Result of FASTA (omim) for pF1KSDA1769
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA1769, 2080 aa
  1>>>pF1KSDA1769 2080 - 2080 aa - 2080 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.6673+/-0.000393; mu= 24.2617+/- 0.025
 mean_var=93.0303+/-18.962, 0's: 0 Z-trim(114.2): 74  B-trim: 282 in 2/50
 Lambda= 0.132973
 statistics sampled from 23911 (23986) to 23911 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.281), width:  16
 Scan time: 16.120

The best scores are:                                      opt bits E(85289)
NP_208384 (OMIM: 611265) helicase with zinc finger (2080) 14093 2715.3       0
NP_001032412 (OMIM: 611265) helicase with zinc fin (2649) 14050 2707.2       0
XP_016880967 (OMIM: 606699) PREDICTED: probable he (1551)  770 159.4 2.9e-37
XP_006722279 (OMIM: 606699) PREDICTED: probable he (1578)  770 159.4   3e-37
XP_016880966 (OMIM: 606699) PREDICTED: probable he (1707)  770 159.4 3.2e-37
XP_006722278 (OMIM: 606699) PREDICTED: probable he (1735)  770 159.4 3.2e-37
NP_055692 (OMIM: 606699) probable helicase with zi (1942)  770 159.4 3.5e-37
NP_001317376 (OMIM: 606699) probable helicase with (1943)  770 159.4 3.5e-37
XP_005257945 (OMIM: 606699) PREDICTED: probable he (1969)  770 159.4 3.5e-37
XP_006722277 (OMIM: 606699) PREDICTED: probable he (1970)  770 159.4 3.5e-37
XP_011523846 (OMIM: 606699) PREDICTED: probable he (1970)  770 159.4 3.5e-37
NP_001310867 (OMIM: 614183) DIS3-like exonuclease  ( 920)  433 94.5 5.7e-18
NP_001310875 (OMIM: 614183) DIS3-like exonuclease  ( 920)  433 94.5 5.7e-18
NP_001310870 (OMIM: 614183) DIS3-like exonuclease  ( 920)  433 94.5 5.7e-18
NP_001310868 (OMIM: 614183) DIS3-like exonuclease  ( 920)  433 94.5 5.7e-18
NP_001310866 (OMIM: 614183) DIS3-like exonuclease  ( 928)  433 94.5 5.8e-18
NP_001310874 (OMIM: 614183) DIS3-like exonuclease  ( 971)  433 94.5   6e-18
NP_588616 (OMIM: 614183) DIS3-like exonuclease 1 i ( 971)  433 94.5   6e-18
NP_001310865 (OMIM: 614183) DIS3-like exonuclease  ( 971)  433 94.5   6e-18
NP_001310877 (OMIM: 614183) DIS3-like exonuclease  ( 994)  433 94.6 6.1e-18
NP_001310873 (OMIM: 614183) DIS3-like exonuclease  (1037)  433 94.6 6.3e-18
