Result of FASTA (ccds) for
pF1KB3039
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3039, 1124 aa
1>>>pF1KB3039 1124 - 1124 aa - 1124 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.5336+/-0.00174; mu= -29.9888+/- 0.100
mean_var=649.9862+/-139.738, 0's: 0 Z-trim(106.7): 330 B-trim: 0 in 0/54
Lambda= 0.050306
statistics sampled from 8862 (9157) to 8862 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.281), width: 16
Scan time: 4.300
The best scores are: opt bits E(32554)
CCDS6519.1 TEK gene_id:7010|Hs108|chr9 (1124) 7688 575.2 3e-163
CCDS75825.1 TEK gene_id:7010|Hs108|chr9 (1081) 5440 412.0 3.8e-114
CCDS78389.1 TEK gene_id:7010|Hs108|chr9 ( 976) 5423 410.7 8.2e-114
CCDS482.1 TIE1 gene_id:7075|Hs108|chr1 (1138) 1949 158.6 7.3e-38
CCDS3354.1 FGFR3 gene_id:2261|Hs108|chr4 ( 694) 851 78.8 4.8e-14
CCDS3353.1 FGFR3 gene_id:2261|Hs108|chr4 ( 806) 851 78.8 5.4e-14
CCDS54706.1 FGFR3 gene_id:2261|Hs108|chr4 ( 808) 851 78.8 5.4e-14
CCDS53584.1 FGFR2 gene_id:2263|Hs108|chr10 ( 707) 843 78.2 7.3e-14
CCDS81514.1 FGFR2 gene_id:2263|Hs108|chr10 ( 593) 832 77.4 1.1e-13
CCDS44488.1 FGFR2 gene_id:2263|Hs108|chr10 ( 680) 832 77.4 1.2e-13
CCDS44485.1 FGFR2 gene_id:2263|Hs108|chr10 ( 704) 832 77.4 1.3e-13
CCDS44487.1 FGFR2 gene_id:2263|Hs108|chr10 ( 705) 832 77.4 1.3e-13
CCDS44486.1 FGFR2 gene_id:2263|Hs108|chr10 ( 709) 832 77.4 1.3e-13
CCDS73210.1 FGFR2 gene_id:2263|Hs108|chr10 ( 732) 832 77.4 1.3e-13
CCDS44489.1 FGFR2 gene_id:2263|Hs108|chr10 ( 769) 832 77.5 1.4e-13
CCDS81515.1 FGFR2 gene_id:2263|Hs108|chr10 ( 819) 832 77.5 1.4e-13
CCDS31298.1 FGFR2 gene_id:2263|Hs108|chr10 ( 821) 832 77.5 1.4e-13
CCDS7620.2 FGFR2 gene_id:2263|Hs108|chr10 ( 822) 832 77.5 1.4e-13
CCDS43731.1 FGFR1 gene_id:2260|Hs108|chr8 ( 731) 829 77.2 1.5e-13
CCDS43730.1 FGFR1 gene_id:2260|Hs108|chr8 ( 733) 829 77.2 1.5e-13
CCDS78096.1 FGFR4 gene_id:2264|Hs108|chr5 ( 734) 828 77.1 1.6e-13
CCDS55221.1 FGFR1 gene_id:2260|Hs108|chr8 ( 812) 829 77.3 1.7e-13
CCDS4411.1 FGFR4 gene_id:2264|Hs108|chr5 ( 762) 828 77.2 1.7e-13
CCDS43732.1 FGFR1 gene_id:2260|Hs108|chr8 ( 820) 829 77.3 1.7e-13
CCDS55222.1 FGFR1 gene_id:2260|Hs108|chr8 ( 820) 829 77.3 1.7e-13
CCDS6107.2 FGFR1 gene_id:2260|Hs108|chr8 ( 822) 829 77.3 1.7e-13
CCDS55223.1 FGFR1 gene_id:2260|Hs108|chr8 ( 853) 829 77.3 1.7e-13
CCDS4410.1 FGFR4 gene_id:2264|Hs108|chr5 ( 802) 828 77.2 1.7e-13
CCDS12574.1 AXL gene_id:558|Hs108|chr19 ( 885) 761 72.3 5.4e-12
CCDS62677.1 AXL gene_id:558|Hs108|chr19 ( 626) 708 68.4 5.9e-11
CCDS12575.1 AXL gene_id:558|Hs108|chr19 ( 894) 708 68.5 7.8e-11
CCDS2094.1 MERTK gene_id:10461|Hs108|chr2 ( 999) 705 68.3 9.9e-11
>>CCDS6519.1 TEK gene_id:7010|Hs108|chr9 (1124 aa)
initn: 7688 init1: 7688 opt: 7688 Z-score: 3044.4 bits: 575.2 E(32554): 3e-163
Smith-Waterman score: 7688; 99.9% identity (99.9% similar) in 1124 aa overlap (1-1124:1-1124)
10 20 30 40 50 60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
CCDS65 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQRMTPKIVDLPDHIE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
::::::::::::::::::::::::::::::::::::::::::::
CCDS65 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
1090 1100 1110 1120
>>CCDS75825.1 TEK gene_id:7010|Hs108|chr9 (1081 aa)
initn: 5224 init1: 5224 opt: 5440 Z-score: 2162.9 bits: 412.0 E(32554): 3.8e-114
Smith-Waterman score: 7228; 96.1% identity (96.1% similar) in 1124 aa overlap (1-1124:1-1081)
10 20 30 40 50 60
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE
:: ::::::::::::::
CCDS75 -------------------------------------------GIQRMTPKIVDLPDHIE
310
370 380 390 400 410 420
pF1KB3 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB3 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB3 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS
440 450 460 470 480 490
550 560 570 580 590 600
pF1KB3 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV
500 510 520 530 540 550
610 620 630 640 650 660
pF1KB3 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT
560 570 580 590 600 610
670 680 690 700 710 720
pF1KB3 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS
620 630 640 650 660 670
730 740 750 760 770 780
pF1KB3 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR
680 690 700 710 720 730
790 800 810 820 830 840
pF1KB3 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK
740 750 760 770 780 790
850 860 870 880 890 900
pF1KB3 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL
800 810 820 830 840 850
910 920 930 940 950 960
