Result of FASTA (omim) for pF1KA2011
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA2011, 1024 aa
  1>>>pF1KA2011 1024 - 1024 aa - 1024 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.4034+/-0.000388; mu= -3.7583+/- 0.024
 mean_var=447.9010+/-90.805, 0's: 0 Z-trim(124.6): 138  B-trim: 0 in 0/62
 Lambda= 0.060601
 statistics sampled from 46481 (46643) to 46481 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.811), E-opt: 0.2 (0.547), width:  16
 Scan time: 15.000

The best scores are:                                      opt bits E(85289)
XP_011538270 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 6983 625.6 4.1e-178
XP_016871923 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 6983 625.6 4.1e-178
XP_016871922 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 6983 625.6 4.1e-178
NP_001257894 (OMIM: 602327) PH and SEC7 domain-con (1024) 6983 625.6 4.1e-178
XP_011538271 (OMIM: 602327) PREDICTED: PH and SEC7 (1024) 6983 625.6 4.1e-178
NP_002770 (OMIM: 602327) PH and SEC7 domain-contai (1024) 6983 625.6 4.1e-178
NP_001257895 (OMIM: 602327) PH and SEC7 domain-con ( 645) 4292 390.2  2e-107
XP_016868750 (OMIM: 614440) PREDICTED: PH and SEC7 (1014) 1919 182.9 7.8e-45
XP_016868749 (OMIM: 614440) PREDICTED: PH and SEC7 (1046) 1919 182.9 7.9e-45
NP_056125 (OMIM: 614440) PH and SEC7 domain-contai (1047) 1919 182.9 7.9e-45
XP_016868748 (OMIM: 614440) PREDICTED: PH and SEC7 (1060) 1919 182.9   8e-45
XP_016868747 (OMIM: 614440) PREDICTED: PH and SEC7 (1067) 1919 182.9 8.1e-45
XP_016868754 (OMIM: 614440) PREDICTED: PH and SEC7 ( 511) 1904 181.3 1.2e-44
NP_996792 (OMIM: 614440) PH and SEC7 domain-contai ( 513) 1904 181.3 1.2e-44
NP_036587 (OMIM: 614442) PH and SEC7 domain-contai (1056) 1440 141.0 3.2e-32
XP_005263691 (OMIM: 614442) PREDICTED: PH and SEC7 (1056) 1440 141.0 3.2e-32
XP_006712455 (OMIM: 614442) PREDICTED: PH and SEC7 (1055) 1435 140.6 4.4e-32
XP_006712456 (OMIM: 614442) PREDICTED: PH and SEC7 ( 965) 1002 102.7   1e-20
XP_006712457 (OMIM: 614442) PREDICTED: PH and SEC7 ( 964)  997 102.3 1.4e-20
XP_011542770 (OMIM: 614440) PREDICTED: PH and SEC7 ( 997)  805 85.5 1.6e-15
XP_011542773 (OMIM: 614440) PREDICTED: PH and SEC7 ( 976)  798 84.9 2.4e-15
XP_011542775 (OMIM: 614440) PREDICTED: PH and SEC7 ( 972)  791 84.3 3.7e-15
XP_011542771 (OMIM: 614440) PREDICTED: PH and SEC7 ( 985)  791 84.3 3.7e-15
XP_011542769 (OMIM: 614440) PREDICTED: PH and SEC7 (1006)  791 84.3 3.8e-15
XP_016868751 (OMIM: 614440) PREDICTED: PH and SEC7 (1008)  791 84.3 3.8e-15
XP_016868753 (OMIM: 614440) PREDICTED: PH and SEC7 ( 701)  652 72.0 1.3e-11
XP_016868752 (OMIM: 614440) PREDICTED: PH and SEC7 ( 945)  652 72.1 1.6e-11
XP_011523777 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322)  382 48.0  0.0001
XP_011523778 (OMIM: 182115) PREDICTED: cytohesin-1 ( 322)  382 48.0  0.0001
XP_016880827 (OMIM: 182115) PREDICTED: cytohesin-1 ( 338)  382 48.0  0.0001
NP_001278948 (OMIM: 182115) cytohesin-1 isoform 3  ( 339)  382 48.0  0.0001
NP_001278947 (OMIM: 182115) cytohesin-1 isoform 3  ( 339)  382 48.0  0.0001
XP_011523779 (OMIM: 182115) PREDICTED: cytohesin-1 ( 339)  382 48.0  0.0001
XP_016880826 (OMIM: 182115) PREDICTED: cytohesin-1 ( 380)  382 48.1 0.00011
NP_059430 (OMIM: 182115) cytohesin-1 isoform 2 [Ho ( 397)  382 48.1 0.00012
NP_004753 (OMIM: 182115) cytohesin-1 isoform 1 [Ho ( 398)  382 48.1 0.00012
XP_016880825 (OMIM: 182115) PREDICTED: cytohesin-1 ( 399)  382 48.1 0.00012
NP_004218 (OMIM: 605081) cytohesin-3 [Homo sapiens ( 399)  374 47.4 0.00019
XP_011536691 (OMIM: 601234) PREDICTED: nascent pol (2078)  384 49.0 0.00032
XP_006719476 (OMIM: 601234) PREDICTED: nascent pol (2082)  384 49.0 0.00032
XP_006719475 (OMIM: 601234) PREDICTED: nascent pol (2082)  384 49.0 0.00032
XP_006719477 (OMIM: 601234) PREDICTED: nascent pol (2082)  384 49.0 0.00032
XP_006723536 (OMIM: 602488) PREDICTED: cytohesin-2 ( 394)  358 46.0 0.00049
NP_004219 (OMIM: 602488) cytohesin-2 isoform 2 [Ho ( 399)  358 46.0 0.00049
NP_059431 (OMIM: 602488) cytohesin-2 isoform 1 [Ho ( 400)  358 46.0  0.0005
XP_006723535 (OMIM: 602488) PREDICTED: cytohesin-2 ( 421)  358 46.0 0.00051
NP_001304953 (OMIM: 606514) cytohesin-4 isoform 2  ( 337)  319 42.5  0.0047
XP_011528449 (OMIM: 606514) PREDICTED: cytohesin-4 ( 337)  319 42.5  0.0047
NP_037517 (OMIM: 606514) cytohesin-4 isoform 1 [Ho ( 394)  319 42.6  0.0052
NP_056047 (OMIM: 612118) IQ motif and SEC7 domain- ( 759)  318 42.8  0.0087