NP_001137160 (OMIM: 614183) DIS3-like exonuclease  (1054)  433 94.6 6.4e-18
NP_001310872 (OMIM: 614183) DIS3-like exonuclease  ( 684)  425 92.9 1.3e-17
NP_001310869 (OMIM: 614183) DIS3-like exonuclease  ( 684)  425 92.9 1.3e-17
XP_005254203 (OMIM: 614183) PREDICTED: DIS3-like e ( 848)  412 90.5 8.8e-17
NP_001309278 (OMIM: 607533) exosome complex exonuc ( 796)  323 73.4 1.2e-11
NP_001309277 (OMIM: 607533) exosome complex exonuc ( 835)  323 73.4 1.2e-11
NP_001121698 (OMIM: 607533) exosome complex exonuc ( 928)  323 73.4 1.3e-11
NP_055768 (OMIM: 607533) exosome complex exonuclea ( 958)  323 73.4 1.3e-11
NP_001244210 (OMIM: 267000,614184) DIS3-like exonu ( 603)  302 69.2 1.5e-10
NP_689596 (OMIM: 267000,614184) DIS3-like exonucle ( 885)  302 69.4   2e-10
NP_002171 (OMIM: 600502,604320,616155) DNA-binding ( 993)  277 64.6 6.2e-09
XP_016873159 (OMIM: 600502,604320,616155) PREDICTE ( 656)  274 63.9 6.8e-09
XP_005274031 (OMIM: 600502,604320,616155) PREDICTE ( 656)  274 63.9 6.8e-09
XP_016873158 (OMIM: 600502,604320,616155) PREDICTE ( 656)  274 63.9 6.8e-09
XP_005270926 (OMIM: 610742) PREDICTED: putative he ( 947)  275 64.2 7.8e-09
NP_001273001 (OMIM: 610742) putative helicase MOV- ( 947)  275 64.2 7.8e-09
XP_005270927 (OMIM: 610742) PREDICTED: putative he ( 947)  275 64.2 7.8e-09
XP_016856807 (OMIM: 610742) PREDICTED: putative he ( 947)  275 64.2 7.8e-09
NP_066014 (OMIM: 610742) putative helicase MOV-10  (1003)  275 64.2 8.1e-09
NP_001123551 (OMIM: 610742) putative helicase MOV- (1003)  275 64.2 8.1e-09
NP_001308253 (OMIM: 610742) putative helicase MOV- (1003)  275 64.2 8.1e-09
XP_016873160 (OMIM: 600502,604320,616155) PREDICTE ( 546)  245 58.3 2.8e-07
NP_001157578 (OMIM: 605794) RNA helicase Mov10l1 i ( 338)  239 57.0 4.3e-07
XP_005261980 (OMIM: 605794) PREDICTED: RNA helicas (1191)  239 57.4 1.1e-06
NP_061868 (OMIM: 605794) RNA helicase Mov10l1 isof (1211)  239 57.4 1.1e-06
NP_001157577 (OMIM: 605794) RNA helicase Mov10l1 i (1165)  219 53.6 1.6e-05
XP_011537719 (OMIM: 601810,615156,615807) PREDICTE ( 700)  198 49.3 0.00017
XP_016871288 (OMIM: 601810,615156,615807) PREDICTE ( 836)  198 49.4  0.0002
NP_001073918 (OMIM: 601810,615156,615807) DNA repl (1060)  198 49.5 0.00024


