Result of FASTA (omim) for pF1KB9348
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB9348, 273 aa
  1>>>pF1KB9348 273 - 273 aa - 273 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.4409+/-0.000295; mu= 5.7242+/- 0.019
 mean_var=120.3386+/-23.081, 0's: 0 Z-trim(121.0): 50  B-trim: 29 in 1/57
 Lambda= 0.116915
 statistics sampled from 36945 (36998) to 36945 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.434), width:  16
 Scan time:  8.520

The best scores are:                                      opt bits E(85289)
NP_001138870 (OMIM: 188595) thyrotroph embryonic f ( 273) 1784 311.1 1.4e-84
NP_003207 (OMIM: 188595) thyrotroph embryonic fact ( 303) 1668 291.6 1.2e-78
NP_002117 (OMIM: 142385) hepatic leukemia factor i ( 295) 1002 179.2 7.6e-45
XP_005257326 (OMIM: 142385) PREDICTED: hepatic leu ( 296)  990 177.2 3.1e-44
NP_001317304 (OMIM: 142385) hepatic leukemia facto ( 210)  815 147.6 1.8e-35
XP_011523007 (OMIM: 142385) PREDICTED: hepatic leu ( 211)  803 145.6 7.2e-35
NP_001343 (OMIM: 124097) D site-binding protein [H ( 325)  753 137.3 3.6e-32
XP_016881877 (OMIM: 124097) PREDICTED: D site-bind ( 182)  647 119.3 5.3e-27
XP_016870233 (OMIM: 605327) PREDICTED: nuclear fac ( 462)  194 43.0  0.0012
NP_005375 (OMIM: 605327) nuclear factor interleuki ( 462)  194 43.0  0.0012
NP_001276928 (OMIM: 605327) nuclear factor interle ( 462)  194 43.0  0.0012
NP_001276929 (OMIM: 605327) nuclear factor interle ( 462)  194 43.0  0.0012
XP_016870232 (OMIM: 605327) PREDICTED: nuclear fac ( 462)  194 43.0  0.0012


>>NP_001138870 (OMIM: 188595) thyrotroph embryonic facto  (273 aa)
 initn: 1784 init1: 1784 opt: 1784  Z-score: 1639.5  bits: 311.1 E(85289): 1.4e-84
Smith-Waterman score: 1784; 100.0% identity (100.0% similar) in 273 aa overlap (1-273:1-273)

               10        20        30        40        50        60
pF1KB9 MDMPEVLKSLLEHSLPWPEKRTDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDMPEVLKSLLEHSLPWPEKRTDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYD
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB9 GESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB9 PSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB9 EDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEK
              190       200       210       220       230       240

              250       260       270   
pF1KB9 ENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
       :::::::::::::::::::::::::::::::::
NP_001 ENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
              250       260       270   

>>NP_003207 (OMIM: 188595) thyrotroph embryonic factor i  (303 aa)
 initn: 1641 init1: 1641 opt: 1668  Z-score: 1533.1  bits: 291.6 E(85289): 1.2e-78
Smith-Waterman score: 1668; 96.3% identity (97.4% similar) in 270 aa overlap (4-273:36-303)

                                          10        20        30   
pF1KB9                            MDMPEVLKSLLEHSLPWPEKRTDKEKGKEKLEE
                                     : :::.:.:.  :  : : :::::::::::
NP_003 GGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMEN--PPREARLDKEKGKEKLEE
          10        20        30        40          50        60   

            40        50        60        70        80        90   
pF1KB9 DEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLL
            70        80        90       100       110       120   

           100       110       120       130       140       150   
pF1KB9 PVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNF
           130       140       150       160       170       180   

           160       170       180       190       200       210   
pF1KB9 NPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKN
           190       200       210       220       230       240   

           220       230       240       250       260       270   
pF1KB9 NVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
           250       260       270       280       290       300   

>>NP_002117 (OMIM: 142385) hepatic leukemia factor isofo  (295 aa)
 initn: 978 init1: 732 opt: 1002  Z-score: 926.1  bits: 179.2 E(85289): 7.6e-45
Smith-Waterman score: 1002; 56.8% identity (79.1% similar) in 278 aa overlap (6-273:21-295)

                              10        20           30        40  
pF1KB9                MDMPEVLKSLLEHSLPWPEKRTD---KEKGKEKLEEDEAAAASTM
                           ::.::::. :  : .. :   :.: :::  .::. .  :.
NP_002 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSP-TV
               10        20        30        40        50          

             50        60        70        80        90       100  
pF1KB9 AVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKE
         :: : : .::::.::::..:.::::::.::: ::::: ::..  :.   :   :.   
NP_002 PQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPP--GLQPAS
      60        70        80        90       100       110         

