Result of FASTA (omim) for pF1KB7091
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB7091, 184 aa
  1>>>pF1KB7091 184 - 184 aa - 184 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2685+/-0.000372; mu= 12.5560+/- 0.023
 mean_var=57.7089+/-11.789, 0's: 0 Z-trim(113.1): 19  B-trim: 984 in 1/54
 Lambda= 0.168831
 statistics sampled from 22243 (22261) to 22243 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.261), width:  16
 Scan time:  5.960

The best scores are:                                      opt bits E(85289)
NP_078851 (OMIM: 612112) tumor necrosis factor alp ( 184) 1181 295.7 2.7e-80
XP_016877657 (OMIM: 616438) PREDICTED: tumor necro ( 203)  682 174.2 1.2e-43
NP_001298104 (OMIM: 616438) tumor necrosis factor  ( 204)  682 174.2 1.2e-43
XP_011519847 (OMIM: 616438) PREDICTED: tumor necro ( 218)  682 174.2 1.2e-43
NP_997264 (OMIM: 616438) tumor necrosis factor alp ( 292)  682 174.3 1.6e-43
XP_011525982 (OMIM: 615869) PREDICTED: tumor necro ( 186)  678 173.2 2.1e-43
NP_689575 (OMIM: 615869) tumor necrosis factor alp ( 186)  678 173.2 2.1e-43
XP_005259544 (OMIM: 615869) PREDICTED: tumor necro ( 186)  678 173.2 2.1e-43
NP_001161414 (OMIM: 615869) tumor necrosis factor  ( 186)  678 173.2 2.1e-43
NP_001071122 (OMIM: 612111) tumor necrosis factor  ( 188)  675 172.5 3.5e-43
NP_055165 (OMIM: 612111) tumor necrosis factor alp ( 198)  675 172.5 3.7e-43
NP_001273742 (OMIM: 612111) tumor necrosis factor  ( 198)  675 172.5 3.7e-43
XP_016864816 (OMIM: 612111) PREDICTED: tumor necro ( 201)  675 172.5 3.7e-43
NP_001273743 (OMIM: 612111) tumor necrosis factor  ( 210)  675 172.5 3.9e-43
NP_001273744 (OMIM: 612111) tumor necrosis factor  ( 166)  604 155.2 5.1e-38
XP_016864817 (OMIM: 612111) PREDICTED: tumor necro ( 166)  604 155.2 5.1e-38
NP_001273746 (OMIM: 612111) tumor necrosis factor  ( 166)  604 155.2 5.1e-38
XP_016877658 (OMIM: 616438) PREDICTED: tumor necro ( 158)  571 147.1 1.3e-35


>>NP_078851 (OMIM: 612112) tumor necrosis factor alpha-i  (184 aa)
 initn: 1181 init1: 1181 opt: 1181  Z-score: 1562.4  bits: 295.7 E(85289): 2.7e-80
Smith-Waterman score: 1181; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184)

               10        20        30        40        50        60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKLLD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKLLD
              130       140       150       160       170       180

           
pF1KB7 EGKL
       ::::
NP_078 EGKL
           

>>XP_016877657 (OMIM: 616438) PREDICTED: tumor necrosis   (203 aa)
 initn: 688 init1: 632 opt: 682  Z-score: 904.9  bits: 174.2 E(85289): 1.2e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:21-200)

                                10        20        30        40   
pF1KB7                  MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELY
                           ::::::::::.::.:::.:...::...::.::::..::::
XP_016 MIHPPVASQVSASVSSGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDTSSEIFDELY
               10        20        30        40        50        60

            50        60        70        80        90       100   
pF1KB7 RVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALS
       .:.::.::.. .:....:::::::::...:.::..:.  ::... .::.:: : ::: .:
XP_016 KVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIVS
               70        80        90       100       110       120

           110       120       130       140       150       160   
pF1KB7 FGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYG--
       : ::..::.  ::..:: ::.:.. :::..::::..:::: :::.::.:  .:..::.  
XP_016 FYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSLD
              130       140       150       160       170       180

