Result of FASTA (omim) for pF1KB5438
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5438, 442 aa
  1>>>pF1KB5438 442 - 442 aa - 442 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.1855+/-0.000434; mu= 9.6015+/- 0.027
 mean_var=139.6679+/-30.601, 0's: 0 Z-trim(114.9): 521  B-trim: 2447 in 2/49
 Lambda= 0.108524
 statistics sampled from 24385 (25003) to 24385 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.293), width:  16
 Scan time:  8.920

The best scores are:                                      opt bits E(85289)
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 2951 473.9 3.8e-133
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 2951 473.9 3.8e-133
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 1184 197.2 6.9e-50
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367)  896 152.0 2.3e-36
NP_000787 (OMIM: 126451,181500,190300) D(3) dopami ( 400)  896 152.1 2.5e-36
NP_001277738 (OMIM: 126451,181500,190300) D(3) dop ( 400)  896 152.1 2.5e-36
NP_001269492 (OMIM: 126451,181500,190300) D(3) dop ( 400)  896 152.1 2.5e-36
XP_016861318 (OMIM: 126451,181500,190300) PREDICTE ( 400)  896 152.1 2.5e-36
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465)  742 128.0 5.1e-29
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462)  693 120.3   1e-26
NP_000788 (OMIM: 126452,143465,601696) D(4) dopami ( 419)  540 96.4 1.6e-19
NP_000729 (OMIM: 118510) muscarinic acetylcholine  ( 460)  527 94.3 6.9e-19
XP_011543044 (OMIM: 118510) PREDICTED: muscarinic  ( 460)  527 94.3 6.9e-19
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432)  500 90.1 1.2e-17
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445)  500 90.1 1.3e-17
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479)  500 90.1 1.3e-17
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328)  489 88.3 3.3e-17
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331)  489 88.3 3.3e-17
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366)  489 88.3 3.6e-17
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389)  489 88.3 3.7e-17
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402)  489 88.4 3.8e-17
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520)  489 88.4 4.7e-17
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556)  489 88.5 4.9e-17
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458)  485 87.8 6.5e-17
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458)  485 87.8 6.5e-17
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422)  478 86.6 1.3e-16
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308)  471 85.5 2.2e-16
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317)  471 85.5 2.2e-16
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324)  471 85.5 2.3e-16
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342)  471 85.5 2.4e-16
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370)  471 85.5 2.5e-16
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372)  471 85.5 2.5e-16
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450)  472 85.7 2.6e-16
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429)  471 85.6 2.8e-16
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429)  471 85.6 2.8e-16
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455)  471 85.6   3e-16
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466)  471 85.6   3e-16
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  471 85.6 3.1e-16
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475)  471 85.6 3.1e-16
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  471 85.6 3.1e-16
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475)  471 85.6 3.1e-16
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572)  467 85.0 5.5e-16
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471)  458 83.6 1.3e-15
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377)  430 79.1 2.2e-14
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446)  415 76.8 1.3e-13
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477)  405 75.3   4e-13
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366)  403 74.9   4e-13
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366)  403 74.9   4e-13
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366)  403 74.9   4e-13
XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366)  403 74.9   4e-13


>>NP_000786 (OMIM: 126450,159900) D(2) dopamine receptor  (443 aa)
 initn: 2336 init1: 2336 opt: 2951  Z-score: 2511.4  bits: 473.9 E(85289): 3.8e-133
Smith-Waterman score: 2951; 99.8% identity (99.8% similar) in 443 aa overlap (1-442:1-443)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
               10        20        30        40        50        60

               70        80        90        100       110         
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTA
       :::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_000 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB5 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
              190       200       210       220       230       240

     240       250       260       270       280       290         
pF1KB5 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
              250       260       270       280       290       300

     300       310       320       330       340       350         
pF1KB5 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
              310       320       330       340       350       360

     360       370       380       390       400       410         
pF1KB5 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
              370       380       390       400       410       420

