Result of FASTA (omim) for pF1KB4571
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4571, 615 aa
  1>>>pF1KB4571 615 - 615 aa - 615 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.2396+/-0.000406; mu= 9.8719+/- 0.025
 mean_var=131.7426+/-26.365, 0's: 0 Z-trim(115.5): 36  B-trim: 14 in 1/56
 Lambda= 0.111741
 statistics sampled from 25972 (26007) to 25972 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.305), width:  16
 Scan time:  9.150

The best scores are:                                      opt bits E(85289)
NP_002287 (OMIM: 169400,215140,600024,613471) lami ( 615) 4128 677.5 3.8e-194
NP_919424 (OMIM: 169400,215140,600024,613471) lami ( 615) 4128 677.5 3.8e-194
XP_011542487 (OMIM: 169400,215140,600024,613471) P ( 615) 4128 677.5 3.8e-194
XP_005273182 (OMIM: 169400,215140,600024,613471) P ( 573) 2623 434.8 3.8e-121
NP_003264 (OMIM: 603414) delta(14)-sterol reductas ( 418) 1676 282.1 2.7e-75
NP_001264162 (OMIM: 603414) delta(14)-sterol reduc ( 391)  551 100.7   1e-20
XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-de ( 456)  430 81.2 8.5e-15
NP_001351 (OMIM: 270400,602858) 7-dehydrocholester ( 475)  425 80.4 1.5e-14
NP_001157289 (OMIM: 270400,602858) 7-dehydrocholes ( 475)  425 80.4 1.5e-14


>>NP_002287 (OMIM: 169400,215140,600024,613471) lamin-B   (615 aa)
 initn: 4128 init1: 4128 opt: 4128  Z-score: 3606.6  bits: 677.5 E(85289): 3.8e-194
Smith-Waterman score: 4128; 99.8% identity (100.0% similar) in 615 aa overlap (1-615:1-615)

               10        20        30        40        50        60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
       :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_002 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
              550       560       570       580       590       600

              610     
pF1KB4 KYCQRVPYRIFPYIY
       :::::::::::::::
NP_002 KYCQRVPYRIFPYIY
              610     

>>NP_919424 (OMIM: 169400,215140,600024,613471) lamin-B   (615 aa)
 initn: 4128 init1: 4128 opt: 4128  Z-score: 3606.6  bits: 677.5 E(85289): 3.8e-194
Smith-Waterman score: 4128; 99.8% identity (100.0% similar) in 615 aa overlap (1-615:1-615)

               10        20        30        40        50        60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
       :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
NP_919 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_919 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
              550       560       570       580       590       600

              610     
pF1KB4 KYCQRVPYRIFPYIY
       :::::::::::::::
NP_919 KYCQRVPYRIFPYIY
              610     

>>XP_011542487 (OMIM: 169400,215140,600024,613471) PREDI  (615 aa)
 initn: 4128 init1: 4128 opt: 4128  Z-score: 3606.6  bits: 677.5 E(85289): 3.8e-194
Smith-Waterman score: 4128; 99.8% identity (100.0% similar) in 615 aa overlap (1-615:1-615)

               10        20        30        40        50        60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
       :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_011 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
              550       560       570       580       590       600

              610     
pF1KB4 KYCQRVPYRIFPYIY
       :::::::::::::::
XP_011 KYCQRVPYRIFPYIY
              610     

>>XP_005273182 (OMIM: 169400,215140,600024,613471) PREDI  (573 aa)
 initn: 3856 init1: 2615 opt: 2623  Z-score: 2295.9  bits: 434.8 E(85289): 3.8e-121
Smith-Waterman score: 3776; 93.0% identity (93.2% similar) in 615 aa overlap (1-615:1-573)

               10        20        30        40        50        60
pF1KB4 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFNLSQESSYIATQYSLRPRREEVKLKEI
       :::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::
XP_005 ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB4 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB4 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
       ::::::::::::::::::::::::::::::::::::                        
XP_005 SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGW------------------------
              370       380       390                              

              430       440       450       460       470       480
pF1KB4 ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
                         ::::::::::::::::::::::::::::::::::::::::::
XP_005 ------------------EALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
                          400       410       420       430        

              490       500       510       520       530       540
pF1KB4 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
      440       450       460       470       480       490        

              550       560       570       580       590       600
pF1KB4 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
      500       510       520       530       540       550        

              610     
pF1KB4 KYCQRVPYRIFPYIY
       :::::::::::::::
XP_005 KYCQRVPYRIFPYIY
      560       570   

>>NP_003264 (OMIM: 603414) delta(14)-sterol reductase is  (418 aa)
 initn: 1419 init1: 1081 opt: 1676  Z-score: 1472.8  bits: 282.1 E(85289): 2.7e-75
Smith-Waterman score: 1676; 59.0% identity (81.0% similar) in 410 aa overlap (207-615:11-418)

        180       190       200       210       220       230      
pF1KB4 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
                                     :::::  :.  ... ::. .: :::  .. 
NP_003                     MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
                                   10        20        30        40