            110       120       130              140       150     
pF1KB9 SASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDVNFNP
       ::. :. .  : ..: ..:.    .  .:       :  .:.:::::::. ..: :...:
NP_002 SAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEP
       120       130       140       150       160       170       

         160       170       180       190       200       210     
pF1KB9 DPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNV
       :::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. ::.:::.::.:::.
NP_002 DPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNM
       180       190       200       210       220       230       

         220       230       240       250       260       270   
pF1KB9 AAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
       ::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...:::
NP_002 AAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
       240       250       260       270       280       290     

>>XP_005257326 (OMIM: 142385) PREDICTED: hepatic leukemi  (296 aa)
 initn: 660 init1: 390 opt: 990  Z-score: 915.2  bits: 177.2 E(85289): 3.1e-44
Smith-Waterman score: 990; 56.6% identity (78.9% similar) in 279 aa overlap (6-273:21-296)

                              10        20           30        40  
pF1KB9                MDMPEVLKSLLEHSLPWPEKRTD---KEKGKEKLEEDEAAAASTM
                           ::.::::. :  : .. :   :.: :::  .::. .  :.
XP_005 MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSP-TV
               10        20        30        40        50          

             50        60        70        80        90       100  
pF1KB9 AVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKE
         :: : : .::::.::::..:.::::::.::: ::::: ::..  :.   :   :.   
XP_005 PQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPP--GLQPAS
      60        70        80        90       100       110         

            110       120       130              140       150     
pF1KB9 SASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDVNFNP
       ::. :. .  : ..: ..:.    .  .:       :  .:.:::::::. ..: :...:
XP_005 SAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEP
       120       130       140       150       160       170       

         160       170       180       190       200        210    
pF1KB9 DPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQK-DEKYWTRRKKNN
       :::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. : :.:::.::.:::
XP_005 DPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARRRKNN
       180       190       200       210       220       230       

          220       230       240       250       260       270   
pF1KB9 VAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
       .::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...:::
XP_005 MAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
       240       250       260       270       280       290      

>>NP_001317304 (OMIM: 142385) hepatic leukemia factor is  (210 aa)
 initn: 809 init1: 732 opt: 815  Z-score: 758.0  bits: 147.6 E(85289): 1.8e-35
Smith-Waterman score: 815; 59.0% identity (81.6% similar) in 212 aa overlap (69-273:1-210)

       40        50        60        70        80        90        
pF1KB9 ASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAEL
                                     :::.::: ::::: ::..  :.   :   :
NP_001                               MDLEEFLSENGIPPSPSQHDHSPHPP--GL
                                             10        20          

      100       110       120       130              140       150 
pF1KB9 EGKESASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDV
       .   ::. :. .  : ..: ..:.    .  .:       :  .:.:::::::. ..: :
NP_001 QPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPV
       30        40        50        60        70        80        

             160       170       180       190       200       210 
pF1KB9 NFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRK
       ...::::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. ::.:::.::.
NP_001 GYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRR
       90       100       110       120       130       140        

             220       230       240       250       260       270 
pF1KB9 KNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYG
       :::.::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...:
NP_001 KNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHG
      150       160       170       180       190       200        

         
pF1KB9 PL
       ::
NP_001 PL
      210

>>XP_011523007 (OMIM: 142385) PREDICTED: hepatic leukemi  (211 aa)
 initn: 521 init1: 390 opt: 803  Z-score: 747.0  bits: 145.6 E(85289): 7.2e-35
Smith-Waterman score: 803; 58.7% identity (81.2% similar) in 213 aa overlap (69-273:1-211)

       40        50        60        70        80        90        
pF1KB9 ASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAEL
                                     :::.::: ::::: ::..  :.   :   :
XP_011                               MDLEEFLSENGIPPSPSQHDHSPHPP--GL
                                             10        20          

      100       110       120       130              140       150 
pF1KB9 EGKESASSSTASPPSSSTAIFQPSETVSSTESS-------LEKERETPSPIDPNCVEVDV
       .   ::. :. .  : ..: ..:.    .  .:       :  .:.:::::::. ..: :
XP_011 QPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPV
       30        40        50        60        70        80        

             160       170       180       190       200        210
pF1KB9 NFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQK-DEKYWTRR
       ...::::::.:::.:: :.:.:::.::.::.::::::::::.:::.::. : :.:::.::
XP_011 GYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKQDDKYWARR
       90       100       110       120       130       140        