>>NP_208384 (OMIM: 611265) helicase with zinc finger dom  (2080 aa)
 initn: 14093 init1: 14093 opt: 14093  Z-score: 14601.2  bits: 2715.3 E(85289):    0
Smith-Waterman score: 14093; 99.8% identity (100.0% similar) in 2080 aa overlap (1-2080:1-2080)

               10        20        30        40        50        60
pF1KSD MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVMYTDRPLSQTDPVTLQYCCLTDDRQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVMYTDRPLSQTDPVTLQYCCLTDDRQA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD FRPPTRAELARHRVVVTTTSQARELRVPVGFFSHILIDEAAQMLECEALTPLAYASHGTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 FRPPTRAELARHRVVVTTTSQARELRVPVGFFSHILIDEAAQMLECEALTPLAYASHGTR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD LVLAGDHMQVTPRLFSVARARAAEHTLLHRLFLCYQQETHEVARQSRLVFHENYRCTDAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 LVLAGDHMQVTPRLFSVARARAAEHTLLHRLFLCYQQETHEVARQSRLVFHENYRCTDAI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD VSFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCHVAGNPDRDMSMASWLNLAEIAQVVE
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_208 VSFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCHVAGSPDRDMSMASWLNLAEIAQVVE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD KVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQELRRRDLGQVSVGSFEILPGRQFRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 KVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQELRRRDLGQVSVGSFEILPGRQFRV
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD VVLSTVHTCQSLLSPGALAPEFFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 VVLSTVHTCQSLLSPGALAPEFFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD SFIRECVERHSVCPEGLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 SFIRECVERHSVCPEGLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD AVVTAMVKAEPGDEALSPASRDITATTAQTEAAAAPAGDAVKEDVVPGACAAGAAAAAGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 AVVTAMVKAEPGDEALSPASRDITATTAQTEAAAAPAGDAVKEDVVPGACAAGAAAAAGV
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD ESTEAEDAEADFWPWDGELNADDAILRELLDESQKVMVTVGEDGLLDTVARPESLQQARL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 ESTEAEDAEADFWPWDGELNADDAILRELLDESQKVMVTVGEDGLLDTVARPESLQQARL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD YENLPPAALRKLLRAEPERYRHCSFVPETFERASAIPLDDASSGPIQVRGRLDCGMAFAG
       :::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::
NP_208 YENLPPAALRKLLHAEPERYRHCSFVPETFERASAIPLDDASSGPIQVRGRLDCGMAFAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD DEVLVQLLSGDKAPEGRLRGRVLGVLKRKRHELAFVCRMDTWDPRIMVPINGSVTKIFVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 DEVLVQLLSGDKAPEGRLRGRVLGVLKRKRHELAFVCRMDTWDPRIMVPINGSVTKIFVA
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD ELKDPSQVPIYSLRKGRLQRVGLERLTAEARHSRLFWVQIVLWRQGFYYPLGIVREVLPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 ELKDPSQVPIYSLRKGRLQRVGLERLTAEARHSRLFWVQIVLWRQGFYYPLGIVREVLPE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD ASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYHTELGRVAGRREDCRAFLTFTVDPQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 ASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYHTELGRVAGRREDCRAFLTFTVDPQG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD ACNLDDALSVRDLGPRCEVAVHITDVASFVPRDGVLDVEARRQGAAFYAPGREPVPMLPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 ACNLDDALSVRDLGPRCEVAVHITDVASFVPRDGVLDVEARRQGAAFYAPGREPVPMLPA
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD SLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLRFAPSVVQSDRQLSYEEAEEVIRQHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 SLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLRFAPSVVQSDRQLSYEEAEEVIRQHP
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD GAGRELPARLDSVDACVVAACYFSRLLRRHRLRSDCFYEQPDEDGTLGFRAAHIMVKEYM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 GAGRELPARLDSVDACVVAACYFSRLLRRHRLRSDCFYEQPDEDGTLGFRAAHIMVKEYM
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD IQFNRLVAEFLVGSECTRTVTPLRWQPAPRSQQLKALCEKHGDRVPLSLHLGHHLHGGGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 IQFNRLVAEFLVGSECTRTVTPLRWQPAPRSQQLKALCEKHGDRVPLSLHLGHHLHGGGG
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD SPPDTRLHLLASLWKQVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 SPPDTRLHLLASLWKQVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGR
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KSD CARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQRQILLALGHGGSAYSARDIDGLCQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 CARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQRQILLALGHGGSAYSARDIDGLCQA
             1090      1100      1110      1120      1130      1140

             1150      1160      1170      1180      1190      1200
pF1KSD FSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFVVDVEAGSRCFRLLFPSNRETLPDPC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 FSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFVVDVEAGSRCFRLLFPSNRETLPDPC
             1150      1160      1170      1180      1190      1200

             1210      1220      1230      1240      1250      1260
pF1KSD PVPYGSLQLAEHPHALAGRPGLRLLWRRRVYSAQGSSPPLPLPGTVPDPHTLAVETALWK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 PVPYGSLQLAEHPHALAGRPGLRLLWRRRVYSAQGSSPPLPLPGTVPDPHTLAVETALWK
             1210      1220      1230      1240      1250      1260

             1270      1280      1290      1300      1310      1320
pF1KSD QLLELVELQRWPEAAALIQEKGEASQRRELVQVQRSHCGHFLEVARELGSGDTLQVQLGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 QLLELVELQRWPEAAALIQEKGEASQRRELVQVQRSHCGHFLEVARELGSGDTLQVQLGT
             1270      1280      1290      1300      1310      1320