     420       430       440  
pF1KB5 VNPIIYTTFNIEFRKAFLKILHC
       :::::::::::::::::::::::
NP_000 VNPIIYTTFNIEFRKAFLKILHC
              430       440   

>>XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) dop  (443 aa)
 initn: 2336 init1: 2336 opt: 2951  Z-score: 2511.4  bits: 473.9 E(85289): 3.8e-133
Smith-Waterman score: 2951; 99.8% identity (99.8% similar) in 443 aa overlap (1-442:1-443)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
               10        20        30        40        50        60

               70        80        90        100       110         
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTA
       :::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
XP_016 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB5 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
              190       200       210       220       230       240

     240       250       260       270       280       290         
pF1KB5 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
              250       260       270       280       290       300

     300       310       320       330       340       350         
pF1KB5 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
              310       320       330       340       350       360

     360       370       380       390       400       410         
pF1KB5 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
              370       380       390       400       410       420

     420       430       440  
pF1KB5 VNPIIYTTFNIEFRKAFLKILHC
       :::::::::::::::::::::::
XP_016 VNPIIYTTFNIEFRKAFLKILHC
              430       440   

>>NP_057658 (OMIM: 126450,159900) D(2) dopamine receptor  (414 aa)
 initn: 2115 init1: 1184 opt: 1184  Z-score: 1016.7  bits: 197.2 E(85289): 6.9e-50
Smith-Waterman score: 2676; 93.2% identity (93.2% similar) in 443 aa overlap (1-442:1-414)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
               10        20        30        40        50        60

               70        80        90        100       110         
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTA
       :::::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
NP_057 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
               70        80        90       100       110       120

     120       130       140       150       160       170         
pF1KB5 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KB5 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
              190       200       210       220       230       240

     240       250       260       270       280       290         
pF1KB5 KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
       :                             ::::::::::::::::::::::::::::::
NP_057 K-----------------------------EAARRAQELEMEMLSSTSPPERTRYSPIPP
                                           250       260       270 

     300       310       320       330       340       350         
pF1KB5 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
             280       290       300       310       320       330 

     360       370       380       390       400       410         
pF1KB5 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
             340       350       360       370       380       390 

     420       430       440  
pF1KB5 VNPIIYTTFNIEFRKAFLKILHC
       :::::::::::::::::::::::
NP_057 VNPIIYTTFNIEFRKAFLKILHC
             400       410    

>>NP_387512 (OMIM: 126451,181500,190300) D(3) dopamine r  (367 aa)
 initn: 1276 init1: 295 opt: 896  Z-score: 773.7  bits: 152.0 E(85289): 2.3e-36
Smith-Waterman score: 1218; 52.9% identity (67.7% similar) in 427 aa overlap (23-442:19-367)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
                             :.. ..  :::  :::     :: .::::: :::::: 
NP_387     MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
                   10        20         30        40        50     

               70        80        90         100       110        
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
       .:.:::::::::.:::::::::::::::::::::::  : :.:::: ::.::::::::::
NP_387 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
          60        70        80        90       100       110     

      120       130       140         150       160       170      
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
       :::::::::::::::::.::. :.  :  :: :::..::. ::::.:..:::::::.:..
NP_387 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
         120       130       140       150       160       170     

         180       190       200       210        220       230    
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
        : . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.     
NP_387 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
         180       190       200       210       220       230     

          240       250       260       270       280       290    
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
              : ..:              .:: .    . :.    ::..           ::
NP_387 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
                                  240           250                

          300       310       320       330       340       350    
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSL
         :          : .  :       :.  :..:. : . :              ::.::
NP_387 YSI--------CQDTALGG-------PGFQERGGELKREEK--------------TRNSL
                 260              270       280                    

          360       370       380       390        400       410   
pF1KB5 KTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSAFTWL
         .        .:::::::.:::::.::.::::::.::.:: ::. :.. : :::: :::
NP_387 MPL--------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWL
                290       300       310       320       330        

           420       430       440  
pF1KB5 GYVNSAVNPIIYTTFNIEFRKAFLKILHC
       ::::::.::.::::::::::::::::: :
NP_387 GYVNSALNPVIYTTFNIEFRKAFLKILSC
      340       350       360       

