Result of FASTA (omim) for pF1KB5120
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB5120, 420 aa
  1>>>pF1KB5120 420 - 420 aa - 420 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 14.1157+/-0.000614; mu= -28.1227+/- 0.037
 mean_var=745.5672+/-171.495, 0's: 0 Z-trim(116.0): 1079  B-trim: 0 in 0/54
 Lambda= 0.046971
 statistics sampled from 25271 (26803) to 25271 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.314), width:  16
 Scan time:  9.270

The best scores are:                                      opt bits E(85289)
NP_001139628 (OMIM: 605004) glycogen synthase kina ( 420) 2798 205.7 1.8e-52
XP_006713674 (OMIM: 605004) PREDICTED: glycogen sy ( 387) 2463 182.9 1.2e-45
NP_063937 (OMIM: 606784) glycogen synthase kinase- ( 483) 2082 157.2 8.2e-38
XP_006713673 (OMIM: 605004) PREDICTED: glycogen sy ( 400) 2034 153.9 6.9e-37
NP_002084 (OMIM: 605004) glycogen synthase kinase- ( 433) 2034 153.9 7.2e-37
NP_002737 (OMIM: 601795) mitogen-activated protein ( 379)  612 57.5 6.7e-08
NP_001035145 (OMIM: 601795) mitogen-activated prot ( 357)  606 57.0 8.6e-08
NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 ( 298)  597 56.3 1.2e-07
NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 ( 305)  594 56.2 1.4e-07
NP_002736 (OMIM: 176948) mitogen-activated protein ( 360)  596 56.4 1.4e-07
NP_620407 (OMIM: 176948) mitogen-activated protein ( 360)  596 56.4 1.4e-07
NP_001790 (OMIM: 601955) cyclin-dependent kinase 7 ( 346)  576 55.0 3.4e-07
XP_016866355 (OMIM: 154235,614181) PREDICTED: seri ( 439)  575 55.0 4.2e-07
NP_620603 (OMIM: 602521) mitogen-activated protein ( 816)  580 55.7   5e-07
NP_002740 (OMIM: 602521) mitogen-activated protein ( 816)  580 55.7   5e-07
NP_620602 (OMIM: 602521) mitogen-activated protein ( 816)  580 55.7   5e-07
NP_001229314 (OMIM: 154235,614181) serine/threonin ( 583)  575 55.2 5.1e-07
XP_011512924 (OMIM: 154235,614181) PREDICTED: seri ( 583)  575 55.2 5.1e-07
NP_005897 (OMIM: 154235,614181) serine/threonine-p ( 623)  575 55.2 5.3e-07
XP_016866353 (OMIM: 154235,614181) PREDICTED: seri ( 623)  575 55.2 5.3e-07
XP_011512922 (OMIM: 154235,614181) PREDICTED: seri ( 648)  575 55.2 5.5e-07
XP_016866352 (OMIM: 154235,614181) PREDICTED: seri ( 648)  575 55.2 5.5e-07
XP_011512921 (OMIM: 154235,614181) PREDICTED: seri ( 648)  575 55.2 5.5e-07
NP_001229886 (OMIM: 154235,614181) serine/threonin ( 648)  575 55.2 5.5e-07
NP_001034892 (OMIM: 610076) cyclin-dependent kinas ( 346)  563 54.1 6.3e-07
XP_016870050 (OMIM: 610076) PREDICTED: cyclin-depe ( 351)  560 53.9 7.4e-07
XP_016864300 (OMIM: 603442) PREDICTED: cyclin-depe ( 479)  559 54.0 9.5e-07
NP_003939 (OMIM: 603442) cyclin-dependent kinase-l ( 493)  559 54.0 9.7e-07
XP_016864299 (OMIM: 603442) PREDICTED: cyclin-depe ( 493)  559 54.0 9.7e-07
NP_002742 (OMIM: 602898) mitogen-activated protein ( 364)  554 53.5   1e-06
XP_006714469 (OMIM: 603442) PREDICTED: cyclin-depe ( 530)  559 54.1   1e-06
XP_016864298 (OMIM: 603442) PREDICTED: cyclin-depe ( 570)  559 54.1 1.1e-06
NP_001317653 (OMIM: 603442) cyclin-dependent kinas ( 570)  559 54.1 1.1e-06
NP_002960 (OMIM: 602399) mitogen-activated protein ( 367)  552 53.4 1.1e-06
NP_055735 (OMIM: 612325,612651) serine/threonine-p ( 632)  555 53.9 1.4e-06
XP_016865977 (OMIM: 612325,612651) PREDICTED: seri ( 632)  555 53.9 1.4e-06
NP_057597 (OMIM: 612325,612651) serine/threonine-p ( 632)  555 53.9 1.4e-06
XP_016865978 (OMIM: 612325,612651) PREDICTED: seri ( 632)  555 53.9 1.4e-06
XP_016865981 (OMIM: 612325,612651) PREDICTED: seri ( 632)  555 53.9 1.4e-06
XP_016865979 (OMIM: 612325,612651) PREDICTED: seri ( 632)  555 53.9 1.4e-06
XP_016865980 (OMIM: 612325,612651) PREDICTED: seri ( 632)  555 53.9 1.4e-06
XP_011512721 (OMIM: 612325,612651) PREDICTED: seri ( 639)  555 53.9 1.4e-06
XP_016865976 (OMIM: 612325,612651) PREDICTED: seri ( 639)  555 53.9 1.4e-06
XP_011512722 (OMIM: 612325,612651) PREDICTED: seri ( 639)  555 53.9 1.4e-06
XP_011512723 (OMIM: 612325,612651) PREDICTED: seri ( 639)  555 53.9 1.4e-06
XP_016865974 (OMIM: 612325,612651) PREDICTED: seri ( 639)  555 53.9 1.4e-06
XP_016865975 (OMIM: 612325,612651) PREDICTED: seri ( 639)  555 53.9 1.4e-06
XP_016870051 (OMIM: 610076) PREDICTED: cyclin-depe ( 329)  536 52.3 2.2e-06
NP_004187 (OMIM: 603441) cyclin-dependent kinase-l ( 358)  536 52.3 2.3e-06
XP_005268214 (OMIM: 603441) PREDICTED: cyclin-depe ( 358)  536 52.3 2.3e-06


