP_683695 (OMIM: 609769) short-chain dehydrogenase ( 313)  291 76.0 1.1e-13
XP_011523034 (OMIM: 109684) PREDICTED: estradiol 1 ( 180)  284 74.2 2.1e-13
NP_954674 (OMIM: 612131) dehydrogenase/reductase S ( 319)  281 73.7 5.6e-13
XP_011508777 (OMIM: 612131) PREDICTED: dehydrogena ( 319)  281 73.7 5.6e-13
NP_001135743 (OMIM: 612131) dehydrogenase/reductas ( 319)  281 73.7 5.6e-13
NP_001135742 (OMIM: 612131) dehydrogenase/reductas ( 319)  281 73.7 5.6e-13
NP_001276692 (OMIM: 612131) dehydrogenase/reductas ( 379)  281 73.7 6.4e-13
XP_005267306 (OMIM: 615194) PREDICTED: dehydrogena ( 280)  274 72.0 1.5e-12
NP_005785 (OMIM: 615194) dehydrogenase/reductase S ( 280)  274 72.0 1.5e-12
XP_006720064 (OMIM: 615194) PREDICTED: dehydrogena ( 280)  274 72.0 1.5e-12
NP_878912 (OMIM: 615194) dehydrogenase/reductase S ( 300)  274 72.1 1.6e-12
NP_835236 (OMIM: 612127) 17-beta-hydroxysteroid de ( 300)  267 70.4   5e-12
XP_016881179 (OMIM: 136440) PREDICTED: 3-ketodihyd ( 255)  262 69.2 9.7e-12
NP_066284 (OMIM: 611596) dehydrogenase/reductase S ( 278)  261 69.0 1.2e-11
XP_005269265 (OMIM: 606623) PREDICTED: 17-beta-hyd ( 317)  259 68.6 1.9e-11


>>NP_056540 (OMIM: 608575) retinol dehydrogenase 8 [Homo  (331 aa)
 initn: 2024 init1: 2024 opt: 2024  Z-score: 2533.2  bits: 477.0 E(85289): 2.3e-134
Smith-Waterman score: 2024; 100.0% identity (100.0% similar) in 311 aa overlap (1-311:21-331)

                                   10        20        30        40
pF1KB7                     MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMR
                           ::::::::::::::::::::::::::::::::::::::::
NP_056 MNGQSQVLPGGGHESREGINMAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMR
               10        20        30        40        50        60

               50        60        70        80        90       100
pF1KB7 DLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLE
               70        80        90       100       110       120

              110       120       130       140       150       160
pF1KB7 GLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKF
              130       140       150       160       170       180

              170       180       190       200       210       220
pF1KB7 ALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLY
              190       200       210       220       230       240

              230       240       250       260       270       280
pF1KB7 LPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRT
              250       260       270       280       290       300

              290       300       310 
pF1KB7 THRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
       :::::::::::::::::::::::::::::::
NP_056 THRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
              310       320       330 

>>NP_000404 (OMIM: 109684) estradiol 17-beta-dehydrogena  (328 aa)
 initn: 727 init1: 402 opt: 748  Z-score: 937.8  bits: 181.7 E(85289): 1.7e-45
Smith-Waterman score: 748; 46.9% identity (73.1% similar) in 286 aa overlap (4-286:2-285)

               10        20        30        40         50         
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
          :  .:::.::::::::.:::.:: ::.. ..: ::.:::  .  : ::: . :    
NP_000   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
                 10        20        30        40        50        

       60        70        80         90       100       110       
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
       .: . :::: ...:::     . .:.::::: :::.::.::::.:.  :. .:.:.:  :
NP_000 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
       60        70        80        90       100       110        

       120       130       140       150       160       170       
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
       .::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
NP_000 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
      120       130       140       150       160       170        

       180       190       200       210       220       230       
pF1KB7 IFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQD
       . .::.: ::: : :  :.:..   . .  :: .:.: : . ::  :...:  ..:::..
NP_000 VHLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEE
      180       190       200        210        220       230      

       240       250       260       270       280       290       
pF1KB7 VVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQ
       :........ . .: ::  :. :. ::  ..  : ::: :: . :: .:           
NP_000 VAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGA
        240       250       260       270       280       290      

       300       310                   
pF1KB7 CLSCGCLPTRVRPR                  
                                       
NP_000 EAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
        300       310       320        

>>NP_001317148 (OMIM: 109684) estradiol 17-beta-dehydrog  (329 aa)
 initn: 695 init1: 364 opt: 736  Z-score: 922.8  bits: 179.0 E(85289): 1.2e-44
Smith-Waterman score: 736; 46.7% identity (72.8% similar) in 287 aa overlap (4-286:2-286)