>>NP_000787 (OMIM: 126451,181500,190300) D(3) dopamine r  (400 aa)
 initn: 1196 init1: 295 opt: 896  Z-score: 773.2  bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
                             :.. ..  :::  :::     :: .::::: :::::: 
NP_000     MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
                   10        20         30        40        50     

               70        80        90         100       110        
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
       .:.:::::::::.:::::::::::::::::::::::  : :.:::: ::.::::::::::
NP_000 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
          60        70        80        90       100       110     

      120       130       140         150       160       170      
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
       :::::::::::::::::.::. :.  :  :: :::..::. ::::.:..:::::::.:..
NP_000 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
         120       130       140       150       160       170     

         180       190       200       210        220       230    
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
        : . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.     
NP_000 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
         180       190       200       210       220       230     

          240       250       260       270       280       290    
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
              : ..:              .:: .    . :.    ::..           ::
NP_000 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
                                  240           250                

          300       310       320       330         340       350  
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
         :    .. .:  :   :..       . ::. .. . : :: :. .:.. . ::.  :
NP_000 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
            260          270       280        290       300        

              360       370       380       390        400         
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
       :::   .. : .   .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
NP_000 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
      310       320        330       340       350       360       

     410       420       430       440  
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
        :::::::::.::.::::::::::::::::: :
NP_000 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
       370       380       390       400

>>NP_001277738 (OMIM: 126451,181500,190300) D(3) dopamin  (400 aa)
 initn: 1196 init1: 295 opt: 896  Z-score: 773.2  bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
                             :.. ..  :::  :::     :: .::::: :::::: 
NP_001     MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
                   10        20         30        40        50     

               70        80        90         100       110        
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
       .:.:::::::::.:::::::::::::::::::::::  : :.:::: ::.::::::::::
NP_001 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
          60        70        80        90       100       110     

      120       130       140         150       160       170      
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
       :::::::::::::::::.::. :.  :  :: :::..::. ::::.:..:::::::.:..
NP_001 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
         120       130       140       150       160       170     

         180       190       200       210        220       230    
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
        : . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.     
NP_001 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
         180       190       200       210       220       230     

          240       250       260       270       280       290    
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
              : ..:              .:: .    . :.    ::..           ::
NP_001 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
                                  240           250                

          300       310       320       330         340       350  
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
         :    .. .:  :   :..       . ::. .. . : :: :. .:.. . ::.  :
NP_001 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
            260          270       280        290       300        

              360       370       380       390        400         
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
       :::   .. : .   .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
NP_001 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
      310       320        330       340       350       360       

     410       420       430       440  
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
        :::::::::.::.::::::::::::::::: :
NP_001 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
       370       380       390       400

>>NP_001269492 (OMIM: 126451,181500,190300) D(3) dopamin  (400 aa)
 initn: 1196 init1: 295 opt: 896  Z-score: 773.2  bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
                             :.. ..  :::  :::     :: .::::: :::::: 
NP_001     MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
                   10        20         30        40        50     

               70        80        90         100       110        
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
       .:.:::::::::.:::::::::::::::::::::::  : :.:::: ::.::::::::::
NP_001 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
          60        70        80        90       100       110     

      120       130       140         150       160       170      
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
       :::::::::::::::::.::. :.  :  :: :::..::. ::::.:..:::::::.:..
NP_001 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
         120       130       140       150       160       170     

         180       190       200       210        220       230    
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
        : . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.     
NP_001 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
         180       190       200       210       220       230     

          240       250       260       270       280       290    
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
              : ..:              .:: .    . :.    ::..           ::
NP_001 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
                                  240           250                

          300       310       320       330         340       350  
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
         :    .. .:  :   :..       . ::. .. . : :: :. .:.. . ::.  :
NP_001 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
            260          270       280        290       300        

              360       370       380       390        400         
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
       :::   .. : .   .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
NP_001 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
      310       320        330       340       350       360       