        240       250       260       270       280       290      
pF1KB4 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
          ::. :  ::.:  ::  :.. ..: :. .:. .::::  ::.::  : :  ::.: .
NP_003 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
               50        60        70        80        90       100

        300       310       320       330       340       350      
pF1KB4 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
       ::: :..::. ..: ..  :. .  .   .: .:..::.   ..:..:::..  :: . :
NP_003 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
              110       120       130       140       150       160

         360       370       380       390       400       410     
pF1KB4 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV
       .:. .::: .::::.::::::::  ::.::::::::::::::.:::..:. : ..  :. 
NP_003 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS
              170       180       190       200       210          

         420       430       440       450       460       470     
pF1KB4 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL
       ::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .:
NP_003 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL
      220       230       240       250       260       270        

         480       490       500       510       520       530     
pF1KB4 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL
       . ::. .. ::::.: ...  :: ::::::::::.::::::::..: :.:: :.::..::
NP_003 LHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLL
      280       290       300       310       320       330        

         540       550       560       570       580       590     
pF1KB4 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY
       ::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .::
NP_003 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY
      340       350       360       370       380       390        

         600       610     
pF1KB4 GVAWEKYCQRVPYRIFPYIY
       :.::..::.::::::.::::
NP_003 GLAWQEYCRRVPYRIMPYIY
      400       410        

>>NP_001264162 (OMIM: 603414) delta(14)-sterol reductase  (391 aa)
 initn: 1255 init1: 551 opt: 551  Z-score: 493.1  bits: 100.7 E(85289): 1e-20
Smith-Waterman score: 1468; 54.4% identity (75.4% similar) in 410 aa overlap (207-615:11-391)

        180       190       200       210       220       230      
pF1KB4 LKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQK
                                     :::::  :.  ... ::. .: :::  .. 
NP_001                     MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSG
                                   10        20        30        40

        240       250       260       270       280       290      
pF1KB4 DPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRL
          ::. :  ::.:  ::  :.. ..: :. .:. .::::  ::.::  : :  ::.: .
NP_001 PARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPI
               50        60        70        80        90       100

        300       310       320       330       340       350      
pF1KB4 NGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDL
       ::: :..::. ..: ..  :. .  .   .: .:..::.   ..:..:::..  :: . :
NP_001 NGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSAL
              110       120       130       140       150       160

         360       370       380       390       400       410     
pF1KB4 SPA-SSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAV
       .:. .::: .::::.::::::::  ::.::::::::::::::.:::..:. : ..  :. 
NP_001 APGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAEL--RGS
              170       180       190       200       210          

         420       430       440       450       460       470     
pF1KB4 PSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYL
       ::::: :::.:::::: ::::.:::.:::::: ::::::::::::..:::: ::.:: .:
NP_001 PSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFL
      220       230       240       250       260       270        

         480       490       500       510       520       530     
pF1KB4 VSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLL
       . ::. .. ::::.:     :   .. :                   :.:: :.::..::
NP_001 LHHPQPLGLPMASVI-----C---LING-------------------LETISTATGRKLL
      280       290                                  300       310 

         540       550       560       570       580       590     
pF1KB4 VSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKY
       ::::::.::::::::::::::::::::: .:.:::::..::: :::::::::: .: .::
NP_001 VSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKY
             320       330       340       350       360       370 

         600       610     
pF1KB4 GVAWEKYCQRVPYRIFPYIY
       :.::..::.::::::.::::
NP_001 GLAWQEYCRRVPYRIMPYIY
             380       390 

>>XP_011543079 (OMIM: 270400,602858) PREDICTED: 7-dehydr  (456 aa)
 initn: 406 init1: 215 opt: 430  Z-score: 386.7  bits: 81.2 E(85289): 8.5e-15
Smith-Waterman score: 453; 28.9% identity (62.2% similar) in 294 aa overlap (203-471:31-321)

            180       190       200        210       220       230 
pF1KB4 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
                                     :: ... :. .  .::..:. : ... ...
XP_011 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
               10        20        30        40        50          

             240           250             260       270           
pF1KB4 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
        : : . .:    ...      : ..:        ..  .: ::  .:::.:        
XP_011 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
      60        70        80        90       100       110         

              280       290       300         310       320        
pF1KB4 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
        .::  .: . ::.    :   ::..::. :..::  .   .. :..      ...... 
XP_011 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
     120       130       140       150       160       170         

      330       340       350       360       370       380        
pF1KB4 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
       .   :...  ..:.. ....   : .  .   .::  :....: :.:::::  ::.: : 
XP_011 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
     180       190       200       210       220       230         

       390       400       410       420       430       440       
pF1KB4 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
       . :::...:..::: .   . .......   ::.::: .: .::.: .:::   : :.::
XP_011 NGRPGIVAWTLINLSFAAKQRELHSHVTN--AMVLVNVLQAIYVIDFFWNETWYLKTIDI
     240       250       260         270       280       290       

