Result of FASTA (omim) for
pF1KA1296
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1296, 781 aa
1>>>pF1KA1296 781 - 781 aa - 781 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.5322+/-0.000435; mu= 1.6306+/- 0.027
mean_var=302.3565+/-62.645, 0's: 0 Z-trim(118.5): 216 B-trim: 39 in 1/57
Lambda= 0.073759
statistics sampled from 31359 (31588) to 31359 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.704), E-opt: 0.2 (0.37), width: 16
Scan time: 13.420
The best scores are: opt bits E(85289)
NP_079267 (OMIM: 605264) sorbin and SH3 domain-con ( 781) 5154 563.0 1.7e-159
NP_001277224 (OMIM: 605264) sorbin and SH3 domain- ( 749) 4792 524.5 6.6e-148
XP_016871026 (OMIM: 605264) PREDICTED: sorbin and ( 772) 4453 488.4 4.9e-137
XP_006717656 (OMIM: 605264) PREDICTED: sorbin and ( 740) 4452 488.3 5.1e-137
NP_001030129 (OMIM: 605264) sorbin and SH3 domain- ( 740) 4452 488.3 5.1e-137
XP_016871013 (OMIM: 605264) PREDICTED: sorbin and ( 863) 4228 464.5 8.5e-130
XP_016871012 (OMIM: 605264) PREDICTED: sorbin and ( 872) 4228 464.5 8.6e-130
XP_016871011 (OMIM: 605264) PREDICTED: sorbin and ( 895) 4228 464.5 8.7e-130
XP_016871009 (OMIM: 605264) PREDICTED: sorbin and ( 904) 4228 464.5 8.8e-130
XP_016870994 (OMIM: 605264) PREDICTED: sorbin and (1143) 4216 463.3 2.5e-129
XP_011537469 (OMIM: 605264) PREDICTED: sorbin and (1141) 3684 406.7 2.8e-112
XP_011537457 (OMIM: 605264) PREDICTED: sorbin and (1380) 3672 405.5 7.6e-112
XP_016871023 (OMIM: 605264) PREDICTED: sorbin and ( 778) 3477 384.5 9e-106
XP_016871025 (OMIM: 605264) PREDICTED: sorbin and ( 774) 3445 381.1 9.5e-105
XP_016871006 (OMIM: 605264) PREDICTED: sorbin and ( 929) 3363 372.5 4.6e-102
XP_016871029 (OMIM: 605264) PREDICTED: sorbin and ( 765) 3328 368.7 5.3e-101
XP_016871019 (OMIM: 605264) PREDICTED: sorbin and ( 806) 3328 368.7 5.5e-101
XP_016871024 (OMIM: 605264) PREDICTED: sorbin and ( 777) 2787 311.1 1.1e-83
XP_016871027 (OMIM: 605264) PREDICTED: sorbin and ( 769) 2785 310.9 1.3e-83
XP_016871002 (OMIM: 605264) PREDICTED: sorbin and (1043) 2784 310.9 1.8e-83
XP_016871000 (OMIM: 605264) PREDICTED: sorbin and (1084) 2784 310.9 1.8e-83
XP_016871010 (OMIM: 605264) PREDICTED: sorbin and ( 900) 2701 302.0 7.2e-81
XP_016870992 (OMIM: 605264) PREDICTED: sorbin and (1171) 2701 302.1 8.7e-81
XP_016871014 (OMIM: 605264) PREDICTED: sorbin and ( 858) 2697 301.6 9.3e-81
NP_001277225 (OMIM: 605264) sorbin and SH3 domain- (1004) 2697 301.7 1e-80
XP_006717652 (OMIM: 605264) PREDICTED: sorbin and (1004) 2697 301.7 1e-80
XP_016871020 (OMIM: 605264) PREDICTED: sorbin and ( 802) 2692 301.0 1.3e-80
XP_016871015 (OMIM: 605264) PREDICTED: sorbin and ( 834) 2692 301.0 1.3e-80
XP_016871022 (OMIM: 605264) PREDICTED: sorbin and ( 793) 2691 300.9 1.4e-80
XP_016871017 (OMIM: 605264) PREDICTED: sorbin and ( 825) 2691 300.9 1.4e-80
XP_016871016 (OMIM: 605264) PREDICTED: sorbin and ( 833) 2679 299.7 3.5e-80
XP_016871008 (OMIM: 605264) PREDICTED: sorbin and ( 916) 2679 299.7 3.7e-80
XP_016871007 (OMIM: 605264) PREDICTED: sorbin and ( 925) 2679 299.7 3.7e-80
XP_016871005 (OMIM: 605264) PREDICTED: sorbin and ( 948) 2679 299.7 3.8e-80
XP_016871004 (OMIM: 605264) PREDICTED: sorbin and ( 957) 2679 299.7 3.8e-80
XP_016870991 (OMIM: 605264) PREDICTED: sorbin and (1196) 2679 299.8 4.4e-80
XP_016870990 (OMIM: 605264) PREDICTED: sorbin and (1227) 2679 299.8 4.5e-80
XP_016871028 (OMIM: 605264) PREDICTED: sorbin and ( 768) 2674 299.1 4.7e-80
XP_016871021 (OMIM: 605264) PREDICTED: sorbin and ( 800) 2674 299.1 4.8e-80
XP_016871018 (OMIM: 605264) PREDICTED: sorbin and ( 809) 2674 299.1 4.9e-80
NP_001277226 (OMIM: 605264) sorbin and SH3 domain- ( 811) 2674 299.1 4.9e-80
NP_001277227 (OMIM: 605264) sorbin and SH3 domain- ( 846) 2674 299.1 5e-80
XP_016870996 (OMIM: 605264) PREDICTED: sorbin and (1140) 2548 285.9 6.8e-76
XP_016870995 (OMIM: 605264) PREDICTED: sorbin and (1143) 2512 282.0 9.6e-75
NP_006425 (OMIM: 605264) sorbin and SH3 domain-con ( 684) 2457 276.0 3.9e-73