>>NP_001139628 (OMIM: 605004) glycogen synthase kinase-3  (420 aa)
 initn: 2798 init1: 2798 opt: 2798  Z-score: 1062.8  bits: 205.7 E(85289): 1.8e-52
Smith-Waterman score: 2798; 100.0% identity (100.0% similar) in 420 aa overlap (1-420:1-420)

               10        20        30        40        50        60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
              370       380       390       400       410       420

>>XP_006713674 (OMIM: 605004) PREDICTED: glycogen syntha  (387 aa)
 initn: 2486 init1: 2463 opt: 2463  Z-score: 940.6  bits: 182.9 E(85289): 1.2e-45
Smith-Waterman score: 2518; 92.1% identity (92.1% similar) in 420 aa overlap (1-420:1-387)

               10        20        30        40        50        60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB5 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB5 NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
       :::::                                 ::::::::::::::::::::::
XP_006 NFTTQ---------------------------------DANTGDRGQTNNAASASASNST
                                               370       380       

>>NP_063937 (OMIM: 606784) glycogen synthase kinase-3 al  (483 aa)
 initn: 2131 init1: 2065 opt: 2082  Z-score: 799.9  bits: 157.2 E(85289): 8.2e-38
Smith-Waterman score: 2082; 78.1% identity (90.8% similar) in 401 aa overlap (21-420:84-483)

                         10        20        30        40        50
pF1KB5           MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDR
                                     ..:    :.  .:..:::::::: ::::.:
NP_063 GAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPER
            60        70        80        90       100       110   

               60        70        80        90       100       110
pF1KB5 PQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
        :::.::: ::::::::::::::.: .. :::::::::::::::::::::::::::::::
NP_063 SQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIV
           120       130       140       150       160       170   

              120       130       140       150       160       170
pF1KB5 RLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA
       :::::::::::::::.::::::.::::::::::::...:: :.:..:::.::::::::::
NP_063 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA
           180       190       200       210       220       230   

              180       190       200       210       220       230
pF1KB5 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
       :::: :.:::::::::::.:::::::::::::::::::::::::::::::::::::::::
NP_063 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFG
           240       250       260       270       280       290   

              240       250       260       270       280       290
pF1KB5 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_063 ATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTE
           300       310       320       330       340       350   

