Result of FASTA (omim) for pF1KB4141
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4141, 749 aa
  1>>>pF1KB4141 749 - 749 aa - 749 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 9.3292+/-0.000424; mu= 1.7307+/- 0.026
 mean_var=241.3525+/-49.043, 0's: 0 Z-trim(118.5): 46  B-trim: 0 in 0/57
 Lambda= 0.082556
 statistics sampled from 31395 (31441) to 31395 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.712), E-opt: 0.2 (0.369), width:  16
 Scan time: 12.810

The best scores are:                                      opt bits E(85289)
XP_016877594 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_011519791 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877593 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877592 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877591 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_011519790 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877590 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_011519792 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877598 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877601 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_011519793 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_011519794 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877600 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877599 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877596 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877595 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
XP_016877597 (OMIM: 602712) PREDICTED: amyloid bet ( 749) 5038 613.9 7.8e-175
NP_005494 (OMIM: 602712) amyloid beta A4 precursor ( 749) 5038 613.9 7.8e-175
XP_011519796 (OMIM: 602712) PREDICTED: amyloid bet ( 702) 4590 560.5 8.6e-159
XP_016877604 (OMIM: 602712) PREDICTED: amyloid bet ( 737) 2827 350.5 1.4e-95
XP_016877602 (OMIM: 602712) PREDICTED: amyloid bet ( 737) 2827 350.5 1.4e-95
XP_016877605 (OMIM: 602712) PREDICTED: amyloid bet ( 737) 2827 350.5 1.4e-95
XP_016877603 (OMIM: 602712) PREDICTED: amyloid bet ( 737) 2827 350.5 1.4e-95
XP_016877606 (OMIM: 602712) PREDICTED: amyloid bet ( 737) 2827 350.5 1.4e-95
NP_001123886 (OMIM: 602712) amyloid beta A4 precur ( 737) 2827 350.5 1.4e-95
XP_011519795 (OMIM: 602712) PREDICTED: amyloid bet ( 739) 2825 350.3 1.7e-95
XP_011519797 (OMIM: 602712) PREDICTED: amyloid bet ( 453) 2801 347.3 8.5e-95
NP_001154 (OMIM: 602414) amyloid beta A4 precursor ( 837) 2278 285.2 7.7e-76
XP_011516919 (OMIM: 602414) PREDICTED: amyloid bet ( 837) 2278 285.2 7.7e-76
XP_016870159 (OMIM: 602414) PREDICTED: amyloid bet ( 837) 2278 285.2 7.7e-76
XP_011519798 (OMIM: 602712) PREDICTED: amyloid bet ( 441) 2163 271.3 6.2e-72
XP_005252025 (OMIM: 602414) PREDICTED: amyloid bet ( 826) 1930 243.7 2.3e-63
NP_004877 (OMIM: 604262) amyloid beta A4 precursor ( 575) 1131 148.4 7.7e-35
XP_006723014 (OMIM: 604262) PREDICTED: amyloid bet ( 408)  772 105.6 4.4e-22
XP_006723013 (OMIM: 604262) PREDICTED: amyloid bet ( 650)  772 105.7 6.3e-22


>>XP_016877594 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_016 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_011519791 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_011 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_016877593 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_016 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_016877592 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_016 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_016877591 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_016 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_011519790 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_011 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_016877590 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_016 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_011519792 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_011 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_016877598 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_016 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         

>>XP_016877601 (OMIM: 602712) PREDICTED: amyloid beta A4  (749 aa)
 initn: 5038 init1: 5038 opt: 5038  Z-score: 3259.8  bits: 613.9 E(85289): 7.8e-175
Smith-Waterman score: 5038; 99.9% identity (99.9% similar) in 749 aa overlap (1-749:1-749)

               10        20        30        40        50        60
pF1KB4 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAHRKLESVGSGMLDHRVRPGPVPHSQEPESEDMELPLEGYVPEGLELAALRPESPAPEE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCPEDDSYLEGMDCNGEE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAHSAHPVDTDECQEAVEEWTDSAGPHPHGHEAEGSQDYPDGQLPIPEDEPSVLEAHDQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDGHYCASKEGYQDYYPEEANGNTGASPYRLRRGDGDLEDQEEDIDQIVAEIKMSLSMT
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SITSASEASPEHGPEPGPEDSVEACPPIKASCSPSRHEARPKSLNLLPEAKHPGDPQRGF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 KPKTRTPEERPKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
       :::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKTRTPEERLKWPHEQVCNGLEQPRKQQRSDLNGPVDNNNIPETKKVASFPSFVAVPGP
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEPEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAQTLTEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSAS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDCIETTPGAQEGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQ
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KEYSDIINTQEMYNDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB4 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTV
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB4 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQAL
              670       680       690       700       710       720

              730       740         
pF1KB4 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
       :::::::::::::::::::::::::::::
XP_016 SNSVGEIHMKTMPAAMFRLLTGQETPLYI
              730       740         




749 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 21:28:04 2016 done: Thu Nov  3 21:28:06 2016
 Total Scan time: 12.810 Total Display time:  0.270

Function used was FASTA [36.3.4 Apr, 2011]
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