pF1KB3 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF
860 870 880 890 900 910
970 980 990 1000 1010 1020
pF1KB3 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD
920 930 940 950 960 970
1030 1040 1050 1060 1070 1080
pF1KB3 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS75 VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
980 990 1000 1010 1020 1030
1090 1100 1110 1120
pF1KB3 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
::::::::::::::::::::::::::::::::::::::::::::
CCDS75 ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
1040 1050 1060 1070 1080
>>CCDS78389.1 TEK gene_id:7010|Hs108|chr9 (976 aa)
initn: 4258 init1: 2965 opt: 5423 Z-score: 2156.8 bits: 410.7 E(32554): 8.2e-114
Smith-Waterman score: 6412; 95.5% identity (95.5% similar) in 1003 aa overlap (122-1124:18-976)
100 110 120 130 140 150
pF1KB3 KASKINGAYFCEGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEE
::::::::::::::::::::::::::::::
CCDS78 MDSLASLVLCGVSLLLSASFLPATLTMTVDKGDNVNISFKKVLIKEE
10 20 30 40
160 170 180 190 200 210
pF1KB3 DAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 DAVIYKNGSFIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRC
50 60 70 80 90 100
220 230 240 250 260 270
pF1KB3 EAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 EAQKWGPECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQ
110 120 130 140 150 160
280 290 300 310 320 330
pF1KB3 EGCKSYVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLC
:::::::::::::::::::::::::::::
CCDS78 EGCKSYVFCLPDPYGCSCATGWKGLQCNE-------------------------------
170 180 190
340 350 360 370 380 390
pF1KB3 SPGWQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGT
:: :::::::::::::::::::::::::::::::::::::::::::::
CCDS78 ------------GIQRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGT
200 210 220 230 240
400 410 420 430 440 450
pF1KB3 VLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 VLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAP
250 260 270 280 290 300
460 470 480 490 500 510
pF1KB3 NVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 NVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRT
310 320 330 340 350 360
520 530 540 550 560 570
pF1KB3 EYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 EYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSE
370 380 390 400 410 420
580 590 600 610 620 630
pF1KB3 DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 DDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTA
430 440 450 460 470 480
640 650 660 670 680 690
pF1KB3 WTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 WTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKN
490 500 510 520 530 540
700 710 720 730 740 750
pF1KB3 ATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 ATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAI
550 560 570 580 590 600
760 770 780 790 800 810
pF1KB3 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNP
:::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
CCDS78 LGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQN-REEPAVQFNSGTLALNRKVKNNP
610 620 630 640 650 660
820 830 840 850 860 870
pF1KB3 DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG
670 680 690 700 710 720
880 890 900 910 920 930
pF1KB3 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 ELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANS
730 740 750 760 770 780
940 950 960 970 980 990
pF1KB3 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 TASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEV
790 800 810 820 830 840
1000 1010 1020 1030 1040 1050
pF1KB3 YVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 YVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL
850 860 870 880 890 900
1060 1070 1080 1090 1100 1110
pF1KB3 PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS78 PQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKF
910 920 930 940 950 960
1120
pF1KB3 TYAGIDCSAEEAA
:::::::::::::
CCDS78 TYAGIDCSAEEAA
970
>>CCDS482.1 TIE1 gene_id:7075|Hs108|chr1 (1138 aa)
initn: 3040 init1: 1843 opt: 1949 Z-score: 793.2 bits: 158.6 E(32554): 7.3e-38
Smith-Waterman score: 3334; 46.9% identity (71.0% similar) in 1143 aa overlap (14-1123:13-1138)
10 20 30 40 50
pF1KB3 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRP
:.:.. : .:.:: :. .: :.. . :::... .: :
CCDS48 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 HEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKR-EKASKINGAYFCEGRVRGEA
:. . .: . . . ::. ..:. ...:. . : : . :.. : : . ..