             1330      1340      1350      1360      1370      1380
pF1KSD SLQHGFLVPSPQLWTVAPGFSLCLEHVERPGDCFSGRVYRAPRDRYRDVDEYACVWEPFC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 SLQHGFLVPSPQLWTVAPGFSLCLEHVERPGDCFSGRVYRAPRDRYRDVDEYACVWEPFC
             1330      1340      1350      1360      1370      1380

             1390      1400      1410      1420      1430      1440
pF1KSD ALESATGAVAENDSVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCADINFSCCYLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 ALESATGAVAENDSVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCADINFSCCYLC
             1390      1400      1410      1420      1430      1440

             1450      1460      1470      1480      1490      1500
pF1KSD IRLEGLLAPTASPRPGPSSLGPGLNVDPGTYTWVAHGQTEDWDQERRADRQEAPRRVHLF
       :::::: ::::::::::::::::::::::::::::::::.::::::::::::::::::::
NP_208 IRLEGLPAPTASPRPGPSSLGPGLNVDPGTYTWVAHGQTQDWDQERRADRQEAPRRVHLF
             1450      1460      1470      1480      1490      1500

             1510      1520      1530      1540      1550      1560
pF1KSD VHHMGMEKVPEEVLRPGTLFTVELLPKQLPDLRKEEAVRGLEEASPLVTSIALGRPVPQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 VHHMGMEKVPEEVLRPGTLFTVELLPKQLPDLRKEEAVRGLEEASPLVTSIALGRPVPQP
             1510      1520      1530      1540      1550      1560

             1570      1580      1590      1600      1610      1620
pF1KSD LCRVIPSRFLERQTYNIPGGRHKLNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 LCRVIPSRFLERQTYNIPGGRHKLNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVF
             1570      1580      1590      1600      1610      1620

             1630      1640      1650      1660      1670      1680
pF1KSD WFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 WFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQA
             1630      1640      1650      1660      1670      1680

             1690      1700      1710      1720      1730      1740
pF1KSD EASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQRGE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 EASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQRGE
             1690      1700      1710      1720      1730      1740

             1750      1760      1770      1780      1790      1800
pF1KSD LFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVRQILVDEAGMATEPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 LFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVRQILVDEAGMATEPE
             1750      1760      1770      1780      1790      1800

             1810      1820      1830      1840      1850      1860
pF1KSD TLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAHMLDTQYRMHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 TLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAHMLDTQYRMHE
             1810      1820      1830      1840      1850      1860

             1870      1880      1890      1900      1910      1920
pF1KSD GICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 GICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNEN
             1870      1880      1890      1900      1910      1920

             1930      1940      1950      1960      1970      1980
pF1KSD SKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREGIAGVAVSSIT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 SKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREGIAGVAVSSIT
             1930      1940      1950      1960      1970      1980

             1990      2000      2010      2020      2030      2040
pF1KSD KSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_208 KSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIG
             1990      2000      2010      2020      2030      2040

             2050      2060      2070      2080
pF1KSD DHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRRPTMPS
       ::::::::::::::::::::::::::::::::::::::::
NP_208 DHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRRPTMPS
             2050      2060      2070      2080

>>NP_001032412 (OMIM: 611265) helicase with zinc finger   (2649 aa)
 initn: 14050 init1: 14050 opt: 14050  Z-score: 14555.2  bits: 2707.2 E(85289):    0
Smith-Waterman score: 14050; 99.7% identity (99.9% similar) in 2075 aa overlap (6-2080:575-2649)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     . ::::::::::::::::::::::::::::
NP_001 PFGTGKTYTLAMASLEVIRRPETKVLICTHTNSAADIYIREYFHSHVSGGHPEATPLRVM
          550       560       570       580       590       600    

          40        50        60        70        80        90     
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTTTSQARELRVPVGFFSHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTTTSQARELRVPVGFFSHI
          610       620       630       640       650       660    