               10        20        30        40         50         
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
          :  .:::.::::::::.:::.:: ::.. ..: ::.:::  .  : ::: . :    
NP_001   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
                 10        20        30        40        50        

       60        70        80         90       100       110       
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
       .: . :::: ...:::     . .:.::::: :::.::.::::.:.  :. .:.:.:  :
NP_001 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
       60        70        80        90       100       110        

       120       130       140       150       160       170       
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
       .::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
NP_001 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
      120       130       140       150       160       170        

        180       190       200       210       220       230      
pF1KB7 IF-ISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQ
       .  .::.: ::: : :  :.:..   . .  :: .:.: : . ::  :...:  ..:::.
NP_001 VHSLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPE
      180       190       200        210        220       230      

        240       250       260       270       280       290      
pF1KB7 DVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGL
       .:........ . .: ::  :. :. ::  ..  : ::: :: . :: .:          
NP_001 EVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAG
        240       250       260       270       280       290      

        300       310                   
pF1KB7 QCLSCGCLPTRVRPR                  
                                        
NP_001 AEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
        300       310       320         

>>XP_011523032 (OMIM: 109684) PREDICTED: estradiol 17-be  (383 aa)
 initn: 648 init1: 402 opt: 649  Z-score: 813.0  bits: 158.9 E(85289): 1.5e-38
Smith-Waterman score: 656; 42.6% identity (68.0% similar) in 303 aa overlap (4-303:2-295)

               10        20        30        40         50         
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
          :  .:::.::::::::.:::.:: ::.. ..: ::.:::  .  : ::: . :    
XP_011   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
                 10        20        30        40        50        

       60        70        80         90       100       110       
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
       .: . :::: ...:::     . .:.::::: :::.::.::::.:.  :. .:.:.:  :
XP_011 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
       60        70        80        90       100       110        

       120       130       140       150       160       170       
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
       .::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
XP_011 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
      120       130       140       150       160       170        

       180       190       200       210       220       230       
pF1KB7 IFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQD
       . .::.: ::: : :  :.:..   . .  :: .:.: : . ::  :...:  ..:::..
XP_011 VHLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEE
      180       190       200        210        220       230      

       240       250       260       270       280       290       
pF1KB7 VVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQ
       :..  :..  ..:     ... .  :  . .   ::. : .  ..      :     . .
XP_011 VAE--VSAGLDSRSGGGASSGAQRWPQLSSRRRRSSSPLCAPRSRPCATSPP-----SAS
          240       250       260       270       280              

       300       310                                               
pF1KB7 CLSCGCLPTRVRPR                                              
       :  :::                                                      
XP_011 CPCCGCAWTTPAAPTTSPPCTGKCSATFRQRPRLGPRLGAGPGLGQRTRPGAVRWGTLSS
     290       300       310       320       330       340         

>>XP_011523031 (OMIM: 109684) PREDICTED: estradiol 17-be  (384 aa)
 initn: 616 init1: 364 opt: 644  Z-score: 806.7  bits: 157.7 E(85289): 3.4e-38
Smith-Waterman score: 644; 42.4% identity (67.8% similar) in 304 aa overlap (4-303:2-296)

               10        20        30        40         50         
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETL-EAAAGEALGQ-
          :  .:::.::::::::.:::.:: ::.. ..: ::.:::  .  : ::: . :    
XP_011   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG
                 10        20        30        40        50        

       60        70        80         90       100       110       
pF1KB7 TLTVAQLDVCSDESVAQCLSCI-QGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG
       .: . :::: ...:::     . .:.::::: :::.::.::::.:.  :. .:.:.:  :
XP_011 SLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG
       60        70        80        90       100       110        

       120       130       140       150       160       170       
pF1KB7 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN
       .::...: :: :::: .:...: .:: ::.:. ::::: ::::::::. ::::. :: :.
XP_011 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG
      120       130       140       150       160       170        

        180       190       200       210       220       230      
pF1KB7 IF-ISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQ
       .  .::.: ::: : :  :.:..   . .  :: .:.: : . ::  :...:  ..:::.
XP_011 VHSLSLIECGPVHTAFMEKVLGSPEEV-LDRTDIHTFHRFYQ-YLAHSKQVFREAAQNPE
      180       190       200        210        220       230      

        240       250       260       270       280       290      
pF1KB7 DVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGL
       .:..  :..  ..:     ... .  :  . .   ::. : .  ..      :     . 
XP_011 EVAE--VSAGLDSRSGGGASSGAQRWPQLSSRRRRSSSPLCAPRSRPCATSPP-----SA
        240         250       260       270       280              

        300       310                                              
pF1KB7 QCLSCGCLPTRVRPR                                             
       .:  :::                                                     
XP_011 SCPCCGCAWTTPAAPTTSPPCTGKCSATFRQRPRLGPRLGAGPGLGQRTRPGAVRWGTLS
     290       300       310       320       330       340         