              220       230       240       250       260       270
pF1KB9 KKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKY
       .:::.::::::::::::::::.:::.::::::.::: :::.::::.::::.:..:::...
XP_011 RKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARH
      150       160       170       180       190       200        

          
pF1KB9 GPL
       :::
XP_011 GPL
      210 

>>NP_001343 (OMIM: 124097) D site-binding protein [Homo   (325 aa)
 initn: 738 init1: 638 opt: 753  Z-score: 698.5  bits: 137.3 E(85289): 3.6e-32
Smith-Waterman score: 753; 51.3% identity (76.3% similar) in 232 aa overlap (48-273:100-325)

        20        30        40        50        60        70       
pF1KB9 PEKRTDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLE
                                     : : .:..:.:. :.   .::.::: ::::
NP_001 TAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAPLLWERTLPF-GD---VEYVDLDAFLLE
      70        80        90       100       110           120     

        80        90       100          110       120       130    
pF1KB9 NGIPASPTHLAHNLLLPVAELEGKES---ASSSTASPPSSSTAIFQPSETVSSTESSLEK
       .:.: ::   .     :        :   .: ..::: ::      :.... .: :. . 
NP_001 HGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSASPRSSPG--HAPARAALGTASGHRA
         130       140       150       160         170       180   

             140       150       160       170       180       190 
pF1KB9 ---ERETPSPIDPNCVEVDVNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKK
           :.::::.::. ::: ..:.::::::.:::.:: : :.::.:.:.::.:::::..::
NP_001 GLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKK
           190       200       210       220       230       240   

             200       210       220       230       240       250 
pF1KB9 AKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAE
       :.:. ::.::::::::.:: ::: ::::::::::::::::..:::::::::. :: ::. 
NP_001 ARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVA
           250       260       270       280       290       300   

             260       270   
pF1KB9 LRKEVGKCKTIVSKYETKYGPL
       .:.:... ....:.:....: :
NP_001 VRQELSHYRAVLSRYQAQHGAL
           310       320     

>>XP_016881877 (OMIM: 124097) PREDICTED: D site-binding   (182 aa)
 initn: 689 init1: 638 opt: 647  Z-score: 605.8  bits: 119.3 E(85289): 5.3e-27
Smith-Waterman score: 647; 64.5% identity (91.3% similar) in 138 aa overlap (136-273:45-182)

         110       120       130       140       150       160     
pF1KB9 SSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNPDPADLVLSSV
                                     :.::::.::. ::: ..:.::::::.:::.
XP_016 GARGRCPPRVCWRHCCGSARCRSAMWSLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSI
           20        30        40        50        60        70    

         170       180       190       200       210       220     
pF1KB9 PGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARR
       :: : :.::.:.:.::.:::::..:::.:. ::.::::::::.:: ::: ::::::::::
XP_016 PGHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDARR
           80        90       100       110       120       130    

         230       240       250       260       270   
pF1KB9 LKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL
       ::::::..:::::::::. :: ::. .:.:... ....:.:....: :
XP_016 LKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL
          140       150       160       170       180  

>>XP_016870233 (OMIM: 605327) PREDICTED: nuclear factor   (462 aa)
 initn: 175 init1: 175 opt: 194  Z-score: 186.5  bits: 43.0 E(85289): 0.0012
Smith-Waterman score: 194; 43.3% identity (71.6% similar) in 67 aa overlap (191-257:61-127)

              170       180       190       200       210       220
pF1KB9 VLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRS
                                     . :. :.:::.::  :: .:.::: :::::
XP_016 ALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRS
               40        50        60        70        80        90

              230       240       250       260       270          
pF1KB9 RDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL       
       :. :::..  .  .   : .::..:..:.  :. . :                       
XP_016 REKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQ
              100       110       120       130       140       150

XP_016 DYQTSKSNVSSFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRS
              160       170       180       190       200       210

>>NP_005375 (OMIM: 605327) nuclear factor interleukin-3-  (462 aa)
 initn: 175 init1: 175 opt: 194  Z-score: 186.5  bits: 43.0 E(85289): 0.0012
Smith-Waterman score: 194; 43.3% identity (71.6% similar) in 67 aa overlap (191-257:61-127)

              170       180       190       200       210       220
pF1KB9 VLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRS
                                     . :. :.:::.::  :: .:.::: :::::
NP_005 ALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRS
               40        50        60        70        80        90

              230       240       250       260       270          
pF1KB9 RDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL       
       :. :::..  .  .   : .::..:..:.  :. . :                       
NP_005 REKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQ
              100       110       120       130       140       150

NP_005 DYQTSKSNVSSFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRS
              160       170       180       190       200       210




273 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 18:22:14 2016 done: Thu Nov  3 18:22:15 2016
 Total Scan time:  8.520 Total Display time:  0.020

Function used was FASTA [36.3.4 Apr, 2011]
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