       450       460       470       480       490       500       
pF1KB4 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
        :: ::..:..:: ::.:..:..:                                    
XP_011 CHDHFGWYLGWGDCVWLPYLYTLQKRTRRQGVCQRQSWGLTPGRWAPEPTLLSSPWAKHR
       300       310       320       330       340       350       

>>NP_001351 (OMIM: 270400,602858) 7-dehydrocholesterol r  (475 aa)
 initn: 881 init1: 355 opt: 425  Z-score: 382.1  bits: 80.4 E(85289): 1.5e-14
Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (203-615:31-475)

            180       190       200        210       220       230 
pF1KB4 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
                                     :: ... :. .  .::..:. : ... ...
NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
               10        20        30        40        50          

             240           250             260       270           
pF1KB4 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
        : : . .:    ...      : ..:        ..  .: ::  .:::.:        
NP_001 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
      60        70        80        90       100       110         

              280       290       300         310       320        
pF1KB4 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
        .::  .: . ::.    :   ::..::. :..::  .   .. :..      ...... 
NP_001 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
     120       130       140       150       160       170         

      330       340       350       360       370       380        
pF1KB4 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
       .   :...  ..:.. ....   : .  .   .::  :....: :.:::::  ::.: : 
NP_001 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
     180       190       200       210       220       230         

       390       400       410       420       430       440       
pF1KB4 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
       . :::...:..::: .   . ......  . ::.::: .: .::.: .:::   : :.::
NP_001 NGRPGIVAWTLINLSFAAKQRELHSHV--TNAMVLVNVLQAIYVIDFFWNETWYLKTIDI
     240       250       260         270       280       290       

       450       460       470       480       490       500       
pF1KB4 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
        :: ::..:..:: ::.:..:..:..::: :: ..: : :  ...: : :: ::: :: :
NP_001 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ
       300       310       320       330       340       350       

       510              520       530           540       550      
pF1KB4 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL
       :. ::.. .        ::. .  .  .. :.    .:::::.:: .:: ::.:::. .:
NP_001 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL
       360       370       380        390       400       410      

        560       570       580       590       600       610     
pF1KB4 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
       :. : :: .:.::::::::...::.::  :::..: .:::  ::.:   ::::..: :.
NP_001 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
        420       430       440       450       460       470     

>>NP_001157289 (OMIM: 270400,602858) 7-dehydrocholestero  (475 aa)
 initn: 881 init1: 355 opt: 425  Z-score: 382.1  bits: 80.4 E(85289): 1.5e-14
Smith-Waterman score: 911; 35.0% identity (65.0% similar) in 449 aa overlap (203-615:31-475)

            180       190       200        210       220       230 
pF1KB4 EEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLE-FGGVPGVFLIMFGLPVFLFLLLL
                                     :: ... :. .  .::..:. : ... ...
NP_001 MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFA-PFIVYYFIM
               10        20        30        40        50          

             240           250             260       270           
pF1KB4 MCKQKDPSL----LNFPPPLPALYELWET------RVFGVYLLWFLIQVLFY--------
        : : . .:    ...      : ..:        ..  .: ::  .:::.:        
NP_001 ACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCH
      60        70        80        90       100       110         

              280       290       300         310       320        
pF1KB4 -LLP--IGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQ
        .::  .: . ::.    :   ::..::. :..::  .   .. :..      ...... 
NP_001 KFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIP
     120       130       140       150       160       170         

      330       340       350       360       370       380        
pF1KB4 FALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGT-FDLKYFC
       .   :...  ..:.. ....   : .  .   .::  :....: :.:::::  ::.: : 
NP_001 LLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFF
     180       190       200       210       220       230         

       390       400       410       420       430       440       
pF1KB4 ELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDI
       . :::...:..::: .   . ......  . ::.::: .: .::.: .:::   : :.::
NP_001 NGRPGIVAWTLINLSFAAKQRELHSHV--TNAMVLVNVLQAIYVIDFFWNETWYLKTIDI
     240       250       260         270       280       290       

       450       460       470       480       490       500       
pF1KB4 IHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQ
        :: ::..:..:: ::.:..:..:..::: :: ..: : :  ...: : :: ::: :: :
NP_001 CHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQ
       300       310       320       330       340       350       

       510              520       530           540       550      
pF1KB4 KNAFRKNPS-------DPKLAHLKTIHTSTGK----NLLVSGWWGFVRHPNYLGDLIMAL
       :. ::.. .        ::. .  .  .. :.    .:::::.:: .:: ::.:::. .:
NP_001 KDLFRRTDGRCLIWGRKPKVIEC-SYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSL
       360       370       380        390       400       410      

        560       570       580       590       600       610     
pF1KB4 AWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
       :. : :: .:.::::::::...::.::  :::..: .:::  ::.:   ::::..: :.
NP_001 AYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
        420       430       440       450       460       470     




615 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 15:09:43 2016 done: Thu Nov  3 15:09:44 2016
 Total Scan time:  9.150 Total Display time:  0.050

Function used was FASTA [36.3.4 Apr, 2011]
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