NP_001030128 (OMIM: 605264) sorbin and SH3 domain- ( 905) 2253 254.4 1.6e-66
XP_016871003 (OMIM: 605264) PREDICTED: sorbin and (1015) 2245 253.6 3.2e-66
NP_056200 (OMIM: 605264) sorbin and SH3 domain-con ( 816) 2233 252.2 6.6e-66
XP_016870999 (OMIM: 605264) PREDICTED: sorbin and (1087) 2221 251.0 2e-65
XP_016870989 (OMIM: 605264) PREDICTED: sorbin and (1365) 2221 251.1 2.3e-65
>>NP_079267 (OMIM: 605264) sorbin and SH3 domain-contain (781 aa)
initn: 5154 init1: 5154 opt: 5154 Z-score: 2984.3 bits: 563.0 E(85289): 1.7e-159
Smith-Waterman score: 5154; 100.0% identity (100.0% similar) in 781 aa overlap (1-781:1-781)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KA1 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KA1 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KA1 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
730 740 750 760 770 780
pF1KA1 L
:
NP_079 L
>>NP_001277224 (OMIM: 605264) sorbin and SH3 domain-cont (749 aa)
initn: 4950 init1: 4792 opt: 4792 Z-score: 2776.4 bits: 524.5 E(85289): 6.6e-148
Smith-Waterman score: 4890; 95.9% identity (95.9% similar) in 781 aa overlap (1-781:1-749)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::: :::
NP_001 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD
10 20
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
30 40 50 60 70 80
130 140 150 160 170 180
pF1KA1 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
90 100 110 120 130 140
190 200 210 220 230 240
pF1KA1 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
150 160 170 180 190 200
250 260 270 280 290 300
pF1KA1 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
210 220 230 240 250 260
310 320 330 340 350 360
pF1KA1 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
270 280 290 300 310 320
370 380 390 400 410 420
pF1KA1 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
330 340 350 360 370 380
430 440 450 460 470 480
pF1KA1 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
390 400 410 420 430 440
490 500 510 520 530 540
pF1KA1 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
450 460 470 480 490 500
550 560 570 580 590 600
pF1KA1 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
510 520 530 540 550 560
610 620 630 640 650 660
pF1KA1 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
570 580 590 600 610 620
670 680 690 700 710 720
pF1KA1 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
630 640 650 660 670 680
730 740 750 760 770 780
pF1KA1 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
690 700 710 720 730 740
pF1KA1 L
:
NP_001 L
>>XP_016871026 (OMIM: 605264) PREDICTED: sorbin and SH3 (772 aa)
initn: 4450 init1: 4450 opt: 4453 Z-score: 2581.3 bits: 488.4 E(85289): 4.9e-137
Smith-Waterman score: 5052; 98.7% identity (98.7% similar) in 781 aa overlap (1-781:1-772)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_016 LTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA
70 80 90 100 110
130 140 150 160 170 180
pF1KA1 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KA1 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KA1 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
240 250 260 270 280 290
310 320 330 340 350 360
pF1KA1 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
300 310 320 330 340 350
370 380 390 400 410 420
pF1KA1 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
360 370 380 390 400 410
430 440 450 460 470 480
pF1KA1 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
420 430 440 450 460 470
490 500 510 520 530 540
pF1KA1 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
480 490 500 510 520 530
550 560 570 580 590 600
pF1KA1 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
540 550 560 570 580 590
610 620 630 640 650 660
pF1KA1 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
600 610 620 630 640 650
670 680 690 700 710 720
pF1KA1 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
660 670 680 690 700 710
730 740 750 760 770 780
pF1KA1 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