CCDS48 --PLLLEKDDRIVRTPPGPPLR----LARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEV
:. .. : .:: .: ::.:::.. .: . :. :.. .:::..... ::.
CCDS48 TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEA
120 130 140 150 160 170
180 190 200 210 220
pF1KB3 PDI-LEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMN
: . ..::..:: ..:.::: :. .. . ::: ::::: : : .::: :.. : .:..
CCDS48 QDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLH
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB3 NGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSC
.::::. :::.::::: : ::.::. ::..:.:.: : ::.. .:::::::::::
CCDS48 GGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSC
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB3 ATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMT
..::.: ::.::: :: .: ::.:.:.:.:: ::::.::.: ::.:..::. :.
CCDS48 GSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKS--DRI-
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB3 PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAI
:.:... ...: : . : : :.: :.:. . : ::::::: . ..:
CCDS48 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB3 FTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSE
: . :.. ::: : : :.: .:. . :...::: : :: :: .. : .. ..
CCDS48 FEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLL-TKQSRQLVVSPLV
420 430 440 450 460
470 480 490 500 510 520
pF1KB3 PYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGE
. :::::.. .: :.: . :. : : .: ::: :.:.: : . ::: : :::::
CCDS48 SFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGE
470 480 490 500 510 520
530 540 550 560 570 580
pF1KB3 GHPGPVRRFTT---ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSSE--DDFYVEVERR
: :: .:: . : .: .. .. : ..:. :. :. : : ...
CCDS48 GAWGPPTLMTTDCPEPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDG
530 540 550 560 570 580
590 600 610 620 630 640
pF1KB3 SVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARV-NTKAQGEWSEDLTAWTLSDILPP
. . ..:.. : :. ::..: : .: . ... . : : . : ::
CCDS48 TRGQERRENVSSPQARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHV-LLPPSGPP
590 600 610 620 630 640
650 660 670 680 690
pF1KB3 QPENIKISNITHSSAVISWT---ILDGYSISSITIRYKVQGKNEDQH-VDVKIKNATITQ
:.... . .. : ..: : : ::. ... .: : : .:: . : :
CCDS48 APRHLHAQALSDSEIQLTWKHPEALPG-PISKYVVEVQVAGGAGDPLWIDVDRPEETST-
650 660 670 680 690 700
700 710 720 730 740
pF1KB3 YQLKGLEPETAYQVDIFAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLL
..::. : : . : ...:. :: . : . ....: :. : ..:.
CCDS48 -IIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLI
710 720 730 740 750 760
750 760 770 780 790 800
pF1KB3 IAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKV
.:..::.. ::::.: :.: .. ..:. ..:: . ..:. :: .::.::::.:.:.