     410       420       430       440  
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
        :::::::::.::.::::::::::::::::: :
NP_001 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
       370       380       390       400

>>XP_016861318 (OMIM: 126451,181500,190300) PREDICTED: D  (400 aa)
 initn: 1196 init1: 295 opt: 896  Z-score: 773.2  bits: 152.1 E(85289): 2.5e-36
Smith-Waterman score: 1276; 53.8% identity (71.0% similar) in 431 aa overlap (23-442:19-400)

               10        20        30        40        50        60
pF1KB5 MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
                             :.. ..  :::  :::     :: .::::: :::::: 
XP_016     MASLSQLSGHLNYTCGAENSTGASQARPH-AYYALSYCALILAIVFGNGLVCMAVL
                   10        20         30        40        50     

               70        80        90         100       110        
pF1KB5 REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV--GEWKFSRIHCDIFVTLDVMMCT
       .:.:::::::::.:::::::::::::::::::::::  : :.:::: ::.::::::::::
XP_016 KERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCT
          60        70        80        90       100       110     

      120       130       140         150       160       170      
pF1KB5 ASILNLCAISIDRYTAVAMPMLYN--TRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNA
       :::::::::::::::::.::. :.  :  :: :::..::. ::::.:..:::::::.:..
XP_016 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTT
         120       130       140       150       160       170     

         180       190       200       210        220       230    
pF1KB5 -DQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLR-RRRKRVNTKRSSRAFRAH
        : . : :.:: ::.:::.::::.:: ::.::: .::.::. :::::. :...:.     
XP_016 GDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQC----
         180       190       200       210       220       230     

          240       250       260       270       280       290    
pF1KB5 LRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRY
              : ..:              .:: .    . :.    ::..           ::
XP_016 -------NSVRP--------------GFPQQTLSPDPAH----LELK-----------RY
                                  240           250                

          300       310       320       330         340       350  
pF1KB5 SPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIA-KI-FEIQTMPNGKTRT
         :    .. .:  :   :..       . ::. .. . : :: :. .:.. . ::.  :
XP_016 YSI---CQDTALGGP---GFQERGGELKREEKTRNSLS-PTIAPKLSLEVRKLSNGRLST
            260          270       280        290       300        

              360       370       380       390        400         
pF1KB5 SLKT--MSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD-CNIPPVLYSA
       :::   .. : .   .:::::::.:::::.::.::::::.::.:: ::. :.. : ::::
XP_016 SLKLGPLQPRGVPL-REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSA
      310       320        330       340       350       360       

     410       420       430       440  
pF1KB5 FTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
        :::::::::.::.::::::::::::::::: :
XP_016 TTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
       370       380       390       400

>>NP_000672 (OMIM: 104210) alpha-2A adrenergic receptor   (465 aa)
 initn: 569 init1: 199 opt: 742  Z-score: 641.9  bits: 128.0 E(85289): 5.1e-29
Smith-Waterman score: 783; 33.6% identity (60.2% similar) in 455 aa overlap (22-442:28-457)

                     10        20           30        40           
pF1KB5       MDPLNLSWYDDDLERQNWSRPFNGSD---GKADRPHYNYYATLLT-----LLIA
                                  .::..   : :    :.  .::       ::. 
NP_000 MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML
               10        20        30        40        50        60

         50        60        70        80        90        100     
pF1KB5 VIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIH
       . ::::::: .::   .::..  : ..:::: ::.::::::.:. .  :: : : :..  
NP_000 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW
               70        80        90       100       110       120

         110       120       130       140       150       160     
pF1KB5 CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTI
       :.:...:::..::.::..:::::.::: .... . :: . .  ::. ..:  :::.: .:
NP_000 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTP-RRIKAIIITVWVISAVI
              130       140       150       160        170         

         170               180       190        200       210      
pF1KB5 SCPLLFGLNNAD--------QNECIIANPAFVVYSSIV-SFYVPFIVTLLVYIKIYIVLR
       : : :.....          . .: : .  . : :: . ::..: .. .:::..:: . .
NP_000 SFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAK
     180       190       200       210       220       230         