>>XP_005257349 (OMIM: 109684) PREDICTED: estradiol 17-be  (359 aa)
 initn: 686 init1: 402 opt: 628  Z-score: 787.2  bits: 154.0 E(85289): 4.2e-37
Smith-Waterman score: 676; 42.3% identity (65.9% similar) in 317 aa overlap (4-286:2-316)

               10        20        30                              
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
          :  .:::.::::::::.:::.:: ::.. ..                          
XP_005   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
                 10        20        30        40        50        

                40         50         60        70        80       
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
            : ::.:::  .  : ::: . :    .: . :::: ...:::     . .:.:::
XP_005 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
       60        70        80        90       100       110        

         90       100       110       120       130       140      
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
       :: :::.::.::::.:.  :. .:.:.:  :.::...: :: :::: .:...: .:: ::
XP_005 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
      120       130       140       150       160       170        

        150       160       170       180       190       200      
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFP
       .:. ::::: ::::::::. ::::. :: :.. .::.: ::: : :  :.:..   . . 
XP_005 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEV-LD
      180       190       200       210       220       230        

        210       220       230       240       250       260      
pF1KB7 GTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTT
        :: .:.: : . ::  :...:  ..:::..:........ . .: ::  :. :. ::  
XP_005 RTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLR
       240        250       260       270       280       290      

        270       280       290       300       310                
pF1KB7 LKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR               
       ..  : ::: :: . :: .:                                        
XP_005 MRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPA
        300       310       320       330       340       350      

>>XP_006721922 (OMIM: 109684) PREDICTED: estradiol 17-be  (360 aa)
 initn: 654 init1: 364 opt: 616  Z-score: 772.1  bits: 151.2 E(85289): 2.9e-36
Smith-Waterman score: 664; 42.1% identity (65.7% similar) in 318 aa overlap (4-286:2-317)

               10        20        30                              
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
          :  .:::.::::::::.:::.:: ::.. ..                          
XP_006   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
                 10        20        30        40        50        

                40         50         60        70        80       
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
            : ::.:::  .  : ::: . :    .: . :::: ...:::     . .:.:::
XP_006 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
       60        70        80        90       100       110        

         90       100       110       120       130       140      
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
       :: :::.::.::::.:.  :. .:.:.:  :.::...: :: :::: .:...: .:: ::
XP_006 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
      120       130       140       150       160       170        

        150       160       170        180       190       200     
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIF-ISLVEPGPVVTEFEGKLLAQVSMAEF
       .:. ::::: ::::::::. ::::. :: :..  .::.: ::: : :  :.:..   . .
XP_006 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHSLSLIECGPVHTAFMEKVLGSPEEV-L
      180       190       200       210       220       230        

         210       220       230       240       250       260     
pF1KB7 PGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLT
         :: .:.: : . ::  :...:  ..:::..:........ . .: ::  :. :. :: 
XP_006 DRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLL
       240       250        260       270       280       290      

         270       280       290       300       310               
pF1KB7 TLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR              
        ..  : ::: :: . :: .:                                       
XP_006 RMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPP
        300       310       320       330       340       350      

>>XP_006721921 (OMIM: 109684) PREDICTED: estradiol 17-be  (414 aa)
 initn: 607 init1: 402 opt: 529  Z-score: 662.4  bits: 131.1 E(85289): 3.7e-30
Smith-Waterman score: 584; 38.6% identity (61.7% similar) in 334 aa overlap (4-303:2-326)

               10        20        30                              
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
          :  .:::.::::::::.:::.:: ::.. ..                          
XP_006   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
                 10        20        30        40        50        

                40         50         60        70        80       
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
            : ::.:::  .  : ::: . :    .: . :::: ...:::     . .:.:::
XP_006 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
       60        70        80        90       100       110        

         90       100       110       120       130       140      
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
       :: :::.::.::::.:.  :. .:.:.:  :.::...: :: :::: .:...: .:: ::
XP_006 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
      120       130       140       150       160       170        

        150       160       170       180       190       200      
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFP
       .:. ::::: ::::::::. ::::. :: :.. .::.: ::: : :  :.:..   . . 
XP_006 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEV-LD
      180       190       200       210       220       230        

        210       220       230       240       250       260      
pF1KB7 GTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTT
        :: .:.: : . ::  :...:  ..:::..:..  :..  ..:     ... .  :  .
XP_006 RTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAE--VSAGLDSRSGGGASSGAQRWPQLS
       240        250       260       270         280       290    

        270       280       290       300       310                
pF1KB7 LKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR               
        .   ::. : .  ..      :     . .:  :::                       
XP_006 SRRRRSSSPLCAPRSRPCATSPP-----SASCPCCGCAWTTPAAPTTSPPCTGKCSATFR
          300       310            320       330       340         