         100       110       120       130       140       150     
pF1KSD LIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFSVARARAAEHTLLHRLFLCY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFSVARARAAEHTLLHRLFLCY
          670       680       690       700       710       720    

         160       170       180       190       200       210     
pF1KSD QQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCH
          730       740       750       760       770       780    

         220       230       240       250       260       270     
pF1KSD VAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQ
       :::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAGSPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQ
          790       800       810       820       830       840    

         280       290       300       310       320       330     
pF1KSD ELRRRDLGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGALAPEFFTDARVLNTVLTR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELRRRDLGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGALAPEFFTDARVLNTVLTR
          850       860       870       880       890       900    

         340       350       360       370       380       390     
pF1KSD AQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQVEQGVAQRRRWPPR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQVEQGVAQRRRWPPR
          910       920       930       940       950       960    

         400       410       420       430       440       450     
pF1KSD GTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEALSPASRDITATTAQTEAAAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEALSPASRDITATTAQTEAAAA
          970       980       990      1000      1010      1020    

         460       470       480       490       500       510     
pF1KSD PAGDAVKEDVVPGACAAGAAAAAGVESTEAEDAEADFWPWDGELNADDAILRELLDESQK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAGDAVKEDVVPGACAAGAAAAAGVESTEAEDAEADFWPWDGELNADDAILRELLDESQK
         1030      1040      1050      1060      1070      1080    

         520       530       540       550       560       570     
pF1KSD VMVTVGEDGLLDTVARPESLQQARLYENLPPAALRKLLRAEPERYRHCSFVPETFERASA
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_001 VMVTVGEDGLLDTVARPESLQQARLYENLPPAALRKLLHAEPERYRHCSFVPETFERASA
         1090      1100      1110      1120      1130      1140    

         580       590       600       610       620       630     
pF1KSD IPLDDASSGPIQVRGRLDCGMAFAGDEVLVQLLSGDKAPEGRLRGRVLGVLKRKRHELAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPLDDASSGPIQVRGRLDCGMAFAGDEVLVQLLSGDKAPEGRLRGRVLGVLKRKRHELAF
         1150      1160      1170      1180      1190      1200    

         640       650       660       670       680       690     
pF1KSD VCRMDTWDPRIMVPINGSVTKIFVAELKDPSQVPIYSLRKGRLQRVGLERLTAEARHSRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCRMDTWDPRIMVPINGSVTKIFVAELKDPSQVPIYSLRKGRLQRVGLERLTAEARHSRL
         1210      1220      1230      1240      1250      1260    

         700       710       720       730       740       750     
pF1KSD FWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYH
         1270      1280      1290      1300      1310      1320    

         760       770       780       790       800       810     
pF1KSD TELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDLGPRCEVAVHITDVASFVPRDGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDLGPRCEVAVHITDVASFVPRDGV
         1330      1340      1350      1360      1370      1380    

         820       830       840       850       860       870     
pF1KSD LDVEARRQGAAFYAPGREPVPMLPASLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDVEARRQGAAFYAPGREPVPMLPASLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLR
         1390      1400      1410      1420      1430      1440    

         880       890       900       910       920       930     
pF1KSD FAPSVVQSDRQLSYEEAEEVIRQHPGAGRELPARLDSVDACVVAACYFSRLLRRHRLRSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAPSVVQSDRQLSYEEAEEVIRQHPGAGRELPARLDSVDACVVAACYFSRLLRRHRLRSD
         1450      1460      1470      1480      1490      1500    

         940       950       960       970       980       990     
pF1KSD CFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVGSECTRTVTPLRWQPAPRSQQLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVGSECTRTVTPLRWQPAPRSQQLK
         1510      1520      1530      1540      1550      1560    

        1000      1010      1020      1030      1040      1050     
pF1KSD ALCEKHGDRVPLSLHLGHHLHGGGGSPPDTRLHLLASLWKQVQFAARTQDYEQMVDLVTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALCEKHGDRVPLSLHLGHHLHGGGGSPPDTRLHLLASLWKQVQFAARTQDYEQMVDLVTT
         1570      1580      1590      1600      1610      1620    