>>XP_011538270 (OMIM: 602327) PREDICTED: PH and SEC7 dom  (1024 aa)
 initn: 6983 init1: 6983 opt: 6983  Z-score: 3318.7  bits: 625.6 E(85289): 4.1e-178
Smith-Waterman score: 6983; 100.0% identity (100.0% similar) in 1024 aa overlap (1-1024:1-1024)

               10        20        30        40        50        60
pF1KA2 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA2 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA2 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA2 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA2 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA2 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA2 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA2 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA2 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA2 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA2 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA2 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA2 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA2 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA2 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA2 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
              970       980       990      1000      1010      1020

           
pF1KA2 RRKP
       ::::
XP_011 RRKP
           

>>XP_016871923 (OMIM: 602327) PREDICTED: PH and SEC7 dom  (1024 aa)
 initn: 6983 init1: 6983 opt: 6983  Z-score: 3318.7  bits: 625.6 E(85289): 4.1e-178
Smith-Waterman score: 6983; 100.0% identity (100.0% similar) in 1024 aa overlap (1-1024:1-1024)

               10        20        30        40        50        60
pF1KA2 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA2 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA2 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA2 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA2 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA2 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA2 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA2 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA2 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA2 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA2 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA2 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA2 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA2 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA2 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA2 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
              970       980       990      1000      1010      1020

           
pF1KA2 RRKP
       ::::
XP_016 RRKP
           

>>XP_016871922 (OMIM: 602327) PREDICTED: PH and SEC7 dom  (1024 aa)
 initn: 6983 init1: 6983 opt: 6983  Z-score: 3318.7  bits: 625.6 E(85289): 4.1e-178
Smith-Waterman score: 6983; 100.0% identity (100.0% similar) in 1024 aa overlap (1-1024:1-1024)

               10        20        30        40        50        60
pF1KA2 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA2 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA2 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA2 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA2 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA2 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA2 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA2 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA2 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA2 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA2 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA2 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA2 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA2 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA2 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA2 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
              970       980       990      1000      1010      1020

           
pF1KA2 RRKP
       ::::
XP_016 RRKP
           

>>NP_001257894 (OMIM: 602327) PH and SEC7 domain-contain  (1024 aa)
 initn: 6983 init1: 6983 opt: 6983  Z-score: 3318.7  bits: 625.6 E(85289): 4.1e-178
Smith-Waterman score: 6983; 100.0% identity (100.0% similar) in 1024 aa overlap (1-1024:1-1024)