XP_006 QRPRLGPRLGAGPGLGQRTRPGAVRWGTLSSAILRPPRSKGFLSRCLPRPSLSPGSVWSL
     350       360       370       380       390       400         

>>XP_006721920 (OMIM: 109684) PREDICTED: estradiol 17-be  (415 aa)
 initn: 542 init1: 364 opt: 524  Z-score: 656.2  bits: 130.0 E(85289): 8.2e-30
Smith-Waterman score: 572; 38.5% identity (61.5% similar) in 335 aa overlap (4-303:2-327)

               10        20        30                              
pF1KB7 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQ--------------------------
          :  .:::.::::::::.:::.:: ::.. ..                          
XP_006   MARTVVLITGCSSGIGLHLAVRLASDPSQSFKGIDRQGQGGREGRSPWRPEGKSDLPP
                 10        20        30        40        50        

                40         50         60        70        80       
pF1KB7 -----VVATMRDLGKKETL-EAAAGEALGQ-TLTVAQLDVCSDESVAQCLSCI-QGEVDV
            : ::.:::  .  : ::: . :    .: . :::: ...:::     . .:.:::
XP_006 LPKPPVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDV
       60        70        80        90       100       110        

         90       100       110       120       130       140      
pF1KB7 LVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGL
       :: :::.::.::::.:.  :. .:.:.:  :.::...: :: :::: .:...: .:: ::
XP_006 LVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGL
      120       130       140       150       160       170        

        150       160       170        180       190       200     
pF1KB7 QGVIFNDVYAASKFALEGFFESLAIQLLQFNIF-ISLVEPGPVVTEFEGKLLAQVSMAEF
       .:. ::::: ::::::::. ::::. :: :..  .::.: ::: : :  :.:..   . .
XP_006 MGLPFNDVYCASKFALEGLCESLAVLLLPFGVHSLSLIECGPVHTAFMEKVLGSPEEV-L
      180       190       200       210       220       230        

         210       220       230       240       250       260     
pF1KB7 PGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLT
         :: .:.: : . ::  :...:  ..:::..:..  :..  ..:     ... .  :  
XP_006 DRTDIHTFHRFYQ-YLAHSKQVFREAAQNPEEVAE--VSAGLDSRSGGGASSGAQRWPQL
       240       250        260       270         280       290    

         270       280       290       300       310               
pF1KB7 TLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR              
       . .   ::. : .  ..      :     . .:  :::                      
XP_006 SSRRRRSSSPLCAPRSRPCATSPP-----SASCPCCGCAWTTPAAPTTSPPCTGKCSATF
          300       310            320       330       340         

XP_006 RQRPRLGPRLGAGPGLGQRTRPGAVRWGTLSSAILRPPRSKGFLSRCLPRPSLSPGSVWS
     350       360       370       380       390       400         

>>NP_001317088 (OMIM: 616160) dehydrogenase/reductase SD  (310 aa)
 initn: 315 init1: 315 opt: 356  Z-score: 448.0  bits: 91.0 E(85289): 3.2e-18
Smith-Waterman score: 356; 33.6% identity (64.3% similar) in 244 aa overlap (8-241:40-275)

                                      10        20         30      
pF1KB7                        MAAAPRTVLISGCSSGIGLELA-VQLAHDPKKRYQVV
                                     :.:.: .::.: : : :  :   :    .:
NP_001 LPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAK----LV
      10        20        30        40        50        60         

         40          50         60          70            80       
pF1KB7 ATMRDLGKKETL--EAAAGEALG-QTLT--VAQLDVCSDESV----AQCLSCIQGEVDVL
          :. :  : :  : .:..:   ::    .. .:. .. ..    :. :.:. : ::.:
NP_001 LCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCF-GYVDIL
          70        80        90       100       110        120    

        90       100       110       120       130       140       
pF1KB7 VNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQ
       :::::..  : .   .. . . :..::.:: : :.::.::.: .:::::::.:::..: .
NP_001 VNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKM
          130       140       150       160       170       180    

       150       160       170       180       190       200       
pF1KB7 GVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPG
       .. : ..::::: : ..::. :  .. :..: .... :: . :..  .. : .. .   :
NP_001 SIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNL--SVNAITADGSRYG
          190       200       210       220         230       240  

       210       220       230       240       250       260       
pF1KB7 TDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTL
       .   :    :.  . ... .. .::.. .::. :                          
NP_001 VMDTTTAQGRS-PVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMASRA
            250        260       270       280       290       300 

       270       280       290       300       310 
pF1KB7 KTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
                                                   
NP_001 RKERKSKNS                                   
             310                                   




311 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 06:11:12 2016 done: Fri Nov  4 06:11:13 2016
 Total Scan time:  7.840 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com