CCDS48 LAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRP
770 780 790 800 810 820
810 820 830 840 850 860
pF1KB3 KNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHR
: .:.: ::::.:.:: :.:.:::::::::..: ::::::.:.:::: .:::::..:::
CCDS48 KLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHR
830 840 850 860 870 880
870 880 890 900 910 920
pF1KB3 DFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFA
:::::::::::::::::::::::::..:::::.::::::.::::::::::::::::::::
CCDS48 DFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFA
890 900 910 920 930 940
930 940 950 960 970 980
pF1KB3 IANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR
..:::::::.:::.::.:.: ::.:::.::::::::::::.::::: ..:::::::::
CCDS48 REHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR
950 960 970 980 990 1000
990 1000 1010 1020 1030 1040
pF1KB3 GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAEL
:.::::::::::::::::::::::::::::.:::::.:::::::::::::::::::::::
CCDS48 GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAEL
1010 1020 1030 1040 1050 1060
1050 1060 1070 1080 1090 1100
pF1KB3 YEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTL
:::::::::.:.: :::::::.:::::::..::::: :::: ..:.:::: ::.::: .:
CCDS48 YEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSL
1070 1080 1090 1100 1110 1120
1110 1120
pF1KB3 YEKFTYAGIDCSAEEAA
.:.::::::: .::::
CCDS48 FENFTYAGIDATAEEA
1130
>>CCDS3354.1 FGFR3 gene_id:2261|Hs108|chr4 (694 aa)
initn: 780 init1: 405 opt: 851 Z-score: 365.6 bits: 78.8 E(32554): 4.8e-14
Smith-Waterman score: 851; 45.8% identity (70.6% similar) in 299 aa overlap (830-1117:366-664)
800 810 820 830 840 850
pF1KB3 TLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKAR---IKKD--GLRMDAAI
.::: ::::. :. : :: . . .:.
CCDS33 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV
340 350 360 370 380 390
860 870 880 890 900 910
pF1KB3 KRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFL
: .:. :. : :...:.:.. .:.: ::::::::: . : ::. .::: .::: .::
CCDS33 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL
400 410 420 430 440 450
920 930 940 950 960 970
pF1KB3 RKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE
: : : .: . :. ..:. : .:::::.::.... :::::::::.:: :
CCDS33 RARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE
460 470 480 490 500 510
980 990 1000 1010 1020 1030
pF1KB3 NYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI
. : :::::::.: . . : : : :::::.::: :.: ::: .:::::.:::::::
CCDS33 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI
520 530 540 550 560 570
1040 1050 1060 1070 1080 1090
pF1KB3 VSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVS
.:::.:: :. ::.. : .:.:..:: :: ..: .::.::. : .::.: :.. .
CCDS33 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED
580 590 600 610 620 630
1100 1110 1120
pF1KB3 LNRMLEERKT--YVNTTL-YEKFTYAGIDCSAEEAA
:.:.: .: :.. . .:... .: :
CCDS33 LDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
640 650 660 670 680 690
>>CCDS3353.1 FGFR3 gene_id:2261|Hs108|chr4 (806 aa)
initn: 780 init1: 405 opt: 851 Z-score: 364.7 bits: 78.8 E(32554): 5.4e-14
Smith-Waterman score: 856; 29.5% identity (55.1% similar) in 780 aa overlap (376-1117:62-776)
350 360 370 380 390 400
pF1KB3 PRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEM--TLVKPDGTVLHPKDFNHTDH
: : . : :. ::: : :.. .
CCDS33 VGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGP
40 50 60 70 80 90
410 420 430 440 450 460
pF1KB3 FSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVI
. ... . :::.. : . .. : :.. : :. . . : ... .:
CCDS33 QRLQVLNASH---EDSGAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGV-
100 110 120 130 140
470 480 490 500 510 520
pF1KB3 NISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRG
.. ::. .:::: :. . .. . : ....:. :. ::
CCDS33 -DTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREF--------RG
150 160 170 180 190
530 540 550 560 570 580
pF1KB3 EGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSV
: : : : :. . ...:... . . . . : : .. . ..: .::
CCDS33 EHRIG--GIKLRHQQWSLVME-----SVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSP
200 210 220 230 240 250
590 600 610 620 630 640
pF1KB3 QKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPE
.. : .:.: :.:: .... . .: . :: :. .
CCDS33 HRPILQA-GLPANQTAVLGSDVE------FHCKVYSDAQ-----------------PHIQ
260 270 280
650 660 670 680 690 700
pF1KB3 NIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNE-DQHVDVKIKNATITQYQLKGL
.: : . : . :: .. :. : : :....: .:...
CCDS33 WLK-----HVEVNGSKVGPDGTPYVTV---LKTAGANTTDKELEV---------LSLHNV
290 300 310 320
710 720 730 740 750 760
pF1KB3 EPETAYQVDIFAENNIGSSNPAFSHELVTLP--ESQAPADLGGGKMLLIAILGSAGMTCL
: : . .: :.:: :. : ::.:: : . :: .:. . : : .:. .