720 730 740 750 760 770
pF1KA1 L
:
XP_016 L
>>XP_006717656 (OMIM: 605264) PREDICTED: sorbin and SH3 (740 aa)
initn: 4608 init1: 4450 opt: 4452 Z-score: 2580.9 bits: 488.3 E(85289): 5.1e-137
Smith-Waterman score: 4788; 94.6% identity (94.6% similar) in 781 aa overlap (1-781:1-740)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::: :::
XP_006 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD
10 20
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
::::::::::::::::::::::::::::::::::::::: :::::::::::
XP_006 LTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA
30 40 50 60 70
130 140 150 160 170 180
pF1KA1 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
80 90 100 110 120 130
190 200 210 220 230 240
pF1KA1 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
140 150 160 170 180 190
250 260 270 280 290 300
pF1KA1 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
200 210 220 230 240 250
310 320 330 340 350 360
pF1KA1 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
260 270 280 290 300 310
370 380 390 400 410 420
pF1KA1 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
320 330 340 350 360 370
430 440 450 460 470 480
pF1KA1 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
380 390 400 410 420 430
490 500 510 520 530 540
pF1KA1 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
440 450 460 470 480 490
550 560 570 580 590 600
pF1KA1 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
500 510 520 530 540 550
610 620 630 640 650 660
pF1KA1 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
560 570 580 590 600 610
670 680 690 700 710 720
pF1KA1 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
620 630 640 650 660 670
730 740 750 760 770 780
pF1KA1 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
680 690 700 710 720 730
pF1KA1 L
:
XP_006 L
740
>>NP_001030129 (OMIM: 605264) sorbin and SH3 domain-cont (740 aa)
initn: 4608 init1: 4450 opt: 4452 Z-score: 2580.9 bits: 488.3 E(85289): 5.1e-137
Smith-Waterman score: 4802; 94.8% identity (94.8% similar) in 781 aa overlap (1-781:1-740)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::: :::
NP_001 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD
10 20
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
:::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_001 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA
30 40 50 60 70
130 140 150 160 170 180
pF1KA1 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
80 90 100 110 120 130
190 200 210 220 230 240
pF1KA1 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
140 150 160 170 180 190
250 260 270 280 290 300
pF1KA1 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
200 210 220 230 240 250
310 320 330 340 350 360
pF1KA1 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
260 270 280 290 300 310
370 380 390 400 410 420
pF1KA1 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
320 330 340 350 360 370
430 440 450 460 470 480
pF1KA1 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
380 390 400 410 420 430
490 500 510 520 530 540
pF1KA1 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
440 450 460 470 480 490
550 560 570 580 590 600
pF1KA1 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
500 510 520 530 540 550
610 620 630 640 650 660
pF1KA1 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
560 570 580 590 600 610
670 680 690 700 710 720
pF1KA1 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
620 630 640 650 660 670
730 740 750 760 770 780
pF1KA1 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
680 690 700 710 720 730
pF1KA1 L
:
NP_001 L
740
>>XP_016871013 (OMIM: 605264) PREDICTED: sorbin and SH3 (863 aa)
initn: 4620 init1: 4195 opt: 4228 Z-score: 2451.3 bits: 464.5 E(85289): 8.5e-130
Smith-Waterman score: 4286; 83.9% identity (83.9% similar) in 822 aa overlap (83-781:51-863)
60 70 80 90 100 110
pF1KA1 LVLPTDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEW
:::::::::::::::::: :::