              300       310       320       330       340       350
pF1KB5 FKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKL
       :::::::::::::::. ::::::::::: ::::::..::.::::::::::::::  ...:
NP_063 FKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQL
           360       370       380       390       400       410   

              360       370       380       390        400         
pF1KB5 PNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAA-SDANTGDRGQTN
       ::.:  : ::::.. ::: .: : .:::::: :  :...: : .. : ... :..  :..
NP_063 PNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQST
           420       430       440       450       460       470   

     410       420
pF1KB5 NAASASASNST
       .: . . .::.
NP_063 DA-TPTLTNSS
            480   

>>XP_006713673 (OMIM: 605004) PREDICTED: glycogen syntha  (400 aa)
 initn: 2449 init1: 2034 opt: 2034  Z-score: 783.3  bits: 153.9 E(85289): 6.9e-37
Smith-Waterman score: 2482; 89.4% identity (89.4% similar) in 433 aa overlap (1-420:1-400)

               10        20        30        40        50        60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
              250       260       270       280       290       300

                           310       320       330       340       
pF1KB5 WTK-------------VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
       :::             ::::::::::::::::::::::::::::::::::::::::::::
XP_006 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
              310       320       330       340       350       360

       350       360       370       380       390       400       
pF1KB5 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
       ::::::::::::::::::                                 :::::::::
XP_006 VKLPNGRDTPALFNFTTQ---------------------------------DANTGDRGQ
              370                                        380       

       410       420
pF1KB5 TNNAASASASNST
       :::::::::::::
XP_006 TNNAASASASNST
       390       400

>>NP_002084 (OMIM: 605004) glycogen synthase kinase-3 be  (433 aa)
 initn: 2034 init1: 2034 opt: 2034  Z-score: 782.9  bits: 153.9 E(85289): 7.2e-37
Smith-Waterman score: 2762; 97.0% identity (97.0% similar) in 433 aa overlap (1-420:1-433)

               10        20        30        40        50        60
pF1KB5 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB5 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB5 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB5 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
              250       260       270       280       290       300

                           310       320       330       340       
pF1KB5 WTK-------------VFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
       :::             ::::::::::::::::::::::::::::::::::::::::::::
NP_002 WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
              310       320       330       340       350       360

       350       360       370       380       390       400       
pF1KB5 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQ
              370       380       390       400       410       420

       410       420
pF1KB5 TNNAASASASNST
       :::::::::::::
NP_002 TNNAASASASNST
              430   

>>NP_002737 (OMIM: 601795) mitogen-activated protein kin  (379 aa)
 initn: 537 init1: 263 opt: 612  Z-score: 262.8  bits: 57.5 E(85289): 6.7e-08
Smith-Waterman score: 619; 33.9% identity (63.4% similar) in 372 aa overlap (43-385:17-372)

             20        30        40        50                    60
pF1KB5 SCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVS------------YTDTK
                                     : : ::  : ::             ::. .
NP_002               MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQ
                             10        20        30        40      

               70        80          90          100       110     
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYF
        ::.:..:.: .:        :::::.  .. . . .:   :.::. .. : :.. .: .
NP_002 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI
         50        60        70        80        90       100      

         120        130       140       150       160       170    
pF1KB5 FYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS
       . .:  :   .::  .: : .   .:.. .     .: :   ..  ..::..:.: ::::
NP_002 LRASTLEAMRDVY--IVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHS
        110         120       130            140       150         

          180       190       200       210            220         
pF1KB5 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRAPELIF
        .. :::.::.:::..  :  ::.:::: :. ..  : .     . :. .:.:::::...
NP_002 ANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIML
     160       170        180        190       200       210       

     230       240       250       260       270       280         
pF1KB5 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR---EMNP
       ..  ::.:::.::.::.:::.: ..:::::   .::: .:. .::.:..:..    .:. 
NP_002 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA
       220       230       240       250       260       270       

         290       300       310       320       330       340     
pF1KB5 -NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD
        :: . ..:.     :.:.: :..  .:. : .:.: ..:. :.:  :: :: ....  :
NP_002 RNYLQ-SLPSKTKVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD
       280        290        300       310       320       330     

         350       360       370         380       390       400   
pF1KB5 PNVKLPNGRDTPALFNFTTQELSSNPP--LATILIPPHARIQAAASTPTNATAASDANTG
       :. . : ... :  :.:. .::.. :   :  ...   ::.:                  
NP_002 PTDE-PVAEE-P--FTFA-MELDDLPKERLKELIFQETARFQPGVLEAP           
          340           350       360       370                    