               10        20        30        40        50        60
pF1KA2 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA2 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA2 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA2 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA2 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA2 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA2 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA2 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA2 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA2 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA2 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA2 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA2 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA2 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA2 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA2 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
              970       980       990      1000      1010      1020

           
pF1KA2 RRKP
       ::::
NP_001 RRKP
           

>>XP_011538271 (OMIM: 602327) PREDICTED: PH and SEC7 dom  (1024 aa)
 initn: 6983 init1: 6983 opt: 6983  Z-score: 3318.7  bits: 625.6 E(85289): 4.1e-178
Smith-Waterman score: 6983; 100.0% identity (100.0% similar) in 1024 aa overlap (1-1024:1-1024)

               10        20        30        40        50        60
pF1KA2 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA2 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA2 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA2 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA2 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA2 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA2 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA2 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA2 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA2 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA2 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA2 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA2 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA2 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA2 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA2 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
              970       980       990      1000      1010      1020

           
pF1KA2 RRKP
       ::::
XP_011 RRKP
           

>>NP_002770 (OMIM: 602327) PH and SEC7 domain-containing  (1024 aa)
 initn: 6983 init1: 6983 opt: 6983  Z-score: 3318.7  bits: 625.6 E(85289): 4.1e-178
Smith-Waterman score: 6983; 100.0% identity (100.0% similar) in 1024 aa overlap (1-1024:1-1024)

               10        20        30        40        50        60
pF1KA2 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLLRRVAGPGPRGREL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA2 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GRVTAPCTPLRGPPSPRVAPSPWAPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPAP
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA2 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GGLSRSWDLGGVSPPRPTPALGPGSNRKLRLEASTSDPLPARGGSALPGSRNLVHGPPAP
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA2 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PQVGADGLYSSLPNGLGGPPERLATLFGGPADTGFLNQGDTWSSPREVSSHAQRIARAKW
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA2 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EFFYGSLDPPSSGAKPPEQAPPSPPGVGSRQGSGVAVGRAAKYSETDLDTVPLRCYRETD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDEDDDEAGGE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA2 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAILESHRAKGTSY
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA2 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQ
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA2 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDSDSELDSTERLA
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA2 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVF
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA2 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA2 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 NTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRS
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA2 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGK
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA2 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASDYSKRPHVFYLR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA2 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQ
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KA2 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEKSRYSTYAALLR
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KA2 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRHSSEPRPGAGSG
              970       980       990      1000      1010      1020

           
pF1KA2 RRKP
       ::::
NP_002 RRKP
           

>>NP_001257895 (OMIM: 602327) PH and SEC7 domain-contain  (645 aa)
 initn: 4292 init1: 4292 opt: 4292  Z-score: 2049.6  bits: 390.2 E(85289): 2e-107
Smith-Waterman score: 4292; 100.0% identity (100.0% similar) in 645 aa overlap (380-1024:1-645)

     350       360       370       380       390       400         
pF1KA2 EDEDDDEAGGEEDVDDEVFEASEGARPGSRMPLKSPVPFLPGTSPSADGPDSFSCVFEAI
                                     ::::::::::::::::::::::::::::::
NP_001                               MPLKSPVPFLPGTSPSADGPDSFSCVFEAI
                                             10        20        30

     410       420       430       440       450       460         
pF1KA2 LESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LESHRAKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSG
               40        50        60        70        80        90

     470       480       490       500       510       520         
pF1KA2 TSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAPLGSEPPLSQLVSDS
              100       110       120       130       140       150

     530       540       550       560       570       580         
pF1KA2 DSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKL
              160       170       180       190       200       210

     590       600       610       620       630       640         
pF1KA2 VAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDG
              220       230       240       250       260       270

     650       660       670       680       690       700         
pF1KA2 AHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQ
              280       290       300       310       320       330

     710       720       730       740       750       760         
pF1KA2 WAIDEEELRRSLSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WAIDEEELRRSLSELADPNPKVIKRISGGSGSGSSPFLDLTPEPGAAVYKHGALVRKVHA
              340       350       360       370       380       390

     770       780       790       800       810       820         
pF1KA2 DPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISIHHALATRASD
              400       410       420       430       440       450

     830       840       850       860       870       880         
pF1KA2 YSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRP
              460       470       480       490       500       510

     890       900       910       920       930       940         
pF1KA2 LLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQRQKEAYLEFEK
              520       530       540       550       560       570