XP_016 NGQDKDMDLTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEW
30 40 50 60 70
120 130 140
pF1KA1 RLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD------------------------
::::::::::::::::::::::::::::::::::::
XP_016 RLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRG
80 90 100 110 120 130
pF1KA1 ------------------------------------------------------------
XP_016 QEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFA
140 150 160 170 180 190
150 160
pF1KA1 ---------------------------------------SSPLLNEVSSSLIGTDSQAFP
:::::::::::::::::::::
XP_016 PISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFP
200 210 220 230 240 250
170 180 190 200 210 220
pF1KA1 SVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPG
260 270 280 290 300 310
230 240 250 260 270 280
pF1KA1 KAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSD
320 330 340 350 360 370
290 300 310 320 330 340
pF1KA1 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP
380 390 400 410 420 430
350 360 370 380 390 400
pF1KA1 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVK
440 450 460 470 480 490
410 420 430 440 450 460
pF1KA1 RESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADY
500 510 520 530 540 550
470 480 490 500 510 520
pF1KA1 LESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLN
560 570 580 590 600 610
530 540 550 560 570 580
pF1KA1 IDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIF
620 630 640 650 660 670
590 600 610 620 630 640
pF1KA1 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE
680 690 700 710 720 730
650 660 670 680 690 700
pF1KA1 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR
740 750 760 770 780 790
710 720 730 740 750 760
pF1KA1 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG
800 810 820 830 840 850
770 780
pF1KA1 TFPGNYVKPLYL
::::::::::::
XP_016 TFPGNYVKPLYL
860
>>XP_016871012 (OMIM: 605264) PREDICTED: sorbin and SH3 (872 aa)
initn: 4353 init1: 4195 opt: 4228 Z-score: 2451.2 bits: 464.5 E(85289): 8.6e-130
Smith-Waterman score: 4312; 84.9% identity (84.9% similar) in 813 aa overlap (92-781:60-872)
70 80 90 100 110 120
pF1KA1 TKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADAN
::::::::::::::::::::::::::::::
XP_016 TKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADAN
30 40 50 60 70 80
130 140
pF1KA1 GNAQPSSLAAKGYRSVHPNLPSDKSQD---------------------------------
:::::::::::::::::::::::::::
XP_016 GNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPT
90 100 110 120 130 140
pF1KA1 ------------------------------------------------------------
XP_016 PLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSF
150 160 170 180 190 200
150 160 170
pF1KA1 ------------------------------SSPLLNEVSSSLIGTDSQAFPSVSKPSSAY
::::::::::::::::::::::::::::::
XP_016 SPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAY
210 220 230 240 250 260
180 190 200 210 220 230
pF1KA1 PSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKD
270 280 290 300 310 320
240 250 260 270 280 290
pF1KA1 DSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFS
330 340 350 360 370 380
300 310 320 330 340 350
pF1KA1 EDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRK
390 400 410 420 430 440
360 370 380 390 400 410
pF1KA1 YRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD
450 460 470 480 490 500
420 430 440 450 460 470
pF1KA1 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
510 520 530 540 550 560
480 490 500 510 520 530
pF1KA1 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS
570 580 590 600 610 620
540 550 560 570 580 590
pF1KA1 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP
630 640 650 660 670 680
600 610 620 630 640 650
pF1KA1 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG
690 700 710 720 730 740
660 670 680 690 700 710
pF1KA1 TSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQT
750 760 770 780 790 800
720 730 740 750 760 770
pF1KA1 SQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP
810 820 830 840 850 860
780
pF1KA1 LYL
:::
XP_016 LYL
870