             170       180    
pF1KB7 PDFTQHLGKICDGLRKLLDEGKL
        :   .: .::.:. :::::   
XP_016 GDCRPNLKRICEGINKLLDEKVL
              190       200   

>>NP_001298104 (OMIM: 616438) tumor necrosis factor alph  (204 aa)
 initn: 688 init1: 632 opt: 682  Z-score: 904.8  bits: 174.2 E(85289): 1.2e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:22-201)

                                 10        20        30        40  
pF1KB7                   MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDEL
                            ::::::::::.::.:::.:...::...::.::::..:::
NP_001 MDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDTSSEIFDEL
               10        20        30        40        50        60

             50        60        70        80        90       100  
pF1KB7 YRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTAL
       :.:.::.::.. .:....:::::::::...:.::..:.  ::... .::.:: : ::: .
NP_001 YKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIV
               70        80        90       100       110       120

            110       120       130       140       150       160  
pF1KB7 SFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYG-
       :: ::..::.  ::..:: ::.:.. :::..::::..:::: :::.::.:  .:..::. 
NP_001 SFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSL
              130       140       150       160       170       180

              170       180    
pF1KB7 -PDFTQHLGKICDGLRKLLDEGKL
         :   .: .::.:. :::::   
NP_001 DGDCRPNLKRICEGINKLLDEKVL
              190       200    

>>XP_011519847 (OMIM: 616438) PREDICTED: tumor necrosis   (218 aa)
 initn: 688 init1: 632 opt: 682  Z-score: 904.4  bits: 174.2 E(85289): 1.2e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:36-215)

                                          10        20        30   
pF1KB7                            MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDE
                                     ::::::::::.::.:::.:...::...::.
XP_011 RDPLAVSCLYQRSPLSELPGYKQLKPGPDVFSSKSLALQAQKKILSKIASKTVANMLIDD
          10        20        30        40        50        60     

            40        50        60        70        80        90   
pF1KB7 TSSEVLDELYRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQK
       ::::..::::.:.::.::.. .:....:::::::::...:.::..:.  ::... .::.:
XP_011 TSSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKK
          70        80        90       100       110       120     

           100       110       120       130       140       150   
pF1KB7 LRQGAMTALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDP
       : : ::: .:: ::..::.  ::..:: ::.:.. :::..::::..:::: :::.::.: 
XP_011 LNQTAMTIVSFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADV
         130       140       150       160       170       180     

           160         170       180    
pF1KB7 GLLTALYG--PDFTQHLGKICDGLRKLLDEGKL
        .:..::.   :   .: .::.:. :::::   
XP_011 EFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL
         190       200       210        

>>NP_997264 (OMIM: 616438) tumor necrosis factor alpha-i  (292 aa)
 initn: 688 init1: 632 opt: 682  Z-score: 902.3  bits: 174.3 E(85289): 1.6e-43
Smith-Waterman score: 682; 55.6% identity (87.2% similar) in 180 aa overlap (4-181:110-289)

                                          10        20        30   
pF1KB7                            MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDE
                                     ::::::::::.::.:::.:...::...::.
NP_997 VDAQPAARSMDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTVANMLIDD
      80        90       100       110       120       130         

            40        50        60        70        80        90   
pF1KB7 TSSEVLDELYRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQK
       ::::..::::.:.::.::.. .:....:::::::::...:.::..:.  ::... .::.:
NP_997 TSSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKK
     140       150       160       170       180       190         

           100       110       120       130       140       150   
pF1KB7 LRQGAMTALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDP
       : : ::: .:: ::..::.  ::..:: ::.:.. :::..::::..:::: :::.::.: 
NP_997 LNQTAMTIVSFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADV
     200       210       220       230       240       250         

           160         170       180    
pF1KB7 GLLTALYG--PDFTQHLGKICDGLRKLLDEGKL
        .:..::.   :   .: .::.:. :::::   
NP_997 EFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL
     260       270       280       290  

>>XP_011525982 (OMIM: 615869) PREDICTED: tumor necrosis   (186 aa)
 initn: 676 init1: 607 opt: 678  Z-score: 900.2  bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)