     950       960       970       980       990      1000         
pF1KA2 SRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPKPSSQPRAQRH
              580       590       600       610       620       630

    1010      1020    
pF1KA2 SSEPRPGAGSGRRKP
       :::::::::::::::
NP_001 SSEPRPGAGSGRRKP
              640     

>>XP_016868750 (OMIM: 614440) PREDICTED: PH and SEC7 dom  (1014 aa)
 initn: 1923 init1: 981 opt: 1919  Z-score: 925.9  bits: 182.9 E(85289): 7.8e-45
Smith-Waterman score: 1970; 48.5% identity (71.2% similar) in 718 aa overlap (331-1023:335-1012)

              310       320       330       340       350          
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDED-DDEAGG
                                     :. :::   :   ...    ::. .::.  
XP_016 SKVPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSG---TFSPVRLDESGEDEVFL
          310       320       330       340          350       360 

     360       370       380            390       400       410    
pF1KA2 EEDVDDEVFEASEGARPGSRMP-----LKSPVPFLPGTSPSADGPDSFSCVFEAILESHR
       .:.  ... .. .  :   :.      .:.    . : . . :. : .:  ::.::..  
XP_016 QEN-KQHLEKTPKPERDRERISEQEEHVKGEDEDILGPGYTEDSTDVYSSQFETILDN--
              370       380       390       400       410          

          420       430       440       450       460              
pF1KA2 AKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSG-----
          . : :  :::.: :  :  . .:.::.:  :   .    .   :   :  ::     
XP_016 --TSLYYSAESLETLYSE-P--DSYFSFEMPLTPMIQQRIKEGGQFL---ERTSGGGHQD
        420       430          440       450       460          470

      470       480       490       500       510           520    
pF1KA2 -TSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAP----LGSEPPLSQ
         : .:::  .. :        . .. : .  :     ::.   ..:     ::.  .. 
XP_016 ILSVSADGGIVM-GYS------SGVTNGLNDAS-----DSIYTKGTPEIAFWGSNAGVKT
              480              490            500       510        

          530       540       550       560       570       580    
pF1KA2 LVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNN
          .. ::. ::: :   . ..:::: ....:::.:::::::.:: :...:::.::::::
XP_016 TRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNN
      520       530       540       550       560       570        

          590       600       610       620       630       640    
pF1KA2 DFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEAL
       .:::::: :::::: ::::::::.:: :.: ..:.:::::::::: :::.::: :::...
XP_016 EFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTI
      580       590       600       610       620       630        

          650       660       670       680       690       700    
pF1KA2 SSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIK
       .:.::.: ::::.::::::::::::::.::: .::.::.:.:.: :: ..::::::.:::
XP_016 ASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIK
      640       650       660       670       680       690        

          710       720            730       740       750         
pF1KA2 NEKLQWAIDEEELRRSLSELADP-----NPKVIKRISGGSGSGSSPFLDLTPEPGAAVYK
       ::::.::.:.:: ..: :: ..      .::.:.::    :: ..::::.  .:.:::::
XP_016 NEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI----GSTTNPFLDIPHDPNAAVYK
      700       710       720       730           740       750    

     760       770       780       790       800       810         
pF1KA2 HGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISI
        : :.::.::: : .::::::::::.:...::: .:::::.:::: ::::: .::::.:.
XP_016 SGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSV
          760       770       780       790       800       810    

     820       830       840       850       860       870         
pF1KA2 HHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAA
       :::::..:.:: :.:.:: :.::::::.:::. : :.::.::..:: :::.:::::::::
XP_016 HHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAA
          820       830       840       850       860       870    

     880       890       900       910       920       930         
pF1KA2 VSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQR
       ..:::::::::::...:.::::::...::.::: ...:: :::.    :: ..:...: .
XP_016 IGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYK
          880       890       900       910       920       930    

     940       950       960       970       980       990         
pF1KA2 QKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPK
        :. ::::::.::  :...    :: :..::      :..  :   ::  :::::::.: 
XP_016 LKDHYLEFEKTRYEMYVSI----LKEGGKEL------LSNDESEAAGLKKSHSSPSLNPD
          940       950           960             970       980    

    1000       1010         1020     
pF1KA2 PSS-QPRAQRHSSE---PRPGAGSGRRKP 
        :    ...:. ::    :: . : ..:  
XP_016 TSPITAKVKRNVSERKDHRPETPSIKQKVT
          990      1000      1010    