CCDS33 TFEDAGEYTCLAGNSIGFSH--HSAWLVVLPAEEELVEADEAGSVYAGILSYG-VGFFLF
330 340 350 360 370 380
770 780 790 800 810
pF1KB3 TVLLAFLIILQLKRANVQRRMAQAFQNVREEP-----AVQFN---SGTLALNR--KVKNN
...: . . .:. . . . ... . : ... : :.. : : .....
CCDS33 ILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSG
390 400 410 420 430 440
820 830 840 850
pF1KB3 PDPTIYPVLD--------WN----DIKFQDVIGEGNFGQVLKAR---IKKD--GLRMDAA
::. : . :. . . .::: ::::. :. : :: . . .:
CCDS33 EGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVA
450 460 470 480 490 500
860 870 880 890 900 910
pF1KB3 IKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDF
.: .:. :. : :...:.:.. .:.: ::::::::: . : ::. .::: .::: .:
CCDS33 VKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREF
510 520 530 540 550 560
920 930 940 950 960 970
pF1KB3 LRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG
:: : : .: . :. ..:. : .:::::.::.... :::::::::.::
CCDS33 LRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT
570 580 590 600 610 620
980 990 1000 1010 1020 1030
pF1KB3 ENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE
:. : :::::::.: . . : : : :::::.::: :.: ::: .:::::.::::::
CCDS33 EDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWE
630 640 650 660 670 680
1040 1050 1060 1070 1080 1090
pF1KB3 IVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV
: .:::.:: :. ::.. : .:.:..:: :: ..: .::.::. : .::.: :..
CCDS33 IFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE
690 700 710 720 730 740
1100 1110 1120
pF1KB3 SLNRMLEERKT--YVNTTL-YEKFTYAGIDCSAEEAA
.:.:.: .: :.. . .:... .: :
CCDS33 DLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
750 760 770 780 790 800
>>CCDS54706.1 FGFR3 gene_id:2261|Hs108|chr4 (808 aa)
initn: 780 init1: 405 opt: 851 Z-score: 364.7 bits: 78.8 E(32554): 5.4e-14
Smith-Waterman score: 851; 45.8% identity (70.6% similar) in 299 aa overlap (830-1117:480-778)
800 810 820 830 840 850
pF1KB3 TLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKAR---IKKD--GLRMDAAI
.::: ::::. :. : :: . . .:.
CCDS54 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV
450 460 470 480 490 500
860 870 880 890 900 910
pF1KB3 KRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFL
: .:. :. : :...:.:.. .:.: ::::::::: . : ::. .::: .::: .::
CCDS54 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL
510 520 530 540 550 560
920 930 940 950 960 970
pF1KB3 RKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE
: : : .: . :. ..:. : .:::::.::.... :::::::::.:: :
CCDS54 RARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE
570 580 590 600 610 620
980 990 1000 1010 1020 1030
pF1KB3 NYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI
. : :::::::.: . . : : : :::::.::: :.: ::: .:::::.:::::::
CCDS54 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI
630 640 650 660 670 680
1040 1050 1060 1070 1080 1090
pF1KB3 VSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVS
.:::.:: :. ::.. : .:.:..:: :: ..: .::.::. : .::.: :.. .
CCDS54 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVED
690 700 710 720 730 740
1100 1110 1120
pF1KB3 LNRMLEERKT--YVNTTL-YEKFTYAGIDCSAEEAA
:.:.: .: :.. . .:... .: :
CCDS54 LDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
750 760 770 780 790 800
>>CCDS53584.1 FGFR2 gene_id:2263|Hs108|chr10 (707 aa)
initn: 780 init1: 408 opt: 843 Z-score: 362.3 bits: 78.2 E(32554): 7.3e-14
Smith-Waterman score: 843; 44.8% identity (71.0% similar) in 297 aa overlap (830-1118:398-689)
800 810 820 830 840 850
pF1KB3 TLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKAR---IKKDGLR--MDAAI
.::: ::::. :. : :: . . .:.
CCDS53 TPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV
370 380 390 400 410 420
860 870 880 890 900 910
pF1KB3 KRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFL
: .:. :.. : :...:.:.. .:.: ::::::::: . : ::. .::: .::: ..:
CCDS53 KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL
430 440 450 460 470 480
920 930 940 950 960 970
pF1KB3 RKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE
: : . .. : .. ..:. . ..::::.::.... :::::::::.:: :
CCDS53 RARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE
490 500 510 520 530 540
980 990 1000 1010 1020 1030
pF1KB3 NYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI
: : :::::::.: . . : : : :::::.::: :.: ::: .:::::.:::.:::
CCDS53 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI
550 560 570 580 590 600
1040 1050 1060 1070 1080 1090
pF1KB3 VSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVS
.:::.:: :. ::.. : .:.:..:: :: .:.: .::.::. : .::.: :.. .