        1060      1070      1080      1090      1100      1110     
pF1KSD DDMHPFLAPAGRDLRKALERSAFGRCARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDMHPFLAPAGRDLRKALERSAFGRCARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQ
         1630      1640      1650      1660      1670      1680    

        1120      1130      1140      1150      1160      1170     
pF1KSD RQILLALGHGGSAYSARDIDGLCQAFSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQILLALGHGGSAYSARDIDGLCQAFSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFV
         1690      1700      1710      1720      1730      1740    

        1180      1190      1200      1210      1220      1230     
pF1KSD VDVEAGSRCFRLLFPSNRETLPDPCPVPYGSLQLAEHPHALAGRPGLRLLWRRRVYSAQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDVEAGSRCFRLLFPSNRETLPDPCPVPYGSLQLAEHPHALAGRPGLRLLWRRRVYSAQG
         1750      1760      1770      1780      1790      1800    

        1240      1250      1260      1270      1280      1290     
pF1KSD SSPPLPLPGTVPDPHTLAVETALWKQLLELVELQRWPEAAALIQEKGEASQRRELVQVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPPLPLPGTVPDPHTLAVETALWKQLLELVELQRWPEAAALIQEKGEASQRRELVQVQR
         1810      1820      1830      1840      1850      1860    

        1300      1310      1320      1330      1340      1350     
pF1KSD SHCGHFLEVARELGSGDTLQVQLGTSLQHGFLVPSPQLWTVAPGFSLCLEHVERPGDCFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHCGHFLEVARELGSGDTLQVQLGTSLQHGFLVPSPQLWTVAPGFSLCLEHVERPGDCFS
         1870      1880      1890      1900      1910      1920    

        1360      1370      1380      1390      1400      1410     
pF1KSD GRVYRAPRDRYRDVDEYACVWEPFCALESATGAVAENDSVTLQHLSVSWEASRTPQGQLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRVYRAPRDRYRDVDEYACVWEPFCALESATGAVAENDSVTLQHLSVSWEASRTPQGQLQ
         1930      1940      1950      1960      1970      1980    

        1420      1430      1440      1450      1460      1470     
pF1KSD GAFRLEAAFLEENCADINFSCCYLCIRLEGLLAPTASPRPGPSSLGPGLNVDPGTYTWVA
       ::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 GAFRLEAAFLEENCADINFSCCYLCIRLEGLPAPTASPRPGPSSLGPGLNVDPGTYTWVA
         1990      2000      2010      2020      2030      2040    

        1480      1490      1500      1510      1520      1530     
pF1KSD HGQTEDWDQERRADRQEAPRRVHLFVHHMGMEKVPEEVLRPGTLFTVELLPKQLPDLRKE
       ::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGQTQDWDQERRADRQEAPRRVHLFVHHMGMEKVPEEVLRPGTLFTVELLPKQLPDLRKE
         2050      2060      2070      2080      2090      2100    

        1540      1550      1560      1570      1580      1590     
pF1KSD EAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYNIPGGRHKLNPSQNVAVREA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYNIPGGRHKLNPSQNVAVREA
         2110      2120      2130      2140      2150      2160    

        1600      1610      1620      1630      1640      1650     
pF1KSD LEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNK
         2170      2180      2190      2200      2210      2220    

        1660      1670      1680      1690      1700      1710     
pF1KSD SVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLH
         2230      2240      2250      2260      2270      2280    

        1720      1730      1740      1750      1760      1770     
pF1KSD HRIRQAPNPYSSEIKAFDTRLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRIRQAPNPYSSEIKAFDTRLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCA
         2290      2300      2310      2320      2330      2340    

        1780      1790      1800      1810      1820      1830     
pF1KSD ASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNL
         2350      2360      2370      2380      2390      2400    

        1840      1850      1860      1870      1880      1890     
pF1KSD GLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKES
         2410      2420      2430      2440      2450      2460    