>>XP_016868749 (OMIM: 614440) PREDICTED: PH and SEC7 dom  (1046 aa)
 initn: 1923 init1: 981 opt: 1919  Z-score: 925.8  bits: 182.9 E(85289): 7.9e-45
Smith-Waterman score: 1970; 48.5% identity (71.2% similar) in 718 aa overlap (331-1023:367-1044)

              310       320       330       340       350          
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDED-DDEAGG
                                     :. :::   :   ...    ::. .::.  
XP_016 SKVPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSG---TFSPVRLDESGEDEVFL
        340       350       360       370          380       390   

     360       370       380            390       400       410    
pF1KA2 EEDVDDEVFEASEGARPGSRMP-----LKSPVPFLPGTSPSADGPDSFSCVFEAILESHR
       .:.  ... .. .  :   :.      .:.    . : . . :. : .:  ::.::..  
XP_016 QEN-KQHLEKTPKPERDRERISEQEEHVKGEDEDILGPGYTEDSTDVYSSQFETILDN--
            400       410       420       430       440       450  

          420       430       440       450       460              
pF1KA2 AKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSG-----
          . : :  :::.: :  :  . .:.::.:  :   .    .   :   :  ::     
XP_016 --TSLYYSAESLETLYSE-P--DSYFSFEMPLTPMIQQRIKEGGQFL---ERTSGGGHQD
                460          470       480       490          500  

      470       480       490       500       510           520    
pF1KA2 -TSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAP----LGSEPPLSQ
         : .:::  .. :        . .. : .  :     ::.   ..:     ::.  .. 
XP_016 ILSVSADGGIVM-GYS------SGVTNGLNDAS-----DSIYTKGTPEIAFWGSNAGVKT
            510              520            530       540       550

          530       540       550       560       570       580    
pF1KA2 LVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNN
          .. ::. ::: :   . ..:::: ....:::.:::::::.:: :...:::.::::::
XP_016 TRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNN
              560       570       580       590       600       610

          590       600       610       620       630       640    
pF1KA2 DFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEAL
       .:::::: :::::: ::::::::.:: :.: ..:.:::::::::: :::.::: :::...
XP_016 EFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTI
              620       630       640       650       660       670

          650       660       670       680       690       700    
pF1KA2 SSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIK
       .:.::.: ::::.::::::::::::::.::: .::.::.:.:.: :: ..::::::.:::
XP_016 ASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIK
              680       690       700       710       720       730

          710       720            730       740       750         
pF1KA2 NEKLQWAIDEEELRRSLSELADP-----NPKVIKRISGGSGSGSSPFLDLTPEPGAAVYK
       ::::.::.:.:: ..: :: ..      .::.:.::    :: ..::::.  .:.:::::
XP_016 NEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI----GSTTNPFLDIPHDPNAAVYK
              740       750       760           770       780      

     760       770       780       790       800       810         
pF1KA2 HGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISI
        : :.::.::: : .::::::::::.:...::: .:::::.:::: ::::: .::::.:.
XP_016 SGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSV
        790       800       810       820       830       840      

     820       830       840       850       860       870         
pF1KA2 HHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAA
       :::::..:.:: :.:.:: :.::::::.:::. : :.::.::..:: :::.:::::::::
XP_016 HHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAA
        850       860       870       880       890       900      

     880       890       900       910       920       930         
pF1KA2 VSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQR
       ..:::::::::::...:.::::::...::.::: ...:: :::.    :: ..:...: .
XP_016 IGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYK
        910       920       930       940       950       960      

     940       950       960       970       980       990         
pF1KA2 QKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPK
        :. ::::::.::  :...    :: :..::      :..  :   ::  :::::::.: 
XP_016 LKDHYLEFEKTRYEMYVSI----LKEGGKEL------LSNDESEAAGLKKSHSSPSLNPD
        970       980           990            1000      1010      

    1000       1010         1020     
pF1KA2 PSS-QPRAQRHSSE---PRPGAGSGRRKP 
        :    ...:. ::    :: . : ..:  
XP_016 TSPITAKVKRNVSERKDHRPETPSIKQKVT
       1020      1030      1040      

>>NP_056125 (OMIM: 614440) PH and SEC7 domain-containing  (1047 aa)
 initn: 1923 init1: 981 opt: 1919  Z-score: 925.8  bits: 182.9 E(85289): 7.9e-45
Smith-Waterman score: 1970; 48.5% identity (71.2% similar) in 718 aa overlap (331-1023:368-1045)