           410       420
pF1KB5 DRGQTNNAASASASNST

>>NP_001035145 (OMIM: 601795) mitogen-activated protein   (357 aa)
 initn: 537 init1: 263 opt: 606  Z-score: 260.9  bits: 57.0 E(85289): 8.6e-08
Smith-Waterman score: 613; 34.7% identity (63.7% similar) in 331 aa overlap (43-346:17-336)

             20        30        40        50                    60
pF1KB5 SCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVS------------YTDTK
                                     : : ::  : ::             ::. .
NP_001               MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQ
                             10        20        30        40      

               70        80          90          100       110     
pF1KB5 VIGNGSFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYF
        ::.:..:.: .:        :::::.  .. . . .:   :.::. .. : :.. .: .
NP_001 YIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDI
         50        60        70        80        90       100      

         120        130       140       150       160       170    
pF1KB5 FYSSG-EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS
       . .:  :   .::  .: : .   .:.. .     .: :   ..  ..::..:.: ::::
NP_001 LRASTLEAMRDVY--IVQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHS
        110         120       130            140       150         

          180       190       200       210            220         
pF1KB5 FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRAPELIF
        .. :::.::.:::..  :  ::.:::: :. ..  : .     . :. .:.:::::...
NP_001 ANVLHRDLKPSNLLINT-TCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIML
     160       170        180        190       200       210       

     230       240       250       260       270       280         
pF1KB5 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR---EMNP
       ..  ::.:::.::.::.:::.: ..:::::   .::: .:. .::.:..:..    .:. 
NP_001 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA
       220       230       240       250       260       270       

         290       300       310       320       330       340     
pF1KB5 -NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD
        :: . ..:.     :.:.: :..  .:. : .:.: ..:. :.:  :: :: ....  :
NP_001 RNYLQ-SLPSKTKVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD
       280        290        300       310       320       330     

         350       360       370       380       390       400     
pF1KB5 PNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDR
       :                                                           
NP_001 PTDEVGQSPAAVGLGAGEQGGT                                      
         340       350                                             

>>NP_001789 (OMIM: 116953) cyclin-dependent kinase 2 iso  (298 aa)
 initn: 454 init1: 337 opt: 597  Z-score: 258.5  bits: 56.3 E(85289): 1.2e-07
Smith-Waterman score: 597; 34.2% identity (65.8% similar) in 304 aa overlap (55-346:3-292)

           30        40        50        60        70        80    
pF1KB5 SMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAI
                                     ..  .. ::.:..::::.:.   .::.::.
NP_001                             MENFQKVEKIGEGTYGVVYKARNKLTGEVVAL
                                           10        20        30  

           90             100       110       120       130        
pF1KB5 KKVLQDKRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPET
       ::.  : . ..      ::......:.: :::.:   ...  :.:    : ::.... . 
NP_001 KKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT--ENK----LYLVFEFLHQD
             40        50        60        70              80      

      140       150       160       170       180       190        
pF1KB5 VYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKL
       . .     . :   .:.  .: :..::...::. ::  . :::.::::::.. . :. ::
NP_001 LKKFMD--ASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI-KL
         90         100       110       120       130       140    

      200       210          220       230       240       250     
pF1KB5 CDFGSAKQLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQP
        ::: :. .  : :  .:   . . .:::::...:   :....:.:: ::..::..  . 
NP_001 ADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRA
           150         160       170       180       190       200 

         260       270          280       290       300       310  
pF1KB5 IFPGDSGVDQLVEIIKVLGTPTR---EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPE
       .::::: .::: .:...:::: .     .  : :.:   .::.   . ..::  :    .
NP_001 LFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM-PDYKP-SFPKWARQDFSKVV-PPLDED
             210       220       230         240       250         

            320       330       340       350       360       370  
pF1KB5 AIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPP
       . .: :..:.: :. :..   : :: ::...  :                          
NP_001 GRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL                    
      260       270       280       290                            

            380       390       400       410       420
pF1KB5 LATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST

>>NP_001249 (OMIM: 123828) cyclin-dependent kinase 3 [Ho  (305 aa)
 initn: 537 init1: 370 opt: 594  Z-score: 257.3  bits: 56.2 E(85289): 1.4e-07
Smith-Waterman score: 594; 35.4% identity (67.0% similar) in 291 aa overlap (62-340:10-286)

              40        50        60        70        80        90 
pF1KB5 KDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK
                                     ::.:..::::.::  ..:.:::.::.  : 
NP_001                      MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDL
                                    10        20        30         

                   100       110       120       130       140     
pF1KB5 RFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARH
       ....      ::......: : :::::    ..  :.:    : ::.... . . .    
NP_001 EMEGVPSTAIREISLLKELKHPNIVRLLDVVHN--ERK----LYLVFEFLSQDLKKYMD-
      40        50        60        70              80        90   

         150       160       170       180       190       200     
pF1KB5 YSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAK
        :   . ::.  .: :..::...... ::  . :::.::::::.. . ...:: ::: :.
NP_001 -STPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLAR
             100       110       120       130        140       150

         210          220       230       240       250       260  
pF1KB5 QLVRGEPNVSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSG
        .  : :  .:   . . .:::::...:.  ::...:.:: ::..::..  . .::::: 
NP_001 AF--GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSE
                160       170       180       190       200        

            270       280          290       300       310         
pF1KB5 VDQLVEIIKVLGTPTREQ---IREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSR
       .::: .:...::::...    . .. :.: . .::.   .   ..  :   ::.  :  .
NP_001 IDQLFRIFRMLGTPSEDTWPGVTQL-PDY-KGSFPKWTRKGLEEIV-PNLEPEGRDLLMQ
      210       220       230         240       250        260     

     320       330       340       350       360       370         
pF1KB5 LLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIP
       ::.: :. :.:   : :: .:                                       
NP_001 LLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH                    
         270       280       290       300                         

>>NP_002736 (OMIM: 176948) mitogen-activated protein kin  (360 aa)
 initn: 504 init1: 263 opt: 596  Z-score: 257.2  bits: 56.4 E(85289): 1.4e-07
Smith-Waterman score: 596; 32.2% identity (64.0% similar) in 367 aa overlap (42-385:5-355)

              20        30        40          50            60     
pF1KB5 ESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPD--RPQ--EVS--YTDTKVIGNG
                                     :. : ::.  : :  .:.  ::. . ::.:
NP_002                           MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEG
                                         10        20        30    

          70        80          90          100       110          
pF1KB5 SFGVVYQAKLCDSGELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYS-S
       ..:.: .:    .   :::::.  .. . . .:   :..:. .. : ::. .  .. . .
NP_002 AYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT
           40        50        60        70        80        90    

     120       130       140       150       160       170         
pF1KB5 GEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICH
        :.  .::  .: : .   .:.. .      : :   ..  ..::..:.: :::: .. :
NP_002 IEQMKDVY--IVQDLMETDLYKLLK-----TQHLSNDHICYFLYQILRGLKYIHSANVLH
          100         110            120       130       140       

     180       190       200       210              220       230  
pF1KB5 RDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN-------VSYICSRYYRAPELIFGAT
       ::.::.::::.  :  ::.:::: :.    ..:.       . :. .:.:::::..... 
NP_002 RDLKPSNLLLNT-TCDLKICDFGLARV---ADPDHDHTGFLTEYVATRWYRAPEIMLNSK
       150        160       170          180       190       200   

            240       250       260       270       280            
pF1KB5 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM----NPNY
        ::.:::.::.::.:::.: ..:::::   .::: .:. .::.:..:..  .      ::
NP_002 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNY
           210       220       230       240       250       260   

      290       300       310       320       330       340        
pF1KB5 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNV
         ...:. .  ::...: : .  .:. : ...: ..:  :.   .: :: ....  ::. 
NP_002 L-LSLPHKNKVPWNRLF-PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD
            270        280       290       300       310       320 

      350       360       370       380       390       400        
pF1KB5 KLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQT
       . : . ..:  :..  ..: ..  :  ...   ::.:                       
NP_002 E-PIA-EAPFKFDMELDDLPKEK-LKELIFEETARFQPGYRS                  
               330       340        350       360                  

      410       420
pF1KB5 NNAASASASNST




420 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 16:07:30 2016 done: Thu Nov  3 16:07:32 2016
 Total Scan time:  9.270 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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