               10        20        30        40        50        60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
       :..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
XP_011 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
       :.:.:::.:...: :. ..:  ::::  :::.. :  ::::.:: .:::::.  :::. :
XP_011 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
               70        80        90       100       110       120

              130       140       150       160         170        
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
        ::::.: . :  ::: :::::: ::: :..:  .:.:::::   . .:: .::.:: ..
XP_011 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
              130       140       150       160       170       180

      180    
pF1KB7 LDEGKL
       ::::.:
XP_011 LDEGSL
             

>>NP_689575 (OMIM: 615869) tumor necrosis factor alpha-i  (186 aa)
 initn: 676 init1: 607 opt: 678  Z-score: 900.2  bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)

               10        20        30        40        50        60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
       :..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
NP_689 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
       :.:.:::.:...: :. ..:  ::::  :::.. :  ::::.:: .:::::.  :::. :
NP_689 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
               70        80        90       100       110       120

              130       140       150       160         170        
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
        ::::.: . :  ::: :::::: ::: :..:  .:.:::::   . .:: .::.:: ..
NP_689 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
              130       140       150       160       170       180

      180    
pF1KB7 LDEGKL
       ::::.:
NP_689 LDEGSL
             

>>XP_005259544 (OMIM: 615869) PREDICTED: tumor necrosis   (186 aa)
 initn: 676 init1: 607 opt: 678  Z-score: 900.2  bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)

               10        20        30        40        50        60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
       :..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
XP_005 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
       :.:.:::.:...: :. ..:  ::::  :::.. :  ::::.:: .:::::.  :::. :
XP_005 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
               70        80        90       100       110       120

              130       140       150       160         170        
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
        ::::.: . :  ::: :::::: ::: :..:  .:.:::::   . .:: .::.:: ..
XP_005 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
              130       140       150       160       170       180

      180    
pF1KB7 LDEGKL
       ::::.:
XP_005 LDEGSL
             

>>NP_001161414 (OMIM: 615869) tumor necrosis factor alph  (186 aa)
 initn: 676 init1: 607 opt: 678  Z-score: 900.2  bits: 173.2 E(85289): 2.1e-43
Smith-Waterman score: 678; 57.0% identity (83.3% similar) in 186 aa overlap (1-184:1-186)

               10        20        30        40        50        60
pF1KB7 MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
       :..::.:::::::.::::::::...:. ...:.:::::::::::...:.:.:: .::...
NP_001 MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKML
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB7 KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
       :.:.:::.:...: :. ..:  ::::  :::.. :  ::::.:: .:::::.  :::. :
NP_001 KNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGL
               70        80        90       100       110       120

              130       140       150       160         170        
pF1KB7 TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLRKL
        ::::.: . :  ::: :::::: ::: :..:  .:.:::::   . .:: .::.:: ..
NP_001 LECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRM
              130       140       150       160       170       180

      180    
pF1KB7 LDEGKL
       ::::.:
NP_001 LDEGSL
             

>>NP_001071122 (OMIM: 612111) tumor necrosis factor alph  (188 aa)
 initn: 687 init1: 593 opt: 675  Z-score: 896.2  bits: 172.5 E(85289): 3.5e-43
Smith-Waterman score: 675; 55.0% identity (87.8% similar) in 180 aa overlap (4-181:6-185)

                 10        20        30        40        50        
pF1KB7   MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQR
            :.::.::.::.::.:.::...:.:  .::.::::::::::::..:::... .:..
NP_001 MATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEK
               10        20        30        40        50        60

       60        70        80        90       100       110        
pF1KB7 VIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAG
       .::.:::..::.:.:.::..:. .::::  .:..:..: :::..:: .::.::.  ::. 
NP_001 IIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSR
               70        80        90       100       110       120

      120       130       140       150       160         170      
pF1KB7 LLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGP--DFTQHLGKICDGLR
       ::.:::..: .....::: :::::. .:::::::  .:.:::.:  .:  :: :.:::. 
NP_001 LLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGIN
              130       140       150       160       170       180

        180    
pF1KB7 KLLDEGKL
       :.:::   
NP_001 KMLDEENI
               




184 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 04:38:24 2016 done: Fri Nov  4 04:38:25 2016
 Total Scan time:  5.960 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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