              310       320       330       340       350          
pF1KA2 IDEVLAEREEADSAIESQPSSEGPPGTAYPPAPRPGPLPGPHPSLGSGNEDED-DDEAGG
                                     :. :::   :   ...    ::. .::.  
NP_056 SKVPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSG---TFSPVRLDESGEDEVFL
       340       350       360       370          380       390    

     360       370       380            390       400       410    
pF1KA2 EEDVDDEVFEASEGARPGSRMP-----LKSPVPFLPGTSPSADGPDSFSCVFEAILESHR
       .:.  ... .. .  :   :.      .:.    . : . . :. : .:  ::.::..  
NP_056 QEN-KQHLEKTPKPERDRERISEQEEHVKGEDEDILGPGYTEDSTDVYSSQFETILDN--
           400       410       420       430       440       450   

          420       430       440       450       460              
pF1KA2 AKGTSYTSLASLEALASPGPTQSPFFTFELPPQPPAPRPDPPAPAPLAPLEPDSG-----
          . : :  :::.: :  :  . .:.::.:  :   .    .   :   :  ::     
NP_056 --TSLYYSAESLETLYSE-P--DSYFSFEMPLTPMIQQRIKEGGQFL---ERTSGGGHQD
               460          470       480       490          500   

      470       480       490       500       510           520    
pF1KA2 -TSSAADGPWTQRGEEEEAEARAKLAPGREPPSPCHSEDSLGLGAAP----LGSEPPLSQ
         : .:::  .. :        . .. : .  :     ::.   ..:     ::.  .. 
NP_056 ILSVSADGGIVM-GYS------SGVTNGLNDAS-----DSIYTKGTPEIAFWGSNAGVKT
           510              520            530       540       550 

          530       540       550       560       570       580    
pF1KA2 LVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNN
          .. ::. ::: :   . ..:::: ....:::.:::::::.:: :...:::.::::::
NP_056 TRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNN
             560       570       580       590       600       610 

          590       600       610       620       630       640    
pF1KA2 DFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEAL
       .:::::: :::::: ::::::::.:: :.: ..:.:::::::::: :::.::: :::...
NP_056 EFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTI
             620       630       640       650       660       670 

          650       660       670       680       690       700    
pF1KA2 SSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIK
       .:.::.: ::::.::::::::::::::.::: .::.::.:.:.: :: ..::::::.:::
NP_056 ASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIK
             680       690       700       710       720       730 

          710       720            730       740       750         
pF1KA2 NEKLQWAIDEEELRRSLSELADP-----NPKVIKRISGGSGSGSSPFLDLTPEPGAAVYK
       ::::.::.:.:: ..: :: ..      .::.:.::    :: ..::::.  .:.:::::
NP_056 NEKLEWAVDDEEKKKSPSESTEEKANGTHPKTISRI----GSTTNPFLDIPHDPNAAVYK
             740       750       760           770       780       

     760       770       780       790       800       810         
pF1KA2 HGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYKPGKALSETELKNAISI
        : :.::.::: : .::::::::::.:...::: .:::::.:::: ::::: .::::.:.
NP_056 SGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKALSEEDLKNAVSV
       790       800       810       820       830       840       

     820       830       840       850       860       870         
pF1KA2 HHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAA
       :::::..:.:: :.:.:: :.::::::.:::. : :.::.::..:: :::.:::::::::
NP_056 HHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAA
       850       860       870       880       890       900       

     880       890       900       910       920       930         
pF1KA2 VSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAQLGKKGRGKEAEEQR
       ..:::::::::::...:.::::::...::.::: ...:: :::.    :: ..:...: .
NP_056 IGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYK
       910       920       930       940       950       960       

     940       950       960       970       980       990         
pF1KA2 QKEAYLEFEKSRYSTYAALLRVKLKAGSEELDAVEAALAQAGSTEDGLPPSHSSPSLQPK
        :. ::::::.::  :...    :: :..::      :..  :   ::  :::::::.: 
NP_056 LKDHYLEFEKTRYEMYVSI----LKEGGKEL------LSNDESEAAGLKKSHSSPSLNPD
       970       980           990            1000      1010       

    1000       1010         1020     
pF1KA2 PSS-QPRAQRHSSE---PRPGAGSGRRKP 
        :    ...:. ::    :: . : ..:  
NP_056 TSPITAKVKRNVSERKDHRPETPSIKQKVT
      1020      1030      1040       




1024 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 01:57:52 2016 done: Fri Nov  4 01:57:54 2016
 Total Scan time: 15.000 Total Display time:  0.340

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com