        1900      1910      1920      1930      1940      1950     
pF1KSD CPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPY
         2470      2480      2490      2500      2510      2520    

        1960      1970      1980      1990      2000      2010     
pF1KSD NAQASEISKALRREGIAGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAQASEISKALRREGIAGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKF
         2530      2540      2550      2560      2570      2580    

        2020      2030      2040      2050      2060      2070     
pF1KSD LGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRR
         2590      2600      2610      2620      2630      2640    

        2080
pF1KSD PTMPS
       :::::
NP_001 PTMPS
            

>>XP_016880967 (OMIM: 606699) PREDICTED: probable helica  (1551 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 789.9  bits: 159.4 E(85289): 2.9e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:308-695)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
XP_016 YGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
       280       290       300       310       320       330       

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
XP_016 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
       340       350       360       370       380       390       

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
XP_016 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
       400       410       420       430       440       450       

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
XP_016 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
       460            470       480       490          500         

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
XP_016 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
     510       520       530       540       550       560         

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
XP_016 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
     570       580       590       600       610       620         

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
XP_016 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
     630       640       650       660       670       680         

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
XP_016 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
       690       700       710       720       730       740       

>>XP_006722279 (OMIM: 606699) PREDICTED: probable helica  (1578 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 789.8  bits: 159.4 E(85289): 3e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:335-722)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
XP_006 YGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
          310       320       330       340       350       360    

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
XP_006 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
          370       380       390       400       410       420    

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
XP_006 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
          430       440       450       460       470       480    

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
XP_006 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
          490            500       510       520          530      

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
XP_006 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
        540       550       560       570       580       590      

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
XP_006 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
        600       610       620       630       640       650      

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
XP_006 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
        660       670       680       690       700       710      

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
XP_006 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
          720       730       740       750       760       770    

>>XP_016880966 (OMIM: 606699) PREDICTED: probable helica  (1707 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 789.3  bits: 159.4 E(85289): 3.2e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:464-851)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
XP_016 PYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
           440       450       460       470       480       490   

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
XP_016 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
           500       510       520       530       540       550   

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
XP_016 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
           560       570       580       590       600       610   

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
XP_016 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
           620            630       640          650       660     

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
XP_016 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
         670       680       690       700       710       720     

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
XP_016 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
         730       740       750       760       770       780     

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
XP_016 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
         790       800       810       820       830       840     

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
XP_016 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
           850       860       870       880       890       900   

>>XP_006722278 (OMIM: 606699) PREDICTED: probable helica  (1735 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 789.2  bits: 159.4 E(85289): 3.2e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:492-879)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
XP_006 YGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
             470       480       490       500       510       520 

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
XP_006 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
             530       540       550       560       570       580 

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
XP_006 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
             590       600       610       620       630       640 

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
XP_006 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
                  650       660       670          680       690   

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
XP_006 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
           700       710       720       730       740       750   

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
XP_006 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
           760       770       780       790       800       810   

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
XP_006 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
           820       830       840       850       860       870   

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
XP_006 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
             880       890       900       910       920       930 

>>NP_055692 (OMIM: 606699) probable helicase with zinc f  (1942 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 788.6  bits: 159.4 E(85289): 3.5e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:699-1086)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
NP_055 PYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
      670       680       690       700       710       720        

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
NP_055 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
      730       740       750       760       770       780        

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
NP_055 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
      790       800       810       820       830       840        

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
NP_055 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
      850            860       870       880          890       900

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
NP_055 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
              910       920       930       940       950       960

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
NP_055 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
              970       980       990      1000      1010      1020

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
NP_055 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
             1030      1040      1050      1060      1070          

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
NP_055 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
     1080      1090      1100      1110      1120      1130        

>>NP_001317376 (OMIM: 606699) probable helicase with zin  (1943 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 788.6  bits: 159.4 E(85289): 3.5e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:700-1087)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
NP_001 YGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
     670       680       690       700       710       720         