CCDS53 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED
610 620 630 640 650 660
1100 1110 1120
pF1KB3 LNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
:.:.: ..:. :: . ...::
CCDS53 LDRILT-----LTTNEEEKKVSGAVDCHKPPCNPSHLPCVLAVDQ
670 680 690 700
>>CCDS81514.1 FGFR2 gene_id:2263|Hs108|chr10 (593 aa)
initn: 750 init1: 408 opt: 832 Z-score: 359.1 bits: 77.4 E(32554): 1.1e-13
Smith-Waterman score: 832; 46.5% identity (72.4% similar) in 275 aa overlap (830-1096:259-533)
800 810 820 830 840 850
pF1KB3 TLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKAR---IKKDGLR--MDAAI
.::: ::::. :. : :: . . .:.
CCDS81 TPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV
230 240 250 260 270 280
860 870 880 890 900 910
pF1KB3 KRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFL
: .:. :.. : :...:.:.. .:.: ::::::::: . : ::. .::: .::: ..:
CCDS81 KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL
290 300 310 320 330 340
920 930 940 950 960 970
pF1KB3 RKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE
: : . .. : .. ..:. . ..::::.::.... :::::::::.:: :
CCDS81 RARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE
350 360 370 380 390 400
980 990 1000 1010 1020 1030
pF1KB3 NYVAKIADFGLSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI
: : :::::::.: . . : : : :::::.::: :.: ::: .:::::.:::.:::
CCDS81 NNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEI
410 420 430 440 450 460
1040 1050 1060 1070 1080 1090
pF1KB3 VSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVS
.:::.:: :. ::.. : .:.:..:: :: .:.: .::.::. : .::.: :.. .
CCDS81 FTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED
470 480 490 500 510 520
1100 1110 1120
pF1KB3 LNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
:.:.:
CCDS81 LDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHIN
530 540 550 560 570 580
>>CCDS44488.1 FGFR2 gene_id:2263|Hs108|chr10 (680 aa)
initn: 809 init1: 408 opt: 832 Z-score: 358.3 bits: 77.4 E(32554): 1.2e-13
Smith-Waterman score: 840; 37.5% identity (64.6% similar) in 421 aa overlap (716-1096:255-673)
690 700 710 720 730 740
pF1KB3 DVKIKNATITQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPAD----L
: ::..: : :..::..:::.
CCDS44 HSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQ--SAWLTVLPKQQAPGREKEIT
230 240 250 260 270 280
750 760 770 780
pF1KB3 GGGKMLLIAI--LGSAGMTCLTVLLAFLIILQLKRA----------NVQRRMAQAFQ-NV
.. .: ::: .: ..:..: . . . . . .. .:. : .:
CCDS44 ASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTV
290 300 310 320 330 340
790 800 810 820 830
pF1KB3 REEPAVQFNSGT--LALNRKVKNNPD-PTIYPVLDWN---DIKFQ---------DVIGEG
: . ..::.: . .. ..... : : . : ... : :.. .:::
CCDS44 SAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEG
350 360 370 380 390 400
840 850 860 870 880
pF1KB3 NFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINL
::::. :. : :: . . .:.: .:. :.. : :...:.:.. .:.: :::::
CCDS44 CFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINL
410 420 430 440 450 460
890 900 910 920 930 940
pF1KB3 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADV
:::: . : ::. .::: .::: ..:: : . .. : .. ..:. . ..
CCDS44 LGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL
470 480 490 500 510 520
950 960 970 980 990 1000
pF1KB3 ARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLPVRWM
::::.::.... :::::::::.:: :: : :::::::.: . . : : : :::::.::
CCDS44 ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWM
530 540 550 560 570 580
1010 1020 1030 1040 1050 1060
pF1KB3 AIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDD
: :.: ::: .:::::.:::.::: .:::.:: :. ::.. : .:.:..:: :: .
CCDS44 APEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTN
590 600 610 620 630 640
1070 1080 1090 1100 1110 1120
pF1KB3 EVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
:.: .::.::. : .::.: :.. .:.:.:
CCDS44 ELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEI
650 660 670 680
1124 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 20:33:47 2016 done: Thu Nov 3 20:33:48 2016
Total Scan time: 4.300 Total Display time: 0.280
Function used was FASTA [36.3.4 Apr, 2011]