>>XP_016871011 (OMIM: 605264) PREDICTED: sorbin and SH3 (895 aa)
initn: 4824 init1: 4195 opt: 4228 Z-score: 2451.1 bits: 464.5 E(85289): 8.7e-130
Smith-Waterman score: 4286; 83.9% identity (83.9% similar) in 822 aa overlap (83-781:83-895)
60 70 80 90 100 110
pF1KA1 LVLPTDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEW
:::::::::::::::::: :::
XP_016 LVLPTDMDLTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEW
60 70 80 90 100
120 130 140
pF1KA1 RLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD------------------------
::::::::::::::::::::::::::::::::::::
XP_016 RLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRG
110 120 130 140 150 160
pF1KA1 ------------------------------------------------------------
XP_016 QEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFA
170 180 190 200 210 220
150 160
pF1KA1 ---------------------------------------SSPLLNEVSSSLIGTDSQAFP
:::::::::::::::::::::
XP_016 PISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFP
230 240 250 260 270 280
170 180 190 200 210 220
pF1KA1 SVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPG
290 300 310 320 330 340
230 240 250 260 270 280
pF1KA1 KAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSD
350 360 370 380 390 400
290 300 310 320 330 340
pF1KA1 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP
410 420 430 440 450 460
350 360 370 380 390 400
pF1KA1 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVK
470 480 490 500 510 520
410 420 430 440 450 460
pF1KA1 RESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADY
530 540 550 560 570 580
470 480 490 500 510 520
pF1KA1 LESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLN
590 600 610 620 630 640
530 540 550 560 570 580
pF1KA1 IDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIF
650 660 670 680 690 700
590 600 610 620 630 640
pF1KA1 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE
710 720 730 740 750 760
650 660 670 680 690 700
pF1KA1 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR
770 780 790 800 810 820
710 720 730 740 750 760
pF1KA1 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG
830 840 850 860 870 880
770 780
pF1KA1 TFPGNYVKPLYL
::::::::::::
XP_016 TFPGNYVKPLYL
890
>--
initn: 510 init1: 510 opt: 510 Z-score: 312.8 bits: 68.9 E(85289): 1.1e-10
Smith-Waterman score: 510; 98.8% identity (98.8% similar) in 82 aa overlap (1-82:1-82)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
:::::::::::::::::::::
XP_016 LTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPDEWRLSSSADANGNAQPSSL
70 80 90 100 110 120
>>XP_016871009 (OMIM: 605264) PREDICTED: sorbin and SH3 (904 aa)
initn: 4195 init1: 4195 opt: 4228 Z-score: 2451.0 bits: 464.5 E(85289): 8.8e-130
Smith-Waterman score: 4312; 84.9% identity (84.9% similar) in 813 aa overlap (92-781:92-904)
70 80 90 100 110 120
pF1KA1 TKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADAN
::::::::::::::::::::::::::::::
XP_016 TKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADAN
70 80 90 100 110 120
130 140
pF1KA1 GNAQPSSLAAKGYRSVHPNLPSDKSQD---------------------------------
:::::::::::::::::::::::::::
XP_016 GNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPT
130 140 150 160 170 180
pF1KA1 ------------------------------------------------------------
XP_016 PLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSF
190 200 210 220 230 240
150 160 170
pF1KA1 ------------------------------SSPLLNEVSSSLIGTDSQAFPSVSKPSSAY
::::::::::::::::::::::::::::::
XP_016 SPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAY
250 260 270 280 290 300
180 190 200 210 220 230
pF1KA1 PSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKD
310 320 330 340 350 360
240 250 260 270 280 290
pF1KA1 DSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFS
370 380 390 400 410 420
300 310 320 330 340 350
pF1KA1 EDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRK
430 440 450 460 470 480
360 370 380 390 400 410
pF1KA1 YRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD
490 500 510 520 530 540