        220       230       240       250       260       270      
pF1KB5 RRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQ
       :: .   ..:.  :    . ::  :.  .:            ::  : .:    .. .:.
NP_000 RRTRVPPSRRGPDA----VAAPPGGTERRP------------NGLGP-ERSAGPGGAEAE
     240       250           260                   270        280  

        280       290       300        310       320       330     
pF1KB5 ELEMEMLSSTSPPERTRYSPIPPSHHQ-LTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPK
        :  .. .. . :     .:  :   . : : . :       : .: .::.. ..: . .
NP_000 PLPTQLNGAPGEP-----APAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKAR
            290            300       310       320       330       

         340                      350       360       370       380
pF1KB5 IAKIFEIQTMPN---------------GKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGV
        ...   ...:                :. :..    :: .  :..::. : .::.:.::
NP_000 ASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGV
       340       350       360       370       380       390       

              390       400       410       420       430       440
pF1KB5 FIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKIL
       :..::.:::.:. :.    :..: .:.. : :.:: ::..::.::: :: .::.:: :::
NP_000 FVVCWFPFFFTYTLTA-VGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL
       400       410        420       430       440       450      

                 
pF1KB5 HC        
        :        
NP_000 -CRGDRKRIV
         460     

>>NP_000674 (OMIM: 104250) alpha-2C adrenergic receptor   (462 aa)
 initn: 680 init1: 187 opt: 693  Z-score: 600.5  bits: 120.3 E(85289): 1e-26
Smith-Waterman score: 705; 32.9% identity (63.1% similar) in 423 aa overlap (38-440:55-452)

        10        20        30        40        50        60       
pF1KB5 WYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQT
                                     :... .::.  : ::::: .::   .::..
NP_000 ERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRA
           30        40        50        60        70        80    

        70        80        90        100       110       120      
pF1KB5 TTNYLIVSLAVADLLVATLVMPWVVYLEV-GEWKFSRIHCDIFVTLDVMMCTASILNLCA
         : ..:::: ::.::::::::. .  :. . : :... : ....:::..::.::..:::
NP_000 PQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCA
           90       100       110       120       130       140    

        130       140       150       160       170           180  
pF1KB5 ISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGL----NNADQNECI
       ::.::: .:.. . :: . .  ::: . :  ::..: .:: : : .:    ..:   .: 
NP_000 ISLDRYWSVTQAVEYNLKRTP-RRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCG
          150       160        170       180       190       200   

            190        200       210       220                  230
pF1KB5 IANPAFVVYSSIV-SFYVPFIVTLLVYIKIYIVLRRRRKRVNTKR-----------SSRA
       . . .. . :: . ::..: ..  ::: .:: : . : . .. ::           .  .
NP_000 LNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENG
           210       220       230       240       250       260   

              240       250       260       270        280         
pF1KB5 FRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAA-RRAQELEMEMLSSTSPP
       . :   :  .:.:. :      . .  ...:  ..::: ..: ::. . .    ....  
NP_000 LGAAAGAGENGHCAPPP-----ADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGA
           270       280            290       300       310        

     290       300       310       320       330       340         
pF1KB5 ERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGK
       .            : . :  .. :  ..  ::.   . ..:..  . ...:       ..
NP_000 D-----------GQGAGPGAAESGALTASRSPGPGGRLSRASS--RSVEFFL------SR
                 320       330       340       350                 

     350       360       370       380       390         400       
pF1KB5 TRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCD--CNIPPVLY
        : . ... :::..: .::. : .::.:.:::..::.:::... :   :   :..:  :.
NP_000 RRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLF
     360       370       380       390       400       410         

       410       420       430       440          
pF1KB5 SAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC        
       . : :.:: ::..::.:::.:: .::..: .::          
NP_000 KFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
     420       430       440       450       460  




442 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 17:20:32 2016 done: Thu Nov  3 17:20:34 2016
 Total Scan time:  8.920 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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