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
NP_001 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
     730       740       750       760       770       780         

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
NP_001 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
     790       800       810       820       830       840         

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
NP_001 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
     850            860       870       880          890       900 

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
NP_001 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
             910       920       930       940       950       960 

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
NP_001 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
             970       980       990      1000      1010      1020 

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
NP_001 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
            1030      1040      1050      1060      1070           

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
NP_001 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
    1080      1090      1100      1110      1120      1130         

>>XP_005257945 (OMIM: 606699) PREDICTED: probable helica  (1969 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 788.5  bits: 159.4 E(85289): 3.5e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:726-1113)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
XP_005 PYGTGKTFTLAQAVKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
         700       710       720       730       740       750     

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
XP_005 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
         760       770       780       790       800       810     

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
XP_005 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
         820       830       840       850       860       870     

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
XP_005 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
         880            890       900       910          920       

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
XP_005 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
       930       940       950       960       970       980       

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
XP_005 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
       990      1000      1010      1020      1030      1040       

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
XP_005 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
      1050      1060      1070      1080      1090      1100       

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
XP_005 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
        1110      1120      1130      1140      1150      1160     

>>XP_006722277 (OMIM: 606699) PREDICTED: probable helica  (1970 aa)
 initn: 906 init1: 229 opt: 770  Z-score: 788.5  bits: 159.4 E(85289): 3.5e-37
Smith-Waterman score: 931; 41.0% identity (66.3% similar) in 398 aa overlap (6-383:727-1114)

                                        10        20        30     
pF1KSD                          MSSSPSRSAADIYIREYFHSHVSGGHPEATPLRVM
                                     : ::::.::..:.: .: .:.:.: ::::.
XP_006 YGTGKTFTLAQAVKHILQQQETSRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVY
        700       710       720       730       740       750      

          40        50        60        70          80         90  
pF1KSD YTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTT--TSQAR-ELRVPVGFF
       . .: .. . ::. ::: ... ...:. : . .. .:::::.:  :::   .: .  :::
XP_006 FRNRWVKTVHPVVHQYCLISSAHSTFQMPQKEDILKHRVVVVTLNTSQYLCQLDLEPGFF
        760       770       780       790       800       810      

            100       110       120       130        140       150 
pF1KSD SHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFS-VARARAAEHTLLHRL
       .:::.::::: .:::.. ::: :...::.::::::::..: ..:  :: :  . .:: ::
XP_006 THILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRL
        820       830       840       850       860       870      

             160       170       180       190       200       210 
pF1KSD FLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPL
       .  :  :        :... ::::  .::... :. :: .:   . : :: : :   :::
XP_006 YEHYPAEF-----PCRILLCENYRSHEAIINYTSELFYEGK---LMASGKQPAHKDFYPL
        880            890       900       910          920        

             220       230       240       250       260        270
pF1KSD MFCHVAGNPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGA-QV
        :  . :.  .. . ... : ::. .:::.:.:    ::  ::  ..  : ::.  : ::
XP_006 TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQV
      930       940       950       960       970       980        

              280       290       300          310       320       
pF1KSD SALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTV---HTCQSLLSPGALAPE------
         .: :::.. :..:.:     . :.::::. ::::   :::.   .:     .      
XP_006 FRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDST
      990      1000      1010      1020      1030      1040        

                   330       340       350       360       370     
pF1KSD ------FFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPE
             :... ..:::..::::: ..:::: .::::.: : :.:: ::  : :  :.  .
XP_006 EDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFIALCHENSSL--H
     1050      1060      1070      1080      1090      1100        

         380       390       400       410       420       430     
pF1KSD GLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEA
       :...::..                                                    
XP_006 GITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGSTNKQQQSPPKGKSLHHTQN
       1110      1120      1130      1140      1150      1160      




2080 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 19:10:16 2016 done: Thu Nov  3 19:10:19 2016
 Total Scan time: 16.120 Total Display time:  0.640

Function used was FASTA [36.3.4 Apr, 2011]
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