420 430 440 450 460 470
pF1KA1 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
550 560 570 580 590 600
480 490 500 510 520 530
pF1KA1 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS
610 620 630 640 650 660
540 550 560 570 580 590
pF1KA1 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP
670 680 690 700 710 720
600 610 620 630 640 650
pF1KA1 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG
730 740 750 760 770 780
660 670 680 690 700 710
pF1KA1 TSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQT
790 800 810 820 830 840
720 730 740 750 760 770
pF1KA1 SQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP
850 860 870 880 890 900
780
pF1KA1 LYL
:::
XP_016 LYL
>--
initn: 572 init1: 572 opt: 572 Z-score: 348.4 bits: 75.5 E(85289): 1.1e-12
Smith-Waterman score: 572; 98.9% identity (98.9% similar) in 91 aa overlap (1-91:1-91)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
::::::::::::::::::::::::::::::
XP_016 LTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
XP_016 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
130 140 150 160 170 180
>>XP_016870994 (OMIM: 605264) PREDICTED: sorbin and SH3 (1143 aa)
initn: 4195 init1: 4195 opt: 4216 Z-score: 2442.8 bits: 463.3 E(85289): 2.5e-129
Smith-Waterman score: 4223; 84.0% identity (88.7% similar) in 798 aa overlap (8-781:347-1143)
10 20 30
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSIS
:..: . . : : ..:.:: .:
XP_016 KPPPAPPPDPPKLFFDIRKDAVNRGESPSLGTQASFPDVRPPVLGP-RVTSDPENRKSKE
320 330 340 350 360 370
40 50 60 70 80
pF1KA1 AVKIIPVKTVKNASG--------LVLP---TDMDPTKICTGKGAVTLRASSSYRETPSS-
. . : .:.:.. .:.: .. : . :.. . : . :..
XP_016 SYLLQPSYPAKDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATA
380 390 400 410 420 430
90 100 110 120 130
pF1KA1 SPASPQE--TRQHESKPGLEPEPSSADEWRLSSSADANGNAQPS--------SLAAKGYR
: ::: : . : :. : .. : :.: ... :: : . :
XP_016 SAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLR
440 450 460 470 480 490
140 150 160 170 180 190
pF1KA1 SV-HPNLPSD-KSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH
: .:.: . .: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH
500 510 520 530 540 550
200 210 220 230 240 250
pF1KA1 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV
560 570 580 590 600 610
260 270 280 290 300 310
pF1KA1 SMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSE
620 630 640 650 660 670
320 330 340 350 360 370
pF1KA1 MSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGK
680 690 700 710 720 730
380 390 400 410 420 430
pF1KA1 SSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVL
740 750 760 770 780 790
440 450 460 470 480 490
pF1KA1 EGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR
800 810 820 830 840 850
500 510 520 530 540 550
pF1KA1 LKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKA
860 870 880 890 900 910
560 570 580 590 600 610
pF1KA1 QTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV
920 930 940 950 960 970
620 630 640 650 660 670
pF1KA1 LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI
980 990 1000 1010 1020 1030
680 690 700 710 720 730
pF1KA1 KRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIP
1040 1050 1060 1070 1080 1090
740 750 760 770 780
pF1KA1 QNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
1100 1110 1120 1130 1140
>--
initn: 1035 init1: 957 opt: 957 Z-score: 568.6 bits: 116.6 E(85289): 6.2e-25
Smith-Waterman score: 957; 98.0% identity (98.0% similar) in 151 aa overlap (1-151:1-151)
10 20 30 40 50 60
pF1KA1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
::::::::::::::::::::::::::: ::
XP_016 NGNAQPSSLAAKGYRSVHPNLPSDKSQVLSPPRPPLPQKDRFAWQSPTIHNTYKDSLYLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
XP_016 SPKPYVPLGTPRQQNPSQPQPISVLLAAGSAPKGVVCPGSLLPDSTFPSASSQPQQRYAA
190 200 210 220 230 240
781 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 01:28:38 2016 done: Fri Nov 4 01:28:40 2016
Total Scan time: 13.420 Total Display time: 0.240
Function used was FASTA [36.3.4 Apr, 2011]